1. Immunoexpression of SOX‐2 in oral leukoplakia.
- Author
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Luiz, Suelen Teixeira, Modolo, Filipe, Mozzer, Izabela, Santos, Emanuela Carla, Nagashima, Seigo, Camargo Martins, Ana Paula, Azevedo, Marina Luise Viola, Azevedo Alanis, Luciana Reis, Hardy, Ana Maria Trindade Grégio, Moraes, Rafaela Scariot, Aguiar, Maria Cássia Ferreira, Ignácio, Sérgio Aparecido, Jham, Bruno Correia, Noronha, Lucia, and Johann, Aline Cristina Batista Rodrigues
- Subjects
EPITHELIUM ,CHI-squared test ,GENE expression ,IMMUNOHISTOCHEMISTRY ,ORAL leukoplakia ,SCIENTIFIC observation ,ORAL mucosa ,STATISTICS ,TRANSCRIPTION factors ,DATA analysis ,ONE-way analysis of variance ,PHYSIOLOGY ,DISEASE risk factors - Abstract
Objective: This study was conducted to correlate and compare the immunoexpression of sex‐determining region Y‐box 2 (SOX‐2) in oral leukoplakia (OL) lesions with that in normal buccal mucosa (control). Materials and Methods: In this observational study, OL with low‐risk (n = 34) and high‐risk (n = 33) dysplasia and control samples (n = 25) were subjected to immunohistochemical analysis for SOX‐2. In the epithelium, SOX‐2 positive and negative cells, as well as semiautomatic segmentation of the immunopositive nuclear area were counted. Statistical tests included chi‐square, one‐way analysis of variance, Tukey, and Games‐Howell. The level of significance was 5%. Results: Groups with OL lesions (low and high‐risk) showed higher mean numbers of SOX‐2 positive cells (63.47 ± 25.70 and 68.18 ± 21.17) compared to the control group (45.85 ± 27.38) (p = 0.00). Groups with OL lesions (low and high‐risk) exhibited higher mean positive nuclear area (0.24 ± 0.47 and 1.09 ± 2.06) compared to the control group (0.00 ± 0.01) (p = 0.01). Conclusion: Oral leukoplakia lesions showed a higher expression of SOX‐2, suggesting its contribution to the pathogenesis of OL. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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