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1. Infants Receiving a Single Dose of Nirsevimab to Prevent RSV Do Not Have Evidence of Enhanced Disease in Their Second RSV Season.

Author

Dagan, Ron, Hammitt, Laura L, Nuñez, Beatriz Seoane, Cots, Manuel Baca, Bosheva, Miroslava, Madhi, Shabir A, Muller, William J, Zar, Heather J, Chang, Yue, Currie, Alexander, Grenham, Amy, Shroff, Manish, Takas, Therese, Mankad, Vaishali S, Leach, Amanda, and Villafana, Tonya

Subjects
THERAPEUTIC use of monoclonal antibodies, IMMUNOGLOBULINS, MONOCLONAL antibodies, RESPIRATORY infections, SEVERITY of illness index, RESEARCH funding, RESPIRATORY syncytial virus infections, SECONDARY analysis, CHILDREN
Abstract

To characterize nirsevimab in the prevention of RSV, children from the Phase 3 MELODY trial were followed through their second RSV season. No increase in medically attended RSV lower respiratory tract infections or evidence of antibody-dependent enhancement of infection or disease severity was found for nirsevimab vs placebo recipients. Clinical Trial Registration: Clinicaltrials.gov, NCT03979313, https://clinicaltrials.gov/ct2/show/NCT03979313. [ABSTRACT FROM AUTHOR]

Published
2024
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