1. Living Kidney Donation in a Type 1 Dent's Disease Patient from His Mother.
- Author
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Gambaro, Giovanni, Naticchia, Alessandro, Ferraro, Pietro Manuel, Spagnoletti, Gionata, Romagnoli, Jacopo, Salerno, Maria Paola, and Citterio, Franco
- Subjects
CHRONIC kidney failure ,KIDNEYS ,KIDNEY transplantation ,MOTHERS - Abstract
Introduction: Dent's disease is a rare X-linked recessive disorder that manifests in childhood or early adulthood and can lead to end-stage renal disease (ESRD). It occurs in males, who are hemizygous. In patients who develop ESRD, a deceased donor kidney transplant cures the disease. Females are obligate carriers of the mutated gene, and some show a mild Dent's disease phenotype. There may be reason for concern when considering a female obligate carrier (i.e., the mother) for kidney donation because of the risk of kidney function deterioration. Case Presentation: We describe the first successful kidney transplantation involving a patient with type 1 Dent's disease and ESRD given a kidney by an obligate carrier of the gene mutation, his mother. Conclusions: After careful assessment of the female obligate carriers, intrafamilial kidney donation in Dent's disease type 1 is feasible. No deteriorating renal function in the donor was observed. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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