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Research summary: The concern of crime in New York City public housing complexes motivated heightened police patrol of buildings and the enforcement of trespass laws. The 2013 federal court settlement of Davis et al. v. City of New York et al. mandated that the New York City Police Department (NYPD) implement a series of reforms, including the deployment of body‐worn cameras (BWCs) on officers, to address unconstitutional use of criminal trespass enforcement and stop and frisk practices in public housing developments. This study employed a stepped wedge quasi‐experimental design that involved the sequential crossover of public housing service area clusters from control to BWC implementation until all NYPD housing bureau officers were equipped with BWCs. Panel regression models at the individual officer and service area levels were used to estimate BWC program impacts on outcomes between 2015 and 2019. Logistic regression models were used to estimate the impact of the BWCs on the lawfulness of officer stop reports that were randomly selected for audit between 2017 and 2019. Results show that BWC deployment in public housing reduced excessive enforcement, citizen complaints, and use of force by NYPD housing officers. Findings further suggest that BWCs can help reduce constitutionally problematic stops and frisks of citizens. Policy implications: Problematic police activities in public housing contexts can be reformed using BWCs. When coupled with routine supervisory review of video footage, the deployment of BWCs on public housing officers can improve compliance with department directives to reduce enforcement actions and increase documentation of citizen stops. [ABSTRACT FROM AUTHOR]

CO2 mineralization in slag has been widely investigated as a potential solution for offsetting steelmaking industry emissions. However, it can be associated with ecotoxic elements release (e.g., V and Cr). The presence of such elements in heterogenous slag at the micro‐scale remains difficult for analysis since microstructural features can be missed during microscopy data inspection, thereby presenting a challenge in understanding how ecotoxic elements exist in slag. Here, an unsupervised machine learning‐based technique is used to analyze slag's microstructural features. Energy Dispersive Spectroscopy (EDS) data are analyzed through Hierarchical Density‐Based Spatial Clustering of Applications with Noise (HDBSCAN) method. Results show that passive CO2 mineralization has occurred in situ in the studied samples, on the surface, and within their pores. Additionally, V and Cr regions with equivalent diameters < 42 µm can exist within slag, potentially making such elements prone to mobilization due to slag pulverization. Interrogation of the samples with Laser Ablation Inductively Coupled Plasma Mass Spectroscopy (LA‐ICP‐MS) confirms the distribution of the elements obtained from the clustering algorithm and further demonstrates that up to 84 and 9 ppm of V and Cr are incorporated in the precipitated calcite, respectively. This implies that ecotoxic elements may be immobilized through calcite precipitation. [ABSTRACT FROM AUTHOR]

Iron and steel slags have a long history of both disposal and beneficial use in the coastal zone. Despite the large volumes of slag deposited, comprehensive assessments of potential risks associated with metal(loid) leaching from iron and steel by-products are rare for coastal systems. This study provides a national-scale overview of the 14 known slag deposits in the coastal environment of Great Britain (those within 100 m of the mean high-water mark), comprising geochemical characterisation and leaching test data (using both low and high ionic strength waters) to assess potential leaching risks. The seaward facing length of slag deposits totalled at least 76 km, and are predominantly composed of blast furnace (iron-making) slags from the early to mid-20th Century. Some of these form tidal barriers and formal coastal defence structures, but larger deposits are associated with historical coastal disposal in many former areas of iron and steel production, notably the Cumbrian coast of England. Slag deposits are dominated by melilite phases (e.g. gehlenite), with evidence of secondary mineral formation (e.g. gypsum, calcite) indicative of weathering. Leaching tests typically show lower element (e.g. Ba, V, Cr, Fe) release under seawater leaching scenarios compared to deionised water, largely ascribable to the pH buffering provided by the former. Only Mn and Mo showed elevated leaching concentrations in seawater treatments, though at modest levels (<3 mg/L and 0.01 mg/L, respectively). No significant leaching of potentially ecotoxic elements such as Cr and V (mean leachate concentrations <0.006 mg/L for both) were apparent in seawater, which micro-X-Ray Absorption Near Edge Structure (μXANES) analysis show are both present in slags in low valence (and low toxicity) forms. Although there may be physical hazards posed by extensive erosion of deposits in high-energy coastlines, the data suggest seawater leaching of coastal iron and steel slags in the UK is likely to pose minimal environmental risk. [ABSTRACT FROM AUTHOR]

O-GlcNAcase (OGA) is the only human enzyme that catalyzes the hydrolysis (deglycosylation) of O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) from numerous protein substrates. OGA has broad implications in many challenging diseases including cancer. However, its role in cell malignancy remains mostly unclear. Here, we report that a cancer-derived point mutation on the OGA's noncatalytic stalk domain aberrantly modulates OGA interactome and substrate deglycosylation toward a specific set of proteins. Interestingly, our quantitative proteomic studies uncovered that the OGA stalk domain mutant preferentially deglycosylated protein substrates with +2 proline in the sequence relative to the O-GlcNAcylation site. One of the most dysregulated substrates is PDZ and LIM domain protein 7 (PDLIM7), which is associated with the tumor suppressor p53. We found that the aberrantly deglycosylated PDLIM7 suppressed p53 gene expression and accelerated p53 protein degradation by promoting the complex formation with E3 ubiquitin ligase MDM2. Moreover, deglycosylated PDLIM7 significantly up-regulated the actin-rich membrane protrusions on the cell surface, augmenting the cancer cell motility and aggressiveness. These findings revealed an important but previously unappreciated role of OGA's stalk domain in protein substrate recognition and functional modulation during malignant cell progression. [ABSTRACT FROM AUTHOR]

The negative impact of vacant and abandoned housing in city neighborhoods is extreme, affecting health and quality of life, promoting violence, and leading to further abandonment. One approach to addressing abandoned housing is to intervene with low-cost interventions that provide a visual sense of ownership. We tested whether a low-cost remediation of abandoned and vacant houses or a trash cleanup intervention would make a noticeable difference in the levels of nearby disrepair, disorder, and public safety. The abandoned housing remediation and trash cleanup interventions were a test of compliance with municipal ordinances. We used an experimental design to test the causal effects of the ordinances and because the scale of abandonment was too large to provide treatment to all abandoned houses in the city. We used systematic social observation methods to rate changes in disrepair, disorder, and litter at housing sites and on the city blocks they were located and police-reported data on gun violence and illegal substance use. Our experimental design allowed us to see whether observed disrepair, disorder, and public safety improved after working windows and doors were installed on abandoned houses compared with a trash cleanup around properties or a no-intervention control condition. Our results showed significant changes in observed disrepair, disorder, and gun violence and illustrate the benefits of experimental evaluations of place-based changes to the built environment. Improving compliance with ordinances to remediate abandoned housing can make a noticeable difference in disrepair in neighborhoods and contribute to improved public safety. We illustrate how planners can use field experiments in partnership with city agencies, nonprofit community groups, and local universities to discover novel approaches to advance place-based changes to the built environment that can help economically disadvantaged communities abate problems of physical disorder. [ABSTRACT FROM AUTHOR]

Unconsolidated artificial ground is an ever‐increasing feature on the Earth's surface but it poses various challenges such as pollutant release and ground instability. The process of lithification could be an important factor in changing the properties of artificial ground and ameliorating these challenges. In this study, a lithified deposit of a furnace slag associated with a former iron and steel works in Scotland was analysed to determine the mechanisms and drivers of lithification. Scanning electron microscope analysis showed that Ca leached from around the edges of clasts of slag through reaction of the chemically unstable slag with water from an adjacent water body. Dissolution of Ca (and OH−) from the slag caused the water in contact with the slag to become hyperalkaline, facilitating ingassing and hydroxylation of CO2 from the atmosphere (fingerprinted through carbon isotope analysis). Reaction of the dissolved Ca and CO2 led to precipitation of calcite. Scanning electron microscope analysis showed the calcite is distributed between slag clasts, forming rims around clasts and cementing clasts together into a solid rock‐like mass. Understanding the mechanisms and drivers of lithification in artificial ground will be important, given its widespread nature particularly in urban areas where artificial ground is the substrate of most development. [ABSTRACT FROM AUTHOR]

Summary: Background: Ulcerative proctitis (UP) is a common highly symptomatic form of ulcerative colitis that can be difficult to treat. Aim: To assess the efficacy of medical treatments for UP. Methods: We searched MEDLINE, EMBASE, and CENTRAL on 23 November 2022 for randomised controlled trials (RCTs) of medical therapy for adults with UP. Primary outcomes included induction and maintenance of clinical remission. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated for each outcome. Results: We included 53 RCTs (n = 4096) including 46 induction studies (n = 3731) and seven maintenance studies (n = 365). First‐line therapies included topical 5‐aminosalicylic acid (5‐ASA), conventional corticosteroids, budesonide, and oral 5‐ASA. Therapy for refractory UP included topical tacrolimus and small molecules. Topical 5‐ASA was superior to placebo for induction (RR 2.72, 95% CI 1.94–3.82) and maintenance of remission (RR 2.09, 95% CI 1.26–3.46). Topical corticosteroids were superior to placebo for induction of remission (RR 2.83, 95% CI 1.62–4.92). Topical budesonide was superior to placebo for induction of remission (RR 2.34, 95% CI 1.44–3.81). Combination therapy with topical 5‐ASA and topical corticosteroids was superior to topical monotherapy with either agent. Topical tacrolimus was superior to placebo. Etrasimod was superior to placebo for induction (RR 4.71, 95% CI 1.2–18.49) and maintenance of remission (RR 2.08, 95% CI 1.31–3.32). Conclusions: Topical 5‐ASA and corticosteroids are effective for active UP. Topical 5‐ASA may be effective for maintenance of remission. Tacrolimus may be effective for induction of remission. Etrasimod may be effective for induction and for maintenance of remission. Trials should include UP to expand the evidence base for this under‐represented population. [ABSTRACT FROM AUTHOR]

Background: Targeting interleukin-23 (IL-23) is an important therapeutic strategy for Crohn's disease (CD). Aims: This systematic review and meta-analysis assessed the efficacy and safety of selective IL-23p19 and IL-12/23p40 inhibitors in patients with moderate-to-severe CD. Methods: MEDLINE, Embase, and the Cochrane library (CENTRAL) were searched from inception to May 24, 2023, for randomized, placebo- or active comparator-controlled induction and/or maintenance trials of selective IL-23p19 and IL-12/23p40 inhibitors in pediatric and adult patients with CD. The primary outcome was the proportion of patients in clinical remission. Secondary outcomes were clinical response, endoscopic remission, endoscopic response, and safety. Data were pooled using a random-effects model. Risk of bias and certainty of evidence were assessed using the Cochrane risk of bias tool and the GRADE criteria, respectively. Results: Eighteen trials (n = 5561) were included. Most studies were rated as low risk of bias. Targeting IL-23 was significantly superior to placebo for inducing clinical (risk ratio [RR] = 1.87, 95% confidence interval [CI] 1.58–2.21) and endoscopic (RR = 3.20, 95%CI 2.17–4.70) remission and maintaining clinical remission (RR = 1.39, 95%CI 1.10–1.77) (GRADE high certainty evidence for all outcomes). Subgroup analysis showed that targeting IL-23 was superior to placebo for inducing clinical remission in biologic-naïve (RR = 2.20, 95%CI 1.46–3.32, I2 = 0%, p = 0.39) and biologic-experienced patients (RR = 1.82, 95%CI 1.27–2.60, I2 = 56.5%, p = 0.01). Targeting IL-23 was associated with a decreased risk of serious adverse events in induction (RR = 0.55, 95%CI 0.44–0.73) and maintenance (RR = 0.72, 95%CI 0.53–0.98) trials compared to placebo (high certainty evidence). Conclusion: Targeting IL-23 is effective and safe for inducing and maintaining clinical and endoscopic remission in patients with moderate-to-severe CD. [ABSTRACT FROM AUTHOR]

Summary: Background and Aims: We conducted a systematic review to assess medical therapy for the treatment and prevention of pouchitis. Methods: Randomised controlled trials (RCTs) of medical therapy in adults with or without pouchitis were searched to March 2022. Primary outcomes included clinical remission/response, maintenance of remission and prevention of pouchitis. Results: Twenty RCTs (N = 830) were included. Acute pouchitis: One study compared ciprofloxacin with metronidazole. At 2 weeks, 100% (7/7) of ciprofloxacin participants achieved remission, compared with 67% (6/9) of metronidazole participants (RR: 1.44, 95% CI: 0.88–2.35, very low certainty evidence). One study compared budesonide enemas with oral metronidazole. Fifty percent (6/12) of budesonide participants achieved remission compared with 43% (6/14) of metronidazole participants (RR: 1.17, 95% CI: 0.51–2.67, low certainty evidence). Chronic pouchitis: Two studies (n = 76) assessed De Simone Formulation. Eighty‐five percent (34/40) of De Simone Formulation participants maintained remission at 9–12 months compared with 3% (1/36) placebo participants (RR: 18.50, 95% CI: 3.86–88.56, moderate certainty evidence). One study assessed vedolizumab. Thirty‐one percent (16/51) of vedolizumab participants achieved clinical remission at 14 weeks compared with 10% (5/51) of placebo participants (RR: 3.20, 95% CI: 1.27–8.08, moderate certainty evidence). Prophylaxis: Two studies assessed De Simone Formulation. Ninety percent (18/20) of De Simone Formulation participants did not develop pouchitis compared with 60% (12/20) of placebo participants (RR: 1.50, 95% CI: 1.02–2.21, moderate certainty evidence). Conclusions: Apart from vedolizumab and the De Simone formulation, the effects of other medical interventions for pouchitis are uncertain. [ABSTRACT FROM AUTHOR]

With supply chains targeting increased efficiency, leadership behaviors are critical in influencing the employee experience, and thus the success of employees in organizations. Yet, behavioral work withdrawal, e.g., lateness and absenteeism, among frontline logistics employees is an acute challenge, estimated to contribute millions annually in related costs such as overtime or temporary workers. Our work seeks to capture potential causes for these withdrawal behaviors in the logistics supply chain. Extending prior work on regulatory focus theory, we propose that behavioral work withdrawal depends on fit or misfit between leadership behavior and the follower's regulatory focus. Leadership behaviors appealing to opportunities and growth (i.e., inspirational styles) are likely effective at reducing withdrawal for employees high in promotion focus, while behaviors appealing to accuracy and avoiding errors or failure (i.e., management‐by‐exception styles) are likely effective at reducing withdrawal for employees high in prevention focus. We combine survey and archival data to test our moderation hypotheses. Support is found for the fit perspective, confirming that no single leadership behavior is consistently better at reducing withdrawal, yet attentiveness to this perspective is critical as misfit increases withdrawal. These findings can help reduce overtime, employee burnout, and service delays and allow managers to reduce associated costs. [ABSTRACT FROM AUTHOR]

Objectives: Outfitting police officers with body-worn cameras (BWCs) has been suggested to improve police-community relations. This study evaluates whether the deployment of BWCs on NYPD officers impacted resident perceptions of the police. Methods: A cluster randomized controlled trial design was used to test the influence of BWCs on resident perceptions of the NYPD in treatment precincts relative to control precincts. Dual-frame randomly selected telephone surveys were used to collect pre-intervention and post-intervention resident perception data. Results: We find no statistically significant differences between BWC treatment and control precincts in general perceptions of the NYPD or the average assessment of police officer behavior among those who have had recent encounters with the NYPD. Conclusion: Strong community support for BWC adoption and citizen expectations for videos of controversial policing events suggests the continued use of this technology. However, BWCs should be implemented with other evidence-based programs to enhance police-community relations. [ABSTRACT FROM AUTHOR]

Rapid and uncontrolled urbanisation in many parts of Africa is a significant driver of earthquake risk. New constructions are usually built with no compliance with seismic codes, which results in a critical increase in the vulnerability of the building stock. To quantitatively assess the potential consequences of unregulated urbanisation, this study investigates the effect of building code enforcement and urban expansion on the future earthquake loss in the city of Blantyre, Malawi. The analysis, performed within a probabilistic loss assessment framework, estimates the net present value of 30-year aggregated seismic loss for different urban expansion rates and code enforcement scenarios. The results show that high urbanisation rates and lack of building regulations could lead to a threefold increase in average seismic losses in the next thirty years. On the contrary, effective code enforcement could cap the seismic loss increase at 13%, highlighting the financial gain from effective disaster risk reduction programmes. [ABSTRACT FROM AUTHOR]

Summary: Background: Effective medical therapies for patients with microscopic colitis (MC) who fail budesonide are lacking. However, conducting randomised controlled trials (RCTs) in MC has been challenging due to small sample sizes. Understanding placebo responses can help inform more efficient future trials. Aims: The aim of this study is to estimate clinical and histologic placebo response rates and to determine factors associated with placebo response in MC. Methods: EMBASE, MEDLINE, and CENTRAL were searched until 7 January 2022, to identify placebo‐controlled RCTs in adult patients with MC. Clinical and histologic response in the placebo arms were pooled using random‐effects models. Stratified analyses based on disease‐ and trial‐level characteristics, leave‐one‐out meta‐analysis, and cumulative meta‐analysis were performed. Results: Twelve RCTs enrolling a total of 391 patients (placebo n = 163) with MC were included. Pooled clinical and histologic placebo response rates were 24.4% (95% CI: 12.4%–38.4%), I2 = 60.8%, p < 0.01, and 19.9% (95% CI: 5.3%–39.0%), I2 = 66.4%, p = 0.01 (tests for heterogeneity), respectively. Clinical response to placebo was numerically higher in patients with lymphocytic compared to collagenous colitis (39.9% vs. 19.8%, p = 0.08). Heterogeneity in clinical response to placebo was significantly reduced when the Miehlke 2014 RCT was excluded in the leave‐one‐out meta‐analysis or when a more stringent secondary definition of response based on the Hjortswang criteria was applied. Conclusions: Approximately one‐quarter of patients in MC trials respond to placebo, although with substantial heterogeneity, reflecting the need for standardised outcome definitions and study designs for MC. This analysis also serves to inform future MC trials that may consider incorporating an external, historical placebo control arm, rather than directly randomising patients to placebo. [ABSTRACT FROM AUTHOR]

This article reviews extant multidisciplinary literature to uncover existing themes and directions in the knowledge of the overlap between natural resource scarcity and illicit supply chain activity. In doing so, the authors present a novel review of this nascent, complex, and multidisciplinary research area. This review has uncovered 127 articles that have not been synthesized or organized in a meaningful way with the supply chain literature. It extracts insights and develops a comprehensive process framework encompassing the following: (a) antecedents associated with natural resource extraction, which foments the opportunity for illicit activity to thrive; (b) resulting economic, social, and environmental outcomes from illicit activity as it relates to natural resource extraction; and (c) potential moderating processes, which either enable or inhibit illicit activity to occur, including firm‐level tactics that businesses can employ to counteract illicit activity throughout the supply chain and to promote sustainable long‐term operations. An extensive agenda is presented suggesting future research paths, methodologies, theories, and potential contributions. [ABSTRACT FROM AUTHOR]

Wildlife trafficking, whether local or transnational in scope, undermines sustainable development efforts, degrades cultural resources, endangers species, erodes the local and global economy, and facilitates the spread of zoonotic diseases. Wildlife trafficking networks (WTNs) occupy a unique gray space in supply chains—straddling licit and illicit networks, supporting legitimate and criminal workforces, and often demonstrating high resilience in their sourcing flexibility and adaptability. Authorities in different sectors desire, but frequently lack knowledge about how to allocate resources to disrupt illicit wildlife supply networks and prevent negative collateral impacts. Novel conceptualizations and a deeper scientific understanding of WTN structures are needed to help unravel the dynamics of interaction between disruption and resilience while accommodating socioenvironmental context. We use the case of ploughshare tortoise trafficking to help illustrate the potential of key advancements in interdisciplinary thinking. Insights herein suggest a significant need and opportunity for scientists to generate new science-based recommendations for WTN-related data collection and analysis for supply chain visibility, shifts in illicit supply chain dominance, network resilience, or limits of the supplier base. [ABSTRACT FROM AUTHOR]

Research Summary: This study examines the extent to which citywide racial and ethnic disparities in arrests are driven by a subset of places within cities. Data are drawn from six U.S. cities from 2014 to 2019. Results indicate that arrests are strongly concentrated within a few block groups, for all race and ethnicities in all cities. Coupled with higher rates of arrests for Blacks and (in some cities) Hispanics compared to Whites and other racial groups, this means that a few places in every city are responsible for driving citywide racial and ethnic disparities in arrests. These arrest hot spots demonstrate very high year‐to‐year stability. There is a strong relationship between crime and arrest hot spots, making crime hot spots key drivers of citywide racial and ethnic disparities in arrests. Policy Implications: Our results indicate that changes to arrest patterns in most parts of a city will have little impact on citywide racial and ethnic disparities in arrests. At the same time, an intense focus on reducing arrests in hot spots may yield outsized reductions in population‐level racial and ethnic disparities, while being especially feasible due to their limited scope. Place‐based and group‐based interventions at these locations may entail the dual benefit of reduced racial disparities in arrests along with enhanced public safety. [ABSTRACT FROM AUTHOR]

Clumped isotope values (Δ47) of carbonates forming in high pH conditions do not correspond to mineral precipitation temperatures due to certain effects including kinetic isotope fractionation and dissolved inorganic carbon (DIC) endmember mixing. Field-based archives of these carbonate environments are needed to evaluate and quantify these effects accurately. In this study, we measure the clumped isotope values of anthropogenic carbonates for the first time. Tufa layers were analyzed from samples precipitating in a high pH (>10) stream that drains a major slag heap in north east England. Δ47 values are 0.044‰–0.183‰ higher than expected equilibrium values. Non-linear distribution of clumped isotope data is diagnostic of DIC endmember mixing, rather than partial equilibration of DIC. Episodic dilution of hydroxide-rich stream waters by equilibrated rainfall surface runoff provides the mechanism by which mixing occurs. Δ47 values are ~0.010‰–0.145‰ higher than linear clumped isotope mixing profiles, suggesting that the majority of Δ47 increase results from a combination of endmember non-linear mixing effects and an atmosphere-hydroxide sourcing of DIC. The diagnostic trends and variation in clumped isotope values present in these results demonstrates the potential of anthropogenic carbonate systems as a useful archive for studying and quantifying kinetic effects in clumped isotopes. [ABSTRACT FROM AUTHOR]

The research literature of supply chain risk and resilience is at a critical developmental stage. Studies have established the importance of these topics both to researchers and practitioners. They also have identified factors contributing to risk, the impact of risk and disruptions on performance, and the strategies and tactics used to build the capacity for supply chain resilience. Although these efforts can provide support for constructing a theory of risk and resilience, researchers are currently restricted in their ability to build such a theory by the difficulty of collecting the necessary data. This paper contributes to this literature development effort by summarising prior research reviews and developing a three-component framework aimed at helping researchers to build better theories. This is accomplished through combining structured experimental design with discrete-event simulations of supply chains. The result is a methodology that allows researchers to develop better understanding of the factors that link a disruption to its impact on supply chain performance through both direct and interaction effects. Following the methodology development, the paper concludes with an example using the factors of shock interarrival time, supply chain connectivity and buffer stocks to illustrate the potential for contributing to the theory-building process. [ABSTRACT FROM AUTHOR]

Objective: Place-based blight remediation programs have gained popularity in recent years as a crime reduction approach. This study estimated the impact of a citywide vacant lot greening program in Philadelphia on changes in crime over multiple years, and whether the effects were moderated by nearby land uses. Methods: The vacant lot greening program was assessed using quasi-experimental and experimental designs. Entropy distance weighting was used in the quasi-experimental analysis to match control lots to be comparable to greened lots on pre-existing crime trends. Fixed-effects difference-in-differences models were used to estimate the impact of the vacant lot greening program in quasi-experimental and experimental analyses. Results: Vacant lot greening was estimated to reduce total crime and multiple subcategories in both the quasi-experimental and experimental evaluations. Remediating vacant lots had a smaller effect on reducing crime when they were located nearby train stations and alcohol outlets. The crime reductions from vacant lot remediations were larger when they were located near areas of active businesses. There is some suggestive evidence that the effects of vacant lot greening are larger when located in neighborhoods with higher pre-intervention levels of social cohesion. Conclusions: The findings suggest that vacant lot greening provides a sustainable approach to reducing crime in disadvantaged neighborhoods, and the effects may vary by different surrounding land uses. To better understand the mechanisms through which place-based blight remediation interventions reduce crime, future research should measure human activities and neighborly socialization in and around places before and after remediation efforts are implemented. [ABSTRACT FROM AUTHOR]

This study focuses on vibration‐based damage detection for a structure that has nonlinear behavior even in the undamaged state. Based on the vibration responses of a single sensor, a non‐Gaussian multivariate probability density function (PDF) is developed and used as a feature. The change between the PDF of the undamaged state and that of a potentially damaged state is used to indicate the damage. Since what of interest is the change of the PDF, instead of estimating the two PDFs separately, the ratio of them is estimated directly using a density ratio estimation method. In addition, principal component analysis is applied to reduce the dimensionality of the PDFs. The effectiveness and advantages of the proposed method are demonstrated in two case studies: an experimental nonlinear beam and simulations of an offshore wind turbine subjected to nonlinear pile‐soil interaction. Compared with a second‐order statistical method, the proposed method shows better damage detection performance due to the integration of higher order statistical information. [ABSTRACT FROM AUTHOR]

For modern electrical rail systems, the pantograph-catenary dynamic performance is one of the most critical challenges. Too much fluctuation in contact forces leads to either accelerated wear of the contacting components or losses of contact and, consequently, arcing. In this work, inertance-integrated pantograph damping systems are investigated with the objective of reducing the contact force standard deviation. Firstly, a multibody pantograph model is developed with its accuracy compared with experimental data. The model is improved through the calibration of the pantograph head suspension parameters and the introduction of both non-ideal joint and flexibility effects. Using the calibrated model, beneficial inertance-integrated damping systems are identified for the pantograph suspension. The results show that the configuration with one inerter provides the best performance among other candidate layouts and contends a 40% reduction of the maximum standard deviation of the contact force over the whole operating speed range in the numerical modelling scenario analysed. Considering the identified configuration, time-domain analysis and modal analysis are investigated. It has been shown that the achieved improvement is due to the fact that with the beneficial inertance-integrated damping system, the first resonance frequency of the pantograph system coincides with the natural frequency of the catenary system. [ABSTRACT FROM AUTHOR]

Background: Patients treated with immune checkpoint inhibitors (ICIs) may develop ICI-associated enterocolitis, for which there is no approved treatment. Aims: We aimed to systematically review the efficacy and safety of medical interventions for the prevention and treatment of ICI-associated enterocolitis. Methods: MEDLINE, EMBASE, and the Cochrane Library were searched to identify randomized controlled trials (RCTs), cohort and case–control studies, and case series/reports, evaluating interventions (including corticosteroids, biologics, aminosalicylates, immunosuppressants, and fecal transplantation) for ICI-associated enterocolitis. Clinical, endoscopic, and histologic efficacy endpoints were evaluated. The Grading of Recommendations, Assessment, Development, and Evaluation criteria were used to assess overall quality of evidence. Results: A total of 160 studies (n = 1514) were included (one RCT, 3 retrospective cohort studies, 156 case reports/case series). Very low quality evidence from one RCT suggests budesonide is not effective for prevention of ICI-associated enterocolitis in ipilimumab-treated patients (relative risk 0.93 [95% confidence interval 0.56, 1.56]). Very low quality evidence suggests that corticosteroids, infliximab, and vedolizumab may be effective for treatment of ICI-associated enterocolitis by inducing clinical response and remission. No validated indices for measuring disease activity were used. Biologic treatment was used in 42% (641/1528) of patients, as reported in 97 studies. ICIs were discontinued in 65% (457/702) of patients, as reported in 63 studies. Conclusions: Current treatment recommendations for ICI-associated enterocolitis are based on very low quality evidence, primarily from case reports and case series. Large-scale prospective cohort studies and RCTs are needed to develop prophylactic and therapeutic treatments to minimize interruption or discontinuation of oncological therapies. [ABSTRACT FROM AUTHOR]

Large-amplitude cable vibrations are remarkably common on cable-stayed bridges due to various aerodynamic loading mechanisms and/or motion of the cable ends. Geometric nonlinearity can be important in the dynamic behavior, and significant local bending stresses can arise at the anchorages, where rotation is restrained. This leads to a concern about the fatigue of these cables from the cyclic stress variations. This paper presents an analytical bending fatigue model for estimating the fatigue life of low-sag cables subjected to harmonic loading. Using this framework, the fatigue life of cables at the anchorage zone and guide deviator (if present) under external loading can be predicted. The results show that the use of a guide deviator can significantly extend the cable's fatigue life at the anchorage. For cables with a guide deviator subject to severe loading conditions, the fatigue life is limited by the behavior at the guide rather than the anchorage, which is consistent with previous observations. The fatigue life is greatly reduced if the cable jumps to a multimodal dynamic response due to the cable nonlinearity. The single-mode zone where the dynamic response of the cable is always stable in a single mode, leading to a relatively long fatigue life, has been identified. Finally, the effect of cable inclination angle and ratio of cable weight to tension on the fatigue life has been analyzed. [ABSTRACT FROM AUTHOR]

CTEA (N,N‐bis[2‐(carboxylmethyl)thioethyl]amine) is a mixed donor ligand that has been incorporated into multiple fluorescent sensors such as NiSensor‐1 that was reported to be selective for Ni2+. Other metal ions such as Zn2+ do not produce an emission response in aqueous solution. To investigate the coordination chemistry and selectivity of this receptor, we prepared NiCast, a photocage containing the CTEA receptor. Cast photocages undergo a photoreaction that decreases electron density on a metal‐bound aniline nitrogen atom, which shifts the binding equilibrium toward unbound metal ion. The unique selectivity of CTEA was examined by measuring the binding affinity of NiCast and the CTEA receptor for Ni2+, Zn2+, Cd2+ and Cu2+ under different conditions. In aqueous solution, Ni2+ binds more strongly to the aniline nitrogen atom than Cd2+; however, in CH3CN, the change in affinity virtually disappears. The crystal structure of [Cu(CTEA)], which exhibits a Jahn–Teller–distorted square pyramidal structure, was also analyzed to gain more insight into the underlying coordination chemistry. These studies suggest that the fluorescence selectivity of NiSensor‐1 in aqueous solution is due to a stronger interaction between the aniline nitrogen atom and Ni2+ compared to other divalent metal ions except Cu2+. [ABSTRACT FROM AUTHOR]

Supply (chain) disruptions present considerable managerial challenges with potentially severe consequences. To protect their firms, managers often must decide whether or not to take proactive measures. Protection motivation theory suggests that individuals' intention to respond to a threat proactively results from their cognitive appraisal (situational interpretation) processes. These processes evaluate the characteristics of potential coping responses (e.g., its effectiveness in averting the threat) and the threat itself (e.g., its severity). Building on this framework, this study presents an analysis of what drives managers to, or deters them from, proactively responding to the threat of a disruption. The results from a discrete choice experiment suggest that decision makers have a strong subconscious focus on cost‐related aspects of a specific proactive action, all the while consciously prioritizing the efficacy (effectiveness) of the action over its costs. Moreover, decision makers' perceptions of the relative importance of proactive action attributes deviate considerably from their actual choice behavior. This study investigates additional behavioral aspects of supply chain risk management such as a proactive personality, risk attitude, control appraisal, and experience, many of which have significant effects on the relative importance of certain proactive action attributes. The improved understanding has three relevant messages for managerial practice, which are related to the perception–action gap, the importance of self‐assessment and self‐awareness, and training. [ABSTRACT FROM AUTHOR]

Early life exposure to environmental lead (Pb) has been linked to decreased IQ, behavior problems, lower lifetime earnings, and increased criminal activity. Beginning in the 1970s, limits on Pb in paint, gasoline, food cans, and regulated water utilities sharply curtailed US environmental Pb exposure. Nonetheless, hundreds of thousands of US children remain at risk. This study reports on how unregulated private well water is an underrecognized Pb exposure source that is associated with an increased risk of teenage juvenile delinquency. We build a longitudinal dataset linking blood Pb measurements for 13,580 children under age 6 to their drinking water source, individual- and neighborhood-level demographics, and reported juvenile delinquency records. We estimate how early life Pb exposure from private well water influences reported delinquency. On average, children in homes with unregulated private wells had 11% higher blood Pb than those with community water service. This higher blood Pb was significantly associated with reported delinquency. Compared to children with community water service, those relying on private wells had a 21 % (95% CI: 5 to 40%) higher risk of being reported for any delinquency and a 38% (95% CI: 10 to 73%) increased risk of being reported for serious delinquency after age 14. These results suggest that there could be substantial but as-yet-unrecognized social benefits from intervention programs to prevent children's exposure to Pb from private wells, on which 13% of the US population relies. [ABSTRACT FROM AUTHOR]

The federal court settlement of Floyd, et al. v. City of New York, et al. (2013) mandated that the New York City Police Department (NYPD) implement a series of reforms to address unlawful stop, question, and frisk patterns and practices. Among other changes, the remedial order required the NYPD to implement and evaluate a pilot body‐worn camera program to determine whether outfitting officers with the technology led to more lawful and civil police–citizen encounters. A cluster randomized controlled trial involving 40 police precincts and 3,889 NYPD officers was used to evaluate the effects of body‐worn cameras on a series of police work activity, civility, and lawfulness outcomes. Relative to control officers, citizen complaints against treatment officers outfitted with body‐worn cameras were reduced by 21 percent. Treatment officers, however, also filed nearly 39 percent more stop reports when compared with control officers. Treatment stop reports tended to involve minority subjects, were less likely to involve arrests and summons, and were significantly more likely to be rated as not meeting constitutional justifications for stops, frisks, and searches. These results suggest that body‐worn cameras improved NYPD officer compliance with mandates to document all stops and could be used to address unlawful policing through better detection of problematic police–citizen encounters. [ABSTRACT FROM AUTHOR]

Summary: Background: Although there is interest in developing pharmacotherapies for the treatment of immune checkpoint inhibitor‐associated enterocolitis (ICIC), there is currently no consensus on how to optimally measure disease activity in this condition. Aims: To identify all scoring indices used for the measurement of disease activity in ICIC, assess their operating properties, and explore their potential utility as outcome measures. Methods: We searched MEDLINE, EMBASE and the Cochrane Library from inception to November 2020 to identify studies that evaluated disease activity and severity in patients with ICI‐associated enterocolitis. These scoring tools could be designed specifically for ICIC or adapted from other diseases, and assessed clinical, endoscopic, or histologic disease activity. Results: Sixty‐four studies were included. The Common Terminology Criteria for Adverse Events is commonly used to describe symptoms, although has only been partially validated and was not designed as a disease activity index. Endoscopic and histologic indices used in inflammatory bowel disease have been adopted for ICIC including the Mayo Endoscopic Subscore, Ulcerative Colitis Endoscopic Index of Severity, Simple Endoscopic Score for Crohn's Disease, Nancy Histological Index, Robarts Histopathological Index, and Geboes Score, among others. None of these indices has been validated for use in ICIC, and all lacked content validity and responsiveness. Conclusions: There are no validated clinical, endoscopic, or histologic outcomes to assess disease activity in ICIC. Development and validation of reliable and responsive outcome measures that can be used to measure disease activity will be paramount for both clinical practice and for the development of treatments. [ABSTRACT FROM AUTHOR]

The detection rates of neuroendocrine tumors (NETs) are rising, which has led to a better understanding of their histopathologic characteristics. We present a case of adrenal pheochromocytoma with an incidental finding of a concurrent ileocecal NET detected on early post-adrenalectomy imaging. A 59-year-old male was noted to have microscopic hematuria on a routine workup. Further imaging identified a right adrenal lesion suggestive of pheochromocytoma. He was reporting intermittent headaches, and his urinary normetanephrine and norepinephrine levels were elevated. He underwent a right retroperitoneal adrenalectomy, and pathology confirmed a pheochromocytoma with no malignancy. Postoperatively, he developed a hematoma at the surgical bed that was identified on CT scan. An incidental lesion at the level of the ileocecal valve was noted on the CT scan as well. This was further investigated by colonoscopy and biopsy that confirmed a carcinoid tumor. He had no gastrointestinal symptoms, chromogranin A was normal, and 24-h urinary 5-hydroxyindolacetic acid levels were slightly elevated. He subsequently underwent a laparoscopic right hemicolectomy 3 months from his initial adrenalectomy. Final pathology confirmed a grade 2 NET with metastatic involvement of 4 regional lymph nodes. We report an extremely rare case of simultaneous pheochromocytoma accompanied with an ileocecal NET. Genetic testing for multiple endocrine neoplasia was undertaken and was found negative for 9 tested genes. [ABSTRACT FROM AUTHOR]

The pedestrian-induced instability of the London Millennium Bridge is a widely used example of Kuramoto synchronisation. Yet, reviewing observational, experimental, and modelling evidence, we argue that increased coherence of pedestrians' foot placement is a consequence of, not a cause of the instability. Instead, uncorrelated pedestrians produce positive feedback, through negative damping on average, that can initiate significant lateral bridge vibration over a wide range of natural frequencies. We present a simple general formula that quantifies this effect, and illustrate it through simulation of three mathematical models, including one with strong propensity for synchronisation. Despite subtle effects of gait strategies in determining precise instability thresholds, our results show that average negative damping is always the trigger. More broadly, we describe an alternative to Kuramoto theory for emergence of coherent oscillations in nature; collective contributions from incoherent agents need not cancel, but can provide positive feedback on average, leading to global limit-cycle motion. The pedestrian-induced oscillation of the London Millennium Bridge is considered as an example of emerging synchronisation. Belykh et al. provide an alternative mechanism for emergence of coherent oscillatory bridge dynamics where synchrony is a consequence, not the cause, of the instability. [ABSTRACT FROM AUTHOR]

The pedestrian-induced instability of the London Millennium Bridge is a widely used example of Kuramoto synchronisation. Yet, reviewing observational, experimental, and modelling evidence, we argue that increased coherence of pedestrians' foot placement is a consequence of, not a cause of the instability. Instead, uncorrelated pedestrians produce positive feedback, through negative damping on average, that can initiate significant lateral bridge vibration over a wide range of natural frequencies. We present a simple general formula that quantifies this effect, and illustrate it through simulation of three mathematical models, including one with strong propensity for synchronisation. Despite subtle effects of gait strategies in determining precise instability thresholds, our results show that average negative damping is always the trigger. More broadly, we describe an alternative to Kuramoto theory for emergence of coherent oscillations in nature; collective contributions from incoherent agents need not cancel, but can provide positive feedback on average, leading to global limit-cycle motion. The pedestrian-induced oscillation of the London Millennium Bridge is considered as an example of emerging synchronisation. Belykh et al. provide an alternative mechanism for emergence of coherent oscillatory bridge dynamics where synchrony is a consequence, not the cause, of the instability. [ABSTRACT FROM AUTHOR]

We here describe a new satyrine species in the genus Chloreuptychia Forster, 1964, C. gordonsmalli Thurman, MacDonald & Nakahara, n. sp., based on four historical specimens all originating from central Panama. Despite the lack of genetic data for this new taxon and the polyphyletic nature of Chloreuptychia, some genitalic characters suggest that this new species might be a member of true Chloreuptychia, and if so would represent the first known species of the genus outside of the Amazon basin. We provide illustrations of the adults and genitalia, as well as images of the habitat of the type locality visited by the pioneering and imaginative lepidopterist, Gordon B. Small, Jr., who collected the entire type series of C. gordonsmalli n. sp. about 45-50 years ago. Chloreuptychia gordonsmalli n. sp. has not been observed subsequently, despite extensive field work in Panama by a number of butterfly researchers. [ABSTRACT FROM AUTHOR]

We re‐diagnose Rhysacephala Benson, 1954, a genus of xiphydriid woodwasps confined to eastern mainland Australia, Tasmania and Lord Howe Island. Rhysacephala leai (Forsius, 1927), including the first description of the female, Rhysacephala obtusiventris (Rohwer, 1918), and Rhysacephala wilsoni Benson, 1954 are redescribed. Six new species from eastern Australia are described: Rhysacephala amplipretarsus Jennings, Parslow & Macdonald, sp. nov., Rhysacephala fulva Jennings, Parslow & Macdonald, sp. nov., Rhysacephala impensa Jennings, Parslow & Macdonald, sp. nov., Rhysacephala monteithi Jennings, Parslow & Macdonald, sp. nov., Rhysacephala phalaros Jennings, Parslow & Macdonald, sp. nov. and Rhysacephala tenebrilata Jennings, Parslow & Macdonald, sp. nov. A monotypic genus, Austroxiphyda Jennings, Macdonald, Schiff & Parslow, gen. nov., is established and includes Austroxiphyda lasallei Jennings, Macdonald, Schiff & Parslow, sp. nov. Keys to identify the 12 Australian species of Xiphydriinae are provided. [ABSTRACT FROM AUTHOR]

Supply chain disruptions negatively impact the economy and individual organizations. However, as many companies recover from disruptions (COVID-19 being a recent example), less attention has been paid to how these events impact business-to-business (B2B) relationships characteristic of supply chains. Drawing on justice theory, we examine how the suppliers' management of the recovery process affects behavioral reactions in the context of supply chain relationships. This study empirically examines the role that partners' recovery process, honesty, effort, availability, and outcome fairness play in influencing satisfaction, future business volumes, and word-of-mouth. Using ordinary least squares (OLS) regression to test survey data, results indicate that how recovery processes are managed positively affects satisfaction, reduces the likelihood of future business loss, and affects the propensity to communicate negatively about a relationship partner. Unexpectedly, outcome fairness (distributive justice) has a significant positive impact on negative word-of-mouth, indicating that increased perceptions of distributive justice actually increase negative behavioral outcomes in certain settings. We conduct exploratory post hoc serial mediation analysis to further examine this finding and uncover a potential extension to the boundaries of a justice lens. These post hoc results, which generally confirm the OLS results, drive opportunity for better understanding of complaining behavior and navigating the tricky environment associated with managing B2B relationships in a postdisruption environment. [ABSTRACT FROM AUTHOR]

Objectives: This study examines the impact of alcohol consumption in a Major League Baseball (MLB) stadium on area level counts of crime. The modal practice at MLB stadiums is to stop selling alcoholic beverages after the seventh inning. Baseball is not a timed game, so the duration between the last call for alcohol at the end of the seventh inning and the end of the game varies considerably, providing a unique natural experiment to estimate the relationship between alcohol consumption and crime near a stadium on game days. Methods: Crime data were obtained from Philadelphia for the period 2006–2015 and geocoded to the area around the MLB stadium as well as popular sports bars. We rely on difference-in-differences regression models to estimate the change in crime on home game days around the stadium as the game time extends into extra innings to other areas of the city and around sports bars in Philadelphia relative to days when the baseball team plays away from home. Results: When there are extra innings and more game-time after the seventh inning alcohol sales stoppage crime declines significantly around the stadium. The crime reduction benefit of the last call alcohol policy is undone when a complex of sports bars opens in the stadium parking lot in 2012. The results suggest that alcohol consumption during baseball games is a contributor to crime. Conclusions: The findings provide further support for environmental theories of crime that note the congregation of people in places with excessive alcohol consumption is a generator of violent crime in cities. The consumption of alcohol in MLB stadiums appears to increase crime. [ABSTRACT FROM AUTHOR]