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OBJECTIVE: Try to create a dose gradient function (DGF) and test its effectiveness in reducing radiation induced lung injury in breast cancer radiotherapy. MATERIALS AND METHODS: Radiotherapy plans of 30 patients after breast-conserving surgery were included in the study. The dose gradient function was defined as D G H = V D V p 3 , then the area under the DGF curve of each plan was calculated in rectangular coordinate system, and the minimum area was used as the trigger factor, and other plans were triggered to optimize for area reduction. The dosimetric parameters of target area and organs at risk in 30 cases before and after re-optimization were compared. RESULTS: On the premise of ensuring that the target dose met the clinical requirements, the trigger factor obtained based on DGF could further reduce the V5, V10, V20, V30 and mean lung dose (MLD) of the ipsilateral lung in breast cancer radiotherapy, P < 0.01. And the D2cc and mean heart dose (MHD) of the heart were also reduced, P < 0.01. Besides, the NTCPs of the ipsilateral lung and the heart were also reduced, P < 0.01. CONCLUSION: The trigger factor obtained based on DGF is efficient in reducing radiation induced lung injury in breast cancer radiotherapy. [ABSTRACT FROM AUTHOR]

Polymeric composites with the hybrid filler network for high-performance electromagnetic interference (EMI) shielding brought increasing interest. Herein, UHMWPE/ground tire rubber (GTR)/conductive carbon black (CCB) (UGC) composites with a hybrid segregated structural CCB-GTR were constructed by solid-phase shear milling (S3M), mechanical blending, and compacted molding processes. The percolation behavior of electrical conductivity and EMI shielding effectiveness (SE) of composites was described using Sigmoidal/Growth models, and its EMI shielding mechanism was discussed. Results showed that the EMI SE of U30G70C20, U50G50C20, and U70G30C20 composites were found to be 37.5, 41.7, and 43.8 dB, respectively, due to constructing a hybrid network. The attenuation rate of microwave radiation is above 99.99%, and the shielding mechanism is mainly electrical loss. Moreover, the relationship between electrical conductivity and EMI SE is consistent with Sigmoidal/Growth models, indicating that Sigmoidal/Growth models can successfully predict the percolation threshold of the EMI SE of UGC composites. [ABSTRACT FROM AUTHOR]

A building may be subjected to a variety of accidental loads during its service life. Partially precast concrete (PC) beams are a primary structural component. Their impact resistance can have a substantial impact on the overall safety of a structure when it is subjected to an impact load. In this study, numerical analyses were performed on the dynamic response of PC beams strengthened with bonded steel plates subjected to impact loading. The model was verified from four aspects: energy conversion, failure form, impact force–time history curve, and midspan displacement–time history curve. The dynamic response eigenvalues of the peak impact force, peak midspan displacement, and residual midspan displacement were compared between the numerical simulations and experimental tests. The relative inaccuracy of the peak impact force ranged from 9.51% to 14.0%, with an average value of 11.9%. The average relative error for the midspan displacement was −0.09%, with the greatest relative errors varying between −0.64% and 0.3%. The residual value errors of the midspan displacement ranged from −0.95% to 2.38%, with an average relative error of 0.94%. On this basis, the effects of the impact mass, impact height, width, and length of the bonded steel plate on the impact resistance of the components were evaluated. Furthermore, the differences in the equivalent plastic strain contours, impact force–time history curves, and midspan displacement–time history curves under different parameters were compared. The results demonstrated that the failure modes and flexural deformations of the test beams were influenced by the impact mass and impact height. The increase in the length and width of the steel plate had no effect on the impact force response, but the peak and residual values of the midspan displacement decreased, which could significantly increase the impact resistance of the beams. Lastly, the impact mass m, the impact height h, the thickness t of the bonded steel plate, the length of the bonded steel plate hs, and the width of the bonded steel plate bs were all taken into account in the fitting formula. These five parameters were used to predict the peak impact force response, the peak value of the midspan displacement, and the residual value of the midspan displacement. The results demonstrated that the fitting formula had small errors and could accurately reflect the dynamic responses of the PC beams strengthened with bonded steel plates under impact loading. [ABSTRACT FROM AUTHOR]

The existing connection between the concrete-filled double steel tubular (CFDST) column and the reinforced concrete (RC) beam is difficult to repair and reuse after damage. In this paper, a self-centering joint between the CFDST column and the RC beam is proposed. The self-centering of the joint is realized by prestressed steel strands, and the energy dissipation is realized by friction. The overall purpose of the research is to analyze the influence of steel strand and friction on the mechanical behavior of the joint. By comparing the envelope curve and the restoring force model of a numerical joint model with theoretical values, accuracy of the numerical model was verified. Then, joints with different parameters, including the friction, prestress of steel strands, and ratio of the resisting moment provided by steel strands to the resisting moment provided by friction in the opening moment of joints, were numerically analyzed. The results showed that the joints with greater friction and prestress of steel strands had higher bearing capacity. Increasing the friction could increase the energy dissipation capacity of the joint, but it would increase the residual deformation of the joint. To reduce residual deformation, the prestress of steel strands should be increased. When the resultant force of the pretension of steel strands was greater than friction, the steel head could be kept pressed on the connecting block, making the stress changes of steel strands and the self-centering performance of the joint stable. [ABSTRACT FROM AUTHOR]

A building may be subjected to multiple accidental loads during its service-life. Partially precast concrete (PC) beam is a primary force-bearing member. When subjected to an impact load, its impact resistance will significantly affect the overall safety of the structure. In this study, five PC beams were designed and manufactured, and drop-hammer impact tests were performed. The influences of impact mass and impact height on the failure mode and the dynamic response of the component under different loading conditions were examined. The typical failure mode of the test beam under a dynamic load was derived from the failure mode and crack distribution. The dynamic responses such as impact force, supporting reaction force, and displacement-time-history curve were obtained by the test. With increasing impact energy, the peak impact force increased from 3,353 to 3,708 kN, the peak mid-span displacement increased from 33.6 to 47.3 mm, and the residual mid-span displacement increased from 11.9 to 15.1 mm. Subsequently, the law of energy dissipation in the impact process was analyzed using the combined curves of the impact force-mid-span displacement and support reaction force-mid-span displacement. Furthermore, the result obtained by the integration of the reaction force-displacement curve in the middle of the span is more suitable for evaluating the overall energy consumption of the beam. The vibration energy and internal energy of the beam itself account for the primary part of the remaining energy. [ABSTRACT FROM AUTHOR]

In order to deepen the understanding of the personality antecedents of students' career decidedness, this study, based on social cognitive career theory and career development theory, examined the effect of proactive personality on career decidedness as well as the mediating mechanism and moderating factors in this process. The results of the survey of 783 Chinese college students showed that proactive personality was positively related to career decidedness via career exploration, and anticipated regret moderated the relationship between proactive personality and career exploration significantly. Both theoretical and practical implications are discussed at the end of this research. [ABSTRACT FROM AUTHOR]

Smart device users spend most of the fragmentation time in the entertainment applications such as videos and films. The migration and reconstruction of video copies can improve the storage efficiency in distributed mobile edge computing, and the prediction of video hits is the premise for migrating video copies. This paper proposes a new prediction approach for video hits based on the combination of correlation analysis and wavelet neural network (WNN). This is achieved by establishing a video index quantification system and analyzing the correlation between the video to be predicted and already online videos. Then, the similar videos are selected as the influencing factors of video hits. Compared with the autoregressive integrated moving average (ARIMA) and gray prediction, the proposed approach has a higher prediction accuracy and a broader application scope. [ABSTRACT FROM AUTHOR]

Objective: To explore the efficacy and sensitivity of 3D gamma analysis and bio-mathematical model for cervical cancer in detecting dose changes caused by dose-calculation-grid-size (DCGS).Methods: 17 patients' plans for cervical cancer were enrolled (Pinnacle TPS, VMAT), and the DCGS was changed from 2.0 mm to 5.0 mm to calculate the planned dose respectively. The dose distribution calculated by DCGS = 2.0 mm as the "reference" data set (RDS), the dose distribution calculated by the rest DCGS as the"measurement"data set (MDS), the 3D gamma passing rates and the (N) TCPs of the all structures under different DCGS were obtained, and then analyze the ability of 3D gamma analysis and (N) TCP model in detecting dose changes and what factors affect this ability.Results: The effect of DCGS on planned dose was obvious. When the gamma standard was 1.0 mm, 1.0 and 10.0%, the difference of the results of the DCGS on dose-effect could be detected by 3D gamma analysis (all p value < 0.05). With the decline of the standard, 3D gamma analysis' ability to detect this difference shows weaker. When the standard was 1.0 mm, 3.0 and 10.0%, the p value of > 0.05 accounted for the majority. With DCGS = 2.0 mm being RDS, ∆gamma-passing-rate presented the same trend with ∆(N) TCPs of all structures except for the femurs only when the 1.0 mm, 1.0 and 10.0% standards were adopted for the 3D gamma analysis.Conclusions: The 3D gamma analysis and bio-mathematical model can be used to analyze the effect of DCGS on the planned dose. For comparison, the former's detection ability has a lot to do with the designed standard, and the latter's capability is related to the parameters and calculated accuracy instrinsically. [ABSTRACT FROM AUTHOR]

In task-switching experiments with bivalent target stimuli, conflicts during response selection give rise to response-congruency effects. Typically, participants respond more slowly and make more errors in trials with incongruent targets that require different responses in the two tasks, compared to trials with congruent targets that are associated with the same response in both tasks. Here we investigate whether participants show response-congruency effects when task rules are not made explicit. In two experiments, we assigned task-irrelevant features to each bivalent target. When participants were instructed to apply the task rules, they showed significant task-switching costs as well as response-congruency effects. Importantly, when the same participants did not know the task rules and responded without applying the task rules, they showed response-congruency effects but no switch costs. The significant congruency effects suggest that associations between bivalent target features and responses can be formed passively, even when participants do not follow the task rules and use task-irrelevant target features to make a response. [ABSTRACT FROM AUTHOR]

Triple-negative breast cancer is a high-risk breast cancer with poor survival rate. To date, there is a lack of targeted therapy for this type of cancer. One unique phenomenon is that inflammatory breast cancer is frequently triple negative. However, it is still ambiguous how inflammation influences triple-negative breast cancer growth and responding to chemotherapy. Herein, we investigated the levels of inflammation-associated enzyme, iNOS, in 20 triple-negative breast cancer patients’ tumors, and examined its correlation with patients’ responses to platinum-based neoadjuvant chemotherapy. Our studies showed that triple-negative breast cancer patients with attenuated iNOS levels in tumor cells after treatment showed better responses to platinum-based neoadjuvant chemotherapy than other triple-negative breast cancer patients. Our further in vitro studies confirmed that induction of proper levels of NO increased the resistance to cisplatin in triple-negative MDA-MB-231 cells. Our data suggest that aberrant high level of iNOS/NO are associated with less effectiveness of platinum-based neoadjuvant chemotherapy in triple-negative breast cancer. Therefore, we propose to monitor iNOS levels as a new predictor for triple-negative breast cancer patient’s response to platinum-based neoadjuvant chemotherapy. Moreover, iNOS/NO is considered as a potential target for combination therapy with platinum drugs for triple-negative breast cancer. [ABSTRACT FROM AUTHOR]

ODQ is a query language for streaming office documents. In order to increase the query efficiency and lower the use difficulty, this paper proposed a method to flatten the ODQ document model and grammar. First, it translated the ODQ document model from the original tree structure into multi-linear structure, and reduced the level of document model. Second, it designed a specific keyword in grammar, which was able to link all levels of document model and created a path that led to the target data. The experimental results show that the flatten procedure can increase the query efficiency and simplify the query operations. [ABSTRACT FROM AUTHOR]

The authors have isolated and characterized a novel serine palmitoyltransferase (SPT)-like gene in marine Emiliania huxleyi virus (EhV-99B1). The open-reading frame (ORF) of EhV99B1-SPT encoded a protein of 496 amino acids with a calculated molecular mass of 96 kDa and Ip 6.01. The results of sequence analysis showed that there was about 31%-45% identity in amino acid sequence with other organisms. The maximum likelihood phylogenetic tree suggested that the EhV99B1-SPT gene possibly horizontally transferred from the eukaryote. Hydrophobic profiles of deduced amino acid sequences suggested a hydrophobic, globular and membrane-associated protein with five transmembrane domains (TMDs) motifs. Several potential N-linked glycosylation sites were presented in SPT. These results suggested that EhV99B1-SPT was an integral endoplasmic reticulum membrane protein. Despite lower sequence identity, the secondary and three-dimensional structures predicted showed that the 'pocket' structure element composed of 2 α-helices and 4 β-sheets was the catalytic center of this enzyme, with a typical conserved 'TFTKSFG' active site in the N-terminal region and was very close to those of prokaryotic organisms. However, the N-terminal domain of EhV99B1-SPT most closely resembled the LCB2 catalysis subunit and the C-terminal domain most closely resembled the LCB1 regulatory subunit of other organisms which together formed a spherical molecule. This 'chimera' was highly similar to the prokaryotic homologous SPT. For a functional identification, the EhV99B1-LCB2 subunit gene was expressed in Escherichia coli, which resulted in significant accumulation of new sphingolipid in E. coli cells. [ABSTRACT FROM AUTHOR]

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