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Introduction: In Australia, the usual approach to breast lesions where core biopsy returns an uncertain result ("B3" breast lesion) is to perform surgical diagnostic open biopsy (DOB). This is associated with patient time off work, costs of hospital admission, risks of general anaesthesia and surgical complications. The majority of B3 lesions return benign results following surgery. Vacuum assisted excision biopsy (VAEB) is a less invasive, lower cost alternative, and is standard of care for selected B3 lesions in the United Kingdom. Similar use of VAEB in Australia, could save many women unnecessary surgery. The aim of this study was to document our experience during the introduction of VAEB as an alternative to DOB for diagnosis of selected B3 lesions. Methods: The multidisciplinary team developed an agreed VAEB pathway for selected B3 lesions. Technically accessible papillary lesions, mucocele‐like lesions and radial scars without atypia measuring ≤ 15mm were selected. Results: Over a 7 month period, 18 women with 20 B3 lesions were offered VAEB. 16 women (18 lesions) chose VAEB over DOB. Papillomas were the commonest lesion type. All lesions were successfully sampled: 17/18 were benign. One lesion (6%) was upgraded to malignancy (ductal carcinoma in situ on VAEB, invasive ductal carcinoma at surgery). No major complications occurred. Patient satisfaction was high: 15/16 respondents would again choose VAEB over surgery. Conclusion: VAEB is a patient‐preferred, safe, well‐tolerated, lower‐cost alternative to DOB for definitive diagnosis of selected B3 breast lesions. [ABSTRACT FROM AUTHOR]

A 4-month-old boy had a faint, confluent, macular erythema involving the forehead, nose, and philtrum, and matlike telangiectases over the forehead and eyelids. The clinical features, course, and laboratory studies were characteristic of neonatal lupus erythematosus. He was otherwise healthy and the product of a preterm twin pregnancy complicated by the development of maternal HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome. The patient had elevated Ro(SSA) and La(SSB) antibody titers, and studies performed on maternal blood disclosed positive antinuclear antibodies and elevated Ro and La antibody titers. [ABSTRACT FROM AUTHOR]

The Pingry School's SMART Team (Students Modeling a Research Topic) has worked with Andrew Vershon to design and produce accurate three-dimensional physical models of Human SirT2 using state of the art rapid prototyping technology. SifT2 is NAD-dependent histone deacetylase that are points of regulation of transcriptional silencing. Sir2 and SirT2 have been characterized to form regulator complexes with other, silent information regulator proteins and is analogous by sequence similarity to Hstl but result in differing function and specificities. Discussion with Dr. Vershon, allowed the Pingry SMART Team to use a modified version of RasMol(RP-Rasmol)to design physical models of sirtuin proteins highlighting areas of each protein shown to be experimentally significant for function. These final designs were then exported as PLY files and are used to direct an automated ZCorp 3D Color Printer to build physical models of the proteins. These models are communication tools that can be used to enhance the further understanding of these pathways among the scientific community. [ABSTRACT FROM AUTHOR]