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Purpose: Transumbilical laparoscopic‐assisted surgery (TULS) mixed benefits of laparoscopic and open surgeries. Transumbilical laparoscopic-assisted appendectomy (TULAA) is a well-known procedure, accepted and currently used by pediatric surgeons for treatment of uncomplicated appendicitis (UA). There is no current agreement in its use for the complicated appendiceal infections (CA). We reported our results using TULAA for both UA and CA. Methods: We retrospectively collected TULAA performed between April 2017 and April 2022. Appendicitis were classified in UA and CA. We analyzed conversion rate, operative time, length of stay, surgical site infections (SSIs) rate, postoperative intra-abdominal abscess and costs. Results: Over 5 years, 316 children underwent TULAA. Conversion rate was 3%. Mean age at surgery was 9.36 years (IQR 2–16). Forty-nine appendicitis were CA. Operative time and hospital stay was higher in CA than in UA group (38.33 vs. 60.73 min, p < 0.00001; 4 vs. 7 days, p < 0.00001). SSIs rate showed no statistically significant difference between two groups. Incidence of postoperative intra-abdominal collections was 11% in CA and 1% in UA. TULAA's cost was 192.07 €. Conclusion: In our series, TULAA seems to be safe, feasible and cost-effective for both uncomplicated and complicated appendicitis, with no disadvantage in terms of outcomes compared to what is reported in literature for CLS. [ABSTRACT FROM AUTHOR]

Purpose: Transumbilical laparoscopic‐assisted surgery (TULS) mixed benefits of laparoscopic and open surgeries. Transumbilical laparoscopic-assisted appendectomy (TULAA) is a well-known procedure, accepted and currently used by pediatric surgeons for treatment of uncomplicated appendicitis (UA). There is no current agreement in its use for the complicated appendiceal infections (CA). We reported our results using TULAA for both UA and CA. Methods: We retrospectively collected TULAA performed between April 2017 and April 2022. Appendicitis were classified in UA and CA. We analyzed conversion rate, operative time, length of stay, surgical site infections (SSIs) rate, postoperative intra-abdominal abscess and costs. Results: Over 5 years, 316 children underwent TULAA. Conversion rate was 3%. Mean age at surgery was 9.36 years (IQR 2–16). Forty-nine appendicitis were CA. Operative time and hospital stay was higher in CA than in UA group (38.33 vs. 60.73 min, p < 0.00001; 4 vs. 7 days, p < 0.00001). SSIs rate showed no statistically significant difference between two groups. Incidence of postoperative intra-abdominal collections was 11% in CA and 1% in UA. TULAA's cost was 192.07 €. Conclusion: In our series, TULAA seems to be safe, feasible and cost-effective for both uncomplicated and complicated appendicitis, with no disadvantage in terms of outcomes compared to what is reported in literature for CLS. [ABSTRACT FROM AUTHOR]

Congenital vaginal atresia is a rare anomaly of the female genital tract. Many vaginoplasty procedures have been described, but the postoperative risk of vaginal stenosis remains a challenge. We report a case of isolated distal vaginal agenesis in a patient with neurological impairment where the use of an "alternative" dilator was needed. An 11-year-old girl with Down syndrome was admitted to the Emergency Department complaining of pelvic pain. The clinical evaluation showed a hard and painful pelvic mass associated with an imperforate hymen. Abdominal ultrasound and pelvic MRI were suggestive for hematometrocolpos and absence of the lower third segment of the vagina. Vaginoscopy confirmed the diagnosis of congenital vaginal agenesis. The patient then underwent a laparoscopic-assisted vaginoplasty. Considering the difficult management of the postoperative period, an epistaxis catheter was used as a vaginal stent and dilator. The use of an epistaxis catheter to provide adequate vaginal patency after vaginoplasty can be an alternative solution especially in those cases where calibrations with dilators are difficult or not tolerated. [ABSTRACT FROM AUTHOR]

Duplex collecting system is a common congenital urinary system anomaly and is usually asymptomatic. Vascular variations associated with a duplex system are common but haven't been reported as obstructive. 14-month-old female had a right sided incomplete ureteral duplication complicated by lower pole hydroureteronephrosis due to distal ureteral obstruction by an aberrant vessel crossing the bifid ureters at ureteric junction of these bifid ureters. Prenatal imaging detected right hydronephrosis. Magnetic resonance suggested a diagnosis of duplicated ureters. At surgery, an aberrant artery compressed the lower moiety ureter at the bifid ureteric junction. The stenotic section was resected and ureter segments were anastomosed. The occluding small artery was not resected to preserve vascularization. An anatomical vascular variation can cause proximal ureteral dilatation and segmental hydronephrosis in a bifid system. [ABSTRACT FROM AUTHOR]

The healthy prostate is a relatively quiescent tissue. Yet, prostate epithelium overgrowth is a common condition during aging, associated with urinary dysfunction and tumorigenesis. For over thirty years, TGF-b ligands have been known to induce cytostasis in a variety of epithelia, but the intracellular pathway mediating this signal in the prostate, and its relevance for quiescence, have remained elusive. Here, using mouse prostate organoids to model epithelial progenitors, we find that intra-epithelial non-canonical Activin A signaling inhibits cell proliferation in a Smad-independent manner. Mechanistically, Activin A triggers Tak1 and p38 ΜAPK activity, leading to p16 and p21 nuclear import. Spontaneous evasion from this quiescent state occurs upon prolonged culture, due to reduced Activin A secretion, a condition associated with DNA replication stress and aneuploidy. Organoids capable to escape quiescence in vitro are also able to implant with increased frequency into immunocompetent mice. This study demonstrates that non-canonical Activin A signaling safeguards epithelial quiescence in the healthy prostate, with potential implications for the understanding of cancer initiation, and the development of therapies targeting quiescent tumor progenitors. [ABSTRACT FROM AUTHOR]

The term exstrophy-epispadias complex refers to a group of midline defects ranging from epispadias to cloacal exstrophy. Bladder exstrophy is the most frequent malformation of this spectrum and it can present as a classical or a variant form. We report a case of a hybrid bladder exstrophy variant having some characteristics of both a duplicate bladder exstrophy and a superior vesical fistula. [ABSTRACT FROM AUTHOR]

We suggest extending testing to all patients undergoing gastrointestinal surgery who have had recently demonstrated SARS-CoV-2 infection (even if they tested negative on admission on nasal swab). We detected SARS-CoV-2 in peritoneal fluid from two children with prior nasopharyngeal detection of SARS-CoV-2 who developed complicated appendicitis. Similarly, patients with a recently demonstrated SARS-CoV-2 infection (although tested negative on admission on nasal swab) should be considered SARS-CoV-2 positive, as per the use of PPE and for the setting of the operating room. [Extracted from the article]

Laboratory investigations included renal function tests, hormonal examinations, urinalysis, and complete blood count which were all normal. A 3-day-old female newborn was consulted for paediatric urology because of an interlabial mass (Fig. A lower abdomen ultrasonography was also performed and it showed a normal uterus and both ovaries. [Extracted from the article]

Endoscopic methods to prevent gastroesophageal reflux (GER) show scarce effectiveness and may narrow the esophageal lumen more or less stiffly, sometimes impairing bolus transit and leading to dysphagia. The aim of this study was to demonstrate the possibility of reinforcing lower esophageal sphincter (LES) tone by implanting endoluminally a magnetic device. The device consists of two small magnetic plaques to be implanted in the submucosa close to LES with opposite polarities facing so that they attract one other, closing the esophageal lumen. The magnets were implanted by means of a special endoluminal device in five esophageal-gastric ex vivo specimens taken from swine. Variation in endoluminal pressure at the LES level was measured by means of slow pull-through of a thin side-hole manometric catheter in each specimen, before and after insertion of the magnets. The new high-pressure zone exhibited a length of about 2 cm and a pressure of 14.2 ± 1.27 mmHg [mean ± standard deviation (SD)], significantly ( p < 0.001) higher than that measured before insertion of the magnetic valve (1.5 ± 0.26 mmHg). The present research demonstrates that it is possible to create at the LES level a dynamic closure of a value considered sufficient to prevent GER, by implanting in the esophageal submucosa of anatomical specimens a magnetic device by means of a special endoluminal probe. Once effectiveness and tolerability of magnets covered by a biocompatible sheath have been demonstrated in vivo, this device could become a simple and effective nonsurgical solution to GER. [ABSTRACT FROM AUTHOR]

Background/Aims: Dietary fibers are frequently included in diets to decrease body weight, but their scarce palatability and the occurrence of meteorism prevent a long-term intake. The aim of this study was to test a mixture of dietary fibers expressly chosen to decrease their negative properties and strengthen their positive effects. Methods: In a series of 10 patients with a slight overweight, the effectiveness of a palatable dietary fibers mixture on gastric emptying and intestinal transit was tested with scintigraphic methods. Then, the effects on body weight and digestive sensations and characteristics of defecations, were evaluated for 4 weeks. Results: The intestinal transit was significantly shortened by the fiber intake, while the gastric emptying was delayed, but not significantly. The body mass index significantly and progressively decreased, whereas the sense of satiation significantly increased. No effect on abdominal bloating was referred, whereas a significant increase in number of defecations with stools of normal consistency was observed. The acceptability of the fiber mixture was good. Conclusions: The present research demonstrated that it is possible to prepare a palatable mixture of dietary fibers that maintains the property of decreasing body weight, favors the sense of satiation and accelerates the intestinal transit, with normalization of the stool consistency without the occurrence of meteorism. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

In this research we propose an original magnetic device to strengthen the hypo-atonic anal sphincter and prevent fecal incontinence. The device consists in a couple of small magnetic plaques to be surgically inserted in the wall of the anal canal between the external and internal anal sphincters with the opposite polarities face to face, so that, attracting themselves, close the anal lumen. Three couples of magnets made of materials of different magnetic force (neodymium > ferrite > plastoferrite) were evaluated in each of three swine anatomical preparations by measuring the endoanal pressure with a manometric catheter, both before and after magnet implantation. The mean pressures obtained before and after magnet insertion were statistically compared with Student t test. The endoanal pressure after the insertion of neodymium magnets was 79.7 ± 13.1 (mean ± SD), after ferrite magnets was 42.1 ± 5.6 mmHg and after plastoferrite magnets was 21.6 ± 4.6 mmHg, all of them significantly higher than the pressure recorded in basal conditions (1.72 ± 0.71 mmHg). This research demonstrated that the implantation of a couple of magnets in the wall of the anal canal is able to create a high pressure zone of a value sufficient to prevent fecal incontinence and that the strength of this “dynamic closure” can be modulated by using magnets of various attraction force, so allowing a “tailored correction” of the anal sphincter hypotension. [ABSTRACT FROM AUTHOR]