1. Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation.
- Author
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Makito Haruta, Naoya Kamiyama, Shun Nakajima, Mayumi Motoyama, Mamiko Kawahara, Yasumi Ohta, Atsushi Yamasaki, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Yasuyuki Ishikawa, Takashi Tokuda, Hitoshi Hashimoto, and Jun Ohta
- Abstract
In this study, we have developed an implantable optogenetic device that can measure and stimulate neurons by an optical method based on CMOS IC technology. The device consist of a blue LED array for optically patterned stimulation, a CMOS image sensor for acquiring brain surface image, and eight green LEDs surrounding the CMOS image sensor for illumination. The blue LED array is placed on the CMOS image sensor. We implanted the device in the brain of a genetically modified mouse and successfully demonstrated the stimulation of neurons optically and simultaneously acquire intrinsic optical images of the brain surface using the image sensor. The integrated device can be used for simultaneously measuring and controlling neuronal activities in a living animal, which is important for the artificial control of brain functions. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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