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Due to the increasingly restrictive limits of pollutant emissions, electrification of automotive engines is now mandatory. For this reason, adopting hybrid boosting systems to improve brake specific fuel consumption and time-to-boost is becoming common practice. In this paper an advanced turbocharging system is analyzed, consisting in an electrically assisted radial compressor and a traditional turbocharger. As a first step, the steady-state performance of each component was measured at the University of Genoa test rig. Subsequently another experimental campaign was carried out to evaluate the transient response of the entire turbocharging system. Two different layouts were compared: upstream and downstream. In the upstream configuration the electrically assisted compressor was placed in front of the traditional turbocharger, in the downstream configuration the e-compressor was positioned after the traditional turbocharger. The two different coupling configurations, upstream and downstream, were then modeled in 1-D simulation software following the dimensions and characteristics of the experimental line from which the exploited data originates. The models were first validated by emulating the steady-state condition and subsequently the transient response was simulated and analyzed. Secondly, the transient response of the two layouts was compared, removing the constraints imposed by the experimental activity. The practical significance of the results is outlined, with reference to the transient response of the turbocharger. The adoption of the boosting system presented here allows a fast and stable transient response. Moreover, a reduction in the engine back pressure could be achieved through an optimization of the boosting system-engine matching calculation. [ABSTRACT FROM AUTHOR]

This article describes an investigation of the unsteady behavior of turbocharger turbines by one-dimensional modeling and experimental analysis. A one-dimensional model has been developed to predict the performance of a vaneless radial-inflow turbine submitted to unsteady flow conditions. Different from other approaches proposed in the literature, the turbine has been simulated by separating the effects of casing and rotor on the unsteady flow and by modeling the multiple rotor entries from the volute. This is a simple and effective way to represent the turbine volute by a network of one-dimensional pipes, in order to capture the mass storage effect due to the system volume, as well as the circumferential variation of fluid dynamic conditions along the volute, responsible for variable admittance of mass into the rotor through blade passages. The method developed is described, and the accuracy of the one-dimensional model is shown by comparing predicted results with measured data, achieved on a test rig dedicated to the investigation of automotive turbochargers. The validation of the code is presented and an analysis of the flow unsteadiness, based on a variety of parameters, is proposed. [ABSTRACT FROM AUTHOR]

A cooperative fuel research (CFR) engine was modified and instrumented in order to control operating conditions and to measure engine parameters and in-cylinder pressure diagrams. Aiming at the comparison of different alternative fuels, an experimental procedure was defined, including cetane number (CN) evaluation and the definition of engine operating quantities in different working points, for fixed levels of compression ratio (CR) and injection advance. An investigation was made considering several blends of methyl-esters of rapeseed oil (RME) and of a mix of vegetable oils (VOME) with conventional diesel oil. The defined experimental procedure was applied to assess CN, engine brake thermal efficiency (bte) and exhaust emissions. Results show that the biodiesel content has a positive influence on soot emissions, with strong reduction, while thermal efficiency and NOXemissions are negatively affected, which can be justified taking into account fuel properties and changes in combustion process. As observed outcomes are generally in line with those presented in literature, the facility proved to be a suitable tool for basic investigations on alternative fuels to be used in specific applications. [ABSTRACT FROM PUBLISHER]

In this paper, the unsteady-state behaviour of a turbocharger wastegated turbine (IHI-RHF3) is investigated using both an experimental approach and a numerical approach. First, an experimental campaign is performed in a specialized test rig operating at the University of Genoa, for different openings of the wastegate valve and under steady flow and unsteady flow operations. An appropriate configuration of the turbine outlet circuit fitted with a separating wall is used to carry out instantaneous measurements downstream of the turbine wheel and the wastegate valve. The above data constitute the basis for the tuning and validation of a one-dimensional turbine model recently developed at the University of Naples. Preliminary model tuning is carried out on the basis of the characteristic map measured for a completely closed wastegate valve under steady flow operations. A refined one-dimensional schematization of the experimental apparatus is implemented within the commercial GT-Power® software, including the turbine, the wastegate circuit and the upstream and downstream measuring stations. In particular, the classical map-based approach is suitably corrected with a sequence of pipes that schematizes each component of the turbine (the inlet and outlet ducts, the volute and the wheel) to account for the wave propagation and storage phenomena inside the machine. A detailed one-dimensional schematization of the wastegate circuit is also implemented and independently tuned. The turbine model capability under unsteady flow conditions is tested for different wastegate openings and pulse frequencies, by applying time-dependent boundary conditions. In particular, the pressures and temperatures measured upstream and downstream are imposed at the model ends, and the instantaneous mass flow rate and the actual power are numerically evaluated. The results are compared with the experimental data, demonstrating good accuracy and showing some improvements with respect to the standard turbine modelling in the case of the mass flow rate prediction. On the contrary, the computed actual power shows some inaccuracies, especially at higher pulse frequencies. [ABSTRACT FROM AUTHOR]

Background As illustrated by the Montreal classification, gastroesophageal reflux disease (GERD) is much more than heartburn and patients constitute a heterogeneous group. Understanding if links exist between patients' characteristics and GERD symptoms, and classify subjects based on symptom-profile could help to better understand, diagnose, and treat GERD. The aim of this study was to identify distinct classes of GERD patients according to symptom profiles, using a specific statistical tool: Latent class analysis. Methods An observational single-visit study was conducted in 5 European countries in 7700 adults with typical symptoms. A latent class analysis was performed to identify "latent classes" and was applied to 12 indicator symptoms. Results On 7434 subjects with non-missing indicators, latent class analysis yielded 5 latent classes. Class 1 grouped the highest severity of typical GERD symptoms during day and night, more digestive and non-digestive GERD symptoms, and bad sleep quality. Class 3 represented less frequent and less severe digestive and non-digestive GERD symptoms, and better sleep quality than in class 1. In class 2, only typical GERD symptoms at night occurred. Classes 4 and 5 represented daytime and nighttime regurgitation. In class 4, heartburn was also identified and more atypical digestive symptoms. Multinomial logistic regression showed that country, age, sex, smoking, alcohol use, low-fat diet, waist circumference, recent weight gain (>5 kg), elevated triglycerides, metabolic syndrome, and medical GERD treatment had a significant effect on latent classes. Conclusion Latent class analysis classified GERD patients based on symptom profiles which related to patients' characteristics. Although further studies considering these proposed classes have to be conducted to determine the reproducibility of this classification, this new tool might contribute in better management and follow-up of patients with GERD. [ABSTRACT FROM AUTHOR]

Proton pump inhibitors are widely used for the treatment of acid-related disorders. Rabeprazole is a potent and irreversible inhibitor of H+/K+-ATPase gastric pump, and it is indicated for the treatment of gastroesophageal reflux disease, Zollinger Ellison syndrome, duodenal and gastric ulcers and for the eradication of Helicobacter pylori in combination with antibiotics. Pharmacokinetic and pharmacodynamic data show that rabeprazole achieves a pronounced acid suppression from the first administration that is maintained with repeated use; this may translate into faster onset of symptom relief for patients, particularly suitable when the indication is for the on-demand long-term maintenance of gastroesophageal reflux disease. Due to its predominantly nonenzymatic metabolism, rabeprazole has a lower potential for drug--drug interactions. The objective of this article is to update efficacy and safety data of rabeprazole in the treatment of acid-related disorders, following a previous review dated 2008. [ABSTRACT FROM AUTHOR]

Background: As weight gain is one of the most frequently cited reasons for not using and for discontinuing hormonal contraceptives, in an open-label, single-arm, multicentre clinical study we evaluated the effect of the ethinylestradiol/norelgestromin contraceptive patch (EVRA, Janssen-Cilag International, Belgium) on body composition using bioelectrical impedance analysis (BIA). Methods: Body weight and impedance vector components (resistance (R) and reactance (Xc), at 50 kHz frequency, Akern-RJL Systems analyzer) were recorded before entry, after 1, 3 and 6 months in 182 Italian healthy women aged 29 yr (18 to 45), and with BMI 21.8 kg/m² (16 to 31). Total body water (TBW) was estimated with a BIA regression equation. Vector BIA was performed with the RXc mean graph method and the Hotelling's T² test for paired and unpaired data. Results: After 6 months body weight increased by 0.64 kg (1.1%) and TBW increased by 0.51 L (1.7%). The pattern of impedance vector displacement indicated a small increase in soft tissue hydration (interstitial gel fluid). Body composition changes did not significantly differ among groups of previous contraceptive methods. Arterial blood pressure did not significantly change over time. Conclusion: After 6 months of treatment with the ethinylestradiol/norelgestromin contraceptive patch we found a minimal, clinically not relevant, increase in body weight less than 1 kg that could be attributed to an adaptive interstitial gel hydration. This fluctuation is physiological as confirmed by the lack of any effect on blood pressure. This could be useful in increasing women's choice, acceptability and compliance of the ethinylestradiol/norelgestromin contraceptive patch. [ABSTRACT FROM AUTHOR]

The WHSC1/MMSET gene, involved in t(4;14)(p16.3;q32) in multiple myeloma, encodes putative isoforms (MMSET I, MMSET II and RE-IIBP) which are thought to be involved in transcription regulation. We investigated their activity in transfected 293T and HeLa cells. Both MMSET I and MMSET II were localised in the nucleus, whereas RE-IIBP showed cytoplasmic and nucleolar staining. MMSET I dose-dependently repressed the transcriptional activity of the promoter region of the thymidine kinase gene, whereas MMSET II and RE-IIBP had no effect. The HDAC inhibitor, trichostatin A, reduced MMSET I repression activity and in vitro co-immunoprecipitation analyses indicated that MMSET I specifically recruits HDAC1 and mSin3b, but not HDAC2 or HDAC4. Our data support the hypothesis that MMSET may act as a transcription regulator; different functions may be associated with distinct isoforms. [ABSTRACT FROM AUTHOR]

The increasingly restrictive limits on exhaust emissions of automotive internal combustion engines imposed in recent years are pushing OEMs to seek new solutions to improve powertrain efficiency. Despite the increase in electric and hybrid powertrains, the turbocharging technique is still one of the most adopted solution in automotive internal combustion engines to achieve good efficiency with high specific power levels. Nowadays, turbocharged downsized engines are the most common solution to lower CO2 emissions. Pulse turbocharging is the most common boosting layout in automotive applications as the best response in terms of time-to-boost and exhaust energy extraction. In a high-fractionated engine with four or more cylinders, a twin entry turbine can be adopted to maximize pulse turbocharging benefits and avoid interaction in the discharge phase of the cylinders. The disadvantages of the twin entry turbine are mainly due to the complexity of the exhaust piping line and the high amount of information required to build a rigorous and reliable matching model. This paper presents a detailed experimental characterization of a twin entry turbine with particular reference to the turbine efficiency and the swallowing capacity under different admission conditions. The steady flow experimental campaign was performed at the turbocharger test bench of the University of Genoa, in order to analyze the behavior of the twin entry turbine in full, partial and unbalanced admission. These are the conditions in which the turbine must work instantaneously during its normal operation in engine application. The results show a different swallowing capacity of each sector and the interactions between the two entries. [ABSTRACT FROM AUTHOR]

Background: As illustrated by the Montreal classification, gastroesophageal reflux disease (GERD) is much more than heartburn and patients constitute a heterogeneous group. Understanding if links exist between patients' characteristics and GERD symptoms, and classify subjects based on symptom-profile could help to better understand, diagnose, and treat GERD. The aim of this study was to identify distinct classes of GERD patients according to symptom profiles, using a specific statistical tool: Latent class analysis.Methods: An observational single-visit study was conducted in 5 European countries in 7700 adults with typical symptoms. A latent class analysis was performed to identify "latent classes" and was applied to 12 indicator symptoms.Results: On 7434 subjects with non-missing indicators, latent class analysis yielded 5 latent classes. Class 1 grouped the highest severity of typical GERD symptoms during day and night, more digestive and non-digestive GERD symptoms, and bad sleep quality. Class 3 represented less frequent and less severe digestive and non-digestive GERD symptoms, and better sleep quality than in class 1. In class 2, only typical GERD symptoms at night occurred. Classes 4 and 5 represented daytime and nighttime regurgitation. In class 4, heartburn was also identified and more atypical digestive symptoms. Multinomial logistic regression showed that country, age, sex, smoking, alcohol use, low-fat diet, waist circumference, recent weight gain (>5 kg), elevated triglycerides, metabolic syndrome, and medical GERD treatment had a significant effect on latent classes.Conclusion: Latent class analysis classified GERD patients based on symptom profiles which related to patients' characteristics. Although further studies considering these proposed classes have to be conducted to determine the reproducibility of this classification, this new tool might contribute in better management and follow-up of patients with GERD. [ABSTRACT FROM AUTHOR]

Background: As weight gain is one of the most frequently cited reasons for not using and for discontinuing hormonal contraceptives, in an open-label, single-arm, multicentre clinical study we evaluated the effect of the ethinylestradiol/norelgestromin contraceptive patch (EVRA, Janssen-Cilag International, Belgium) on body composition using bioelectrical impedance analysis (BIA).Methods: Body weight and impedance vector components (resistance (R) and reactance (Xc), at 50 kHz frequency, Akern-RJL Systems analyzer) were recorded before entry, after 1, 3 and 6 months in 182 Italian healthy women aged 29 yr (18 to 45), and with BMI 21.8 kg/m2 (16 to 31). Total body water (TBW) was estimated with a BIA regression equation. Vector BIA was performed with the RXc mean graph method and the Hotelling's T2 test for paired and unpaired data.Results: After 6 months body weight increased by 0.64 kg (1.1%) and TBW increased by 0.51 L (1.7%). The pattern of impedance vector displacement indicated a small increase in soft tissue hydration (interstitial gel fluid). Body composition changes did not significantly differ among groups of previous contraceptive methods. Arterial blood pressure did not significantly change over time.Conclusion: After 6 months of treatment with the ethinylestradiol/norelgestromin contraceptive patch we found a minimal, clinically not relevant, increase in body weight less than 1 kg that could be attributed to an adaptive interstitial gel hydration. This fluctuation is physiological as confirmed by the lack of any effect on blood pressure. This could be useful in increasing women's choice, acceptability and compliance of the ethinylestradiol/norelgestromin contraceptive patch. [ABSTRACT FROM AUTHOR]