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The study of oceanic internal waves remains a critical area of research within oceanography. With the rapid advancements in oceanic remote sensing and deep learning, it is now possible to extract valuable insights from vast datasets. In this context, by building datasets using deep learning models, we propose a novel stripe segmentation algorithm for oceanic internal waves, leveraging synthetic aperture radar (SAR) images based on the SegFormer architecture. Initially, a hierarchical transformer encoder transforms the image into multilevel feature maps. Subsequently, information from various layers is aggregated through a multilayer perceptron (MLP) decoder, effectively merging local and global contexts. Finally, a layer of MLP is utilized to facilitate the segmentation of oceanic internal waves. Comparative experimental results demonstrated that SegFormer outperformed other models, including U-Net, Fast-SCNN (Fast Segmentation Convolutional Neural Network), ORCNet (Ocular Region Context Network), and PSPNet (Pyramid Scene Parsing Network), efficiently and accurately segmenting marine internal wave stripes in SAR images. In addition, we discuss the results of oceanic internal wave detection under varying settings, further underscoring the effectiveness of the algorithm. [ABSTRACT FROM AUTHOR]

A high-calorie diet and lack of exercise are the most important risk factors contributing to metabolic dysfunction-associated steatotic liver disease (MASLD) initiation and progression. The precise molecular mechanisms of mitochondrial function alteration during MASLD development remain to be fully elucidated. In this study, a total of 60 male C57BL/6J mice were maintained on a normal or amylin liver NASH (AMLN) diet for 6 or 10 weeks. Some of the mice were then subjected to voluntary wheel running, while the other mice were fed a normal or AMLN diet until 14 and 18 weeks. The results showed that hepatic lipid deposition and the PERK-eIF2α-ATF4 pathway were significantly increased with prolonged duration of AMLN diet. However, expression of mitochondrial unfolded protein response (UPRmt) genes and mitokine FGF21 secretion were significantly enhanced in the 14-week AMLN diet mice, but were markedly reduced with the excessive lipid deposition induced by longer AMLN diet. Additionally, the exercise intervention acts as a regulator to optimize UPRmt signal transduction and to enhance mitochondrial homeostasis by improving mitochondrial function, reversing the UPRmt activation pattern, and increasing FGF21 secretion, which plays a pivotal role in delaying the occurrence and development of MASLD. [ABSTRACT FROM AUTHOR]

This is a meta‐analysis study to assess the relationship between multimorbidity and disability among older adults over 50 years old. Population‐based studies, aged ≥ 50 years, assessing associations between multimorbidity (numbers and patterns) and disability in older adults, and reporting risk estimation with odds ratios (OR), were included. Homogeneity (I2), risk of bias, and publication bias were assessed. PROSPERO registration: 411007, and this meta‐analysis was reported in accordance with the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) recommendations. Twelve studies were included. For the older adults with 2 chronic conditions and ≥ 3 chronic conditions, the ORs of disability are 2.52 (95% CI 2.30–2.76) and 3.38 (95% CI 3.05–3.75), respectively. Among three multimorbidity patterns, the combination of cardiovascular and metabolic diseases pattern (OR 8.01, 95% CI 7.60–8.44) had the highest disability incidence rate. Chronic conditions in the multimorbidity patterns of combination of cardiovascular and metabolic diseases and mental health problems have an enhancement effect (1 + 1 > 2) on old‐age disability impairment, whereas those in the multimorbidity pattern of musculoskeletal disorders have a dampening effect (1 + 1 < 2). The differentiated and specific early interventions should be developed based on the different multimorbidity patterns to prevent the old‐age functional decline and disability in older adults. [ABSTRACT FROM AUTHOR]

Changes in both lignin biosynthesis and DNA methylation have been reported to be associated with chilling stress in plants. When stored at low temperatures, red-fleshed loquat is prone to lignification, with increased lignin content and fruit firmness, which has deleterious effects on taste and eating quality. Here, we found that 5 °C storage mitigated the increasing firmness and lignin content of red-fleshed 'Dahongpao' ('DHP') loquat fruit that occurred during 0 °C storage. EjNAC5 was identified by integrating RNA sequencing with whole-genome bisulfite sequencing analysis of 'DHP' loquat fruit. The transcript levels of EjNAC5 were positively correlated with changes in firmness and negatively correlated with changes in DNA methylation level of a differentially methylated region in the EjNAC5 promoter. In white-fleshed 'Baisha' ('BS') loquat fruit, which do not undergo chilling-induced lignification at 0 °C, the transcripts of EjNAC5 remained low and the methylation level of the differentially methylated region in the EjNAC5 promoter was higher, compared with 'DHP' loquat fruit. Transient overexpression of EjNAC5 in loquat fruit and stable overexpression in Arabidopsis and liverwort led to an increase in lignin content. Furthermore, EjNAC5 interacts with EjERF39 and EjHB1 and activates the transcription of Ej4CL1 and EjPRX12 genes involved in lignin biosynthesis. This regulatory network involves different transcription factors from those involved in the lignification pathway. Our study indicates that EjNAC5 promoter methylation modulates EjNAC5 transcript levels and identifies novel EjNAC5–EjERF39– Ej4CL1 and EjNAC5–EjHB1– EjPRX12 regulatory modules involved in chilling induced-lignification. [ABSTRACT FROM AUTHOR]

Background China is currently making efforts to transform the current hospital-centric service delivery system to people-centred primary health care (PHC)-based delivery system, with service delivery organized around the health needs and expectations of people. To help direct China's PHC reform efforts, a profile of high-quality PHC from the public's perspective is required. Objectives To profile high-quality PHC from the perspective of the Chinese public. Methods Semistructured interviews were conducted in 6 provinces (Henan, Shandong, Zhejiang, Shaanxi, Shanxi, and Heilongjiang) in China. In total, 58 interviewees completed the recorded interview. For transcription, trained research assistant listened to the recording of the interviews, summarizing each 30-s segment in English. Next, thematic analysis was performed on the narrative summaries to identify thematic families. Results Seven themes and 16 subthemes were generated from the analysis of our interview data. In order of their frequency, the interviewees expressed a high expectation for interpersonal communication and technical quality; followed by access, comprehensive care, cost, continuity, and coordination. Conclusions Using qualitative data from 6 provinces in China, knowledge was generated to reveal the public's views and expectations for high-quality PHC. Our results confirm the urgent need for quality improvement efforts to improve patient experience and technical quality. The government also needs to further improve the delivery system and medical training programme to better meet public expectation in these areas, especially in establishing an innovative integrated primary care model, and strengthening interpersonal and clinical competency training for family doctors. [ABSTRACT FROM AUTHOR]

This study investigates the association between equity pledges and classification shifting earnings management in Chinese listed firms, spanning the period from 2016 to 2022. Additionally, it explores the moderating influence of product market competition (PMC) and analyst attention on this relationship. By analyzing a sample comprising 12,583 firm-year observations, several notable findings are observed. The regression results reveal a positive and statistically significant relationship between equity pledges and classification shifting earnings management (coefficient = 0.00234, p < 0.01). Moreover, this positive impact is further magnified when specifically considering downward classification shifting (coefficient = 0.00368, p < 0.01). Regarding the moderating factors, the results demonstrate a positive moderating effect of PMC on the relationship between equity pledges and classification shifting, with an interaction coefficient of 0.0165 (p < 0.01). This moderating effect is particularly pronounced in the context of downward classification shifting, with an interaction coefficient of 0.0142 (p < 0.01). Similarly, analyst attention also positively moderates the relationship, as indicated by an interaction coefficient of 0.00144 (p < 0.05), with a stronger effect observed in the case of downward classification shifting, with an interaction coefficient of 0.00329 (p < 0.01). Furthermore, additional tests reveal that leverage strengthens the aforementioned moderating effects. The threeway interaction involving debt, PMC, and equity pledges significantly influences classification shifting, with a coefficient of 0.0415 (p < 0.05). Specifically, debt exacerbates the moderating impact of competition on highly leveraged firms that engage in downward classification shifting, as evidenced by a coefficient of 0.0599 (p < 0.05). Similarly, debt reinforces the moderating role of analyst attention (coefficient = 0.00820, p < 0.05), especially for downward classification shifting (coefficient = 0.00902, p < 0.1). Propensity score matching and robustness tests validate the findings. Therefore, this research contributes to the understanding of the economic implications of equity pledge by focusing on earnings manipulation through classification shifting. It also examines this relationship within different competitive environments and external regulatory frameworks, aiming to promote the long-term viability of companies. [ABSTRACT FROM AUTHOR]

Background and objective: Developing harmonious doctor-patient relationships is a powerful way to promote the construction of a new pattern of medical reform in developing countries. We aim to analyze the effects of China's hierarchical medical system on doctor-patient relationships, thus contributing to China's medical and health system reform. Methods: With panel data on prefectural-level cities in China from 2012 to 2019, we used a time-varying difference-in-differences model to evaluate the effect of hierarchical medical treatment policy. Results: Hierarchical medical treatment policies can significantly improve doctor-patient relationships, and this conclusion is supported by various robustness tests. And improving doctor-patient relationships can be indirectly realized by the optimization of resource allocation and saving of medical costs. In addition, the marginal effect of the pilot policy on doctor-patient relationships decreased with age within the city population. In focal cities and cities with high levels of fiscal spending on health care, the effect of the pilot policy on doctor-patient relationships was stronger. Conclusion: While reinforcing the literature on the doctor-patient relationship, this study also provides a reference for further exploration of the pilot policy of hierarchical medical treatment and the development of new medical and health system reform in developing countries. [ABSTRACT FROM AUTHOR]

Intergenerational health mobility serves as a crucial indicator that reflects both social class mobility and health inequality. In this study, we constructed a comprehensive index to evaluate the health of residents in terms of physical, psychological and social adaptation dimensions using data from the China Family Panel Studies from 2010 to 2018. It then measured intergenerational health mobility using the intergenerational rank correlation coefficient method. Furthermore, the dynamic evolutionary trend, spatial differences and their sources, and the convergence characteristics of intergenerational health mobility were revealed by nonparametric kernel density estimation, the Dagum Gini coefficient, and the σ(β) convergence model, respectively. The formation mechanisms were explored using the quadratic assignment procedure. The results showed a general improvement but unbalanced trend of intergenerational health mobility in China, and hypervariable density was identified as the primary factor contributing to this difference. The σ convergence characteristics and β convergence mechanism were verified in China and its three regions. Environmental quality, industrial structure, and accessibility of medical and health resources had significant and decreasing effects on the spatial differences in intergenerational health mobility across China, with varying impacts observed among the three regions. This study not only provides empirical insights into understanding the dynamics laws of intergenerational health mobility and promoting regional coordinated development in China but also offers valuable guidance for formulating healthcare policies in developing countries and for achieving the United Nations Sustainable Development Goals. [ABSTRACT FROM AUTHOR]

Understanding vegetation seasonality and its driving mechanisms improves decision-making in the management of ecological systems in a warming global climate. Using multiple statistical methods (i.e., trend analysis, abrupt changes, and partial correlation analysis), this study analyzed the spatiotemporal variations in the Normalized Difference Vegetation Index (NDVI) in the Equatorial Africa (EQA) region and their responses to climate factors from 1982 to 2021. The NDVI values declined at a rate of 0.00023 year−1, while the precipitation (P) and mean temperature (TMEAN) values increased at rates of 0.22 mm year−1 and 0.22 °C year−1, respectively. The mean minimum temperature (TMIN) had a higher rate of 0.2 °C year−1 than the mean maximum temperature (TMAX) at 0.02 °C year−1. An abrupt change analysis showed that the TMAX, P, and NDVI breakpoints occurred in 2000, 2002, and 2009, respectively; TMEAN and TMIN breakpoints occurred in 2001. The NDVI trends declined in forest and cropland areas but increased in shrubland and grassland areas. The summer NDVI trends declined for all vegetation types and were reversed in the winter season. The NDVI positively correlated with the P (r = 0.50) and TMEAN (r = 0.60). All seasonal analyses varied across four seasons. A temporal analysis was conducted using partial correlation analysis (PCR), and the results revealed that TMIN had a greater impact on the NDVI (PCR = −0.45), followed by the TMAX (PCR = 0.31) and then the P (PCR = −0.19). The annual trend showed that areas with significant greening were consistent with stronger wetter and weaker warming trends. Both precipitation and temperature showed a positive relationship with vegetation in semi-arid and arid regions but a negative relationship with humid regions. Our findings improve our insight into scientific knowledge on ecological conservation. [ABSTRACT FROM AUTHOR]

The sensitivity strength of air temperature (T) to surface soil temperature (sST) (namely β hereafter) constitutes a significant factor in how global climate models quantify changes in the climate. This study examines how this sensitivity is represented in the CMIP6 models. Results show regional differences and even contrasts in the β trends at interannual scales between climate models and two reanalysis products during 1980–2014. At high latitudes in the Northern Hemisphere (NH), β is stronger in the CMIP6 models than in the reanalysis data. Additionally, the β trends differ between the CMIP6 and reanalysis data, which may be related to the different precipitation (PR) and soil water availability (PR-ET) trends between the models. In the regions of increasing β intensity at high latitudes in the NH, sST is more sensitive to PR and PR-ET. Consequently, increasing PR and PR-ET leads to slower sST changes, potentially making β intensity stronger in CMIP6 models. However, in the reanalysis data, decreases in PR and PR-ET accelerate sST changes, leading to a weakening of the β intensity. A resulting implication is that β, based on high-emission scenarios, shows a stronger trend during 2015–2100, although this trend could potentially be overestimated. The findings contribute to a better understanding of the sensitivity of T to sST and facilitate the assessment of energy exchange between the land surface and the atmosphere in climate models. [ABSTRACT FROM AUTHOR]

Agricultural production across the African continent is subjected to various effects of climate variability. One of the main staple foods in Sub-Saharan Africa is maize. However, limited scientific research has recently focused on understanding the possible effects of hydro-climatic variability on maize production. The aim of the present work was to contribute to policy and climate adaptation, thus reducing the vulnerability of maize production to climate change over Equatorial Africa. This study firstly examined long-term trends of precipitation (PRE), soil moisture (SM), actual evapotranspiration (E), and potential evapotranspiration (Ep), as well as surface air temperatures, including the minimum (TMIN) and maximum (TMAX). Secondly, the relationship between maize production and these climate variables was quantified for 18 Equatorial African countries (EQCs) over 1980−2021. To assess the linear trends, Mann–Kendall and Sen's slope tests were used to quantify the magnitude of the hydro-climatic variable trends at the 5% significance level, and Pearson's correlation coefficient was used to evaluate the relation of these climate parameters with the maize production. The annual mean PRE declined at 0.03 mm day−110a−1. Other climate variables increased at different rates: SM at 0.02 mmday−110a−1, E at 0.03 mm day−110a−1, Ep at 0.02 mm day−1 10a−1, TMIN and TMAX at 0.01 °C day−110a−1. A regional analysis revealed heterogeneous significant wet–dry and warm–cool trends over the EQCs. While, spatially, dry and warm climates were observed in the central to eastern areas, wet and warm conditions dominated the western regions. Generally, the correlations of maize production with the E, Ep, TMAX, and TMIN were strong (r > 0.7) and positive, while moderate (r > 0.45) correlations of maize production with PRE and SM were obvious. These country-wide analyses highlight the significance of climate change policies and offer a scientific basis for designing tailored adaptation strategies in rainfed agricultural regions. [ABSTRACT FROM AUTHOR]

The sensitivity strength of air temperature (T) to surface soil temperature (sST) (namely β hereafter) constitutes a significant factor in how global climate models quantify changes in the climate. This study examines how this sensitivity is represented in the CMIP6 models. Results show regional differences and even contrasts in the β trends at interannual scales between climate models and two reanalysis products during 1980–2014. At high latitudes in the Northern Hemisphere (NH), β is stronger in the CMIP6 models than in the reanalysis data. Additionally, the β trends differ between the CMIP6 and reanalysis data, which may be related to the different precipitation (PR) and soil water availability (PR-ET) trends between the models. In the regions of increasing β intensity at high latitudes in the NH, sST is more sensitive to PR and PR-ET. Consequently, increasing PR and PR-ET leads to slower sST changes, potentially making β intensity stronger in CMIP6 models. However, in the reanalysis data, decreases in PR and PR-ET accelerate sST changes, leading to a weakening of the β intensity. A resulting implication is that β, based on high-emission scenarios, shows a stronger trend during 2015–2100, although this trend could potentially be overestimated. The findings contribute to a better understanding of the sensitivity of T to sST and facilitate the assessment of energy exchange between the land surface and the atmosphere in climate models. [ABSTRACT FROM AUTHOR]

Both exercise and metformin are common effective clinical treatments of type 2 diabetic mellitus. This study investigated the functional role of exercise, metformin, and combination treatment on type 2 diabetic mellitus–induced muscle atrophy. In this experiment, a total of 10 BKS mice were set as the control group. A total of 40 BKS-db/db mice were randomly divided into the control group (db/db); the exercise intervention group (db/db + Ex), which ran on a treadmill at 7–12 m/min, 30–40 min/day, 5 days/week; the metformin administration group (db/db + Met), which was administered 300 mg/kg of metformin solution by gavage daily; and the exercise combined with metformin administration group (db/db + Ex + Met). After 8 weeks of intervention, their tibialis anterior muscles were removed. The levels of insulin signaling pathway proteins, ubiquitin proteasome, and autophagic lysosome–associated proteins were detected using western blot, the expression of MuRF1 and Atrogin-1 was detected using immunohistochemical staining, and the degradation of autophagosomes was detected using double-labeled immunofluorescence. The db/db mice exhibited reduced insulin sensitivity and inhibition of the autophagic–lysosome system, the ubiquitin–proteasome system was activated, and protein degradation was exacerbated, leading to skeletal muscle atrophy. Exercise and metformin and their combined interventions can increase insulin sensitivity, whereas exercise alone showed more effective in inhibiting the ubiquitin–proteasome system, improving autophagy levels, and alleviating skeletal muscle atrophy. Compared with metformin, exercise demonstrated superior improvement of muscle atrophy by promoting the synthesis and degradation of autophagy through the AMPK/ULK1 pathway. However, the combination treatment exhibits no synergistic effect on muscle atrophy. [ABSTRACT FROM AUTHOR]

SUMMARY: Chromoplasts act as a metabolic sink for carotenoids, in which plastoglobules serve as versatile lipoprotein particles. PGs in chloroplasts have been characterized. However, the features of PGs from non‐photosynthetic plastids are poorly understood. We found that the development of chromoplast plastoglobules (CPGs) in globular and crystalloid chromoplasts of citrus is associated with alterations in carotenoid storage. Using Nycodenz density gradient ultracentrifugation, an efficient protocol for isolating highly purified CPGs from sweet orange (Citrus sinensis) pulp was established. Forty‐four proteins were defined as likely comprise the core proteome of CPGs using comparative proteomics analysis. Lipidome analysis of different chromoplast microcompartments revealed that the nonpolar microenvironment within CPGs was modified by 35 triacylglycerides, two sitosterol esters, and one stigmasterol ester. Manipulation of the CPG‐localized gene CsELT1 (esterase/lipase/thioesterase) in citrus calli resulted in increased lipids and carotenoids, which is further evidence that the nonpolar microenvironment of CPGs contributes to carotenoid accumulation and storage in the chromoplasts. This multi‐feature analysis of CPGs sheds new light on the role of chromoplasts in carotenoid metabolism, paving the way for manipulating carotenoid content in citrus fruit and other crops. [ABSTRACT FROM AUTHOR]

Aim: The purpose of this study was to comprehend the need for incorporating death education within the curriculum of undergraduate nursing students and to assess the factors that impact the desire for such education. Design: We enlisted undergraduate nursing students from several nursing colleges located in the central and west region of China. Undergraduate students who fulfilled the eligibility criteria between January and February 2021 were chosen to participate. Data were collected via an online platform called Questionnaire Star. The survey encompassed a general information questionnaire and a scale for assessing the need for education on the topic of death. Descriptive statistical analysis was performed using the SPSS 20.0 software, while multivariate stepwise regression was employed for more complex analysis. Statistical significance was indicated when the p‐value was below 0.05, and high statistical significance was noted when the p‐value fell below 0.01. Methods: We designed a descriptive quantitative approach to investigate the need for death education and its associated factors. The research involved 907 undergraduate nursing students from the central and west region of China. The data collection was done through the Questionnaire Star platform. Results: Following the collection of completed surveys, individuals displaying contradictory responses were omitted. Out of 911 surveys disseminated, 907 were successfully collected, resulting in a recovery rate of 99.6%. Among the participants, 769 identified as female, constituting 84.8% of the total, while 138 identified as male, making up 15.2%. The survey findings indicated that factors such as residency, parental educational history and exposure to hospice care education significantly impacted the need for death education among undergraduate nurses (p < 0.05). Conclusions: Among students pursuing a nursing degree at the undergraduate level, there was a pronounced need for education related to the topic of death. Offering such education to these students is essential, as it helps cultivate a proper understanding of death. This, in turn, contributes to enhancing the overall quality of patient care throughout their life journey. Patient or Public Contribution: A total of 907 nursing undergraduates from central and western China participated in the questionnaire. [ABSTRACT FROM AUTHOR]

This study was designed to probe the effect of chaperone-assisted selective autophagy (CASA) on the maintenance of proteostasis during exhaustive exercise and uncover the alteration of CASA in muscle fibers with pre-high-intensity interval training (HIIT) intervention-induced muscle adaptation in response to exhaustive exercise. Rats were randomly divided into a control group; an exhaustive exercise group; and an HIIT + exhaustive exercise group. Results show myofibril damage and BiP levels were increased after exhaustive exercise, and the levels of the HSP70, BAG3, ubiquitin, autophagy-related proteins, and their interactions were increased. HIIT intervention before exhaustive exercise could decrease myofibril injury and BiP levels, accompanied by down-regulation of HSP70/BAG3 complex and selective autophagy. In conclusion, exhaustive exercise promotes CASA to clear protein aggregation for keeping proteostasis in muscle fibers; pre-HIIT intervention improves myofibril injury and unfold protein response caused by exhaustive exercise, which might contribute to inhibit the augmentation of CASA. [ABSTRACT FROM AUTHOR]

It is valuable to develop simple and environmentally friendly methods for converting biowaste into functional nanomaterials with multiple applications. However, there are few reports on the facile preparation of multifunctional carbon–metal nanocomposites based on biowastes and their application from sensing to information technology. Herein, we used fish scale-derived carbon nanoparticles (FSCN) as reducing agents to directly and facilely prepare multifunctional carbon–gold nanocomposites (FSCN-AuNPs) in one step. Our prepared FSCN-AuNPs have multisignal response capabilities and can be used for colorimetric and fluorescence quantitative sensing of Pb2+ and Cu2+ with detection limits of 86.29 nM (for Pb2+) and 53.74 nM (for Cu2+), respectively. Additionally, FSCN-AuNPs can detect Pb2+ in milk and serum, as well as Cu2+ in water and serum. The multisignal selective responses of FSCN-AuNPs can be converted into binary strings by setting thresholds, which were further applied to encrypt and hide two types of information (like text and two-dimensional pattern information). Overall, this research not only promotes the preparation and comprehensive application of multifunctional carbon–metal nanocomposites but also accelerates the cross-integration of molecular science, such as the integration of molecular sensing and molecular information science. [ABSTRACT FROM AUTHOR]

The ability of soil moisture (SM) to affect precipitation (P) is a vital part of the water-energy cycles. Accurately quantifying this coupling enhances the ability to predict hydroclimatic extremes like floods and droughts. In this study, the ability of soil moisture to affect precipitation (SM-P) is characterized by two parts: the influence of soil moisture on evapotranspiration (SM-ET), and the influence of evapotranspiration on precipitation (ET-P). We determined localized ET-P by incorporating the coupling between latent heat flux (LH) and LCL height, to optimize the estimation of the SM-P. This approach links SM more closely to P by considering the influence of surface fluxes. The results indicate that CMIP6 models exhibited the anticipated hotspot patterns for the three coupling metrics in transition regions. However, we observed that climate models generally exhibit weaker SM-P coupling compared to reanalysis models. Both SM-ET and SM-P showcase higher values wherein wet climate regions during dry years, and the converse occurs in dry regions. Due to sensitivity to climate change, the ET-P exhibits a more pronounced upward trend in the future. This study helps understand P's response to SM shifts in climate models, crucial for predicting hydrological extremes and coupled global warming impact. [ABSTRACT FROM AUTHOR]

Soil moisture over the Tibetan Plateau (TP) can affect hydrological cycles on local and remote scales through land–atmosphere interactions. However, TP long-term surface soil moisture characteristics and their response to climate change are still unclear. In this study, we firstly evaluate two satellite-based products—SSM/I (the Special Sensor Microwave Imagers) and ECV COMBINED (the Essential Climate Variable combined)—and three reanalysis products—ERA5-Land (the fifth generation of the land component of the European Centre for Medium-Range Weather Forecasts atmospheric reanalysis), MERRA2 (the second version of Modern-Era Retrospective Analysis for Research and Applications), and GLDAS Noah (the Noah land surface model driven by Global Land Data Assimilation System)—against two in situ observation networks. SSM/I and GLDAS Noah outperform the other soil moisture products, followed by MERRA2 and ECV COMBINED, and ERA5-Land has a certain degree of uncertainty in evaluating TP surface soil moisture. Analysis of long-term soil moisture characteristics during 1988–2008 shows that annual and seasonal mean soil moisture have similar spatial distributions of soil moisture decreasing from southeast to northwest. Additionally, a significant increasing trend of soil moisture is found in most of the TP region. With a non-linear machine learning method, we quantify the contribution of each climatic variable to warm-season soil moisture. It indicates that precipitation dominates soil moisture changes rather than air temperature. Pixel-wise partial correlation coefficients further show that there are significant positive correlations between precipitation and soil moisture over most of the TP region. The results of this study will help to understand the role of TP soil moisture in land–atmosphere coupling and hydrological cycles under climate change. [ABSTRACT FROM AUTHOR]

Two new Cu−Ln 1D coordination chains with formula [Ln(hfac)3Cu(hfac)2 (NIT‐3Py‐5‐3Py)(H2O)]n (LnIII=Gd 1, Dy 2; hfac=hexafluoroacetylacetonate, NIT‐3Py‐5‐3Py=2‐(5‐(3‐pyridyl)‐3‐pyridyl)‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl‐3‐oxide) were successfully constructed by means of a new nitronyl nitroxide radical ligand containing two pyridine groups. In these two complexes, the radical ligand binds two CuII ions through its two pyridine groups to produce 1D chain while the aminoxyl moiety of the radical is bound to a Ln (III) ion. Direct‐current magnetic susceptibility investigations indicate that ferromagnetic exchanges are dominant and magnetic susceptibility data of Gd derivative are analyzed using a magnetic model, indicating that Cu‐NO coupling through pyridine group and Gd‐NO direct exchange are ferromagnetic interactions. There is no magnetic relaxation behavior for Dy analogue. [ABSTRACT FROM AUTHOR]

Background: A health‐promoting lifestyle is acknowledged as a 'positive ageing' strategy for older people. The inevitable decline in their social networks may lead to loneliness and subsequently damage their health‐promoting lifestyle. Therefore, pet owning has become a popular way for them to alleviate loneliness. However, the attachment resulting from pet ownership may either facilitate or impede older people's ability to counteract the negative effect of loneliness on health‐promoting lifestyles, and this effect may only be observed when pet owners have limited human confidants. Objectives: To identify the role of pet attachment in alleviating the negative impact of loneliness on a health‐promoting lifestyle and its supplementary role in the deficiency of social relationships by analysing the correlation mechanism between pet attachment, loneliness and a health‐promoting lifestyle. Methods: Self‐report questionnaires were sent to 879 older people (aged ≥60) with pets in China by using a multistage stratified random sampling method. Cross‐sectional threshold regression models were established to analyse the nonlinear effects of loneliness on a health‐promoting lifestyle and the different threshold effects among different social relationship levels. Results: A single threshold value (0.444) was drawn to determine the action mode of pet attachment on the negative relationship between loneliness and a health‐promoting lifestyle. When the level of pet attachment exceeded 0.444, the inhibition of loneliness on a health‐promoting lifestyle decreased significantly. Additionally, this threshold effect was evident among older people at different levels of social relationships. Conclusions: The negative effect of loneliness on a health‐promoting lifestyle is alleviated by the single threshold effect of pet attachment. Pet–owner relationships can compensate for a lack of social relationships to some extent and alleviate both an individual's loneliness and its negative effect on a health‐promoting lifestyle. Implications for practice: To alleviate loneliness and promote healthy ageing in older people who lack social relationships, the tailored pet intervention strategies that prioritize 'one health' at the animal‐ecosystem interface that consider their different individual levels of social relationship should be developed. [ABSTRACT FROM AUTHOR]

Objectives of the Study: The aim of this study is to investigate whether fisetin can effectively reduce the myocardial damage induced by patulin. This study also aims to reveal the mechanism and target of fisetin in inhibiting myocardial damage. Materials and Methods: Network pharmacology was used to screen the targets of fisetin on myocardial damage and the regulatory network of active ingredients-drug targets was constructed. GO and KEGG enrichment analyses were performed to screen out the key pathways and targets of fisetin on myocardial damage. Patulin induced apoptosis in H9c2 cardiomyocytes to verify the key targets. The mechanism of fisetin in inhibiting myocardial damage was determined. Results: FIS can reduce the apoptosis of cardiomyocytes by protecting cardiomyocytes from PAT injury. According to the results of network pharmacology analysis, combined with enzyme activity detection and WB experiment, it was found that the mechanism of FIS to reduce myocardial damage may be related to the P53 signaling pathway, Caspase3/8/9 and Bax/Bcl-2. Conclusion: FIS plays a protective role in PAT-induced myocardial damage. On the one hand, FIS inhibits the protein overexpression of P53, Caspase-9 and Bax. On the other hand, FIS enhances the protein expression of Bcl-2. [ABSTRACT FROM AUTHOR]

Objectives: Non-suicidal self-injury (NSSI) behavior is a severe public health issue in adolescents. This study investigated the possible impact of the coronavirus disease 2019 (COVID-19) and analyzed psychological risk factors on adolescent NSSI. Methods: A one-year follow-up study was conducted in September 2019 (Time 1) and September 2020 (Time 2) among 3588 high school students. The completed follow-up participants (N = 2527) were classified into no NSSI (negative at both time points), emerging NSSI (negative at Time 1 but positive at Time 2), and sustained NSSI (positive at both time points) subgroups according to their NSSI behaviors before and during the COVID-19 pandemic. Perceived family functioning, perceived school climate, negative life events, personality traits (neuroticism, impulsivity, and self-control) were assessed using self-report scales. Results: The data indicated an increase (10.3%) in the incidence of NSSI. Compared to no NSSI subjects, the emerging NSSI and sustained NSSI subgroups had lower perceived family functioning, higher neuroticism, higher impulse-system but lower self-control scores, and more negative life events. Logistic regressions revealed that after controlling for demographics, neuroticism and impulse-system levels at Time 1 positively predicted emerging NSSI behavior, and similarly, higher neuroticism and impulsivity and lower self-control at Time 1 predicted sustained NSSI behavior. Conclusions: These findings highlighted the aggravated impact of the COVID-19 on NSSI, and suggested that individual neuroticism, impulsivity, and self-control traits might be crucial for the development of NSSI behavior among adolescent students. [ABSTRACT FROM AUTHOR]

This study investigated the actual evapotranspiration (AET) and potential evapotranspiration (PET) seasonality, trends, abrupt changes, and driving mechanisms with global sea surface temperature (SST) and atmospheric circulation patterns over Equatorial Africa (EQA) during 1980–2020. The spatiotemporal characteristics of mean ET were computed based on a 40-year average at annual and seasonal scales. The Mann-Kendall statistical test, the Sen slope test, and the Bayesian test were used to analyze trends and detect abrupt changes. The results showed that the mean annual PET (AET) for 1980–2020 was 110 (70) mm. Seasonal mean PET (AET) values were 112 (72) in summer, 110 (85) in autumn, 109 (84) in winter, and 110 (58) in spring. The MK test showed an increasing (decreasing) rate, and the Sen slope identified upward (downward) at a rate of 0.35 (0.05) mm yr−10. The PET and AET abrupt change points were observed to happen in 1995 and 2000. Both dry and wet regions showed observed weak (strong) correlation coefficient values of 0.3 (0.8) between PET/AET and climate factors, but significant spatiotemporal differences existed. Generally, air temperature, soil moisture, and relative humidity best explain ET dynamics rather than precipitation and wind speed. The regional atmospheric circulation patterns are directly linked to ET but vary significantly in space and time. From a policy perspective, these findings may have implications for future water resource management. [ABSTRACT FROM AUTHOR]

A reliable estimate of the gross primary productivity (GPP) is crucial for understanding the global carbon balance and accurately assessing the ability of terrestrial ecosystems to support the sustainable development of human society. However, there are inconsistencies in variations and trends in current GPP products. To improve the estimation accuracy of GPP, a deep learning method has been adopted to merge 23 CMIP6 data to generate a monthly GPP merged product with high precision and a spatial resolution of 0.25°, covering a time range of 1850–2100 under four climate scenarios. Multi-model ensemble mean and the merged GPP (CMIP6DL GPP) have been compared, taking GLASS GPP as the benchmark. Compared with the multi-model ensemble mean, the coefficient of determination between CMIP6DL GPP and GLASS GPP was increased from 0.66 to 0.86, with the RMSD being reduced from 1.77 gCm−2d−1 to 0.77 gCm−2d−1, which significantly reduced the random error. Merged GPP can better capture long-term trends, especially in regions with dense vegetation along the southeast coast. Under the climate change scenarios, the regional average annual GPP shows an upward trend over China, and the variation trend intensifies with the increase in radiation forcing levels. The results contribute to a scientific understanding of the potential impact of climate change on GPP in China. [ABSTRACT FROM AUTHOR]

Soil moisture as a key variable of land processes greatly influences the weather and climate. This study investigates the observed linkage between Tibetan Plateau (TP) spring soil moisture and summer precipitation and floods in the Yangtze River basin during 1988–2008 using satellite and in‐situ observations. A significant (p = 1%) proportion of interannual variations of summer precipitation (about 25%) in the Yangtze River basin can be attributed to spring TP soil moisture anomalies which show a dipole pattern. When spring soil moisture anomalies are positive (negative) over eastern (western) TP, there is more summer precipitation and consequently river discharge in the Yangtze River basin, or vice versa. The possible mechanisms can be explained from the perspectives of surface energy balance and atmospheric thermodynamics. More (less) spring soil moisture over the eastern (western) plateau enhances summer diabatic heating, which may be related to soil moisture memory. The enhanced summer diabatic heating stimulates vigorous ascending motions over TP, which diverge in the upper troposphere (200 hPa) and descend over the western Pacific. This is conducive to the enhancement and mutual proximity of the South Asian High (SAH) and the Western Pacific Subtropical High (WPSH). As a result, the warm and humid air flows from the Bay of Bengal and the western Pacific and the cold and dry air flows from the boreal continent converge in the Yangtze River basin, causing excessive summer precipitation. Therefore, TP spring soil moisture can be considered a seasonal predictor of summer precipitation and possible subsequent floods in the Yangtze River basin. Plain Language Summary: Spring soil moisture over the Tibetan Plateau (TP) explains a significant proportion of interannual variations of summer precipitation (about 25%) in the Yangtze River basin. When spring soil moisture anomalies are positive (negative) over the eastern (western) TP, there is more summer precipitation and consequently river discharge in the Yangtze River basin, or vice versa. The possible mechanisms can be attributed to the perspectives of surface energy balance and atmospheric thermodynamics. More (less) spring soil moisture over the eastern (western) plateau enhances summer diabatic heating. The diabatic heating controls the atmospheric circulation changes over the TP and surrounding regions associated with the enhancement and eastward (westward) stretching of the South Asian High (Western Pacific Subtropical High), favoring the convergence of the warm and humid (cold and dry) air flows from Tropical Ocean (boreal continent) to the Yangtze River basin, resulting in excessive summer precipitation. Key Points: Spring soil moisture over the Tibetan Plateau (TP) explains about 25% of interannual variations of summer precipitation in the Yangtze River basinPositive (negative) soil moisture anomalies over eastern (western) TP lead to more precipitation and discharge in the Yangtze River basinMore precipitation is due to moisture‐rich airflow convergence linked to South Asian High and Western Pacific Subtropical High affected by soil moisture‐induced diabatic heating [ABSTRACT FROM AUTHOR]

This study evaluated the historical precipitation simulations of 49 global climate models (GCMs) of the Coupled Model Intercomparison Project Phase 6 (CMIP6) in reproducing annual and seasonal precipitation climatology, linear trends, and their spatial correlation with global SST across Africa and the Arabian Peninsula during the period of 1980–2014, using Global Precipitation Climatology Centre (GPCP) data as a reference. Taylor's diagram was used to quantify the strengths and weaknesses of the models in simulating precipitation. The CMIP6 multi-mean ensemble (MME) and the majority of the GCMs replicated the dominant features of the spatial and temporal variations reasonably well. The CMIP6 MME outperformed the majority of the individual models. The spatial variation of the CMIP6 MME closely matched the observation. The results showed that at annual and seasonal scales, the GPCP and CMIP6 MME reproduced a coherent spatial pattern in terms of the magnitude of precipitation. The humid region received >300 mm and the arid region received <50 mm across Africa and the Arabian Peninsula. The models from the same modeling centers replicated the precipitation levels across different seasons and regions. The CMIP6 MME and the majority of the individual models overestimate (underestimate) in humid (arid and semi-arid)-climate zones. The annual and pre-monsoon seasons (i.e., DJFMA) were better replicated in the CMIP6 GCMs than in the monsoon-precipitation model (MJJASON). The CMIP6 MME (GPCP) showed stronger wetting (drying) trends in the northern hemisphere. In contrast, a strong drying trend in the CMIP6 MME and a weak wetting trend in the GPCP were shown in the Southern Hemisphere. The CMIP6 MME captures the spatial pattern of linear trends better than individual models across different climate zones and regions. The relationship between precipitation and sea-surface temperature (SST) exhibited a high spatial correlation (−0.80 and 0.80) with large variability across different regions and climate zones. The GPCP (CMIP6 MME) exhibited a heterogenous (homogeneous) spatial pattern, with higher correlation coefficients recorded in the CMIP6 MME than in the GPCP in all cases. Individual models from the same modeling centers showed spatial homogeneity in correlation values. The differences exhibited by the individual GCMs highlight the significance of each model's unique dynamics and physics; however, model selection should be considered for specific applications. [ABSTRACT FROM AUTHOR]

Cold water immersion (CWI) is very popular as a method reducing post-exercise muscle stiffness, eliminating fatigue, decreasing exercise-induced muscle damage (EIMD), and recovering sports performance. However, there are conflicting opinions as to whether CWI functions positively or negatively. The mechanisms of CWI are still not clear. In this systematic review, we used meta-analysis aims to examine the effect of CWI on fatigue recovery after high-intensity exercise and exercise performance. A total of 20 studies were retrieved and included from PubMed, PEDro and Elsevier databases in this review. Publication years of articles ranged from 2002 to 2022. In selected studies including randomized controlled trials (RCTs) and Crossover design (COD). Analyses of subjective indicators such as delayed-onset muscle soreness (DOMS) and ratings of perceived exertion (RPE), and objective indicators such as countermovement jump (CMJ) and blood plasma markers including creatine kinase(CK), lactate/lactate dehydrogenase(LDH), C-reactive protein(CRP), and IL-6 were performed. Pooled data showed as follows: CWI resulted in a significant decline in subjective characteristics (delayed-onset muscle soreness and perceived exertion at 0 h); CWI reduced countermovement jump(CMJ) significantly at 0 h, creatine kinase(CK) was lowered at 24 h, and lactate at 24 and 48 h. There was no evidence that CWI affects C-reactive protein(CRP) and IL-6 during a 48-h recovery period. Subgroup analysis revealed that different CWI sites and water temperatures have no effect on post-exercise fatigue recovery. Recommended athletes immersed in cold water immediately after exercise, which can effectively reduce muscle soreness and accelerate fatigue recovery. [ABSTRACT FROM AUTHOR]

Purpose: To systematically evaluate the effect of exercise rehabilitation as an adjuvant to clinical treatment for myofascial trigger points (MTrPs). Patients and Methods: ESBCO, PubMed, Science Direct, Web of Science, China Knowledge Network (CNKI), and Wanfang databases were comprehensively searched from database inception date through July 2022. Randomized controlled trials comparing MTrPs treatments that included exercise rehabilitation with a single clinical treatment. Two researchers independently screened articles using inclusion/exclusion criteria, scored methodologic quality, and extracted data including patient demographics, interventions, and outcomes. Results: We included 14 RCTs (N = 734). Results showed short-term (mean difference [MD], − 2.25; 95% confidence interval [CI], − 4.08 to − 0.41; Z = 2.40; P = 0.02) and long-term (MD = − 0.47; 95% CI: − 0.80 to − 0.17; Z = 3.05; P = 0.02) adjuvant exercise rehabilitation treatments were superior in reducing musculoskeletal pain intensity to single clinical treatment in controls, but long-term versus short-term effectiveness was not significantly different. The exercise rehabilitation group more effectively increased the range of motion (ROM) (standardized mean difference [SMD], 1.04; 95% CI: 0.32 to 1.77; Z = 2.84; P = 0.005) and decreased dysfunction (SMD = − 0.93; 95% CI: − 1.82 to − 0.05; Z = 2.06; P = 0.04) than controls; no significant difference was observed in the pressure pain threshold (PPT) between two groups. Conclusion: Exercise rehabilitation as an adjuvant to clinical treatment for MTrPs was moderately effective in relieving pain intensity, increasing ROM, and improving dysfunction versus single clinical intervention. These findings must be validated by larger, higher-quality studies. [ABSTRACT FROM AUTHOR]

Global climate change is projected to increase the probability of occurrence and severity of droughts. Increased CO2 concentration drives partial closure of plant stomata and reduces evapotranspiration. However, the impact of reduced evapotranspiration due to CO2 on future droughts characteristics in China is unclear. In this study, we have used the Coupled Model Intercomparison Project Phase 6 (CMIP6) global climate model simulations (GCMs) under historical period, and four shared socioeconomic pathway scenarios (SSP1‐2.6, SSP2‐4.5, SSP3‐7.0, and SSP5‐8.5) to estimate drought. We used a widely applicable drought index (i.e., the self‐calibrating Palmer Drought Severity Index [scPDSI]) to evaluate the historical and future drought conditions, using the Penman–Monteith formula with and without the CO2 concentrations. The results show that the increasing trend of scPDSI slows down when the CO2 effect is considered in all scenarios, especially in Heilongjiang, northern Xinjiang, and the Qinghai–Tibet Plateau. The divergence in the slowdown trend among the different scenarios becomes greater after 2030, with higher emission scenarios implying a greater slowdown in the increasing trend of scPDSI. After considering CO2, drought characteristics such as the drought frequency, intensity, and drought area decrease. Increased CO2 concentration on vegetation physiological processes could mitigate future drought. Therefore, the effects of CO2 on plant physiology should be considered in studies of future drought trends to develop more realistic response and adaptation policies to future drought changes. [ABSTRACT FROM AUTHOR]

Actual evapotranspiration (ET) is an essential variable in the hydrological process, linking carbon, water, and energy cycles. Global ET has significantly changed in the warming climate. Although the increasing vapor pressure deficit (VPD) enhances atmospheric water demand due to global warming, it remains unclear how the dynamics of ET are affected. In this study, using multiple datasets, we disentangled the relative contributions of precipitation, net radiation, air temperature (T1), VPD, and wind speed on the annual ET linear trend using an advanced separation method that considers the Budyko framework. We found that the precipitation variability dominantly controls global ET in the dry climates, while the net radiation has substantial control over ET in the tropical regions, and VPD impacts ET trends in the boreal mid-latitude climate. The critical role of VPD in controlling ET trends is particularly emphasized due to its influence in controlling the carbon–water–energy cycle. [ABSTRACT FROM AUTHOR]

Background: The internet has greatly improved the availability of medical knowledge and may be an important avenue to improve patients' trust in physicians and promote primary healthcare seeking by reducing information asymmetry. However, very few studies have addressed the interactive impacts of both patients' internet use and trust on primary healthcare-seeking decisions. Objective: To explore the impact of internet use on the relationship between patients' trust in physicians and primary healthcare seeking among Chinese adults 18 years of age and older to understand the varieties of effects in different cities. Methods: Generalized linear mixed models were applied to investigate the interactive impacts of internet use and patients' trust in physicians on primary healthcare seeking using pooled data from the China Family Panel Study of 2014 to 2018. We also compared these effects based on different levels of urbanization, ages, and PHC services. Results: Overall, a higher degree of patients' trust (p < 0.001) was able to directly predict better primary healthcare seeking, and internet use significantly increased the positive effect of patients' trust on primary healthcare seeking (p < 0.001). However, the marginal effect analysis showed that this effect was related to the level of patients' trust and that internet use could reduce the positive effect of patients' trust on primary healthcare seeking when the individual had a low level of trust (≤ 3 units). Further, the heterogeneity analysis indicated that the benefits from internet use were higher in cities with high urbanization, high aging, and high PHC service levels compared to cities with low levels of these factors. Conclusions: The internet use may enhance patients' trust-related PHC utilization. However, this impact is effective only if patients' benchmark trust remains at a relatively high level. Comparatively, the role of internet use is more effective in areas with high urbanization, high aging and high PHC level. Thus, with increasing accessibility to the internet, the internet should be regulated to disseminate correct healthcare information. Moreover, in-depth integration of the internet and PHC should be promoted to provide excellent opportunities for patient participation, and different strategies should be set according to each city's characteristics. [ABSTRACT FROM AUTHOR]

Addressing the urgent need for aged care providers in Australia to enhance their accountability, this study examines whether and how downward accountability (to clients) and lateral accountability (to employees) in aged care organisations are affected by beliefs and boundary controls exercised by the organisations’ management. Analyses were performed on survey data collected from 228 not-for-profit aged care providers across Australia. The analyses show that beliefs control positively affects both downward and lateral accountability, whereas boundary control positively affects downward accountability. Further, boundary control marginally moderates the relation between beliefs control and lateral accountability. The study contributes to both not-for-profit accountability and management control literatures. Its findings have implications for aged care providers, which are experiencing significant reforms that aim to improve accountability to senior Australians and employees in the organisations. [ABSTRACT FROM AUTHOR]

Smallpox, an epidemic disease caused by Orthopoxvirus variola, was eradicated worldwide through immunization. The immunization against smallpox was discontinued in 1980. However, incidences of monkeypox virus infection in humans have occurred sporadically, and there is also great fear that engineered forms of poxvirus could be used as biological weapons. Therefore, monoclonal antibodies against poxvirus are urgently needed for the detection and treatment of poxvirus infection. The vaccinia virus' extracellular envelope protein A33 is a potential candidate for a subunit vaccine. We used multi-fluorescence-labeled tetrameric A33 antigen to identify rare poxvirus-specific memory B cells from the PBMC of volunteers with vaccinia virus immunization more than 40 years ago. Despite extremely low frequencies of the poxvirus-specific memory B cells, we successfully sorted A33 tetramer-labeled single memory B cells and reconstructed the antibodies with the single-cell RT-PCR of the B-cell receptor. Among the monoclonal antibodies, one clone H2 exhibited high specificity and affinity with A33. H2 efficiently inhibited viral infection and spread in cells. Passive immunotherapy of H2 in mice protected mice from lethal infection when administered either prophylactically or therapeutically. These results suggest the potential of anti-A33 human-antibody-based detection and therapeutics for poxvirus infection. [ABSTRACT FROM AUTHOR]

This study aimed to understand the types and characteristics of lonely elderly from the perspective of social isolation and compare their differences in quality of life (QOL). A cross-sectional survey of 2148 lonely elderly in Shanxi province, China was conducted. The latent profile analysis was used to classify the lonely elderly and describe their characteristics. A hierarchical multilinear regression method was applied to evaluate their differences in QOL. The lonely elderly can be divided into two categories: Class-Ι, in low social isolation with a significant correlation between social isolation and loneliness (p < 0.05), and Class-ΙΙ, in high social isolation with no significant correlation between social isolation and loneliness (p > 0.05).QOL of Class-Ι was significantly higher than that of Class-ΙΙ. Class-ΙΙ was in a state of self-imposed isolation with poor QOL and should be the focus-group during practical intervention. [ABSTRACT FROM AUTHOR]

Invasion and migration are major characteristics of malignant cancers. Inhibiting the migration of cancer cells, rather than simply removing the primary tumor, is essential for improving the survival rates. Two-dimensional (2D) materials have important application prospects in the field of biomedicine (especially in cancer therapy) due to their unique physicochemical properties. However, the basic biological effects of 2D material cobalt-based layered double hydroxides, especially its cytotoxicity and migration effects on a variety of cells, have not yet been revealed. Herein, the effect of 5 nm thick β-Co(OH)2 nanosheets (NSs) on cell viability and migration of normal cells and various cancer cells and their possible mechanisms were investigated. The cell viability assay and migration ability analysis found that β-Co(OH)2 NSs had a concentration-dependent and selective biological effects on normal cells HUVEC and cancer cells (4T1, SMMC-7721, and B16 cells). Compared with normal cells HUVEC, β-Co(OH)2 NSs showed remarkably stronger and differentiated cytotoxicity to cancer cells (4T1, SMMC-7721, and B16 cells), and it was found by wound healing and transwell assays that β-Co(OH)2 NSs also can inhibit cancer cell migration more sensitively which may be attributed to the down-regulation of the key epithelial-mesenchymal transition protein Snail2. This study on revealing the basic biological effects of cobalt-based nanosheets will not only promote the understanding of the interaction between nanosheets and cells, but will also help in developing cancer treatment platforms based on cobalt-based nanosheets to promote their applications in the inhibition of tumor migration and metastasis. [ABSTRACT FROM AUTHOR]

In a warming climate, drought events are projected to increase in many regions across the world, which would have detrimental impacts on water resources for agriculture activity and human life. Thus, projecting drought changes, especially the frequency of future drought events, is very important for the African continent. This study investigates the future changes in drought events based on the France Centre National de Recherches Météorologiques (CNRM-CM6) model in the Coupled Model Intercomparison Project phase six (CMIP6) datasets for four shared socio-economic pathways (SSP): SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5; and three time slices: near future (2020–2039), mid-century (2050–2069), and end-of-century (2080–2099), relative to a historical baseline period (1995–2014). The interannual variability and trends of the self-calibrating Palmer Drought Severity Index (scPDSI) based on the Penman–Monteith methods for measuring potential evapotranspiration (PET) are used to estimate future droughts. The temporal analysis shows that the drought frequency, intensity, and affected area will increase throughout the 21st century. Among the scenarios, SSP3-7.0 and SSP5-8.5 project a larger upward trend in drought characteristics than SSP1-2.6 and SSP2-4.5. The spatial pattern shows drought frequency decreases in humid regions and increases in non-humid regions across Africa. For all SSP scenarios, the projected wetting trend per decade ranges from 0.05 to 0.25, while the drying trend per decade ranges from −0.05 to 0.25. A regional trend analysis revealed key differences in spatial pattern, with varied trend projections of wetter and drier conditions in humid and non-humid regions under all SSP scenarios. Drier conditions are expected to intensify in Southern Africa under all SSP scenarios but are projected to be more intense under either SSP3-7.0 and SSP5-8.5. In general, the projected wetter trends in humid areas may favor agricultural production and ecological conservation, and drier trends in non-humid regions may call for the possible adoption of tailor-made drought adaptation strategies and development programmes to minimize impacts. [ABSTRACT FROM AUTHOR]

A harmonized global land evaporation dataset from model-based products covering 1980-2017 Table 3 The verification results including HT ht and RMSD between monthly ground-measured ET and monthly ET from different products in different ecosystems. In this work, assuming the importance of the two criteria is equal, HT ht and HT ht were both assigned the value of 1. The parameters HT ht and HT ht in Eq. (4) are used to measure the relative importance of the two criteria. In addition, when HT ht and HT ht are less than HT ht , HT ht and HT ht are set to 1. [Extracted from the article]