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We empirically establish that unemployed individuals maintain significant access to credit and that upon a layoff, the unconstrained borrow while the constrained default and delever. Motivated by these findings, we develop a theory of credit lines and labor income risk to analyze optimal transfers to the unemployed. Since credit lines offer fixed interest rates and limits, credit lines are unresponsive to layoffs and provide greater consumption insurance relative to when debt is repriced period by period. At US levels of credit lines, the government can optimally reduce transfers to the unemployed, whereas this is not true when debt is counterfactually repriced period by period. [ABSTRACT FROM AUTHOR]

A variety of viruses establish latency by integrating their genome into the host genome. The integration event generally occurs in a nonspecific manner, precluding the prediction of functional consequences from resulting disruptions of affected host genes. The nonpathogenic adeno-associated virus (AAV) is unique in its ability to stably integrate in a site-specific manner into the human MBS85 gene. To gain a better understanding of the integration mechanism and the consequences of MBS85 disruption, we analyzed the molecular structure of AAV integrants in various latently infected human cell lines. Our study led to the observation that AAV integration causes an extensive but partial duplication of the target gene. Intriguingly, the molecular organization of the integrant leaves the possibility that a functional copy of the disrupted target gene could potentially be preserved despite the resulting rearrangements. A latently infected, Mbs85-targeted mouse ES cell line was generated to study the functional consequences of the observed duplication-based integration mechanism. AAV-modified ES cell lines continued to self-renew, maintained their multilineage differentiation potential and contributed successfully to mouse development when injected into blastocysts. Thus, our study reveals a viral strategy for targeted genome addition with the apparent absence of functional consequences. [ABSTRACT FROM AUTHOR]

The limitations of keratometry and photokeratoscopy are briefly discussed. A new photogrammetric technique of measuring corneal topography is described. Contours and cross-sections of abnormal corneas are presented to illustrate the scope and application of the new technique. [ABSTRACT FROM AUTHOR]

Most previous studies aim to predict ecosystem sustainability from the perspective of a sole human or natural system and have frequently failed to achieve their desired outcome. Based on the coupled human and natural system (CHANS) and its interaction with other systems, we attempted to analyze the effectiveness of the Grain to Green Program and predict future trends in the Hexi Corridor, the hub of the ancient silk road of China. At different scales, we applied a metacoupling framework to investigate the flows, effects, and causes of the complex CHANS. Three typical inner river watersheds within the corridor at three different geographic scales (local, regional and national) were estimated and compared. The Telecoupling Geo App, additional models, and software tools were employed to evaluate the CHANS series of the focal system (Hexi Corridor, local), adjacent system (Gansu Province, regional), and distant system (China, national). The results showed that most flows can be screened and quantitatively analyzed across focal, adjacent and distant systems. The social and economic transformations in adjacent and distant systems could affect the possibility and whereabouts of labor transfer in the focal system. Moreover, the labor migration increased the implementation efficiency of the Grain to Green Program as a Payment for Ecosystem Services (PES) strategy, thereby improving its ecological benefits. For the first time, we established a metacoupled model to quantitatively evaluate aspects of ecosystem sustainability in China, providing insight to the theory and application of sustainability science. [ABSTRACT FROM AUTHOR]

Graded-index, moth eye-inspired anti-reflective features were fabricated in ZnS and ZnSe via nanosphere lithography using a Langmuir–Blodgett dip-coating method with plasma-based mask reduction and pattern transfer. Arrays of hexagonally close-packed conical frusta (top diameter = 300 nm, pitch = 690 nm, height = 2800 nm) were realized by isotropic etching (size-reduction) of the colloidal mask with CF4/Ar, followed by pattern transfer into the substrate using CH4/H2 plasma etching. Substantial increases in broadband transmission were achieved across the 2–20 μm range, yielding 23% and 26% single-side transmission improvement, and 92% and 88% absolute double-side transmission for ZnS and ZnSe, respectively, in excellent agreement with finite difference time domain (FDTD) optical simulations. Experimental differences in direct versus total transmission, and the general fall off of transmission at short wavelengths, were attributed to diffuse forward scattering and diffractive effects, as predicted by far-field scattering patterns using FDTD. The fabrication method presented can be used to enhance efficiency for multiple IR applications by minimizing reflective losses, while offering the further advantages of scalability and low cost. [ABSTRACT FROM AUTHOR]

We combine optical, near-infrared, and mid-infrared spectra and photometry to construct expanded spectral energy distributions for 145 field age (>500 Myr) and 53 young (lower age estimate <500 Myr) ultracool dwarfs (M6-T9). This range of spectral types includes very low mass stars, brown dwarfs, and planetary mass objects, providing fundamental parameters across both the hydrogen and deuterium burning minimum masses for the largest sample assembled to date. A subsample of 29 objects have well constrained ages as probable members of a nearby young moving group. We use 182 parallaxes and 16 kinematic distances to determine precise bolometric luminosities (Lbol) and radius estimates from evolutionary models give semi-empirical effective temperatures (Teff) for the full range of young and field age late-M, L, and T dwarfs. We construct age-sensitive relationships of luminosity, temperature, and absolute magnitude as functions of spectral type and absolute magnitude to disentangle the effects of degenerate physical parameters such as Teff, surface gravity, and clouds on spectral morphology. We report bolometric corrections in J for both field age and young objects and find differences of up to a magnitude for late-L dwarfs. Our correction in Ks shows a larger dispersion but not necessarily a different relationship for young and field age sequences. We also characterize the NIR–MIR reddening of low gravity L dwarfs and identify a systematically cooler Teff of up to 300 K from field age objects of the same spectral type and 400 K cooler from field age objects of the same MH magnitude. [ABSTRACT FROM AUTHOR]