Search

Fibrous Dysplasia (FD) is a benign non-inherited and rare skeletal disorder that can affect any bone of human body. FD is caused by a mutation in GNAS1 gene, but the mutation is not inherited from parents. While there are some reports of post-traumatic fibrous dysplasia, but the relationship between fibrous dysplasia and trauma or previous injury is unclear. Most of the time, fibrous dysplasia is diagnosed by accident in x-ray imaging. While there is much information on fibrous dysplasia, the main etiology is still unknown, however it seems to be linked to a gene mutation .A mutation in this gene affects differentiation and proliferation of cells. This benign fibro-osseous lesion is a result of disturbances of normal bone metabolism by a mutation of the alpha subunit of guanine nucleotide binding protein alpha stimulating. Here we report a case with two adjacent ribs involvement in a 25-year old man who admitted to our hospital with an acute right chest pain and swelling with history of major trauma in a motor vehicle accident 4 years ago with associated hemopneumothorax resulted in thoracostomy tube insertion and with subcutaneous mass was detected in the right chest wall which was located exactly at the thoracostomy tube insertion site. [ABSTRACT FROM AUTHOR]

Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare, slow-growing mass, which is locally aggressive and classified as tumors of borderline malignancy. In this study, we report a case of subcutaneous ankle mass in 43-year-old female since 2 years ago with a pathological diagnosis of PHAT, characterized by clusters of ectatic, fibrin-lined, and thin-walled vessels which are surrounded by a spindled or pleomorphic neoplastic stroma. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to translate the EORTC quality of life questionnaire for brain cancer, the QLQ-BN20, into Persian, and to evaluate its psychometric properties when used among brain cancer patients in Iran. Methods: A standard backward and forward translation procedure was used to generate the Persian language version of the QLQ-BN20. The QLQ-BN20 was administered together with the QLQ-C30 to 194 patients diagnosed with primary brain cancer. Multitrait scaling and confirmatory factor analysis (CFA) were used to evaluate the hypothesized scale structure of the questionnaire. Internal consistency reliability was estimated with Cronbach's alpha. The ability of the QLQ-BN20 to distinguish between patient subgroups formed on the basis of performance status and cognitive status was evaluated, as was the responsiveness of the questionnaire to changes in performance status over time. Results: Multitrait scaling and CFA results confirmed the hypothesized scale structure. The measurement model was consistent across men and women. Internal consistency reliability of the multi-item scales ranged from 0.74 to 0.89. The QLQ-BN20 distinguished clearly between patients with relatively good versus poor performance and cognitive status, and changes in scores over time reflected changes observed in performance status ratings. Conclusions: These results support the validity and reliability of the QLQ-BN20 for use among Iranian patients diagnosed with primary brain cancer. Future studies should examine the psychometrics of the questionnaire when used in patients with brain metastasis. [ABSTRACT FROM AUTHOR]