1. MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin.
- Author
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Cecchin, E, Perrone, G, Nobili, S, Polesel, J, De Mattia, E, Zanusso, C, Petreni, P, Lonardi, S, Pella, N, D'Andrea, M, Errante, D, Rizzolio, F, Mazzei, T, Landini, I, Mini, E, and Toffoli, G
- Subjects
COLON cancer treatment ,METHYLENETETRAHYDROFOLATE reductase ,FLUOROPYRIMIDINES ,CANCER chemotherapy ,ADJUVANT treatment of cancer ,OXALIPLATIN ,COHORT analysis - Abstract
Adjuvant treatment based on fluoropyrimidines (FL) improves the prognosis of stage II/III colorectal cancer (CRC). Validated predictive/prognostic biomarkers would spare therapy-related morbidity in patients with a good prognosis. We compared the impact of a set of 22 FL-related polymorphisms with the prognosis of two cohorts of CRC patients treated with adjuvant FL with or without OXA, including a total of 262 cases. 5,10-Methylentetrahydrofolate reductase (MTHFR) MTHFR-1298 A>C (rs1801131) polymorphism had a concordant effect: MTHFR-rs1801131-1298CC genotype carriers had a worse disease free survival (DFS) in both the cohorts. In the pooled population MTHFR-rs1801131-1298CC carriers had also a worse overall survival. We computed a clinical score related to DFS including MTHFR-rs1801131, tumor stage, sex and tumor location, where rs1801131 is the most detrimental factor (hazard ratio=5.3, 95% confidence interval=2.2-12.9; P-value=0.0006). MTHFR-rs1801131 is a prognostic factor that could be used as an additional criteria for the choice of the proper adjuvant regimen in stage II/III colorectal cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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