19 results on '"Picca, Stefano"'
Search Results
2. Gravity-assisted continuous flow peritoneal dialysis technique use in acute kidney injury in children: a randomized, crossover clinical trial.
- Author
-
Nourse, Peter, McCulloch, Mignon, Coetzee, Ashton, Bunchman, Tim, Picca, Stefano, Rusch, Jody, Brooks, Andre, Heydenrych, Hilton, and Morrow, Brenda
- Subjects
PILOT projects ,CONTINUOUS ambulatory peritoneal dialysis ,UREA ,PERITONEAL dialysis ,MEDICAL care costs ,TREATMENT effectiveness ,RANDOMIZED controlled trials ,T-test (Statistics) ,DESCRIPTIVE statistics ,CROSSOVER trials ,STATISTICAL sampling ,ACUTE kidney failure ,CREATININE ,PHOSPHATES ,EVALUATION ,CHILDREN - Abstract
Background: Our previously demonstrated continuous flow peritoneal dialysis (CFPD) technique in children with acute kidney injury (AKI), although effective, was manpower heavy and expensive due to the high-volume pumps required. The aim of this study was to develop and test a novel gravity-driven CFPD technique in children using readily available, inexpensive equipment and to compare this technique to conventional PD. Methods: After development and initial in vitro testing, a randomised crossover clinical trial was conducted in 15 children with AKI requiring dialysis. Patients received both conventional PD and CFPD sequentially, in random order. Primary outcomes were measures of feasibility, clearance and ultrafiltration (UF). Secondary outcomes were complications and mass transfer coefficients (MTC). Paired t-tests were used to compare PD and CFPD outcomes. Results: Median (range) age and weight of participants were 6.0 (0.2–14) months and 5.8 (2.3–14.0) kg, respectively. The CFPD system was easily and rapidly assembled. There were no serious adverse events attributed to CFPD. Mean ± SD UF was significantly higher on CFPD compared to conventional PD (4.3 ± 3.15 ml/kg/h vs. 1.04 ± 1.72 ml/kg/h; p < 0.001). Clearances for urea, creatinine and phosphate for children on CFPD were 9.9 ± 3.10 ml/min/1.73 m
2 , 7.9 ± 3.3 ml/min/1.73 m2 and 5.5 ± 1.5 ml/min/1.73 m2 compared to conventional PD with values of 4.3 ± 1.68 ml/min/1.73 m2 , 3.57 ± 1.3 ml/min/1.73 m2 and 2.53 ± 0.85 ml/min/1.73 m2 , respectively (all p < 0.001). Conclusion: Gravity-assisted CFPD appears to be a feasible and effective way to augment ultrafiltration and clearances in children with AKI. It can be assembled from readily available non-expensive equipment. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
3. Dialysis modalities for the management of pediatric acute kidney injury.
- Author
-
de Galasso, Lara, Picca, Stefano, and Guzzo, Isabella
- Subjects
ACUTE kidney failure ,ANTICOAGULANTS ,HEMODIALYSIS ,KIDNEY diseases ,PEDIATRICS ,PERITONEAL dialysis ,THERAPEUTICS - Abstract
Acute kidney injury (AKI) is an increasingly frequent complication among hospitalized children. It is associated with high morbidity and mortality, especially in neonates and children requiring dialysis. The different renal replacement therapy (RRT) options for AKI have expanded from peritoneal dialysis (PD) and intermittent hemodialysis (HD) to continuous RRT (CRRT) and hybrid modalities. Recent advances in the provision of RRT in children allow a higher standard of care for increasingly ill and young patients. In the absence of evidence indicating better survival with any dialysis method, the most appropriate dialysis choice for children with AKI is based on the patient's characteristics, on dialytic modality performance, and on the institutional resources and local practice. In this review, the available dialysis modalities for pediatric AKI will be discussed, focusing on indications, advantages, and limitations of each of them. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
4. Chronic haemodialysis in small children: a retrospective study of the Italian Pediatric Dialysis Registry.
- Author
-
Paglialonga, Fabio, Consolo, Silvia, Pecoraro, Carmine, Vidal, Enrico, Gianoglio, Bruno, Puteo, Flora, Picca, Stefano, Saravo, Maria, Edefonti, Alberto, and Verrina, Enrico
- Subjects
ANEMIA ,BLOOD vessels ,COMPUTED tomography ,REPORTING of diseases ,HEMODIALYSIS ,KIDNEY transplantation ,MEDICAL equipment ,SURVIVAL analysis (Biometry) ,ULTRASONIC imaging ,RETROSPECTIVE studies ,CENTRAL venous catheters - Abstract
Background: Chronic haemodialysis (HD) in small children has not been adequately investigated. Methods: This was a retrospective investigation of the use of chronic HD in 21 children aged <2 years ( n = 12 aged <1 year) who were registered in the Italian Pediatric Dialysis Registry. Data collected over a period of >10 years were analysed. Results: The median age of the 21 children at start of HD was 11.4 [interquartile range (IQR) 6.2-14.6] months, and HD consisted mainly of haemodiafiltration for 3-4 h in ≥4 sessions/week. A total of 51 central venous catheters were placed, and the median survival of tunnelled and temporary lines was 349 and 31 days, respectively ( p < 0.001). Eight children (38 %) showed evidence of central vein thrombosis. Although 19 % of patients received growth hormone and 63.6 % received enteral feeding, the weight and height of these patients remained suboptimal. During the HD period the haemoglobin level increased in all patients, but not to normal levels (from 8.5 to 9.6 g/dl) despite erythropoietin administration (503-600 U/kg/week). The hospitalisation rate was 1.94/patient-year. Seventeen patients underwent renal transplantation at a median age of 3.0 years. Four patients, all affected by severe comorbidities, died during follow-up (in 2 cases due to absence of a vascular access). The 5- and 10-year cumulative survival was 82.4 and 68.7 %, respectively. Conclusions: Extracorporeal dialysis is feasible in children aged <2 years, but comorbidities, vascular access, growth and anaemia remain major concerns. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
5. Liver transplant in ethylmalonic encephalopathy: a new treatment for an otherwise fatal disease.
- Author
-
Dionisi-Vici, Carlo, Diodato, Daria, Torre, Giuliano, Picca, Stefano, Pariante, Rosanna, Picardo, Sergio Giuseppe, Di Meo, Ivano, Rizzo, Cristiano, Tiranti, Valeria, Zeviani, Massimo, De Goyet, Jean De Ville, Giuseppe Picardo, Sergio, and De Ville De Goyet, Jean
- Subjects
LIVER transplantation ,MITOCHONDRIAL pathology ,HYDROGEN sulfide ,GENETIC transformation ,THIOSULFATES - Abstract
Ethylmalonic encephalopathy is a fatal, rapidly progressive mitochondrial disorder caused by ETHE1 mutations, whose peculiar clinical and biochemical features are due to the toxic accumulation of hydrogen sulphide and of its metabolites, including thiosulphate. In mice with ethylmalonic encephalopathy, liver-targeted adeno-associated virus-mediated ETHE1 gene transfer dramatically improved both clinical course and metabolic abnormalities. Reasoning that the same achievement could be accomplished by liver transplantation, we performed living donor-liver transplantation in an infant with ethylmalonic encephalopathy. Unlike the invariably progressive deterioration of the disease, 8 months after liver transplantation, we observed striking neurological improvement with remarkable achievements in psychomotor development, along with dramatic reversion of biochemical abnormalities. These results clearly indicate that liver transplantation is a viable therapeutic option for ETHE1 disease. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
6. Continuous renal replacement therapy in children: fluid overload does not always predict mortality.
- Author
-
Galasso, Lara, Emma, Francesco, Picca, Stefano, Nardo, Matteo, Rossetti, Emanuele, and Guzzo, Isabella
- Subjects
TREATMENT of acute kidney failure ,CATASTROPHIC illness ,CHI-squared test ,CHILD mortality ,CONFIDENCE intervals ,DIAGNOSIS ,FISHER exact test ,HEMODIALYSIS ,INTENSIVE care units ,PEDIATRICS ,PROBABILITY theory ,REGRESSION analysis ,SURVIVAL analysis (Biometry) ,SURVIVAL ,T-test (Statistics) ,WATER-electrolyte imbalances ,MULTIPLE regression analysis ,RETROSPECTIVE studies ,SEVERITY of illness index ,DATA analysis software ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,ODDS ratio ,MANN Whitney U Test ,CHILDREN - Abstract
Background: Mortality among critically ill children requiring continuous renal replacement therapy (CRRT) is high. Several factors have been identified as outcome predictors. Many studies have specifically reported a positive association between the fluid overload at CRRT initiation and the mortality of critically ill pediatric patients. Methods: This study is a retrospective single-center analysis including all patients admitted to the pediatric intensive care unit (PICU) of our hospital who received CRRT between 2000 and 2012. One hundred thirty-one patients were identified and subsequently classified according to primary disease. Survival rates, severity of illness and fluid balance differed among subgroups. The primary outcome was patient survival to PICU discharge. Results: Overall survival to PICU discharge was 45.8 %. Based on multiple regression analysis, mortality was independently associated with onco-hematological disease [odds ratio (OR) 11.7, 95 % confidence interval (CI) 1.3-104.7; p = 0.028], severe multiple organ dysfunction syndrome (MODS) (OR 5.1, 95 % CI 1.7-15; p = 0.003) and hypotension (OR 11.6, 95 % CI 1.4-93.2; p = 0.021). In the subgroup analysis, a fluid overload (FO) of more than 10 % (FO>10 %) at the beginning of CRRT seems to be a negative predictor of mortality (OR 10.9, 95 % CI 0.78-152.62; p = 0.07) only in children with milder disease (renal patients). Due to lack of statistical power, the independent effect of fluid overload on mortality could not be analyzed in all subgroups of patients. Conclusions: In children treated with CRRT the underlying diagnosis and severity of illness are independent risk factors for mortality. The degree of FO is a negative predictor only in patients with milder disease. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
7. Short-term survival of hyperammonemic neonates treated with dialysis.
- Author
-
Picca, Stefano, Dionisi-Vici, Carlo, Bartuli, Andrea, De Palo, Tommaso, Papadia, Francesco, Montini, Giovanni, Materassi, Marco, Donati, Maria, Verrina, Enrico, Schiaffino, Maria, Pecoraro, Carmine, Iaccarino, Emilia, Vidal, Enrico, Burlina, Alberto, and Emma, Francesco
- Subjects
METABOLIC disorder treatment ,AMMONIA ,APGAR score ,CONFIDENCE intervals ,CONTINUOUS arteriovenous hemofiltration ,FISHER exact test ,HEMODIALYSIS ,MEDICAL cooperation ,INBORN errors of metabolism ,PERITONEAL dialysis ,RESEARCH ,SURVIVAL analysis (Biometry) ,SURVIVAL ,T-test (Statistics) ,RETROSPECTIVE studies ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio ,MANN Whitney U Test ,DISEASE complications ,CHILDREN - Abstract
Background: In severe neonatal hyperammonemia, extracorporeal dialysis (ECD) provides higher ammonium clearance than peritoneal dialysis (PD). However, there are limited outcome data in relation to dialysis modality. Methods: Data from infants with hyperammonemia secondary to inborn errors of metabolism (IEM) treated with dialysis were collected in six Italian centers and retrospectively analyzed. Results: Forty-five neonates born between 1990 and 2011 were enrolled in the study. Of these, 23 were treated with PD and 22 with ECD (14 with continuous venovenous hemodialysis [CVVHD], 5 with continuous arteriovenous hemodialysis [CAVHD], 3 with hemodialysis [HD]). Patients treated with PD experienced a shorter duration of predialysis coma, while those treated with HD had a shorter ammonium decay time compared with all the other patients ( p < 0.05). No difference in ammonium reduction rate was observed between patients treated with PD, CAVHD or CVVHD. Carbamoyl phosphate synthetase deficiency (CPS) was significantly associated with increased risk of death (OR: 9.37 [1.52-57.6], p = 0.016). Predialysis ammonium levels were significantly associated with a composite end-point of death or neurological sequelae (adjusted OR: 1.13 [1.02-1.27] per 100 μmol/l, p = 0.026). No association was found between outcome and dialysis modality. Conclusions: In this study, a delayed ECD treatment was not superior to PD in improving the short-term outcome of neonates with hyperammonemia secondary to IEM. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
8. ANTERIOR ISCHEMIC OPTICAL NEUROPATHY IN CHILDREN ON CHRONIC PERITONEAL DIALYSIS: REPORT OF 7 CASES.
- Author
-
Di Zazzo, Giacomo, Guzzo, Isabella, De Galasso, Lara, Fortunato, Michele, Leozappa, Giovanna, Peruzzi, Licia, Vidal, Enrico, Corrado, Ciro, Verrina, Enrico, Picca, Stefano, and Emma, Francesco
- Published
- 2015
- Full Text
- View/download PDF
9. Pediatric RIFLE for Acute Kidney Injury Diagnosis and Prognosis for Children Undergoing Cardiac Surgery: A Single-Center Prospective Observational Study.
- Author
-
Ricci, Zaccaria, Di Nardo, Matteo, Iacoella, Claudia, Netto, Roberta, Picca, Stefano, and Cogo, Paola
- Subjects
KIDNEY injuries ,PROGNOSIS ,CARDIAC surgery ,INTENSIVE care units ,CARDIOPULMONARY bypass - Abstract
This study evaluated the performance of the pediatric RIFLE (pRIFLE) score for acute kidney injury (AKI) diagnosis and prognosis after pediatric cardiac surgery. It was a single-center prospective observational study developed in a pediatric cardiac intensive care unit (pCICU) of a tertiary children's hospital. The study enrolled 160 consecutive children younger than 1 year with congenital heart diseases and undergoing cardiac surgery with cardiopulmonary bypass. Of the 160 children, 50 (31 %) were neonates, and 20 (12 %) had a univentricular heart. Palliative surgery was performed for 53 patients (33 %). A diagnosis of AKI was determined for 90 patients (56 %), and 68 (42 %) of these patients achieved an 'R' level of AKI severity, 17 patients (10 %) an 'I' level, and 5 patients (3 %) an 'F' level. Longer cross-clamp times ( p = 0.045), a higher inotropic score ( p = 0.02), and a higher Risk-Adjusted Classification for Congenital Heart Surgery score ( p = 0.048) but not age ( p = 0.27) correlated significantly with pRIFLE class severity. Patients classified with a higher pRIFLE score required a greater number of mechanical ventilation days ( p = 0.03) and a longer pCICU stay ( p = 0.045). Renal replacement therapy (RRT) was needed for 13 patients (8.1 %), with two patients receiving continuous hemofiltration, and 11 patients receiving peritoneal dialysis. At the start of dialysis, the distribution of RRT patients differed significantly within pRIFLE classes ( p = 0.015). All deceased patients were classified as pRIFLE 'I' or 'F' ( p = 0.0001). The findings showed that pRIFLE is easily and feasibly applied for pediatric patients with congenital heart disease. The pRIFLE classification showed that AKI incidence in pediatric cardiac surgery infants is high and associated with poorer outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
10. Primary hyperoxaluria Type 1: indications for screening and guidance for diagnosis and treatment.
- Author
-
Cochat, Pierre, Hulton, Sally-Anne, Acquaviva, Cécile, Danpure, Christopher J., Daudon, Michel, De Marchi, Mario, Fargue, Sonia, Groothoff, Jaap, Harambat, Jérôme, Hoppe, Bernd, Jamieson, Neville V., Kemper, Markus J., Mandrile, Giorgia, Marangella, Martino, Picca, Stefano, Rumsby, Gill, Salido, Eduardo, Straub, Michael, and van Woerden, Christiaan S.
- Subjects
OXALURIA ,KIDNEY disease diagnosis ,KIDNEY disease treatments ,LIVER enzymes ,AMINOTRANSFERASES ,OXALATES ,URINARY calculi ,KIDNEY calcification - Abstract
Primary hyperoxaluria Type 1 is a rare autosomal recessive inborn error of glyoxylate metabolism, caused by a deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase. The disorder results in overproduction and excessive urinary excretion of oxalate, causing recurrent urolithiasis and nephrocalcinosis. As glomerular filtration rate declines due to progressive renal involvement, oxalate accumulates leading to systemic oxalosis. The diagnosis is based on clinical and sonographic findings, urine oxalate assessment, enzymology and/or DNA analysis. Early initiation of conservative treatment (high fluid intake, pyridoxine, inhibitors of calcium oxalate crystallization) aims at maintaining renal function. In chronic kidney disease Stages 4 and 5, the best outcomes to date were achieved with combined liver–kidney transplantation. [ABSTRACT FROM AUTHOR]
- Published
- 2012
11. Parathyroid hormone levels in long-term renal transplant children and adolescents.
- Author
-
Guzzo, Isabella, Zazzo, Giacomo, Laurenzi, Chiara, Ravà, Lucilla, Giannone, Germana, Picca, Stefano, and Strologo, Luca
- Subjects
KIDNEY surgery ,TREATMENT of chronic kidney failure ,ANALYSIS of variance ,CALCIUM ,CHEMILUMINESCENCE assay ,CHRONIC kidney failure ,HYPERPARATHYROIDISM ,KIDNEY transplantation ,MULTIVARIATE analysis ,PARATHYROID hormone ,PHOSPHORUS ,REGRESSION analysis ,RETROSPECTIVE studies - Abstract
Secondary hyperparathyroidism is a common complication of chronic renal failure. Kidney transplantation corrects renal insufficiency and most metabolic abnormalities but hyperparathyroidism persists in 50% of children after transplantation. The aim of this study was to investigate parathyroid hormone (PTH) course and potential risk factors for hyperparathyroidism in children after renal transplant. We collected data from 145 transplanted children (mean follow-up 4.7 years). Intact PTH level (iPTH) rapidly decreased in the first 6 months post-transplant and continued to decline in the following years. iPTH was above the normal range in 69.1% of the patients at the time of transplant and in 47% 1 year later, this improvement continuing thereafter. Hypercalcemia was present in 20.3% of the patients before transplant and in 6.3 and 4.1% of patients 6 months and 1 year after transplant, respectively. Hypophosphatemia was present in 5.5% of the patients at 6 months, and 45.5% of the patients needed phosphorus supplements during the first 6 months after transplant. Multivariate analysis indicated pre-transplant hyperparathyroidism, dialysis duration, creatinine clearance and hypophosphatemia as predictors of persistent hyperparathyroidism. In kidney transplanted children, serum iPTH normalized in the long term in the majority of cases. Thus, parathyroidectomy should be reserved for selected patients. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
12. Cobalamin C defect presenting as severe neonatal hyperammonemia.
- Author
-
Martinelli, Diego, Dotta, Andrea, Massella, Laura, Picca, Stefano, Di Pede, Alessandra, Boenzi, Sara, Aiello, Chiara, and Dionisi-Vici, Carlo
- Subjects
VITAMIN B12 deficiency ,HOMOCYSTEINE ,PERITONEAL dialysis ,VITAMIN synthesis ,METHIONINE - Abstract
Unlabelled: Cobalamin C (Cbl-C) defect is the most common inborn error of cobalamin metabolism which causes a block in the pathway responsible for the synthesis of its two metabolically active forms methyl- and adenosylcobalamin. Cbl-C defect causes the accumulation of methylmalonic acid and homocysteine and decreased methionine synthesis. The clinical presentation of patients with early-onset Cbl-C defect, characterized by a multisystem disease with severe neurological, ocular, hematological, renal, gastrointestinal, cardiac, and pulmonary manifestations, differs considerably from what observed in the "classical" form of methylmalonic aciduria caused by defect of methylmalonyl-CoA mutase. This last condition is in most cases dominated in the neonatal period by a metabolic encephalopathy "intoxication type" with severe hyperammonemia and ketoacidosis. We report a Cbl-C defect patient presenting a neonatal encephalopathy with severe hyperammonemia and ketoacidosis who was successfully treated with peritoneal dialysis.Conclusion: To the best of our knowledge, there are no reported cases of Cbl-C defect showing an acute presentation resembling a classical methylmalonic aciduria. This observation enlarges the spectrum of inherited diseases to be considered in the differential diagnosis of neonatal hyperammonemia. [ABSTRACT FROM AUTHOR]- Published
- 2011
- Full Text
- View/download PDF
13. Kidney diseases beyond nephrology: intensive care.
- Author
-
Ricci, Zaccaria, Picca, Stefano, Guzzo, Isabella, and Ronco, Claudio
- Subjects
CHRONIC kidney failure in children ,NEPHROLOGY ,SODIUM bicarbonate ,SEPSIS ,HEMODIALYSIS ,BIOMARKERS ,CRITICAL care medicine - Published
- 2011
- Full Text
- View/download PDF
14. Residual renal function and nutrition in young patients on chronic hemodialysis.
- Author
-
Guzzo, Isabella, Mancini, Elvira, Wafo, Séverin Kengne, Ravà, Lucilla, and Picca, Stefano
- Subjects
HEMODIALYSIS patients ,NUTRITION ,SOMATOTROPIN ,URINALYSIS ,LOW-protein diet - Abstract
Residual renal function (RRF) has been associated with a better nutritional status in adult patients on chronic dialysis, but there is as yet no data available for young patients on chronic hemodialysis (HD). We have retrospectively analyzed 3-day dietary reports and simultaneous urea kinetic monitoring data ( n = 179) of 30 children, adolescents and young adults on chronic HD. The protein catabolic rate (PCR) was calculated and normalized by body weight (nPCR). The HD dialysis dose (Kt/VHD), RRF (calculated by urea clearance, Ku, and expressed as residual Kt/V) and total Kt/V (Kt/Vtot) were evaluated. In all patients, nPCR was correlated with dietary protein intake (nDPI) ( p < 0.0001) and Kt/Vtot ( p < 0.0001) but not with Kt/VHD ( p = 0.11). In patients with RRF, Ku was associated with nPCR ( p < 0.0001), while Kt/VHD was not ( p = 0.10), and nPCR was higher than in patients without RRF (1.46 ± 0.41 vs. 1.03 ± 0.33 g/kg/day; p < 0.0001). Patients on recombinant growth hormone (rhGH) treatment showed higher nPCR values than those without rhGH (1.34 ± 0.41 vs. 1.01 ± 0.39 g/kg/day; p < 0.0001). In a multiple regression model including age, rhGH treatment, RRF, Kt/Vtot and Kt/VHD, and nPCR showed the best correlation with RRF (β = 0.128; p < 0.0001). In conclusion, in children, adolescents and young adults on chronic HD treatment, RRF positively affects nutrition independently of HD efficiency and rhGH treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
15. Oxalosis in primary hyperoxaluria in infancy : Report of a case in a 3-month-old baby. Follow-up for 3 years and review of literature.
- Author
-
Orazi, Cinzia, Picca, Stefano, Schingo, Paolo M S, Fassari, Fausto M, and Canepa, Giuseppe
- Abstract
Primary hyperoxaluria (PH1) is a rare inborn autosomal recessive metabolic disorder due to the deficiency of hepatic alanine-glyoxylate-aminotransferase. This deficiency results in excessive synthesis and urinary excretion of oxalate, inducing renal stone formation and deposition of calcium oxalate in the kidney, bone, myocardium, and vessels (systemic oxalosis, SO) in the most severely affected individuals. We report renal and skeletal changes in a 3-month-old girl with PH1 and SO. Intense cortico-medullary hyperechogenicity and increased homogeneous radiopacity of normal-sized kidneys suggested the diagnosis of SO. Skeletal survey showed osteopenia and characteristic symmetrical metaphyseal transverse bands in long bones, progressively becoming more dense and migrating towards the diaphysis. Multiple pathological and slowly healing fractures of the limbs occurred at the dense band level. A radiopaque rim was then observed in flat bones, epiphyseal nuclei, and vertebral bodies. Inflammatory granulomatous reaction, induced by the presence of oxalate crystals in the marrow spaces, coexisted with progressively evident radiological signs of secondary hyperparathyroidism, with partially overlapping features. The patient was treated by peritoneal dialysis and hemodialysis until combined liver-kidney transplantation. There are no previous reports of infants treated with hemodialysis for more than 2 years. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
16. Treatment of boric acid overdose in two infants with Continuous Venovenous Hemodialysis.
- Author
-
Pedicelli, Stefania, Picca, Stefano, Di Nardo, Matteo, Perrotta, Daniela, Cecchetti, Corrado, and Marano, Marco
- Subjects
BORIC acid ,PEDIATRIC toxicology ,HEMODIALYSIS ,INFANT formulas ,DIURESIS - Abstract
The article discusses 2 cases of infants treated with Continuous Venovenous Hemodialysis (CVVHD) following accidental ingestion of boric-acid-saturated water to prepare milk formula. One infant showed moderate dehydration, prolonged capillary refill time and tachypnea and the other infant was treated with intravenous fluids to induce forced diuresis. CVVHD was started 14 and 21 hours after last ingestion respectively considering the elevated amount of boric acid ingested in both patients.
- Published
- 2015
- Full Text
- View/download PDF
17. Parathyroid hormone levels in pubertal uremic adolescents treated with growth hormone.
- Author
-
Picca, Stefano, Martinez, Chiara, Rizzoni, Gianfranco, Cappa, Marco, Osborn, John, Montini, Giovanni, Perfumo, Francesco, Ardissino, Gianluigi, Bonaudo, Roberto, and Moges, Seyoum Ido
- Subjects
HYPERPARATHYROIDISM ,PUBERTY ,SOMATOTROPIN ,ENDOCRINE diseases ,DISEASES in teenagers ,PARATHYROID gland diseases ,MULTIVARIATE analysis ,HEALTH outcome assessment ,DISEASE risk factors - Abstract
We have previously described severe hyperparathyroidism during the pubertal growth spurt in three uremic adolescents treated with recombinant human growth hormone (rhGH). Here we investigate the possible role of puberty in the genesis of hyperparathyroidism during rhGH treatment of a large cohort of patients. Data from 67 uremic patients treated with rhGH from five Italian pediatric nephrology centers were retrospectively recorded every 3 months starting 1 year before rhGH administration. The mean (±SD) rhGH treatment observation period was 19.9±5.9 months. The mean age at the start of rhGH treatment was 8.3±3.6 years. Of the 67 patients, 15 reached pubertal stage 2 during the 1st year of rhGH treatment and 12 of these 15 progressed to pubertal stage 3. The relative increase in parathyroid hormone (PTH) levels after rhGH initiation was greater in pubertal [1.95, 95% confidence interval (CI) 1.43–2.66] than in prepubertal patients (1.19, 95% CI 1.01–1.40). Increases in PTH levels were significantly different between the two groups (Δ=1.64, 95% CI 1.16–3.19, P=0.007). Multiple regression analysis showed an inverse correlation between PTH and calcium levels and a positive correlation between PTH and pubertal stage 3. There was no correlation with phosphate levels and calcitriol dosage. In conclusion, these results suggest that in uremic adolescents treated with rhGH puberty may influence PTH levels. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
18. Immediate use of an arteriovenous prosthetic graft for life-saving dialysis in a child.
- Author
-
Grimaldi, Chiara, Crocoli, Alessandro, Galasso, Lara, Picca, Stefano, Natali, Gian, and De Ville De Goyet, Jean
- Subjects
CENTRAL venous catheterization ,CATHETERIZATION complications ,TREATMENT of chronic kidney failure ,THROMBOSIS diagnosis ,DIALYSIS (Chemistry) ,TRANSPLANTATION of organs, tissues, etc. ,DIAGNOSIS - Abstract
Background: Autologous arteriovenous fistulas (AVFs) are the current gold standard for vascular access in hemodialysis (HD). However, in pediatric patients, specific clinical settings may contraindicate the procedure, thus mandating the use of a prosthetic graft (PG). Case-Diagnosis/Treatment: We report a case of successful polycarbonate urethane graft implantation and subsequent resumption of HD 12 h after the procedure in a young girl with end-stage renal disease (ESRD), challenging vascular anatomy and the absence of vascular access. Conclusions: The use of polycarbonate urethane PGs in children with ESRD and difficult vascular accesses may represent a valid alternative for early resumption of HD. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
19. Hyperparathyroidism during growth hormone treatment: a role for puberty?
- Author
-
Picca, Stefano, Cappa, Marco, and Rizzoni, Gianfranco
- Subjects
HYPERPARATHYROIDISM ,PARATHYROID hormone ,DISEASES in teenagers ,SOMATOTROPIN ,HEMODIALYSIS ,DIAGNOSIS ,THERAPEUTICS - Abstract
We describe three adolescent patients on chronic hemodialysis with a pubertal growth spurt who developed severe hyperparathyroidism during recombinant human growth hormone treatment. Parathyroid hormone levels were raised in parallel with the increase in linear growth in all patients. In two patients, hyperparathyroidism was successfully controlled with an increase in calcitriol dosage. In the third patient, growth hormone had to be withdrawn. We discuss the possibility that puberty is a risk factor for the development of hyperparathyroidism during growth hormone therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.