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Copyright of Libyan Journal of Medicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Open wound ulcer treatment remains a great challenge in wound care management especially involving multi drug resistant (MDR) pathogen. Currently, lack of effectiveness of commercially available wound dressing material is one of the primary factors delaying the wound healing. Therefore, transformation of plain Chitosan (Cs) to antibacterial polymer nanocomposite with embedment of Quercetin-ZnO/CuO biocide through green synthesis approach shed light for an efficient wound healing management. The present work studied the phytochemicals, biodegradation, storage, cytocompatibility and wound healing profiles of Cs film embedded with Quercetin-ZnO/CuO from Calotropis gigantea (C. gigantea). HPLC was used to detect Quercetin bioactive constituent. Our cytocompatibility study demonstrated ZnO/CuO-Cs-1wt.% displayed highest cell viability (168.52 ± 14.46%) at 72 h treatment. Besides, the ZnO/CuO-Cs-1wt.% is fully biodegradable. The ZnO/CuO-Cs-1wt.% also exhibited significantly enhanced cell migration (26.81 μm/h) and wound closure (62.35 ± 9.46%) at 12 h. This finding is also supported by our in vivo excisional open wound studies in Sprague-Dawley (SD) rats, which showed progressive recovery in 14 days. The controllable release of multiple metal ions from ZnO/CuO-Cs might contribute to the wound recovery. This study highlighted the promising outcomes exhibited from ZnO/CuO-Cs-1wt.% in wound healing management. [ABSTRACT FROM AUTHOR]

Background: No systematic review/meta-analysis has been conducted on the microbiological profile associated with the occurrence of periodontitis in patients with HIV. The aim of this study was to evaluate the prevalence of identified bacteria in HIV-infected patients with periodontal disease. Methods: Three English electronic databases (MEDLINE (via PubMed), SCOPUS, and Web of Science) were searched systematically from the beginning to February 13, 2021. The frequency of each identified bacteria in HIV-infected patients with periodontal disease was extracted. All meta-analysis methods were performed using STATA software. Results: Twenty-two articles met inclusion criteria and were enrolled into the systematic review. This review analyzed a total of 965 HIV-infected patients with periodontitis. The prevalence of periodontitis was higher in HIV-infected male patients (83% (CI 95%: 76 - 88%)) compared to females (28% (CI 95%: 17 - 39%)). In our study, the pooled prevalence of necrotizing ulcerative periodontitis and necrotizing ulcerative gingivitis in patients with HIV infection was 67% (CI 95%: 52 - 82%) and 60% (CI 95%: 45 - 74%), while a lower prevalence of linear gingivitis erythema was reported (11% (CI 95%: 5 - 18%)). More than 140 bacterial species were identified from HIV-infected patients with periodontal disease. High prevalence of Tannerella forsythia (51% (CI 95%: 5 - 96%)), Fusobacterium nucleatum (50% (CI 95%: 21 - 78%)), Prevotella intermedia (50% (CI 95%: 32 - 68%)), Peptostreptococcus micros (44% (CI 95%: 25 - 65%)), Campylobacter rectus (35% (CI 95%: 25 - 45%)), and Fusobacterium spp. (35% (CI 95%: 3 - 78%)) in HIV-infected patients with periodontal disease was found. Conclusions: Our study demonstrated that the prevalence of the red and orange complex of bacteria in HIV patients with periodontal disease is relatively high. [ABSTRACT FROM AUTHOR]

Abstract: Background: Most patients suspected of having heart failure (HF) will get a 12-lead electrocardiogram (ECG) but its utility for excluding HF or assisting in its management has rarely been investigated. Methods: The EuroHeart Failure survey identified 11,327 patients hospitalised with a suspected diagnosis of HF from 115 hospitals in 24 countries. ECGs were obtained from 9315 patients, of whom 5934 had cardiac imaging tests. The utility of the ECG was assessed for excluding or diagnosing major structural heart disease (MSHD) or major left ventricular systolic dysfunction (MLVSD) and for therapeutic decision making. Findings: MSHD was present in 70% and MLVSD in 54% of patients overall but in only 21% and 5%, respectively, if the ECG was entirely normal. However, <2% of patients had a normal ECG. No single ECG characteristic identified a probability <25% of MSHD or <20% of MLVSD. Patients with QRS width ≥120 ms or anterior pathological Q-waves had a probability >80% of MSHD and >70% of MLVSD. Diagnostic models suggested that electrocardiographic criteria alone were not accurate for the diagnosis or exclusion of important heart disease in this population. However, 2468 patients (42%) had an electrocardiographic finding that should be used to guide the choice of therapy. Conclusions: A normal ECG is rare in patients with suspected HF but has limited diagnostic value in this setting. The ECG has an important role in guiding therapy. [Copyright &y& Elsevier]