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Trazodone is a serotonin receptor antagonist and reuptake inhibitor used extensively as an anxiolytic in human and small animal veterinary medicine. The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of oral trazodone in clinical horses. Six experimental horses were administered trazodone at 7.5 or 10 mg/kg. Plasma concentrations of trazodone and its metabolite (m‐CPP) were determined via UPLC‐MS/MS. Noncompartmental pharmacokinetic analysis, sedation and ataxia scores were determined. Trazodone was rapidly absorbed after oral administration with a maximum concentration of 2.5–4.1 μg/ml and half‐life of the terminal phase of approximately 7 hr. The metabolite was present at low levels in all horses, representing only 2.5% of the total area under the curve. In experimental horses, concentration‐dependent sedation and ataxia were noted, lasting up to 12 hr. For clinical cases, medical records of horses treated with trazodone for various abnormal behaviours were reviewed and data were summarized. Trazodone was successful in modifying behavioural problems to some degree in 17 of 18 clinical cases. Tolerance and subsequent lack of drug effect occurred in two of 18 clinical cases following 14 or 21 days of use. In both populations of horses, adverse effects attributed to trazodone include oversedation, muscle fasciculations and transient arrhythmias. [ABSTRACT FROM AUTHOR]

The article presents information about the Campus of the Future: A Meeting of the Minds conference to be held in Honolulu, Hawaii, during July 8-11, 2006. The 2006 conference will provide an opportunity for individuals and teams to come together as a campus administration community and experience fresh ideas and perspectives in a stimulating environment. The confluence of economic, political, technological, and competitive forces demands a collaborative approach to campus administration now and in the future. In fact, success will depend on a shared ownership across campus in meeting challenges. The program will offer insights, informed predictions, expert analysis, and proposed direction. A futures panel will kick off the program with an interactive overview of the key trends and issues driving society and higher education. With this background in mind, conference attendees will work together to uncover specific strategies to help institutions successfully plan and navigate the future.