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1. LACK OF SMARCB1 EXPRESSION CHARACTERIZES A SUBSET OF PERIPHERAL T‐CELL LYMPHOMAS ENRICHED IN CHILDREN AND YOUNG ADULTS.

Author

Fischer, A., Moreno, N., Interlandi, M., Albert, T. K., Mormann, J., Glaser, S., Patil, P., Balbach, S., Wagener, R., Bens, S., Dahlum, S., Göbel, C., Graf, M., Kremer, E., de Faria, F. W., Melcher, V., Hartmann, W., Herbrüggen, H., Robert, S., and Dugas, M.

Subjects
GENE expression, YOUNG adults, LYMPHOMAS, T cells, DNA analysis
Abstract

LACK OF SMARCB1 EXPRESSION CHARACTERIZES A SUBSET OF PERIPHERAL T-CELL LYMPHOMAS ENRICHED IN CHILDREN AND YOUNG ADULTS B Methods: b SMARCB1 (INI1) gene and protein expression was assessed in 315 patients with diverse mature T cell lymphomas by array-based mRNA profiling, immunohistochemistry and/or Western Blot. Comparison of the DNA methylome of human and murine PTCL-NOS SP Smarcb1- sp showed similar DNA methylation profiles, with hypermethylation of T-cell-related genes and hypomethylation of genes involved in myeloid development. [Extracted from the article]

Published
2023
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