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Unlabelled: Clinical parameters, available on day 4, were collected for 204 ventilated neonates < 32 weeks gestation. Logistic regression was used to identify factors significantly and independently associated with chronic neonatal lung disease (CNLD) at 36 weeks postconception, which developed in 29% of neonates. At 36 weeks birth weight, peak inspiratory ventilator pressure and requirement for assisted ventilation on day 4 were such factors. The logistic regression equation for this association was applied to each infant resulting in a value between 0 and 1. By knowing which neonates developed CNLD, the discriminatory ability in this value was assessed. A receiver-operator characteristic curve for this value had an area under the curve of 0.97 (SE 0.03) in a unrelated population. A logistic equation value > 0.4 had a sensitivity of 90% and a specificity of 88% in predicting CNLD at 36 weeks.Conclusion: Use of logistic regression to identify factors independently associated with chronic drug disease at 36 weeks postconception, allowed accurate prediction of this disorder. This would allow reduction in size of randomised trials of early intervention in chronic lung disease. [ABSTRACT FROM AUTHOR]

Presents a letter to the editor, on the use of percutaneously inserted central venous lines in neonatal intensive care to administer parenteral nutrition and medications.

Presents a randomized controlled trial of treatment with inhaled nitric oxide (INO) therapy and intravenous dexamethasone in preterm infants at risk of developing chronic lung disease. Concern on the introduction of INO; Comparison of oxygenation index between infants in the INO group and control infants.