Search

This study examined the effect of exposure of small and large intestinal epithelial cells to the bacterial lipopolysaccharide (LPS) on uptake of free form of vitamin B1, i.e., thiamin. The intestinal tract encounters two sources of thiamin: diet and the gut microbiota. Absorption of thiamin in both the small and large intestine occurs via a carrier-mediated process that involves thiamin transporters 1 and 2 (THTR-1 and -2). Complementary in vitro (human duodenal epithelial HuTu-80 cells and human colonic epithelial NCM460 cells), in vivo (mice), and ex vivo (human primary differentiated enteroid and colonoid monolayers) models were used. The results showed that exposure to LPS causes a significant inhibition in carrier-mediated [3H]-thiamin uptake by small and large intestinal epithelia, with no change in the levels of expression of THTR-1 and -2 mRNAs and their total cellular proteins. However, a significant decrease in the fractions of the THTR-1 and -2 proteins that are expressed at the cell membranes of these epithelial cells was observed. These effects of LPS appeared to involve a protein kinase A (PKA) signaling pathway as activating this pathway caused a reversal in the inhibition of thiamin uptake and level of expression of its transporters at the cell membrane. These findings demonstrate that exposure of gut epithelia to LPS (a situation that occurs under different pathological conditions) leads to inhibition in thiamin uptake due to a decrease in level of expression of its transporters at the cell membrane that is likely mediated via a PKA signaling pathway. NEW & NOTEWORTHY: This study shows that the exposure of gut epithelial cells to bacterial LPS negatively impact the uptake process of the free form of vitamin B1 (i.e., thiamin). This appears to be mediated via suppression in the level of thiamin transporters 1 and 2 (THTR-1 and -2) expression at the cell membrane and involves a protein kinase A (PKA) signaling pathway. [ABSTRACT FROM AUTHOR]

The ontogenetic development in teleost fish is sensitive to temperature, and the developmental rate has a direct relationship with the environmental temperature within a species' thermal tolerance limit. Temperature determines time to and survival at hatching. Yellow perch is a North American species of ecological and commercial importance, and its phenology is vulnerable to climate change. The embryonic development of yellow perch was comparable to closely related members of the family Percidae. Developmental progression was fastest at 18°C and slowest at 12°C, with medial progression at 15°C. Time to hatch and swim‐up, feeding onset, and exogenous feeding phases were different across all incubation temperatures regardless of a gradual post‐hatch warming of the 12 and 15°C groups to a common garden temperature of 18°C. Incubation temperature may lower the rate of survival to hatch at 15°C and had complex impacts on developmental abnormalities. Temperature had significant effects on the development rate, time of hatch, survival, and incidence of developmental abnormalities. Early ontogenetic thermal history in ectotherms is an important factor determining phenotypic variation. It will be important to link the thermally induced changes in development described here to the physiological and morphological differences and to link the developmental abnormalities to functional performance. [ABSTRACT FROM AUTHOR]

The analysis of traumatic injuries in human skeletal remains from archaeological contexts offers important challenges for the reconstruction of past populations’ behaviors. In this study, a sample of 303 buried skeletons retrieved from the Etruscan necropolis of Spina (Ferrara, Italy) and dated back to the 5th to the 3rd century BC, were macroscopically analyzed for traumatic injuries. The sample consisted of 38% males, 22% females, and 40% undetermined individuals. Subadults represented 25% of the entire sample. The aim of this study was to collect and describe new data on antemortem and perimortem injuries in the Spina Etruscans, bringing a new perspective to the understanding of social behaviors in this population. In the sample of Etruscans examined 16 individuals showed evidence of one injury and two individuals of two injuries. The analysis revealed 18 cases of antemortem trauma and 2 cases of perimortem trauma. No traumatic injuries were detected among subadults, while men and women presented different types of traumas: women were more prone to stress fractures involving the spine, whereas men were affected by antemortem and perimortem inflicted traumas, suggesting a division of labor and a major exposition of the latter to interpersonal violence. The reduced presence of sharp force traumas found exclusively in males (3 cases, 1.3% of the adult sample) is basically consistent with archaeological and historical data that described this site as a free port without an explicit history of violence. [ABSTRACT FROM AUTHOR]

Many water treatment methods have been developed to remove organic pollutants from contaminated waters. Their efficiency is usually assessed by removal measurements, and the effect of operational factors on the process is rarely explored. To bridge this gap, an experimental design methodology has been applied to optimise an advanced oxidation process combining adsorption and photocatalysis, using AZURAD® software. This approach was applied to the removal of carbamazepine (CBZ) in aqueous solution by a bio-sourced activated carbon and TiO2 composite material under light exposure. Two experimental designs were performed considering three quantitative factors (pH, catalyst dose and temperature) and one qualitative factor (dissolved oxygen concentration). From the response surface methodology (RSM), the optimised operational factors for CBZ adsorption and degradation were independently determined. Using desirability function approach, commonly optimised conditions for both processes were assessed with a catalyst dose of 0.13 g.L−1, oxygen saturated medium and either pH = 9.5 and T = 40°C or pH = 7.8 and T = 10°C. The Quality by Design approach showed that the experimental conditions could vary maintaining the adsorption and photocatalysis process removal efficiency (with more than 70% and 80%, respectively) with a high probability of 80%. This highlights the robustness of the treatment process and its potential upscaling. [ABSTRACT FROM AUTHOR]

In this article, an anthropologist and a theologian explore an analytical framework for the comparative study of Christian churches, focusing in particular on ritual life among Roman Catholics and Baptist Protestants in Italy. Catholics and Baptists have different ways of articulating what it means to be "the Body of Christ"—that is, the ecclesia. If ecclesiology is a theme well explored by theologians, social scientists have hesitated to pronounce themselves on this topic. This contribution proposes a way to look at ecclesiology from an anthropological angle through the analysis of the liturgical orders of two different ecclesiastical bodies. By mapping foundational rituals and rites of passage, we aspire to isolate the different "ecclesiological axioms" that underpin liturgy and church form in these two polities. We hope that our reflection will stimulate discussion on a hitherto little-developed topic in the anthropology of Christianity, and strengthen interdisciplinary conversations between anthropologists and theologians. [ABSTRACT FROM AUTHOR]

Thiamin (vitamin B1) plays a vital role in cellular energy metabolism/ATP production. Pancreatic acinar cells (PACs) obtain thiamin from circulation and convert it to thiamin pyrophosphate (TPP) in the cytoplasm. TPP is then taken up by the mitochondria via a carrier-mediated process that involves the mitochondrial TPP transporter (MTPPT; encoded by the gene SLC25A19). We have previously characterized different aspects of the mitochondrial carrier-mediated TPP uptake process, but nothing is known about its possible regulation at the posttranscriptional level. We address this issue in the current investigations focusing on the role of miRNAs in this regulation. First, we subjected the human (and rat) 3′-untranslated region (3′-UTR) of the SLC25A19 to three in-silico programs, and all have identified putative binding sites for miR-122-5p. Transfecting pmirGLO-hSLC25A19 3′-UTR into rat PAC AR42J resulted in a significant reduction in luciferase activity compared with cells transfected with pmirGLO-empty vector. Mutating as well as truncating the putative miR-122-5p binding sites in the hSLC25A19 3′-UTR led to abrogation of inhibition in luciferase activity in PAC AR42J. Furthermore, transfecting/transducing PAC AR42J and human primary PACs with mimic of miR-122-5p led to a significant inhibition in the level of expression of the MTPPT mRNA and protein as well as in mitochondrial carrier-mediated TPP uptake. Conversely, transfecting PAC AR42J with an inhibitor of miR-122-5p increased MTPPT expression and function. These findings show, for the first time, that expression and function of the MTPPT in PACs are subject to posttranscriptional regulation by miR-122-5p. NEW & NOTEWORTHY This study shows that the expression and function of mitochondrial TPP transporter (MTPPT) are subject to posttranscriptional regulation by miRNA-122-5p in pancreatic acinar cells. [ABSTRACT FROM AUTHOR]

In the Design of Experiments, we seek to relate response variables to explanatory factors. Response Surface methodology (RSM) approximates the relation between output variables and a polynomial transform of the explanatory variables using a linear model. Some researchers have tried to adjust other types of models, mainly nonlinear and nonparametric. We present a large panel of Machine Learning approaches that may be good alternatives to the classical RSM approximation. The state of the art of such approaches is given, including classification and regression trees, ensemble methods, support vector machines, neural networks and also direct multi-output approaches. We survey the subject and illustrate the use of ten such approaches using simulations and a real use case. In our simulations, the underlying model is linear in the explanatory factors for one response and nonlinear for the others. We focus on the advantages and disadvantages of the different approaches and show how their hyperparameters may be tuned. Our simulations show that even when the underlying relation between the response and the explanatory variables is linear, the RSM approach is outperformed by the direct neural network multivariate model, for any sample size (<50) and much more for very small samples (15 or 20). When the underlying relation is nonlinear, the RSM approach is outperformed by most of the machine learning approaches for small samples (n ≤ 30). [ABSTRACT FROM AUTHOR]

Extensive tropical floodplain wetlands, such as the Brazilian Pantanal, are complex ecosystems composed of mosaics of permanently and seasonally flooded habitats and are increasingly threatened by land use and climate change. Spatial and interannual variability in the seasonal flood pulse is a fundamental ecological driver in these ecosystems. This study analyzes optical imagery from the Sentinel-2 satellite to determine the extent and seasonal patterns of inundation over five years in the northern Pantanal, a Ramsar site renowned for its wildlife. The study site is bordered by the Cuiabá and São Lourenço rivers, each with distinct flow regimes. Inundation patterns were revealed with a combination of water indices, supervised classification of land cover, and a digital elevation model. Total extent of flooding was underestimated by the optical imagery, but open water bodies were readily delineated with the land cover classification. [ABSTRACT FROM AUTHOR]

The controlled use of fires to reduce combustible materials in prescribed burning helps to prevent the occurrence of forest fires. In recent decades, these fires have mainly been caused by anthropogenic activities. The study area is located in the Pantanal biome. In 2020, the greatest drought in 60 years happened in the Pantanal. The fire affected almost one third of the biome. The objective of this study is to evaluate the effect of prescribed burnings carried out in 2021 on three macrohabitats (M1: natural grassland flooded with a proliferation of Combretum spp., M2: natural grassland of seasonal swamps, and M3: natural grassland flooded with a proliferation of Vochysia divergens) inside the SESC Pantanal Private Natural Heritage Reserve. Multispectral and thermal data analyses were conducted with remotely piloted aircraft systems in 1 ha plots in three periods of the dry season with early, mid, and late burning. The land use and land cover classification indicate that the predominant vegetation type in these areas is seasonally flooded grassland, with percentages above 73%, except in zone three, which has a more diverse composition and structure, with the presence of arboreal specimens of V. divergem Pohl. The pattern of the thermal range showed differentiation pre- and post-burning. The burned area index indicated that fire was more efficient in the first two macrohabitats because they are natural grasslands, reducing the grass species in the burnings. Early and mid prescribed burnings are a good option to reduce the continuous accumulation of dry forest biomass fuel material and help to promote landscape heterogeneity. The use of multispectral sensor data with high spatial/spectral resolution can show the effects of fires, using highly detailed scales for technical decision making. [ABSTRACT FROM AUTHOR]

We present a case report of a child with features of hyperphosphatasia with neurologic deficit (HPMRS) or Mabry syndrome (MIM 239300) with variants of unknown significance in two post-GPI attachments to proteins genes, PGAP2 and PGAP3, that underlie HPMRS 3 and 4. Background: In addition to HPMRS 3 and 4, disruption of four phosphatidylinositol glycan (PIG) biosynthesis genes, PIGV, PIGO, PIGW and PIGY, result in HPMRS 1, 2, 5 and 6, respectively. Methods: Targeted exome panel sequencing identified homozygous variants of unknown significance (VUS) in PGAP2 c:284A>G and PGAP3 c:259G>A. To assay the pathogenicity of these variants, we conducted a rescue assay in PGAP2 and PGAP3 deficient CHO cell lines. Results: Using a strong (pME) promoter, the PGAP2 variant did not rescue activity in CHO cells and the protein was not detected. Flow cytometric analysis showed that CD59 and CD55 expression on the PGAP2 deficient cell line was not restored by variant PGAP2. By contrast, activity of the PGAP3 variant was similar to wild-type. Conclusions: For this patient with Mabry syndrome, the phenotype is likely to be predominantly HPMRS3: resulting from autosomal recessive inheritance of NM_001256240.2 PGAP2 c:284A>G, p.Tyr95Cys. We discuss strategies for establishing evidence for putative digenic inheritance in GPI deficiency disorders. [ABSTRACT FROM AUTHOR]

Anthropogenic impacts can lead to increased temperatures in freshwater environments through thermal effluent and climate change. Thermal preference of aquatic organisms can be modulated by abiotic and biotic factors including environmental temperature. Whether increased temperature during embryogenesis can lead to long-term alterations in thermal preference has not been explicitly tested in native freshwater species. Lake (Coregonus clupeaformis) and round (Prosopium cylindraceum) whitefish were incubated at natural and elevated temperatures until hatching, following which, all groups were moved to common garden conditions (15°C) during the post-hatching stage. Temperature preference was determined at 8 months (Lake whitefish only) and 12 months of age (both species) using a shuttle box system. Round whitefish preferred a cooler temperature when incubated at 2 and 6°C compared with 0.5°C. Lake whitefish had similar temperature preferences regardless of age, weight and incubation temperature. These results reveal that temperature preference in freshwater fish can be programmed during early development, and that round whitefish may be more sensitive to incubation temperature. This study highlights the effects that small increases in temperature caused by anthropogenic impacts may have on cold-adapted freshwater fish. [ABSTRACT FROM AUTHOR]

The Pediatric Genomics Discovery Program (PGDP) at Yale uses next‐generation sequencing (NGS) and translational research to evaluate complex patients with a wide range of phenotypes suspected to have rare genetic diseases. We conducted a retrospective cohort analysis of 356 PGDP probands evaluated between June 2015 and July 2020, querying our database for participant demographics, clinical characteristics, NGS results, and diagnostic and research findings. The three most common phenotypes among the entire studied cohort (n = 356) were immune system abnormalities (n = 105, 29%), syndromic or multisystem disease (n = 103, 29%), and cardiovascular system abnormalities (n = 62, 17%). Of 216 patients with final classifications, 77 (36%) received new diagnoses and 139 (64%) were undiagnosed; the remaining 140 patients were still actively being investigated. Monogenetic diagnoses were found in 67 (89%); the largest group had variants in known disease genes but with new contributions such as novel variants (n = 31, 40%) or expanded phenotypes (n = 14, 18%). Finally, five PGDP diagnoses (8%) were suggestive of novel gene‐to‐phenotype relationships. A broad range of patients can benefit from single subject studies combining NGS and functional molecular analyses. All pediatric providers should consider further genetics evaluations for patients lacking precise molecular diagnoses. [ABSTRACT FROM AUTHOR]

Purpose: Epidemiologic studies have documented lower rates of active smokers compared to former or non-smokers in symptomatic patients affected by coronavirus disease 2019 (COVID-19). We assessed the efficacy and safety of nicotine administered by a transdermal patch in critically ill patients with COVID-19 pneumonia. Methods: In this multicentre, double-blind, placebo-controlled trial conducted in 18 intensive care units in France, we randomly assigned adult patients (non-smokers, non-vapers or who had quit smoking/vaping for at least 12 months) with proven COVID-19 pneumonia receiving invasive mechanical ventilation for up to 72 h to receive transdermal patches containing either nicotine at a daily dose of 14 mg or placebo until 48 h following successful weaning from mechanical ventilation or for a maximum of 30 days, followed by 3-week dose tapering by 3.5 mg per week. Randomization was stratified by centre, non- or former smoker status and Sequential Organ Function Assessment score (< or ≥ 7). The primary outcome was day-28 mortality. Main prespecified secondary outcomes included 60-day mortality, time to successful extubation, days alive and free from mechanical ventilation, renal replacement therapy, vasopressor support or organ failure at day 28. Results: Between November 6th 2020, and April 2nd 2021, 220 patients were randomized from 18 active recruiting centers. After excluding 2 patients who withdrew consent, 218 patients (152 [70%] men) were included in the analysis: 106 patients to the nicotine group and 112 to the placebo group. Day-28 mortality did not differ between the two groups (30 [28%] of 106 patients in the nicotine group vs 31 [28%] of 112 patients in the placebo group; odds ratio 1.03 [95% confidence interval, CI 0.57–1.87]; p = 0.46). The median number of day-28 ventilator-free days was 0 (IQR 0–14) in the nicotine group and 0 (0–13) in the placebo group (with a difference estimate between the medians of 0 [95% CI -3–7]). Adverse events likely related to nicotine were rare (3%) and similar between the two groups. Conclusion: In patients having developed severe COVID-19 pneumonia requiring invasive mechanical ventilation, transdermal nicotine did not significantly reduce day-28 mortality. There is no indication to use nicotine in this situation. [ABSTRACT FROM AUTHOR]

Chromosomal microarray analysis using single nucleotide polymorphism probes can detect regions of homozygosity (ROH). This confers a potential utility in revealing autosomal recessive (AR) diseases and uniparental disomy (UPD). Results of genetic testing among pediatric patients from 2015 to 2019 were evaluated. Diagnostic findings with detected ROH from large consecutive case series in the literature were reviewed. Of 2050 pediatric patients, 65 (3%) had one or more ROH and 31 (53%) had follow‐up whole exome sequencing (WES) and methylation studies. Seven homozygous variants were detected and four of them from three patients (9.6%) were within the detected ROH and classified as pathogenic or likely pathogenic variants for AR diseases. One patient (3%) had segmental UPD15q for a diagnosis of Prader–Willi syndrome. Additive diagnostic yield from ROH reporting was at least 0.2% (4/2050) of pediatric patients. These results were consistent with findings from several large case series reported in the literature. Detecting ROH had an estimated baseline predictive value of 10% for AR diseases and 3% for UPD. Consanguinity revealed by multiple ROH was a strong predictor for AR diseases. These results provide evidence for genetic counseling and recommendation of follow‐up WES and methylation studies for pediatric patients reported with ROH. [ABSTRACT FROM AUTHOR]

Located in the historic center of Rio de Janeiro, the Museum of Art of Rio (MAR) is an institution created to take a transversal approach to the city's history by exhibiting art and culture visual collections. The museum's mission is based on the principle of articulating museum and art education through the creation of the "Escola do Olhar," which contributes to the education of teachers that work in the municipal system. The MAR was conceived from a partnership between the City of Rio de Janeiro and the Roberto Marinho Foundation (FRM), a private nonprofit institution linked to "Grupo Globo," the largest Brazilian communication conglomerate. The FRM has been exploring the concept of edutainment in Brazilian museums since the beginning of the twenty-first century. The connection between museum and school is also reflected in curatorial practices, as we can see at the exhibitions "When the Neighbor Becomes a Curator" and "Women in the MAR Collection", interesting cases of collaborative curatorship supported by "Escola do Olhar." The equivalent importance between museum and school can be architecturally seen in the MAR project. Designed by Bernardes and Jacobsen Arquitetura, the MAR integrates three existing buildings in the Mauá Square through the creation of a suspended walkway and a concrete marquee. This study aims to examine the symbolic and spatial relations established between education and museum at the MAR, analyzing both architectural, curatorial conception, and the public's approach. As a research methodology, we studied the Management Reports (2013-2020) and applied questionnaires with the public. [ABSTRACT FROM AUTHOR]

Background: Parent involvement in school is a consistent predictor of educational success. However, research has been inconsistent in addressing how parent involvement ought to be defined and measured, which has led to varied findings across schools and educational systems. Aims: Attending to the multidimensionality of the construct, this study adopted a person‐centred approach to identify subpopulations of school‐based parent involvement. Subsequently, profile differences were investigated in relation to student engagement and three antecedent variables (gender, socio‐economic status, and authoritative parenting). Sample: Data were obtained from primary (10‐year old; N = 4,284) and secondary (14‐year old; N = 3,346) school students in Singapore. Methods: Latent profile analysis was conducted on student‐rated surveys of multiple parent involvement behaviours in school and their perceptions. Subsequently, the manual BCH method was employed to concurrently model covariates and outcomes on the latent profile model. Pairwise comparisons between profiles were examined for statistical significance. Results: Consistent across both cohorts, four distinct profiles emerged that revealed high, moderate, selective, and low parent involvement patterns. High parent involvement reflected high ratings across multiple activities, combined with positive perceptions of parental involvement. These profiles differed significantly in terms of their antecedent characteristics, particularly, authoritative parenting, and in relation to their impact on student engagement. Conclusion: Results from this study clarify relations between multi‐faceted dimensions of parent involvement in school. Additionally, there is a case for continued school‐family partnerships among secondary students as students remain academically engaged when parents are involved in school and students relate positively to their involvement. [ABSTRACT FROM AUTHOR]

Also shown are protected areas (dark grey polygons; UNEP-WCMC and IUCN, 2021), forest cover >15% (olive green; Hansen/UMD/Google/USGS/NASA; Hansen et al., 2013), and current northern range extents for giant pangolin (purple line), white-bellied pangolin (dark blue line) and black-bellied pangolin (light blue line; IUCN, 2021). Three species of pangolin occur in West Africa (IUCN, 2021), which include the two small arboreal species, the white-bellied and black-bellied pangolins ( I Phataginus tricuspis i and I Phataginus tetradactyla i , respectively), and the fossorial giant pangolin ( I Smutsia gigantea i ). While a few studies have now investigated the local uses of pangolins in several West African countries, knowledge on the distribution and local uses of pangolins remains limited in the western-most countries (e.g. Guinea, Guinea-Bissau, Senegal, Sierra Leone), at the periphery of currently reported pangolin distributions. Mali borders several pangolin range countries and is currently not listed as a pangolin range state on the IUCN Red List. [Extracted from the article]

Elucidating factors that promote or hinder successful implementation of evidence-based practices in real-world settings is an essential component of intervention research. This qualitative study assessed implementation of an attachment-based parenting intervention, Attachment and Biobehavioral Catch-up (ABC), delivered in the context of federal Early Head Start (EHS) home visiting services, from the perspectives of EHS home visitors and ABC parent coaches. Findings demonstrated that the EHS plus ABC model was acceptable, appropriate, and feasible from the perspective of both the EHS home visitors and the ABC parent coaches. Home visitors described important ways in which ABC enhanced EHS, such as through its emphasis on strengthening child-parent attachment and its use of video feedback. EHS home visitors and parent coaches suggested specific improvements for this enhanced model that will inform future program implementation and research. Highlights: EHS home visitors perceived ABC as acceptable, appropriate, feasible, and useful. EHS home visitors described unique benefits of ABC, such as the use of video feedback. Supplementing EHS with brief interventions such as ABC may help improve supportive parenting. [ABSTRACT FROM AUTHOR]

The article assesses the environmental pollution level in urban areas of the Russian Federation regions. Environmental monitoring data were used as data sources. For each Russian region the environmental pollution level was considered as the sum of pollution indices for the basic environmental media: air, surface water and soil. It allowed ranking regions and grouped them into categories (from extremely high polluted to extremely low ones). The air pollution monitoring network in cities and industrial centres does not cover all regions of the country, leading to undetermined air pollution level in 12 of 85 regions and thus to underestimated environmental pollution level there. The paper proposes to use the monitoring network data of the snow cover chemistry for the air pollution assessment in problematic regions and more accurate calculation of the environmental pollution level in them. Based on the air monitoring data for 2018 we revealed regions with high and extremely high levels of air pollution, their list was added after analyzing the snow cover chemistry data. As a result, the total assessment of environmental pollution was recalculated upward. [ABSTRACT FROM AUTHOR]

Data on the fluoride fallout to the snow cover in Bratsk (the Irkutsk oblast) are analyzed to enhance the snow cover pollution presentation and monitoring data interpretation. The simulation of the fallout of fluorides emitted by the aluminum plant in Bratsk in the winter of 2016/2017 was carried out using the MRR-2017 approach. The comparison of the calculated fluoride fallout density fields with the data provided by the local Administration for Hydrometeorology and Environmental Monitoring demonstrated that the calculated values of long-period concentrations and fallout densities of fluorides at the individual observation points in the Bratsk area are in good agreement. The results support the applicability of the MRR-2017 approach for evaluating and generalizing measurements of snow cover chemistry. [ABSTRACT FROM AUTHOR]

Background: The Savanna Nightjar (Caprimulgus affinis) is a widespread, polytypic species which was previously treated as two or three species. It is currently treated as a single species based on superficial similarity of their songs but no detailed comparisons of the songs in this complex have been made. Methods: A total of 15 acoustic variables were measured for the songs of 86 individuals representing 8 of the 10 subspecies in the complex. Results: Three major groups can be distinguished based on univariate and multivariate analyses: a northern group consisting of the subspecies C. a. monticolus, C. a. amoyensis and C. a. stictomus; a southern group consisting of C. a. affinis, C. a. kasuidori, C. a. timorensis and C. a. propinquus; and a third group in the Philippines consisting of C. a. griseatus. Conclusions: It is here argued that these groups are best treated as species, and that Franklin's Nightjar (C. monticolus) and Kayumanggi Nightjar (C. griseatus) are reinstated as separate species. [ABSTRACT FROM AUTHOR]

Introduction. In Italy, the number of elder is growing and people over 70 may be a problem in public health on present and next years. Methods. In this paper we analysed 150 patients aged 60÷99 by medical and instrumental examinations. Results. We analysed all data patients into three age groups: "A" patients aged 60÷69 years; "B" patients aged 70÷79 years, and "C" patients aged 80÷99 years. Conclusion. This is the first study carried out on old and very old dentistry patients. Our people sample showed lost teeth, and bone retractions more than 6 millimetres associated with unilateral and/or bilateral carotidal plaques. They also suffered for many other pathologies connected with cardiovascular system. In our paper, we showed these specific aspects more in "B" subjects than in "A" and "C" elder patients. [ABSTRACT FROM AUTHOR]

Copyright of Mouseion (19817207) is the property of Editora Unilasalle and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Field-measured soil respiration (RS , the soil-to-atmosphere CO2 flux) observations were compiled into a global soil respiration database (SRDB) a decade ago, a resource that has been widely used by the biogeochemistry community to advance our understanding of RS dynamics. Novel carbon cycle science questions require updated and augmented global information with better interoperability among datasets. Here, we restructured and updated the global RS database to version SRDB-V5. The updated version has all previous fields revised for consistency and simplicity, and it has several new fields to include ancillary information (e.g., RS measurement time, collar insertion depth, collar area). The new SRDB-V5 includes published papers through 2017 (800 independent studies), where total observations increased from 6633 in SRDB-V4 to 10 366 in SRDB-V5. The SRDB-V5 features more RS data published in the Russian and Chinese scientific literature and has an improved global spatio-temporal coverage and improved global climate space representation. We also restructured the database so that it has stronger interoperability with other datasets related to carbon cycle science. For instance, linking SRDB-V5 with an hourly timescale global soil respiration database (HGRsD) and a community database for continuous soil respiration (COSORE) enables researchers to explore new questions. The updated SRDB-V5 aims to be a data framework for the scientific community to share seasonal to annual field RS measurements, and it provides opportunities for the biogeochemistry community to better understand the spatial and temporal variability in RS , its components, and the overall carbon cycle. The database can be downloaded at https://github.com/bpbond/srdb and will be made available in the Oak Ridge National Laboratory's Distributed Active Archive Center (ORNL DAAC). All data and code to reproduce the results in this study can be found at 10.5281/zenodo.3876443 (Jian and Bond-Lamberty, 2020). [ABSTRACT FROM AUTHOR]

Unlike the initiatory processes documented in Africanist scholarship that transformed boys and girls into men and women, among the Mande today—where the large-scale initiations of yore have virtually disappeared—initiations are neither required nor collective. They constitute a component of the practices that this article studies, in an effort to illuminate the construction of the religious specialists who undergo them. The analysis contrasts to this effect the hunting body—light, silent, odorless, seeking invisibility while in the bush—with the possessed body, ostensibly displayed in a space saturated with smell, sound, and touch. The formation of these two types of bodies allows the construction of the complex identity of ritual experts: on the one hand, donsow , seen as brave but also adopting the typically feminine attitude of devotion to others' well-being as a part of sacrificial ethos, and on the other hand, jinatigiw , leaders of possession cults who emphasize their femininity while simultaneously appropriating certain masculine-associated qualities, gestures, prerogatives, and roles. The apparent asymmetry of these male and female experts' gender construction is less pronounced than it might be, which suggests that ritual expertise always rests upon a spatial and bodily singularity among those who wield it. Paradoxically perhaps, this conclusion also sheds new light on the identity of various anthropologists, to whom access to the two initiatory paths may be offered, but whose habitus is necessarily out of sync with the male and female habitus of their hosts as well as of their own society. [ABSTRACT FROM AUTHOR]

Recessive variants in the GLDN gene, which encodes the gliomedin protein and is involved in nervous system development, have recently been associated with Arthrogryposis Multiplex Congenita (AMC), a heterogenous condition characterized by congenital contractures of more than one joint. Two cohorts of patients with GLDN‐associated AMC have previously been described, evolving the understanding of the condition from lethal to survivable with the provision of significant neonatal support. Here, we describe one additional patient currently living with the syndrome, having one novel variant, p.Leu365Phe, for which we provide functional data supporting its pathogenicity. We additionally provide experimental data for four other previously reported variants lacking functional evidence, including p.Arg393Lys, the second variant present in our patient. We discuss unique and defining clinical features, adding calcium‐related findings which appear to be recurrent in the GLDN cohort. Finally, we compare all previously reported patients and draw new conclusions about scope of illness, with emphasis on the finding of pulmonary hypoplasia, suggesting that AMC secondary to GLDN variants may be best fitted under the umbrella of fetal akinesia deformation sequence (FADS). [ABSTRACT FROM AUTHOR]

Heterozygous variants in the DYNC1H1 gene have been associated chiefly with intellectual disability (ID), malformations in cortical development (MCD), spinal muscular atrophy (SMA), and Charcot–Marie‐Tooth axonal type 20 (CMT), with fewer reports describing other intersecting phenotypes. To better characterize the variable syndromes associated with DYNC1H1, we undertook a detailed analysis of reported patients in the medical literature through June 30, 2019. In sum we identified 200 patients from 143 families harboring 103 different DYNC1H1 variants, and added reports for four unrelated patients identified at our center, three with novel variants. The most common features associated with DYNC1H1 were neuromuscular (NM) disease (largely associated with variants in the stem domain), ID with MCD (largely associated with variants in the motor domain), or a combination of these phenotypes. Despite these trends, exceptions are noted throughout. Overall, DYNC1H1 is associated with variable neurodevelopmental and/or neuromuscular phenotypes that overlap. To avoid confusion DYNC1H1 disorders may be best categorized at this time by more general descriptions rather than phenotype‐specific nomenclature such as SMA or CMT. We therefore propose the terms: DYNC1H1‐related NM disorder, DYNC1H1‐related CNS disorder, and DYNC1H1‐related combined disorder. Our single center's experience may be evidence that disease‐causing variants in this gene are more prevalent than currently recognized. [ABSTRACT FROM AUTHOR]

Field-measured soil respiration (RS, the soil-to-atmosphere CO2 flux) observations were compiled into a global soil respiration database (SRDB) a decade ago, a resource that has been widely used by the biogeochemistry community to advance our understanding of RS dynamics. Novel carbon cycle sciences questions require updated and augmented global information with better interoperability among datasets. Here, we restructured and updated the global RS database to version SRDB-V5. The updated version has all previous fields revised for consistency and simplicity, and it has several new fields to include ancillary information (e.g., RS measurement time, collar insertion depth, collar area). The new SRDB-V5 includes published papers through 2017 (800 independent studies) where total observations increased from 6633 in SRDB-V4 to 10366 in SRDB-V5. The SRDB-V5 features more RS data published in Russian and Chinese scientific literature, has an improved global spatio-temporal coverage, and improved global climate-space representation. We also restructured the database so that it has stronger interoperability with other datasets related to carbon-cycle science. For instance, linking SRDB-V5 with an hourly timescale global soil respiration database (HGRsD) and an open community database for continuous soil respiration and other chamber flux data (COSORE) enables researchers to explore new questions. The updated SRDB-V5 aims to be a data framework for the scientific community to share seasonal to annual field RS measurements, and it provides opportunities for the biogeochemistry community to better understand the spatial and temporal variability of RS, its components, and the overall carbon cycle. The database can be downloaded at https://github.com/bpbond/srdb and ORNL DAAC [Submitted]. All data and code to reproduce the results in this study can be found at: Jian, Jinshi, Bond-Lamberty, Ben. (2020). jinshijian/ESSD: SRDB-V5 first release (Version v1.0.0) [Data set]. Zenodo. http://doi.org/10.5281/zenodo.3876443. [ABSTRACT FROM AUTHOR]

A laboratory flume was constructed to examine substrate effects on aquatic development. The flume was designed as a once‐through system with a submerged cobble‐filled corebox. Lake whitefish (Coregonus clupeaformis) embryos and temperature probes were deployed at multiple sites within the cobble and in the open water channel. Embryos were incubated in the flume for two different experimental periods: one to examine substrate impacts during natural lake cooling (37 days: 5 December 2016 to 10 January 2017) and the second to investigate substrate effects while administering a twice weekly 1 h heat shock (51 days: 11 January to 2 March 2017). During incubation, no significant difference was found in the average temperature between locations; however, temperatures were more stable within the cobble. Following both incubation periods, embryos retrieved from the cobble were significantly smaller in both dry mass and body length by up to 20%. These results demonstrate differences between embryos submerged in a cobble substrate and in the open water column, highlighting the need to consider the physical influences from the incubation environment when assessing development effects as part of any scientific study or environmental assessment. [ABSTRACT FROM AUTHOR]

Employers and students are increasingly demanding applied, relevant skills. Eye tracking technology is used extensively by companies to test consumer attention and awareness of advertisements, packaging, and websites, but the marketing education literature lacks a pedagogy for teaching it in a marketing classroom. An experiential learning activity is presented where students conduct their own eye tracking studies in the classroom to test the effectiveness of marketing materials. A study is presented that shows students effectively gained knowledge, experience, and confidence in eye tracking through the activity. Results also demonstrate the effectiveness of experiential learning compared to observing the same activity. [ABSTRACT FROM AUTHOR]

Action follows from being. One's way of doing and understanding comparative education follows from one's being. It springs from the soul. Using [Kim, T., and R. Brooks' (2013). "Internationalisation, Mobile Academics, and Knowledge Creation in Universities: A Comparative Analysis." SRHE Research Award (2011/12) Final Report] framework on the relationship between academic mobility and knowledge creation, I will reflect here on my personal and intellectual journey and how it has shaped my work on comparative histories of the field of comparative education. As this article is written, I am commencing a new transition in my professional life, this time in Japan. I am reflecting on a possible new research agenda building on my past work and the new panorama opened from my new vantage point in the field. [ABSTRACT FROM AUTHOR]

Reduced representation (RRL) sequencing approaches (e.g., RADSeq, genotyping by sequencing) require decisions about how much to invest in genome coverage and sequencing depth, as well as choices of values for adjustable bioinformatics parameters. To empirically explore the importance of these "simple" methodological decisions, we generated two independent sequencing libraries for the same 142 individual lake whitefish (Coregonus clupeaformis) using a nextRAD RRL approach: (1) a larger number of loci at low sequencing depth based on a 9mer (library A); and (2) fewer loci at higher sequencing depth based on a 10mer (library B). The fish were selected from populations with different levels of expected genetic subdivision. Each library was analyzed using the STACKS pipeline followed by three types of population structure assessment (FST, DAPC and ADMIXTURE) with iterative increases in the stringency of sequencing depth and missing data requirements, as well as more specific a priori population maps. Library B was always able to resolve strong population differentiation in all three types of assessment regardless of the selected parameters, largely due to retention of more loci in analyses. In contrast, library A produced more variable results; increasing the minimum sequencing depth threshold (-m) resulted in a reduced number of retained loci, and therefore lost resolution at high -m values for FST and ADMIXTURE, but not DAPC. When detecting fine population differentiation, the population map influenced the number of loci and missing data, which generated artefacts in all downstream analyses tested. Similarly, when examining fine scale population subdivision, library B was robust to changing parameters but library A lost resolution depending on the parameter set. We used library B to examine actual subdivision in our study populations. All three types of analysis found complete subdivision among populations in Lake Huron, ON and Dore Lake, SK, Canada using 10,640 SNP loci. Weak population subdivision was detected in Lake Huron with fish from sites in the north-west, Search Bay, North Point and Hammond Bay, showing slight differentiation. Overall, we show that apparently simple decisions about library construction and bioinformatics parameters can have important impacts on the interpretation of population subdivision. Although potentially more costly on a per-locus basis, early investment in striking a balance between the number of loci and sequencing effort is well worth the reduced genomic coverage for population genetics studies. More conservative stringency settings on STACKS parameters lead to a final dataset that was more consistent and robust when examining both weak and strong population differentiation. Overall, we recommend that researchers approach "simple" methodological decisions with caution, especially when working on non-model species for the first time. [ABSTRACT FROM AUTHOR]

Background: Array comparative genomic hybridization (aCGH), karyotyping and fluorescence in situ hybridization (FISH) analyses have been used in a clinical cytogenetic laboratory. A systematic analysis on diagnostic findings of cytogenomic abnormalities in current prenatal and pediatric settings provides approaches for future improvement. Methods: A retrospective analysis was performed on abnormal findings by aCGH, karyotyping, and FISH from 3,608 prenatal cases and 4,509 pediatric cases during 2008–2017. The diagnostic accuracy was evaluated by comparing the abnormality detection rate (ADR) and the relative frequency (RF) of different types of cytogenomic abnormalities between prenatal and pediatric cases. A linear regression correlation between known prevalence and ADR of genomic disorders was used to extrapolate the prevalence of other genomic disorders. The diagnostic efficacy was estimated as percentage of detected abnormal cases by expected abnormal cases from served population. Results: The composite ADR for numerical chromosome abnormalities, structural chromosome abnormalities, recurrent genomic disorders, and sporadic pathogenic copy number variants (pCNVs) in prenatal cases were 13.03%, 1.77%, 1.69%, and 0.9%, respectively, and were 5.13%, 2.84%, 7.08%, and 2.69% in pediatric cases, respectively. The chromosomal abnormalities detected in prenatal cases (14.80%) were significantly higher than that of pediatric cases (7.97%) (p < 0.05), while the pCNVs detected in prenatal cases (2.59%) were significantly lower than that of pediatric cases (9.77%) (p < 0.05). The prevalence of recurrent genomic disorders and total pCNVs was estimated to be 1/396 and 1/291, respectively. Approximately, 29% and 35% of cytogenomic abnormalities expected from the population served were detected in current prenatal and pediatric diagnostic practice, respectively. Conclusion: For chromosomal abnormalities, effective detection of Down syndrome (DS) and Turner syndrome (TS) and under detection of sex chromosome numerical abnormalities in both prenatal and pediatric cases were noted. For pCNVs, under detection of pCNVs in prenatal cases and effective detection of DiGeorge syndrome (DGS) and variable efficacy in detecting other pCNVs in pediatric cases were noted. Extend aCGH analysis to more prenatal cases with fetal ultrasonographic anomalies, enhanced non-invasive prenatal (NIPT) testing screening for syndromic genomic disorders, and better clinical indications for pCNVs are approaches that could improve diagnostic yield of cytogenomic abnormalities. [ABSTRACT FROM AUTHOR]

Among the graft materials that can be used clinically, xenografts are the most common. Xenografts are of bovine, porcine, or equine origin and require the complete removal of proteins to avoid immunologic problems and the risk of transmission of prions, viruses, etc. Protein destruction can be achieved by a chemical procedure using organic solvents and heat treatment. After this process, a carbonated hydroxyapatite similar to human bone remains. The aim of this case report is to investigate the bone formation in a sinus augmentation procedure using a high temperature-treated bovine porous hydroxyapatite. A 58-year-old woman underwent bilateral sinus augmentation using this biomaterial. After 9 months, during stage-two surgery, two core biopsy specimens were retrieved and treated to obtain thin ground undecalcified sections. Microscopically, newly formed bone was present at the interface with most particles. The major portion of the particles appeared to be completely lined and surrounded by bone. No obvious signs of resorption were present on the biomaterial surface. No gaps or connective tissue were present at the bone-biomaterial interface. No inflammatory infiltrate or fibrous encapsulation of the particles was present. Histomorphometry showed that the percentages of newly formed bone, residual grafted particles, and marrow spaces were 25.1% ± 2.3%, 37.3% ± 1.1%, and 38.5% ± 3.1%, respectively. The excellent properties demonstrated by Endobon are probably a result of its particular hydroxyapatite porous microstructure with a high percentage of interconnected micropores that promote the ingrowth of osteogenic cells and vessels, making graft integration easier and faster. [ABSTRACT FROM AUTHOR]

Background: Array comparative genomic hybridization (aCGH), karyotyping and fluorescence in situ hybridization (FISH) analyses have been used in a clinical cytogenetic laboratory. A systematic analysis on diagnostic findings of cytogenomic abnormalities in current prenatal and pediatric settings provides approaches for future improvement. Methods: A retrospective analysis was performed on abnormal findings by aCGH, karyotyping, and FISH from 3,608 prenatal cases and 4,509 pediatric cases during 2008–2017. The diagnostic accuracy was evaluated by comparing the abnormality detection rate (ADR) and the relative frequency (RF) of different types of cytogenomic abnormalities between prenatal and pediatric cases. A linear regression correlation between known prevalence and ADR of genomic disorders was used to extrapolate the prevalence of other genomic disorders. The diagnostic efficacy was estimated as percentage of detected abnormal cases by expected abnormal cases from served population. Results: The composite ADR for numerical chromosome abnormalities, structural chromosome abnormalities, recurrent genomic disorders, and sporadic pathogenic copy number variants (pCNVs) in prenatal cases were 13.03%, 1.77%, 1.69%, and 0.9%, respectively, and were 5.13%, 2.84%, 7.08%, and 2.69% in pediatric cases, respectively. The chromosomal abnormalities detected in prenatal cases (14.80%) were significantly higher than that of pediatric cases (7.97%) (p < 0.05), while the pCNVs detected in prenatal cases (2.59%) were significantly lower than that of pediatric cases (9.77%) (p < 0.05). The prevalence of recurrent genomic disorders and total pCNVs was estimated to be 1/396 and 1/291, respectively. Approximately, 29% and 35% of cytogenomic abnormalities expected from the population served were detected in current prenatal and pediatric diagnostic practice, respectively. Conclusion: For chromosomal abnormalities, effective detection of Down syndrome (DS) and Turner syndrome (TS) and under detection of sex chromosome numerical abnormalities in both prenatal and pediatric cases were noted. For pCNVs, under detection of pCNVs in prenatal cases and effective detection of DiGeorge syndrome (DGS) and variable efficacy in detecting other pCNVs in pediatric cases were noted. Extend aCGH analysis to more prenatal cases with fetal ultrasonographic anomalies, enhanced non-invasive prenatal (NIPT) testing screening for syndromic genomic disorders, and better clinical indications for pCNVs are approaches that could improve diagnostic yield of cytogenomic abnormalities. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Fisheries & Aquatic Sciences is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: To evaluate several clinical and functional parameters by administration of specific questionnaires to an elderly patient's cohort wearing three different types of removable partial denture (RPD): VALPLAST‐RPD (Polyamide VALPLAST), CoCr‐RPD (cobalt‐chromium alloy), and PMMA‐RPD (heat polymerized polymethyl methacrylate). Materials and Methods: One hundred twenty patients (mean age 73 years) were included in this study. All patients were treated with a removable partial denture for the maxillary arch. After 1 year of use, patients and clinicians were asked to compile specific questionnaire on patient satisfaction, including aesthetic, functional, and clinical outcomes. It was also evaluated whether the localization of the missing teeth according to Kennedy classification may affect these parameters. Categorical data obtained from the questionnaires were analyzed by chi‐squared test. Results: VALPLAST‐RPD was the most satisfactory aesthetically. Nevertheless, patients of VALPLAST‐RPD group reported increased difficulty in cleaning the prosthesis, roughness perceived by the tongue, and increased retention loss (p < 0.001). Patients with PMMA‐RPD claimed a higher level of encumbrance (p < 0.001) and increased speech difficulties (p = 0.002). Clinically, patients of VALPLAST‐RPD and PMMA‐RPD groups displayed redness of the mucosa area around abutment teeth (p < 0.001). Patients of VALPLAST‐RPD group had four cases of artificial teeth loss and two cases of discoloration. The position of missing teeth did not significantly influence any parameter. Conclusions: Each RPD material utilized may present advantages and disadvantages in an elderly population. VALPLAST‐RPD may be recommended to older patients with non‐extensive edentulous areas supported by anterior and posterior teeth, and not subjected to strong chewing loads. The main advantages are aesthetic satisfaction and easiness to insert and remove it. [ABSTRACT FROM AUTHOR]

The objective is to determine the portion of sulfur fallout from a large source of sulfur dioxide emission (TPS-1 thermal power station) occurred in the local area (30 × 30 km) in Yuzhno-Sakhalinsk in winter. The sulfate fallout in the analyzed area is calcutated with the ISC3 stationary model. To validate the model based on the coefficient of sulfate washout by snow precipitation, the study used the results of sulfate determination in the snow cover at the end of winter obtained at the network of stations that monitored snow cover chemical composition in 2000–2013. According to the simulation results, 8–17% (the mean value is 12%) of sulfur emitted by TPS-1 deposited in the analyzed area in winters in 2000–2013. [ABSTRACT FROM AUTHOR]

Copyright of Revista CPC is the property of Revista CPC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this paper, we use a postcolonial lens to analyze the impacts of Aboriginal youth’s participation in Alberta’s Future Leaders Program’s youth leadership retreat. While the retreat appeared to have positive lasting impacts on many of the participants, it seemed to have the greatest impact on those who already displayed Eurocentric leadership skills; it had little effect on those who did not display these skills prior to retreat participation and it focused on North American, Eurocentric approaches to leadership. By becoming more culturally relevant, we argue that the retreat could have broader impacts on a greater number of Aboriginal youth. [ABSTRACT FROM AUTHOR]

This article examines the effect of tax factors on the equity values of U.S. multinational corporations making foreign acquisitions. Abnormal stock returns are found to be related to a tax variable that captures differences in the international tax status of acquiring firms but not related to a naive tax variable that captures differences between tax rates in target countries and the United States. Our evidence suggests that aggregate intercountry differentials in after-tax returns are competed away, while firm-specific, tax-related advantages (or disadvantages) are reflected in abnormal returns around the announcement date of the acquisition. [ABSTRACT FROM AUTHOR]

The aim of this study was to make a comparative analysis between the bone response to machined and sandblasted implants. The sandblasting was done with 150-µm aluminum oxide particles. Under scanning electron microscopic examination, the machined implants presented typical machining grooves, while a very rough, highly irregular surface with depressions and indentations was present on the sandblasted implants. Light microscopy showed a different bone growth pattern on machined (implantopetal growth) and sandblasted (implantofugal growth) implants. No negative effects on the rate of bone growth were observed in spite of the presence of aluminum ions. The histomorphometric analysis showed that sandblasted implants presented, from the third week onwards, a significantly higher contact percentage (P < .0001). These values could point to higher osteo-conductivity as a result of the higher surface roughness of sandblasted surfaces. [ABSTRACT FROM AUTHOR]

Abstract: During incubation, round whitefish embryos may experience fluctuating or elevated temperatures from natural (e.g., seasonal temperature changes) and/or anthropogenic sources. Anthropogenic sources like once‐through cooling discharges from nuclear power plants can also expose embryos to chemicals (e.g., morpholine) and/or radiation. To examine the effects of these potential stressors on embryogenesis, round whitefish were incubated under fluctuating or constant temperatures, with morpholine or 137Cs gamma rays. We report the percentage of prehatch and posthatch mortality, developmental rate, hatch dynamics, and morphometrics at 4 development stages. Embryos reared at constant temperatures had delayed developmental stage onset and median hatch, higher mortality at constant 8 °C, and lower mortality at ≤5 °C, compared with embryos reared under seasonal temperature regimes. Embryos incubated with ≥500 mg L−1 morpholine (>200× regulatory limits) had advanced hatch, reduced body size, and increased prehatch (100% at 1000 mg L−1) and posthatch (≈95% at 500 mg L−1) mortality compared with controls. Relative to controls, embryos irradiated with ≥0.16 mGy/d had larger body mass early in development, and all irradiated embryos had decreased posthatch mortality; the lowest dose was >300× discharge limits. Our study suggests that fluctuating or elevated temperatures and high‐dose morpholine can alter development rate, hatch dynamics, and growth, and/or increase mortality compared with embryos reared at constant temperatures of ≤5 °C; conversely, low‐dose irradiation had transient developmental effects but may benefit early posthatch survival. Environ Toxicol Chem 2018;37:2593–2608. © 2018 SETAC. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Fisheries & Aquatic Sciences is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)