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Copyright of Veterinary Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Estimation of the quality of commercial diets is a topic of interest for the majority of dog owners. Recently, in a French consumer association magazine, an evaluation of eight dog commercial dry diets (from super-premium, basic-nutrition, private-label and economy brands) according to several nutritional criteria was published. The aims of the study were: (1) to evaluate the apparent digestibility of these diets; (2) to score these diets according to digestibility results; and (3) to compare these data with the scoring of the magazine. Six adult Beagle dogs were enrolled for the digestibility trials. Diets were scored according to energy, crude protein and crude fat (CF) apparent digestibility coefficients, digestible protein-to-energy ratios and ash content. Each of the five criteria was scored from 4 to 20 points. The ranges of crude protein, CF, crude fibre and ash content were 20·9-30·6%, 6·8-19·7%, 2·2-3·3% and 4·6-9·7% on a DM basis, respectively. The ranges of energy, crude protein and CF apparent digestibility coefficients were 72·6-87·7%, 70·4-82·5% and 76·1-95·4%, respectively. The range of the protein-to-energy ratio was 10-14 digestible crude protein per MJ metabolisable energy. Little overlap in the scoring systems was found, but the private-label brand and economy brand diets presented the lowest scores in the two systems. These results showed that the evaluation of commercial diets should take into account multiple nutritional aspects. In particular, analytical and biological (digestibility) criteria should be considered as complementary in the evaluation of dry dog commercial diets. [ABSTRACT FROM AUTHOR]

In cats, the incidence of obesity and diabetes is increasing, and little is known about specific aspects of the endocrine control of food intake in this species. Recent data suggest that ghrelin has an important role in the control of insulin secretion and vice versa, but this role has never been demonstrated in cats. Here we aimed to improve our understanding about the relationship between insulin, amylin and ghrelin secretion in response to a nutrient load in overweight cats. After a 16 h fast, weekly, six overweight male cats underwent randomly one of the four testing sessions: saline, glucose, arginine and TAG. All solutions were isoenergetic and isovolumic, and were injected intravenously as a bolus. Glucose, insulin, acylated ghrelin (AG), amylin and prolactin were assayed in plasma before and 10, 20, 40, 60, 80 and 100 min after the nutrient load. A linear mixed-effects model was used to assess the effect of bolus and time on the parameters. A parenteral bolus of glucose or arginine increased insulin and ghrelin concentrations in cats. Except for with the TAG bolus, no suppression of ghrelin was observed. The absence of AG suppression after the intravenous load of arginine and glucose may suggest: (1) that some nutrients do not promote satiation in overweight cats; or that (2) AG may be involved in non-homeostatic consumption mechanisms. However, the role of ghrelin in food reward remains to be assessed in cats. [ABSTRACT FROM AUTHOR]

The increased prevalence of obesity after neutering in cats is problematic in veterinary practice. Although many factors seem to be involved, the role of prolactin (PRL) and insulin-like growth factor-I (IGF-I), both implicated in adipose tissue development and glucose intolerance, should be considered. Seven male cats were castrated when 11 months old. Body weight was then recorded for 56 weeks and PRL, IGF-I and leptin assayed for 44 weeks. Body weight increased steadily but only significantly after 36 weeks. It stabilised after 44 weeks, and the cats then gained about 20% of their initial body weight. IGF-I increased rapidly and was significantly higher by week 3. PRL and leptin increased with initial peaks during the eighth and eleventh weeks, respectively. This study confirms that castration rapidly modifies the hormonal balance, partly explaining the body weight increase, and that hormonal changes precede this body weight increase. Hyperleptinaemia is apparently a consequence of excess weight. [Copyright &y& Elsevier]

Studies the adipose tissue in obese insulin-resistant dogs by researchers from France. Modulation of uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor (PPAR) γ expression; Role of PPAR in inflammatory status; Plausibility for UCP1 to contribute to the adaptive change in energy expenditure.

Investigates the relationship between electrolyte apparent absorption and fecal quality in adult dogs differing in body size by researchers from France. Presentation of diversity on body weight and size of the domestic dog among other mammalian species; Evaluation on the potential physiological consequences in relation to the extreme variation; Indications that large-breed dogs have higher fecal water content and greater frequency of soft feces compared with small-breed dogs.

We previously demonstrated improvements of colonic lesions due to dextran sulfate sodium (DSS) in rats after 7 d of supplementation with resistant starch (RS) type 3, a substrate yielding high levels of butyrate (C(4)), a colonic cell fuel source. In the present study, we hypothesized that if inflammation is related to decreased C(4) utilization by the colonic mucosa, RS supplementation should restore C(4) use simultaneously with an increase in the amount of C(4) present in the digestive tract. Hence, we compared, in vivo, the cecocolonic uptake of C(4) and its oxidation into CO(2) and ketone bodies in control and DSS-treated rats fed a fiber-free basal diet (BD) or a RS-supplemented diet. Sprague-Dawley rats (n = 60) were used. DSS treatment was performed to induce acute colitis and then to maintain chronic colitis. After cecal infusion of [1-(13)C]-C(4) (20 micro mol in 1 h), concentrations and (13)C-enrichment of C(4), ketone bodies, and CO(2) were quantified in the abdominal aorta and portal vein. Portal blood flow was recorded. During acute colitis, (13)C(4) uptake and (13)CO(2) production were lower in DSS rats than in controls. During chronic colitis, DSS rats did not differ from controls. After 7 d of chronic colitis, RS-DSS rats exhibited the same C(4) uptake as BD-DSS rats in spite of higher C(4) cecocolonic disposal. After 14 d, C(4) uptake was higher in RS-DSS than in BD-DSS rats. Thus, the increased utilization of C(4) by the mucosa is subsequent to evidence of healing and appears to be a consequence rather than a cause of this RS healing effect. [ABSTRACT FROM AUTHOR]

Butyrate is recognised as efficient in healing colonic inflammation, but cannot be used as a long-term treatment. Dietary fibre that produces a high-butyrate level when fermented represents a promising alternative. We hypothesised that different types of dietary fibre do not have the same efficiency of healing and that this could be correlated to their fermentation characteristics. We compared short-chain fructo-oligosaccharides (FOS) and type 3 resistant starch (RS) in a previously described dextran sulfate sodium (DSS)-induced colitis model. Seventy-two Sprague???Dawley rats received water (control rats) or DSS (50g DSS/l for 7d then 30g DSS/l for 7 (day 7) or 14 (day 14) d). The rats were fed a basal diet (BD), or a FOS or RS diet creating six groups: BD-control, BD-DSS, FOS-control, FOS-DSS, RS-control and RS-DSS. Caeco-colonic inflammatory injuries were assessed macroscopically and histologically. Short-chain fatty acids (SCFA) were quantified in caeco-colon, portal vein and abdominal aorta. At days 7 and 14, caecal and distal macroscopic and histological observations were improved in RS-DSS compared with BD-DSS and also with FOS-DSS rats. Caeco-colonic SCFA were reduced in FOS-DSS and RS-DSS groups compared with healthy controls. The amount of butyrate was higher in the caecum of the RS-DSS rats than in the BD-DSS and FOS-DSS rats, whereas distal butyrate was higher in FOS-DSS rats. Partially explained by higher luminal levels of SCFA, especially butyrate, the healing effect of RS confirms the involvement of some types of dietary fibre in inflammatory bowel disease. Moreover, the ineffectiveness of FOS underlines the importance of the type of dietary substrate. [ABSTRACT FROM PUBLISHER]

Portal appearance of short-chain fatty acids (SCFA) produced from fermentation of three different resistant starch (RS) sources (raw potato starch, high-amylose maize starch and retrograded high-amylose maize starch) was investigated in pigs. The catheterization technique coupled with determination of portal blood flow was used to estimate SCFA uptake by the colonic mucosa. Our hypothesis was that these three RS were not equivalent butyrate providers for the colonic mucosa and that butyrate uptake would therefore be different after in vivo fermentation of each starch. The starches induced different patterns of appearance of SCFA in the portal blood; raw potato starch was the only RS source to show a significant appearance of butyrate in the portal blood. Thus, uptake of butyrate by the colonic mucosa apparently differed between starches. This finding suggests that butyrate uptake does not only depend on the flow of butyrate appearing in the lumen. Indeed, for unexplained reasons, utilization of butyrate by the colonic mucosa appeared to be less efficient when the butyrate was produced from fermentation of potato starch than when it was produced from fermentation of the other RS sources. [ABSTRACT FROM PUBLISHER]

Postprandial hyperglycemia and insulin secretion depend on many factors, such as food composition, carbohydrate type and processing. The purpose of this study was to evaluate the effects of foods differing in composition in nonobese clinically normal dogs. These dogs were offered in a single meal one of the four foods. Blood samples were collected before feeding and during the 180 min after the meal. Plasma glucose and insulin concentrations were determined. The integrated areas under the postprandial glucose and insulin response curves were calculated. Times to response peaks, maximum plasma insulin elevation, area under the insulin response curve and the insulinemic index differed between dog foods. Crude fiber content had no significant effect. The time to glucose peak was higher and the time to insulin peak lower with the food highest in protein and ether extract content. The time to glucose peak was correlated to protein, fat and nitrogen-free extract content of foods, whereas the time to insulin peak and the area under the insulin curve were correlated to protein and nitrogen-free extract. [ABSTRACT FROM AUTHOR]

The article presents a comparative study on insulin sensitivity, insulin secretion, and plasma leptin and insulin-like growth factor-1 (IGF-1) in cats fed diets differing in protein and carbohydrate content. The study utilized normal-weight cats and were assessed with insulin sensitivity and insulin secretion, plasma leptin and IGF-1 level. Findings show that high protein diet do not affect insulin sensitivity or insulin secretion in reaction to glucose in normal-weight cats and present lower IGF-1 level in opposition to results from previous studies. Furthermore, plasma leptin is consistent with the normal weight of the cats. However, further analysis is needed to obtain specific results on the effects of diets on metabolic equilibrium of glucose in cats.

The article presents a study that determines the effect of the two dietary supplements, hydroxycitric acid and conjugated linoleic acid, on body composition, total energy expenditure, and least observed metabolism of adult neutered cats. Normal weight cats, who were fed 50 kilocalorie of a food of metabolizable energy was used in the study. The results show that cats were nonobese and their body weight was stable. It shows that dietary supplements could be more effective in young growing cats.

Examines the effects of high protein intake in nonobese neutered cats by researchers from France. Influence of dietary composition on lean body mass in the cat models; Induction of weight loss with the administration of high-protein diets; Determination on the effect of a limited energy intake of a high-protein diet on the body composition.

Studies on the gastric emptying rate of different dog breeds by researchers from France. Relationship between gastric emptying rate and body weight in different canine body sizes; Tendency for large and giant breeds of dog to defecate more frequently with poor quality of feces when fed with an identical diet to smaller breeds; Efforts of the researchers to gain insight as to the effect of body size on fecal variables in otherwise healthy dogs.

Presents a study that evaluated body composition in dogs by isotopic dilution. Techniques used for evaluation of body composition; List of isotopes that are commonly used as water labels; Experimental procedures; Results and discussion.

Presents information on a study that estimated the effects of graded dietary protein levels on protein synthesis, breakdown and oxidation in dogs during the postabsorptive phase, using the C-leucine method. Methodology; Results and discussion.

Presents a study that assessed the influence of weight loss on body composition, energy expenditure and protein turnover rate, and compared the effects on the parameters of two diets differing mainly in protein content. Experimental procedures; Results and discussion.