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Copyright of Timocki Medicinski Glasnik is the property of Timocki Medicinski Glasnik and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Timocki Medicinski Glasnik is the property of Timocki Medicinski Glasnik and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article presents the pharmacokinetic study which investigates the effects of sodium cholate and sodium 12-monoketecholate in the apical-to-basolateral (AP-BL) permeation of methotrexate across Caco-2 cell monolayers. The study uses high performance liquid chromatography (HPLC) to identify the methotrexate with photochemically induced fluorescence detection. Results show that the monokecholate decreases transcellular permeation of methotrexate and reduces the intestinal absorption in rats.