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Objective: The purpose of this study was to predict the four cold–heat patterns in patients who have the subjective symptoms of the cold–heat pattern described in the International Classification of Diseases Traditional Medicine Conditions – Module 1 by applying a machine learning algorithm. Methods: Subjects were first-visit Kampo outpatients at six institutions who agreed to participate in this multicenter prospective observational study. The cold pattern model and the heat pattern model were created separately with 148 symptoms, body mass index, blood pressure (systolic and diastolic), age, and sex. Along with a single cold or heat pattern, the tangled heat/cold pattern is defined as being predicted by both cold and heat patterns, while the moderate (heat/cold) pattern is defined as being predicted by neither the cold pattern nor the heat pattern. Results: We included 622 participants (mean age ±standard deviation, 54.4 ± 16.9; with female 501). The accuracy, macro-recall, precision, and F1-score of a combination of the two prediction models were 96.7%, 93.2%, 85.6%, and 88.5% respectively. The important items were compatible with the definitions of the cold–heat pattern. Conclusion: We developed a prediction model on cold–heat patterns with data from patients whose subjective cold/heat-related symptoms matched the cold–heat pattern diagnosis by the physician. [ABSTRACT FROM AUTHOR]

Aim: We aimed to elucidate the present clinical situation, future challenges, and potential need for diagnostic support software in Kampo medicine. Methods: We conducted an online survey (comprising 28 questions) of Japanese physicians from the 23 to 24 January 2024 via MedPeer. The participants' responses were stratified according to their age distribution. Results: We evaluated data for 652 respondents. The most common respondent age groups were those in their 30s and 40s. The most common specialty of respondents was internal medicine (43.7%). Only 33.7% of respondents had received education on Kampo medicine at university. Most respondents (90.0%) were not licensed as certified physicians or members of the Japan Society for Oriental Medicine. Most respondents (86.7%) currently prescribed Kampo formulas (current users); only 3.8% had no experience in prescribing Kampo formulas. The conditions for which Kampo formulas were frequently prescribed were muscle cramps, constipation, medically unexplained symptoms/menopausal syndrome, appetite loss/malnutrition, and fatigue. However, 48.3% of current users did not use traditional Kampo patterns (sho). The most frequent issues reported by respondents were the lack of scientific evidence and standardization of diagnostic methods in Kampo medicine. Respondents indicated the need for postgraduate education and implementation of diagnostic support software for using Kampo patterns by non‐specialists in Kampo medicine. Conclusion: There was a discrepancy between the high frequency of Kampo formula prescriptions and the low use of traditional Kampo patterns in Japan. Diagnostic support software is likely to become a useful method of improving appropriate Kampo formula prescriptions by non‐specialists. [ABSTRACT FROM AUTHOR]

Background: The source of ninjin'yoeito (NYT) is considered the 'Formulary of Bureau of Taiping People's Welfare Pharmacy', written around 1241–52 AD. NYT is used to treat patients with chronic fatigue, malaise with qi deficiency, and exhaustion of all five parenchymatous viscera with difficulty in recovering. Key Findings: NYT formula consists of 12 crude drugs. NYT extract for medical use is covered by the National Health Insurance system of Japan for convalescence after recovery from diseases, fatigue and malaise, anorexia, perspiration during sleep, cold limbs, and anemia. Studies have shown clinical effects of NYT: treatment of anemia, cancer treatment support, frailty, cognitive dysfunction, apathy, fatigue/malaise, anorexia, and lung diseases. Preclinical studies support clinical studies; activating ghrelin‐neuropeptide Y pathway‐mediated appetite‐enhancing effects, inhibiting muscle volume loss through the Akt/mTOR pathway‐mediated hyperphosphorylation of 4E‐BP1 and FoxO1‐mediated Atrogin‐1, suppressing the hypothalamic–pituitary–adrenal axis by downregulating the sympathetic‐adrenal‐medullary axis and GABA neurons for improving sociability, promoting recovery from skeletal muscle atrophy through the activation of PGC‐1α, hematopoiesis‐promoting effects, and increasing the number of immune cells in immunocompromised models. The incidence of adverse events of NYT was reported as 3.09 or 2.03%. The most significant adverse effects of NYT are gastrointestinal disorders. Conclusion: Recently, NYT has been widely used to treat several symptoms and conditions under the National Health Insurance System of Japan. Clinical studies showed the efficacy of NYT to treat anemia, frailty, cognitive dysfunction, anorexia, apathy, and fatigue/malaise, as well as for long‐term cancer treatment support. The pharmacological mechanisms supporting its effects are also being reported. [ABSTRACT FROM AUTHOR]

Background: The source of yokukansan (YKS) is thought to be Baoying‐Jinjiang (Hoeikinkyōroku in Japanese) by Xue Ji. YKS was originally designed for children and indicated for spasms, clenching of teeth, digestive dysfunction due to mental instability, and insomnia. Key Findings: YKS formula consists of seven types of crude drugs. Clinical studies have revealed that YKS exerts physiological effects including the treatment of behavioral and psychiatric symptoms of dementia (BPSD), preoperative sedation and anxiety, and postoperative delirium. A meta‐analysis showed that YKS could improve BPSD and daily living activities; however, no improvement in cognitive function was observed. Preclinical studies have also reported that YKS modulates neuronal pathways in the central nervous system, including the serotonergic, glutamatergic, GABAergic, and other neurotransmitter pathways. The incidence of adverse events associated with YKS was 5.17%, with the major adverse effect being pseudoaldosteronism. Routine blood sampling is considered for hypokalemia prevention. Conclusion: YKS is useful for BPSD and perioperative mental instability. The modulation of the serotonergic and glutamatergic neural pathways is one of mechanisms. Pseudoaldosteronism is one of the side effects. [ABSTRACT FROM AUTHOR]

This article discusses the use of Zokumeito (ZMT), a traditional medicine, for the rapid recovery of consciousness and physical function in a patient with cerebral infarction. ZMT is a combination of various herbs and is not available as an extract, so the authors prescribed similar medicines that contained some of the same ingredients. The patient, a 91-year-old male, showed significant improvement in his condition after starting the treatment, including increased vocalizations, the ability to sit in a wheelchair, and eventually being able to eat and drink without assistance. The authors note that further research is needed to fully understand the effects of ZMT in stroke patients. [Extracted from the article]

This article discusses the successful treatment of menopausal arthralgia using a combination of two traditional Japanese herbal formulas, unkeito and boiogito. Menopausal arthralgia, characterized by joint pain, is a common symptom of menopause, but there is no established treatment for it. The three cases presented in the article showed significant improvement in arthralgia symptoms after treatment with unkeito and boiogito. The authors suggest that these herbal formulas may be effective for menopausal arthralgia that does not respond to nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen. Further research is needed to evaluate the effectiveness of this treatment. [Extracted from the article]

Background: The origin of hangekobokuto (HKT) is from Jin Gui Yao Lue (Kinkiyōryaku in Japanese), and it has been indicated for treating throat discomfort in women. Key Findings: HKT consists of five crude drugs. Clinical studies have shown that HKT can improve the swallowing reflex by increasing the substance P level in saliva; improve the cough reflex; reduce pneumonia in patients with dementia, cerebrovascular disease, Alzheimer's disease, or Parkinson's disease; reduce postoperative aspiration pneumonia in patients who undergo cardiovascular surgery; and improve depression and anxiety scores in patients with globus hystericus. Furthermore, HKT has been reported to increase serotonin (5‐HT) and noradrenaline levels in the hypothalamus, and dopamine (DA) levels in the striatum in a healthy rodent model; improve 5‐HT levels in the striatum and hippocampus, and ameliorate 5‐HT and DA reductions in the whole brain in an acute stress model; improve 5‐HT levels in the striatum, and ameliorate 5‐HT and DA reductions in the prefrontal cortex in a chronic stress model; and decrease corticosterone and corticotropin‐releasing factor levels in a chronic stress model. Reported adverse events of HKT include interstitial pneumonia (0.38 per 100 000 cases) and liver damage (0.89 per 100 000 cases), which are rare. Conclusion: HKT is widely used and shows a low rate of adverse events. Several clinical studies have reported its effects in reducing aspiration pneumonia and improving depression and anxiety, some of which may be explained by the regulation of monoamines and stress hormones in the brain and substance P levels in the oral cavity. [ABSTRACT FROM AUTHOR]

Background: Behavioural and psychological symptoms of dementia (BPSD) are challenging to manage, leading to caregiver burden and often to subsequent transfer of patients to a nursing home or psychiatric hospital for treatment. Eliciting favourable positive emotions should be an important goal in the treatment of negative emotions associated with BPSD. To date, no data have indicated that antipsychotic medications can improve positive emotions. BPSD are known to be associated with anxiety in patients with dementia. The traditional Chinese medicine Jia Wei Gui Pi Tang is officially indicated and approved for anxiety treatment in Japan. Methods: Here, we performed a multicentre, randomised, observer‐blind control study of the effect of Jia Wei Gui Pi Tang on BPSD in Alzheimer's disease (AD) patients. Patients with AD or AD with cerebral vascular disease were randomly divided into the Jia Wei Gui Pi Tang treatment group and the control group that received no traditional Chinese medicine. BPSD were scored using the Neuropsychiatric Inventory Nursing Home Version (NPI‐NH) and by favourable positive emotions using the Delightful Emotional Index (DEI). Results: A total of 63 participants (18 male and 45 female; mean age: 83.3 ± 6.0 years) were included in the study. Changes in NPI‐NH scores differed significantly between the two groups (one‐way analysis of variance, P < 0.001). Within the treatment group, there was a significant improvement in the NPI‐NH score from 29.8 ± 17.3 at baseline to 13.2 ± 9.4 at the endpoint (paired t‐test, P < 0.001), whereas there was no statistically significant change in the control group. Changes in DEI scores differed significantly between the two groups. Within the treatment group, there was a significant improvement in the DEI score from 24.3 ± 23.0 at baseline to 32.5 ± 21.2 at the endpoint (paired t‐test, P = 0.001), whereas there was no statistically significant change in the control group. Conclusion: The traditional Chinese medicine Jia Wei Gui Pi Tang significantly improved both BPSD and positive emotions. [ABSTRACT FROM AUTHOR]

There exist certain behaviors that people tend to do in disaster situations before evacuation. Such behaviors include warning confirmation behavior (for example, seeking information) and family-oriented behavior (for example, contacting one's family). Identifying factors that affect these behaviors is of particular importance in building a better understanding of why people often fail to respond quickly to evacuation orders. For this purpose, the present study employed some of the established factors affecting evacuation behavior as predictor variables along with the timing of an evacuation order. A total of 518 participants took part in a 12-item online questionnaire survey that contained a hypothetical disaster scenario. The results of ordinal logistic regression analyses revealed that only risk area residence and disaster preparedness were associated with warning confirmation behavior, while gender, age, disaster preparedness, and risk perception had some associations with family-oriented behavior. Also, the participants were not more likely to engage in these behaviors in the morning and the afternoon than the evening in the hypothetical scenario. These findings imply the possibility that people engage in warning confirmation behavior and family-oriented behavior before evacuation regardless of individual characteristics and the circumstances surrounding them. [ABSTRACT FROM AUTHOR]

Aim: We present the study protocol of a multicenter, retrospective observational study that aims to investigate the efficacy of the actual treatment (the efficacy of conventional and Kampo medicines) of patients with mild to moderate or suspected coronavirus disease (COVID‐19). Methods: This study is designed as a multicenter, retrospective observational study. Outpatients and inpatients will be recruited from Japanese hospitals. The inclusion criteria are as follows: having or suspected to have COVID‐19, mild to moderate COVID‐19, symptomatic, ≥20 years of age, male or female, able to communicate in Japanese, and treated with conventional and Kampo medicine. The exclusion criteria are: unable to provide informed consent due to dementia, psychosis, or psychiatric symptoms, severe COVID‐19, or determined unsuitable for this study. The sample size is set at 1000, as this number of people can be treated at the collaborating medical institutions during the study period. Results: The main outcome is the number of days without fever, with a body temperature of less than 37°C. The secondary outcome is set at common cold‐like symptoms other than fever (fatigue, cough, shortness of breath, sputum, diarrhea) and severity of illness and hospitalization up to 14 days after the visit. Trial registration: The trial was registered in the University Hospital Medical Information Network (Reservation No. UMIN000041301) on August 4, 2020. Conclusion: Our study will explore the contribution of conventional and Kampo medicine in the treatment of patients with mild and moderate COVID‐19. [ABSTRACT FROM AUTHOR]

Context: In Japan, many patients who cannot consume food orally are managed using external tube feeding over long periods. Although helpful in nutritional management, tube feeding significantly reduces a patient's quality of life. Aims: We examined the factors that affected the transition from tube to oral feeding in elderly people. Settings and Design: Single-center, retrospective, pilot study conducted from January 1, 2018 to December 28, 2019. Methods and Materials: We recruited patients who attempted to return to oral intake following tube feeding for >12 months at Miyama Hospital. Fourteen participants (male-to-female ratio = 6:8; age = 83.9 ± 2.6 years) attempted to resume oral feeding. We investigated patient diagnoses, duration of tube feeding, sex, swallowing reflex time, and Kohnan consciousness score. Patients with a swallowing reflex >4 s were administered banxia houpu tang. Results: Of the 14 patients, seven managed to resume oral feeding (group 1), while the remaining seven failed (group 2). The two groups of patients showed no significant difference in terms of mean age, duration of tube feeding, swallowing reflex time, and sex. However, the consciousness level of group 1 was significantly higher than that of group 2. Conclusions: Higher consciousness level in patients who successfully resumed oral feeding suggests that oral feeding should be considered in patients with adequate consciousness. [ABSTRACT FROM AUTHOR]

The present study was designed to shed light on the origin of disaster myths, such as panic, looting, crime, and psychological shock in postdisaster situations, by examining effects of secondhand information and the moderating effect of anxiety on such negative misconceptions. It was hypothesized that secondhand information on disaster behaviour, such as media reports and word‐of‐mouth rumours, and trait anxiety would increase the degrees to which people gave credit to four popular disaster myths. Also, trait anxiety was predicted to moderate the association between information sources and disaster myths. Questionnaire data obtained from 1,500 Japanese participants indicated that people relying on secondhand information gave more credit to all the four misconceptions than those relying on firsthand information such as direct disaster experience. However, trait anxiety was not found to significantly affect the degrees of the disaster myths. Furthermore, the moderating effect of trait anxiety on the association between the information sources and the disaster myths was not observed in any of the four myths. The present results imply that although reliance on secondhand information increases the degree of disaster myths to some extent, there should be other causes from which disaster myths originate. [ABSTRACT FROM AUTHOR]

Objective: This study assessed the effect of the kampo medicine kamikihito (KKT) on platelet count irrespective of type of illness. Methods: A single‐center, retrospective pilot study was performed from March 2014 to March 2017. The subjects were patients who received KKT treatment and had blood samples collected in the 2 weeks prior to treatment initiation and ≤9 weeks after treatment completion at Toyama University Hospital. Results: A total of 16 patients were identified as potential subjects, and their medical records were assessed. Their diagnoses were patent ear canal, insomnia, idiopathic thrombocytopenic purpura, aplastic anemia, and chemotherapy‐induced thrombocytopenia. Three cases of chemotherapy‐induced thrombocytopenia were excluded from the analysis. Eight of 13 patients receiving KKT had elevated platelet count after treatment, but the increase was not statistically significant. Interestingly, three patients with platelet count below the lower limit of the standard value prior to KKT treatment had a statistically significantly increased platelet count after treatment completion (P < 0.05). Conclusion: Kamikihito increased the platelet count in most patients, specifically in all patients with thrombocytopenia. [ABSTRACT FROM AUTHOR]

Case: An 81‐year‐old man who had many symptoms, including body pain, was receiving 13 different drugs. We used kampo medicine to improve his symptoms and to reduce the number of drugs he received. Outcome: Keishikajutsubuto (KSTJB) was given to the patient, and gradually the number of drugs he received was reduced. All symptoms were improved with only two drugs, KSTJB and epinastine, and the patient's condition has been improved for more than 10 years. Conclusion: By introducing kampo medicine, we were able to reduce the patient's daily regimen from 13 to 2 medications. A pharmaceutical cost estimate indicated savings of approximately ¥1m over the past 10 years. Thus, use of kampo medicine can resolve polypharmacy and potentially reduce pharmaceutical costs. [ABSTRACT FROM AUTHOR]

Objectives. Traditional Japanese Kampo medicines have been integrated into the Japanese national health-care system. In Japan, the Ministry of Health, Labor, and Welfare's website discloses adverse drug-event data that have been obtained from medical personnel reports investigated by the Pharmaceutical and Medical Devices Agency. Using these data, we investigated adverse events associated with ethical Kampo formulations. Methods. Reports of adverse events associated with ethical Kampo formulations from the domestic adverse-event data were obtained from July 30, 2003, to March 31, 2018. Adverse events were then categorized, and the relationships between categories of adverse events and crude drugs were analyzed. Results. There were 4,232 reported adverse events associated with ethical Kampo formulations. The numbers of events by category were as follows: events related to liver injury, 1,193; lung injury, 1,177; pseudoaldosteronism, 889; mesenteric phlebosclerosis, 223; drug eruption, 185; and others, 565. Among events related to both liver injury and lung injury, approximately 70% were suspected to be induced by Kampo formulations containing Scutellariae Radix. The pseudoaldosteronism-related events, which are induced by Glycyrrhizae Radix, included several events related to muscle injury, heart failure, and arrhythmia. Events related to mesenteric phlebosclerosis, believed to be induced by long-term use of Kampo formulas containing Gardeniae Fructus, increased remarkably during the study period. Among the events related to drug eruption, approximately 35% were suspected to be induced by Kampo formulations containing Ephedrae Herba. Conclusion. Kampo medicines may cause various adverse events. The present results provide valuable information regarding adverse events associated with Kampo medicines from the viewpoint of patient safety. [ABSTRACT FROM AUTHOR]

Aim: At present, traditional Japanese medicines, termed kampo medicines, are integrated into the Japanese national health‐care system. In Japan, interstitial pneumonia is described as an adverse drug event in the drug package insert of some prescription kampo formulations. Additionally, many of the kampo formulas that induce interstitial pneumonia contain Scutellariae Radix (SR). The incidence of kampo medicine‐induced interstitial pneumonia has not been sufficiently studied. The aim of the present study was therefore to assess the incidence of kampo medicine‐induced interstitial pneumonia in the kampo medicine department of a clinical institution. Methods: We selected patients who had developed interstitial pneumonia due to kampo formulas on the basis of the medical records of the Department of Japanese Oriental Medicine, Toyama University Hospital, from 2008 to 2017. Moreover, we investigated the number of patients who were prescribed kampo formulas and the number of patients who were prescribed kampo formulas containing SR during the study period. Results: Of the 3590 patients who received kampo medications in the 10 year survey period, three patients developed kampo medicine‐induced interstitial pneumonia (incidence, 0.08%). The causal kampo formulas in all three of these cases contained SR. For the 1111 patients who were prescribed SR‐containing formulas, the incidence of kampo medicine‐induced interstitial pneumonia was 0.27%. Conclusion: Although the incidence is not high, physicians should keep in mind that kampo formulas, particularly SR‐containing formulas, might cause kampo medicine‐induced interstitial pneumonia. [ABSTRACT FROM AUTHOR]

This study examined how pervasive disaster myths would be among disaster response professionals (n = 401) compared to lay people (n = 600), as well as sources of disaster myths among them. Results revealed that both of the groups believed five common disaster myths to some extent. Moreover, the mass media had a positive association with only one myth among these professionals, while the media was positively associated with all the five myths among lay people. In summary, the present findings indicated that disaster response professionals were not more insightful into all the myths than lay people, and that the mass media and popular culture were not the principal sources of the disaster myths among these professionals. [ABSTRACT FROM AUTHOR]

Objective: We aimed to test our hypothesis that traditional Japanese (Kampo) medicine, hochuekkito (Hochu-ekki-to: HET) has a preventive effect for the symptoms on COVID-19.Trial Design: The study is designed as a multi-center, interventional, parallel-group, randomized (1:1 ratio), investigator sponsored, two-arm study.Participants: Six thousand participants will be recruited from healthy hospital workers in 7 Japanese University Hospitals.Inclusion Criteria: 1. Age from 20 to 75 years old at the time of registration 2. Asymptomatic and body temperature below 37°C at the time of registration 3. Capable of eating orally Exclusion criteria: 1. Previous upper respiratory inflammation due to viral infection (including suspected COVID-19) 2. Taking immunosuppressants 3. Allergic to the Kampo medicines used in this study 4. History of hypokalaemia, severe hypertension, severe liver dysfunction, and interstitial pneumonia 5. Regularly taking other Kampo medicines 6. Pregnant or possibly pregnant 7. Participating in other research 8. Judged to be unsuitable for this study by the doctor in charge INTERVENTION AND COMPARATOR: Kampo group: participants receive HET in 9 tablets 2 times per day for 8 weeks.Control Group: participants receive placebo in the same dosage as the Intervention group - 9 tablets 2 times per day for 8 weeks. Placebo tablets are identical in appearance and package to HET. Taste of placebo is different from that of HET. The Ohsugi Pharmaceutical Co. Ltd, Osaka, Japan manufactured the placebo and HET.Main Outcomes: Primary outcome: Number of patients with a SARS-CoV-2 RNA by ploymerase chain reaction (PCR) positive result with at least one symptom (fever, cough, sputum, malaise, shortness of breath) during the 12-week study period (including the 4-week observation period after oral administration).Secondary Outcomes: 1. Period from infection to onset 2. Period from the appearance of symptoms to the disappearance of PCR positive 3. Number of days until the appearance or improvement of symptoms 4. Severe stage: presence of hospitalization 5. Shock stage: ICU management required for mechanical ventilation, shock vitals or failure of organ(s) other than lungs Safety endpoints include numbness in the hands and/or feet, edema, skin rash or other allergic symptoms, and gastric discomfort.Randomisation: Patients are randomized (1:1 ratio) to each group using minimization implemented with the Electric data capture system (DATATRAK Enterprise Cloud), with balancing of the arms with age range (under 50 years of age or not) and having a history of risk factors for COVID-19 (cardiovascular disease, hypertension, diabetes, respiratory diseases).Blinding (masking): Only participants will be randomized.Numbers To Be Randomised (sample Size): The main research hypothesis of this study is that Kampo medicines significantly prevent the onset of COVID-19. It is assumed that the infection rate before the administration of the drug under consideration will be 0% and that the incidence of COVID-19 thereafter will be 2- 3%, of which 70%-80% will show symptoms of COVID-19. Assuming that the pharmaceutical effect of the drug will be effective in 50% of patients and that the incidence rates in the placebo and drug groups will be 1.4%-2.4% and 0.7%-1.2%, respectively, the placebo is calculated at 2%, and the study drug at 1%. Since the frequency of verification is low and the number of cases will be large, we set a total of 10 analyses (9 interim analyses and a final analysis). Since the number of cases at the time of the final analysis will be 4,986 under the conditions of α = 0.05 and a power of 80% by the Peto method. We set at 600 cases in each interim analysis with an estimated dropout rate of 16.9%. Finally, the total number of cases is set to 6,000 with 3,000 in the placebo group and 3,000 in the HET group.Trial Status: Protocol version 1.3 of October 23rd , 2020. Recruitment start (expected): December 1st, 2020. Recruitment finish (expected): December 31st, 2022.Trial Registration: This trial is registered in the Japan Registry of Clinical Trials (jRCT) ( jRCTs031200150 ) on 14 October 2020.Full Protocol: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest of expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. [ABSTRACT FROM AUTHOR]

ABSTRACT: Case: An obese 17‐year‐old male patient with right hemiparesis secondary to cerebral infarction presented for kampo treatment. The hemiparesis and resultant lack of exercise had led to an increase in bodyweight. Serum alanine aminotransferase (ALT) was elevated and abdominal ultrasound identified fatty liver. The patient was diagnosed with non‐alcoholic fatty liver disease (NAFLD). Aspirin and tocopherol acetate (vitamin E), previously prescribed, were continued, and kampo medicines were prescribed. Outcome: Two years and 6 months after the initial visit, we prescribed keishikashakuyakuto (Gui Zhi Jia Shao Yao Tang) extract, in addition to keishibukuryogan (Gui Zhi Fu Ling Wan) extract. Thereafter, serum ALT gradually decreased, despite no significant change in bodyweight or blood platelet count. Conclusion: Kampo medicine may be effective for the treatment of NAFLD. [ABSTRACT FROM AUTHOR]

A 40-year-old man presented with refractory pulmonary Mycobacterium avium complex infection, despite administration of antituberculous drugs for 2 years. We administered ninjinyoeito (NYT) to the patient, who experienced weight gain and demonstrated marked reduction in the lung cavity lesions. Thus, the traditional Japanese medicine, NYT could serve as an adjunct to the conventional pharmacotherapy for pulmonary Mycobacterium avium complex infection. [ABSTRACT FROM AUTHOR]

ABSTRACT Aim Systemic scleroderma is a connective tissue disease of unknown etiology characterized by fibrosis of the skin and internal organs. There are few effective treatments for this disease. In this study, we examined the effectiveness of the traditional Japanese medicines keishibukuryogan ( KBG), tokishakuyakusan ( TSS), and ogikenchuto ( OKT) in treating systemic scleroderma. Methods Dermal sclerosis was induced in mice by daily injection of bleomycin. The mice were randomly divided into five groups based on treatment: KBG, TSS, and OKT groups (250 mg/kg/day), and two groups given water only (the sham and control groups). The sham group received local phosphate-buffered saline injections (without bleomycin), and the control group received local bleomycin injections (without treatment). Kampo treatment groups also received local bleomycin injections. A daily dose of 0.01 mL of either kampo solution or water/g·bodyweight was given orally (through a stomach tube) for 4 weeks. Results On histology at week 4, significantly fewer mast cells had infiltrated into the dermis in the TSS and OKT groups than in the control group; dermal sclerosis was also less severe in these groups. Furthermore, at week 1, the KBG, TSS, and OKT groups had significantly reduced serum transforming growth factor β1 ( TGF-β1). OKT and TSS had significantly reduced the level of malondialdehyde in the skin tissue. Conclusion OKT and TSS suppressed the progression of dermal sclerosis by inhibiting mast cell infiltration, as well as by decreasing TGF-β1 and oxidative stress. [ABSTRACT FROM AUTHOR]

In the subalpine zone on Mt. Hakusan, Japan, Plantago asiatica, an alien plant, and Plantago hakusanensis, a native alpine species, grow sympatrically along with their putative hybrids. Here, their flowering behavior, which affects the frequency of hybridization and the colonizing ability of P. asiatica and its hybrids, is described. The flowering behavior of each species and of two F1 hybrids from different seed parents was determined based on the position of the flower in the inflorescence by using a generalized linear mixed model. The percentage fruit set of individually bagged inflorescences was calculated to corroborate the assumptions of the opportunities for self-pollination. All the flowers were protogynous; however, many P. asiatica anthers dehisced before browning of the stigma in the flower and the sex presentations in the inflorescence were asynchronous. The percentage of fruit set was high. Consequently, P. asiatica has the opportunity for self-pollination within the flower and in the inflorescence. In contrast, the P. hakusanensis anthers dehisced after browning of the stigma in the flower; their sex presentation was synchronous in the inflorescence, showing negligible opportunities for self-pollination, and the fruit set was low. Accordingly, in the field, P. hakusanensis might require pollination among the inflorescences for seed production and be actively outcrossed, while P. asiatica is able to outcross in the early flowering phase. Therefore, P. asiatica and P. hakusanensis have opportunities for hybridization. The F1 hybrids exhibited intermediate flowering behavior and produced fruits, demonstrating the potential to reproduce by selfing. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this paper is to explore what would make disaster donors different from non-donors, with particular attention paid to differences in two forms of donations: the monetary donation that directly benefits the beneficiary and the charitable donation that is used by charitable organizations to support their disaster relief activities. Differences in the perceived effectiveness of other disaster relief activities, skepticism about charitable organizations, disaster experience, disaster preparedness, and disaster insight were also examined between the two groups. Design/methodology/approach – A total of 300 Japanese participants were asked to complete a14-item questionnaire online. A series of comparative analyses were conducted to examine differences between donors and non-donors in the questionnaire items. Findings – Although non-donors evaluated the effectiveness of the monetary donation more positively than the charitable donation, donors evaluated the effectiveness of all the disaster relief activities more positively than non-donors. Moreover, donors were more prepared for disasters and more insightful into the current situation of the disaster victims than non-donors. Research limitations/implications – Along with the internal and external factors previously found, disaster awareness may be a key to increasing people's intention to donate for disaster victims. Such awareness could be fostered through successful disaster education and appropriate media coverage of disasters. Originality/value – The findings that non-donors generally have a less positive view of disaster relief activities imply that non-donors may be less knowledgeable than donors about how charitable activities can work and benefit disaster victims. [ABSTRACT FROM AUTHOR]

This study examines how well disaster myths were rooted in Japanese people after the Great East Japan Disaster, as well as the effects of information sources on these misconceptions. Five common disaster myths are covered (panic, psychological shock, looting, increases in the crime rate, and material convergence), and information sources were divided into two types: public and private. Three hundred participants were asked how much credit they would give the five myths and which information sources they would rely on in post-disaster situations. The results found that, as in Western societies, these disaster myths do exist among Japanese people. Also, only public sources of disaster information, such as television and Internet news websites, had some effect on the degree of belief in disaster myths, while private sources, such as one's family, friends, and social networking sites, did not. Factors affecting the degree to which people believe in disaster myths are also discussed. [ABSTRACT FROM AUTHOR]

The present study examined how soon people would make a decision to break existing rules in an anonymous situation, with particular attention paid to the degree of anonymity. A total of 100 participants were randomly assigned to either a self-reward condition or an other-reward condition, in both of which they were asked to flip a coin twice in each of the four coin-flip trials to win the assigned reward. As predicted, the results showed that only participants in the self-reward condition broke the assignment rules for obtaining the reward, and they only did so in the very last coin-flip trial. In sum, the present findings suggest that people do not break existing rules for material gain as soon as they become anonymized, but some may do so at the very last moment. [ABSTRACT FROM AUTHOR]

The present study examined whether psychological self-interest would instigate rule breaking in an anonymous situation. In total, 66 individuals were observed whether they would pursue material or psychological self-interest by breaking existing rules under the cloak of anonymity. Anonymity was defined to minimize accountability for one's behavior, and was strictly manipulated to make all participants equally anonymous during the experiment. Results showed that only participants in the material-reward condition broke the rules, whereas those in the psychological-reward condition did not. Also, there was no difference found between the two conditions in subjective feelings of anonymity and public self-awareness although rule breaking was observed only in the material-reward condition. Implications for socially undesirable behavior in anonymous situations are discussed. [ABSTRACT FROM AUTHOR]

We evaluated the effect of keishibukuryogan (KBG; Guizhi-Fuling-Wan), a traditional Japanese (Kampo) formula, on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (Endo-PAT2000) in patients with metabolic syndromerelated factors by controlled clinical trial with crossover design. Ninety-two patients were assigned to group A (first KBG-treatment period, then control period; each lasting 4 weeks, with about one-year interval) or group B (first control, then KBG-treatment). In forty-nine (27, group A; 22, group B) patients completing all tests, the mean value of the natural logarithmic-scaled reactive hyperemia index (L RHI) increased and those of serum nonesterified fatty acid (NEFA), malondialdehyde, and soluble vascular cell adhesion molecule 1 decreased significantly during the KBG-treatment period, but not during the control period, and 4-week changes of L RHI, NEFA, and malondialdehyde between the 2 periods showed significance. These results suggest that KBG has beneficial effect on endothelial function in patients with metabolic syndrome-related factors. [ABSTRACT FROM AUTHOR]

Mutations of the ATRX gene, which encodes an ATP-dependent chromatin-remodeling factor, were identified in patients with α-thalassemia X-linked mental retardation (ATR-X) syndrome. There is a milder variant of ATR-X syndrome caused by mutations in the Exon 2 of the gene. To examine the impact of the Exon 2 mutation on neuronal development, we generated ATRX mutant ( ATRX) mice. Truncated ATRX protein was produced from the ATRX mutant allele with reduced expression level. The ATRX mice survived and reproduced normally. There was no significant difference in Morris water maze test between wild-type and ATRX mice. In a contextual fear conditioning test, however, total freezing time was decreased in ATRX mice compared to wild-type mice, suggesting that ATRX mice have impaired contextual fear memory. ATRX mice showed significantly reduced long-term potentiation in the hippocampal CA1 region evoked by high-frequency stimulation. Moreover, autophosphorylation of calcium-calmodulin-dependent kinase II (αCaMKII) and phosphorylation of glutamate receptor, ionotropic, AMPA 1 (GluR1) were decreased in the hippocampi of the ATRX mice compared to wild-type mice. These findings suggest that ATRX mice may have fear-associated learning impairment with the dysfunction of αCaMKII and GluR1. The ATRX mice would be useful tools to investigate the role of the chromatin-remodeling factor in the pathogenesis of abnormal behaviors and learning impairment. © 2010 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

We evaluated the effect of kigikenchuto (KKT), a traditional Japanese formula, in a modified rat pressure-loading skin ulcer model. Rats were divided into three groups, KKT extract orally administered (250 or 500mg/kg/day for 35 days) and control. KKT shortened the duration until healing. Immunohistochemically, KKT increased CD-31-positive vessels in early phase and increased α-smooth muscle actin-(α-SMA-) positive fibroblastic cells in early phase and decreased them in late phase of wound healing. By Western blotting, KKT showed the potential to decrease inflammatory cytokines (MCP-1, IL-1β, and TNF-α) in early phase, decrease vascular endothelial growth factor in early phase and increase it in late phase, andmodulate the expression of extracellular protein matrix (α-SMA, TGF-β1, bFGF, collagen III, and collagen I). These results suggested the possibility that KKT accelerates pressure ulcer healing through decreases of inflammatory cytokines, increase of angiogenesis, and induction of extracellular matrix remodeling. [ABSTRACT FROM AUTHOR]

The well-established notion that the frequency of self-interested unethical behavior increases among anonymous people was reexamined employing a more strict definition of anonymity, voluntary unethical behavior, and adult individuals. Anonymity was defined as nonassociability of the participant's traits with respect to unethical behavior. The participant's identity and a monetary reward were manipulated as the independent variables, while cheating behavior was observed as the dependent variable. A sample of 143 undergraduate students were randomly assigned to 1 of 4 conditions (nonidentifiable--reward, identifiable--reward, nonidentifiable--nonreward, or identifiable--nonreward condition) to flip a coin twice in the experimental assignment. Results indicated that participants behaved differently depending on anonymity status and reward status. Implications for unethical behavior among anonymous individuals are discussed. [ABSTRACT FROM AUTHOR]

The present study examined association between anonymity and anti-social individual behavior without any influence from the presence of others. Anonymity was operationally defined as consisting of two components, nonidentifiabiity and nonaccountabiity. Antisocial behavior was defined as rule-breaking behavior seeking a monetary reward. It was hypothesized that anonymity would increase antisocial behavior among individuals. Undergraduate students (20 men, 50 women) were recruited from two psychology classes and were randomly assigned to four experimental conditions (Anonymous, Nonidentifiable, Nonaccountable, and Nonanonymous) to examine whether they would violate game rules to obtain the monetary reward through anonymity. Only participants in the Anonymous condition violated the rules to obtain the reward. Implications for the effects of anonymity on antisocial individual behavior are discussed. [ABSTRACT FROM AUTHOR]

Banxia Houpu Tang, a traditional Chinese medicine, helped in initiating oral feeding in a stroke patient, after three years of nasogastric tube feeding. This Chinese medicine has potential in eliminating the need for nasogastric feeding and for physical restraints in geriatric individuals after a stroke. [ABSTRACT FROM AUTHOR]