Search

Reports that two neurodegenerative disease models in a mouse progress with little or no abatement on a transgenic background in which neurofilaments are withheld from the axonal compartment. Dystonia musculorum and a superoxide dismutase 1 (SOD1)-mediated form of human motor neuron disease (amyotrophic lateral sclerosis, ALS); The suggestions that the observations redefine the components of the pathogenic pathway leading to axon disruption in the two degenerative diseases; Methods.