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The coupling of an electron gas confined by a harmonic potential and submitted to a strong magnetic field tilted in relation to the confining direction creates an excitation called here magneto-polariton. This work describes the origin of this excitation and calculates the energy eigenvalues for different tilted angles. It presents the reasons leading to the crossings and repulsions of the energy bands, the degeneracy of the states, the way the Fermi levels change with the magnetic field, the influence of an external electric field, and how the Hall resistance plateaus change with the change in the tilted angle. [ABSTRACT FROM AUTHOR]

Background: Cancer treatment–related cognitive impairment (CTRCI) can substantially reduce the quality of life of cancer survivors. Many treatments of CTRCI have been evaluated in randomized controlled trials (RCTs), including psychological interventions, pharmacologic interventions, and other therapies. There is a pressing need to establish the benefits and harms of previously studied CTRCI treatments. The proposed systematic review and network meta-analyses will assess the relative efficacy and safety of competing interventions for the management of CTRCI. Methods: In consultation with the review team, an experienced medical information specialist will draft electronic search strategies for MEDLINE®, Embase, CINAHL, PsycINFO, and the Cochrane Trials Registry. We will seek RCTs of interventions for the treatment of CTRCI in adults with any cancer, except cancers/metastases of the central nervous system. Due to the anticipated high search yields, dual independent screening of citations will be expedited by use of an artificial intelligence/machine learning tool. The co-primary outcomes of interest will be subjective and objective cognitive function. Secondary outcomes of interest will include measures of quality of life, mental and physical health symptoms, adherence to treatment, and harms (overall and treatment-related harms and harms associated with study withdrawal), where feasible, random-effects meta-analyses and network meta-analyses will be pursued. We will address the anticipated high clinical and methodological heterogeneity through meta-regressions, subgroup analyses, and/or sensitivity analyses. Discussion: The proposed systematic review will deliver a robust comparative evaluation of the efficacy and safety of existing therapies for the management of CTRCI. These findings will inform clinical decisions, identify evidence gaps, and identify promising therapies for future evaluation in RCTs. [ABSTRACT FROM AUTHOR]

Copyright of Archivos de Zootecnia is the property of Archivos de Zootecnia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Astrometric studies and orbital modelling of planetary moons have contributed significantly to advancing our understanding of their orbital dynamics. These studies require precise positions measured over extended periods. In this paper, we present the results of the 2021 Brazilian Jovian mutual phenomena campaign. The data correspond to eight events between Galilean satellites, in addition to a rare eclipse of Thebe, an inner satellite, totalling nine events. A geometric model along with the DE440/JUP365 ephemerides was used to reproduce the events and simulate the light curves. A Monte Carlo method and chi-squared statistics were used to fit the simulated light curves to the observations. The reflectance model adopted for our simulations was the complete version of the Oren–Nayer model. The average uncertainty of the relative positions of the Galilean satellites was 5 mas (15 km) and for the inner Thebe satellite 32 mas (96 km). The seven mutual events (nine independent observations) here analysed represent an addition of 17 per cent events (10 per cent light curves) with respect to the 2021 international mutual phenomena campaign. Furthermore, our result of Thebe eclipse is only the second measurement published to date. Our results contribute to the ephemeris data base, being fundamental to improving satellite orbits and thus minimizing their uncertainties. [ABSTRACT FROM AUTHOR]

Let p be a prime and E an extra-special p-group of exponent p and order p 2 n + 1 . Suppose that E acts by automorphisms on a finite p ′ -group G. We prove that if γ n (C G (a)) is nilpotent for any a ∈ E # , then γ n (G) is nilpotent. If, for some integer d such that 2 d ≤ n , the dth derived group of C G (a) is nilpotent for any a ∈ E # , then the dth derived group G (d) is nilpotent. We also prove similar results for Lie algebras. [ABSTRACT FROM AUTHOR]

The search for sustainability in integrated production systems is a constant challenge, especially when it comes to balancing the levels of shading provided by trees in agroforestry systems. The objective of this study was to evaluate the effects of three shading levels (0, 30 and 60%) casted by native Babaçú trees (Attalea speciosa, Mart) on the agronomic and structural characteristics of Mombaça grass in the ecotone Cerrado-Amazon. A total area of 3 ha was stratified into 36 subdivisions measuring 270 m² each, in order to collect agronomic samples from the three shading levels, totaling 108 experimental units, where the structural and agronomic characteristics of Mombaça grass were assessed. Increased shading leads to reduction in tiller population density, forage volumetric density, leaf area index and yield and proportion of morphological components of Mombaça grass, reducing forage yield. The 65% and 78% reduction in tiller population in areas with 30 and 60% shading, respectively, in comparison to full sun light exposure, was the main factor in the reduced productivity of the grasses managed in the agropastoral system. Therefore, Mombaça grass should be managed at a level of 30% shading, which can be considered adequate to maximize forage yield, balancing the benefits of soil and water conservation with the possible negative impacts on forage production. [ABSTRACT FROM AUTHOR]

This work is a numerical simulation of the bond percolation in an array of junctions and bifurcations mimicking a section of a graphene slab. We calculate the size distribution of graphene clusters as a filler of a polymer aiming to obtain the percolation threshold. We obtained the sigmoidal distribution of graphene clusters as a function of concentration of persistent conducting bonds creating these clusters. The probability density of this distribution shows a universal complementary Fermi–Dirac behavior as a signature of a topological response. Using a tight-binding model for the transmission from the source to the drain, we obtain a smooth transition from an insulator to a conductor through a dirty metal as the concentration of conductive bonds increases for small arrays. As the array size increases, the simulation shows a sharp non-metal-to-metal transition from a pure polymer into a pristine suspended graphene layer. [ABSTRACT FROM AUTHOR]

Introduction: The use of contralateral prophylactic mastectomy (CPM) continues to grow despite the absence of evidence supporting a survival benefit. This study's objectives were to (1) describe the trends in the rates of unilateral and bilateral mastectomy (BM) in women diagnosed with unilateral breast cancer (UBC) in Ontario, Canada from 1991 to 2013, and (2) identify factors associated with BM to treat UBC. Methods: This retrospective cohort analysis included all women aged 18 and older diagnosed with UBC between January 1991 and December 2013. Health administrative data from the Institute for Clinical Evaluative Sciences, the Ontario Cancer Registry, and the Discharge Abstract Database were used to identify all breast cancer and mastectomy cases. Age-adjusted mastectomy rates were plotted over time. Univariable and multivariable analyses included clinically significant covariates. Results: From 1991 to 2013 there were 172,165 cases of UBC and 64,886 mastectomies (37.7%) performed in Ontario. 13.6% of the mastectomies were bilateral. BM rates increased over sixfold (from 4 to 25%) across all age groups under age 70 over a 23-year period. On multivariable analysis, younger age, higher income, rural community, earlier breast cancer stage, lobular histology, availability of reconstruction and teaching hospitals were associated with increased odds of BM. Conclusions: This is the largest population study of breast cancer patients in Canada and shows an increasing rate of BM for UBC. The results are similar to those already described in the US and highlight the importance of continued efforts to promote efficient communication and evidence-based decision-making prior to breast surgery. [ABSTRACT FROM AUTHOR]

Background: The nonunion fracture is a relatively frequent complication in both human and veterinary medicine. Specifically, atrophic fracture nonunions are difficult to treat, with revision surgery usually providing the best prognosis. Anabolic steroids, such as nandrolone decanoate (ND), have been reported to have beneficial clinical effects on bone mass gain during osteoporosis; however, their utility in promoting regeneration in atrophic nonunions has not been documented. Our objective was to examine morphological changes induced by the ND in experimental fracture nonunion with vascular deficit in the rat model.Methods: Fourteen adult Wistar rats had an atrophic fracture nonunion induced in the diaphysis of their left femur. Rats were allocated into two groups: control group and nandrolone decanoate group. Rats in the latter group were given nandrolone decanoate (1.5 mg/kg IM, once a week, during 4 weeks after confirmation of fracture nonunion radiographically). Radiographic and anatomopathological examination, micro-tomography and histological analysis were assessed to characterize the morphological changes promoted by the nandrolone decanoate use.Results: Based on radiology, anatomopathological evaluation, computed micro-tomography and conventional microscopy, nandrolone decanoate promoted bone regeneration at the fracture nonunion site by increasing the cellularity at the fracture site. Percentage of collagen was not significantly different between groups, consistent with high-quality regenerated bone.Conclusion: The anabolic steroid nandrolone decanoate improved bone mass and regeneration without affecting collagen production and therefore has potential for improving outcomes for atrophic fracture nonunion. [ABSTRACT FROM AUTHOR]

This work uses Computational Fluid Dynamics (CFD) to simulate the two-phase flow (oil and water) through a reservoir represented by a sandbox model. We investigated the influence in the flows of water having higher and lower mobilities than oil. To accomplish this, we also developed a dedicated solver, with the appropriated equations and representative models implemented in the open-source CFD OpenFOAM platform. In this solver, the black-oil model represented the oil. The results show that the Buckley–Leverett water-flood equation is a good approach for the three-dimensional flow. We observe that the water wall front is mixed to some extent with the oil and evolves obeying an exponential law. Water with mobility lower than oil is not common. However, in this case, the oil recovery is improved and the amount of injected water is reduced. The results comparing different mobilities show that a careful economic assessment should be performed before the field development. We have shown that the low water mobility can increase, as in this studied example, the water front saturation from 0.57 to 0.73, giving a substantial improvement in the oil recovery. The reservoir simulation can provide all process information needed to perform an economical assessment in an oil field exploration. [ABSTRACT FROM AUTHOR]

We investigate the spin-polarized transport of GaMnAs nanolayers in which a ferromagnetic order exists below a certain transition temperature. Our calculation for the self-averaged resistivity takes into account the existence of an impurity band determining the extended ('metallic' transport) or localized (hopping by thermal excitation) nature of the states at and near the Fermi level. Magnetic order and resistivity are inter-related due to the influence of the spin polarization of the impurity band and the effect of the Zeeman splitting on the mobility edge. We obtain, for a given range of Mn concentration and carrier density, a 'metallic' behavior in which the transport by extended carriers dominates at low temperature, and is dominated by the thermally excited localized carriers near and above the transition temperature. This gives rise to a conspicuous hump of the resistivity which has been experimentally observed and brings light onto the relationship between transport and magnetic properties of this material. [ABSTRACT FROM AUTHOR]

This paper explores the interaction of different flow paths in a porous medium by observing the effect of having more than one drain in a simple model domain with a single source. The work is based on three-dimensional numerical simulations of the flow of injected water in a sandbox domain with porous volume completely filled by water and oil. The calculation uses the OpenFOAM library to solve Darcy's equations for the dynamics of a two-phase flow: water as the wetting, oil as the nonwetting fluid. We observe the interactions of flows in different paths under changes of number of drains and their relative positions. [ABSTRACT FROM AUTHOR]

Introduction: The role of vitamin D on bone microarchitecture and fragility is not clear. Objective: To investigate whether vitamin D deficiency (25(OH)D <20 ng/mL) increases cortical bone loss and the severity of fractures. Design: Cross-sectional study of 287 elderly women with at least one prevalent low-impact fracture. Methods: Biochemistry, X-rays to identify vertebral fractures (VFs) and to confirm non-vertebral fractures (NonVFs), and high-resolution peripheral quantitative computed tomography (HR-pQCT) to evaluate bone microstructure. Results: Serum 25(OH)D levels were associated with body mass index (BMI: r = -0.161, P = 0.006), PTH (r = -0.165; P = 0.005), CTX (r =-0.119; P = 0.043) and vBMD at cortical bone (Dcomp: r = 0.132; P = 0.033) and entire bone (D100: r=0.162 P = 0.009) at the distal radius, but not at the tibia. Age and PTH levels were potential confounding variables, but in the multiple linear regressions only BMI (95% CI: 0.11-4.16; P< 0.01), 25(OH)D (95% CI: -0.007 to 1.70; P = 0.05) and CTX (95% CI: -149.04 to 21.80; P<0.01) predicted Dcomp, while BMI (95% CI: 1.13-4.18; P<0.01) and 25(OH)D (95% CI: 0.24-1.52; P < 0.01) predicted D100. NonVFs predominated in patients with 25(OH)D <20 ng/mL (P = 0.013). Logistic regression analysis showed a decrease in the likelihood of presenting grade 2-3 VFs/NonVFs for every increase in 25(OH)D (OR = 0.962, 95% CI: 0.940-0.984; P = 0.001), BMI (OR = 0.932, 95% CI: 0.885-0.981; P = 0.007) and D100 at radius (OR = 0.994, 95% CI: 0.990-0.998; P = 0.005). Conclusion: In elderly patients with prevalent fractures, vitamin D deficiency was associated with cortical bone loss and severity of fractures. [ABSTRACT FROM AUTHOR]

The optimised use of mixed crude glycerin (MCG) and ractopamine hydrochloride (RH) in diets for finishing pigs requires a better understanding of glycerol metabolism. Therefore, the present study evaluated the performance, blood parameters, metabolite concentrations in the Longissimus lumborum muscle and the activity of enzymes in the liver, subcutaneous adipose tissue and kidney of pigs fed diets containing MCG and/or RH. According to the initial weight, 64 barrows were distributed in a 4 × 2 factorial design, corresponding to four concentrations of MCG (0, 100, 150, and 200 g/kg) in diets containing 0 or 10 mg/kg of RH. There was no MCG × RH interaction for any of the evaluated parameters (P > 0.05). Moreover, there was no isolated effect of dietary MCG or RH on the weight gain and the blood concentrations of glucose, insulin, triacylglycerols, total cholesterol, total protein, albumin, creatinine, cortisol and lactate (P > 0.05). There was a higher rate of phosphorylation of glycerol in the liver, stimulation of lipogenesis in adipose tissue and a likely increase in the utilisation of glycerol by muscle fibres in response to an increased concentration of circulating glycerol from the diet (P < 0.05). In contrast, when the diet contained up to 200 g/kg MCG and 10 mg/kg RH, there were indications of a lower utilisation of glycerol for the synthesis of triacylglycerols in muscle, liver and adipose tissue, in addition to increased oxidation of amino acids in the liver followed by improved feed conversion of pigs (P < 0.05). Crude glycerin is an important alternative energy ingredient in the diet of pigs and the ractopamine is a feed additive that has been associated with improvements in animal performance and meat quality. The present study contributes to the advancement of the animal science, because it provides information about a subject that remains still little explored, namely, the glycerol metabolism in pigs fed diets containing glycerin and ractopamine. Such understanding is necessary to contribute to the formulation of diets that are nutritionally more adequate. [ABSTRACT FROM AUTHOR]

The clinical manifestation and course of Leishmania infections depend on factors such as species, virulence and host-immunity. Although trypanosomatids are considered to have clonal propagation, genetic hybridization has produced successful natural hybrid lineages. Hybrids displaying strong selective advantages may have an impact on pathogenesis and the eco-epidemiology of leishmaniasis. Thus, characterization of phenotypic properties of Leishmania hybrids could bring significant insight into the biology, infectivity, pathogenicity and transmission dynamics of these atypical strains. The present study focuses on phenotypic features and survival capacity of Leishmania infantum/Leishmania major hybrid isolates as compared with representative putative parental species, L. infantum and L. major. In vitro assays (growth kinetics, susceptibility to different conditions) and in vivo infection (parasite detection and histopathological alterations) showed that hybrids present higher growth capacity and decreased susceptibility to reactive oxygen species. Furthermore, evaluation of infected spleen tissue suggests that hybrids induce a stronger immune reaction than their putative parents, leading to the development of white pulp hyperplasia in B-lymphocyte compartments. Overall, these hybrids have shown high plasticity in terms of their general behaviour within the different phenotypic parameters, suggesting that they might have acquired genetic features conferring different mechanisms to evade host cells. [ABSTRACT FROM AUTHOR]

Presents a study which examined linear and nonlinear characteristics of superconductor superlattice perpendicular conduction. Linear mobilities from the balance-equation theory; Comparisons between theories and experiments; Conclusions.

The stochastic process of a turbulent flow in a pipeline provides a time series of the velocity field at any point of the domain by solving numerically the Navier-Stokes equation. The turbulent flow was produced by obstacles near the inlet, injecting eddies into the current. Moving downstream, these eddies evolve to a fully turbulent flow. Many length and time scales are involved in this process. We explore the cross-correlations of the velocity field time series at different points and also at different time scales using the detrended cross-correlation coefficient, ρDCCA, designed to analyze the cross-correlations in non-stationary time series. Thus, the results with ρDCCA allow interpreting how these eddies propagate downstream, and also quantify how adherent the velocity fields are with respect to the pipeline position. [ABSTRACT FROM AUTHOR]

Improving understanding of the pathogen-specific seasonality of enteric infections is critical to informing policy on the timing of preventive measures and to forecast trends in the burden of diarrhoeal disease. Data obtained from active surveillance of cohorts can capture the underlying infection status as transmission occurs in the community. The purpose of this study was to characterise rotavirus seasonality in eight different locations while adjusting for age, calendar time and within-subject clustering of episodes by applying an adapted Serfling model approach to data from a multi-site cohort study. In the Bangladesh and Peru sites, within-subject clustering was high, with more than half of infants who experienced one rotavirus infection going on to experience a second and more than 20% experiencing a third. In the five sites that are in countries that had not introduced the rotavirus vaccine, the model predicted a primary peak in prevalence during the dry season and, in three of these, a secondary peak during the rainy season. The patterns predicted by this approach are broadly congruent with several emerging hypotheses about rotavirus transmission and are consistent for both symptomatic and asymptomatic rotavirus episodes. These findings have practical implications for programme design, but caution should be exercised in deriving inferences about the underlying pathways driving these trends, particularly when extending the approach to other pathogens. [ABSTRACT FROM AUTHOR]

Improving understanding of the pathogen-specific seasonality of enteric infections is critical to informing policy on the timing of preventive measures and to forecast trends in the burden of diarrhoeal disease. Data obtained from active surveillance of cohorts can capture the underlying infection status as transmission occurs in the community. The purpose of this study was to characterise rotavirus seasonality in eight different locations while adjusting for age, calendar time and within-subject clustering of episodes by applying an adapted Serfling model approach to data from a multi-site cohort study. In the Bangladesh and Peru sites, within-subject clustering was high, with more than half of infants who experienced one rotavirus infection going on to experience a second and more than 20% experiencing a third. In the five sites that are in countries that had not introduced the rotavirus vaccine, the model predicted a primary peak in prevalence during the dry season and, in three of these, a secondary peak during the rainy season. The patterns predicted by this approach are broadly congruent with several emerging hypotheses about rotavirus transmission and are consistent for both symptomatic and asymptomatic rotavirus episodes. These findings have practical implications for programme design, but caution should be exercised in deriving inferences about the underlying pathways driving these trends, particularly when extending the approach to other pathogens. [ABSTRACT FROM AUTHOR]

The magnetic order resulting from an indirect exchange between magnetic moments in the metallic phase of a Ga[SUB1-x]Mn[SUBx]As bilayered structure is studied via Monte Carlo simulation. The coupling mechanism involves a perturbative calculation in second order of the interaction between the magnetic moments and carriers (holes). We take into account a possible polarization of the hole gas establishing, thus self-consistency between the magnetic order and the electronic structure. It leads to a ferromagnetic order even in the case of thin layers. This fact is analyzed in terms of the inter-and intralayer interactions. [ABSTRACT FROM AUTHOR]

The magnetic order in the diluted magnetic semiconductor barrier of double AlAs/GaAs:Mn quantum well structures is investigated by Monte Carlo simulations. A confinement adapted RKKY mechanism is implemented for indirect exchange between Mn ions mediated by holes. It is shown that, depending on the barrier width and the hole concentration, a ferromagnetic or a spin-glass order can be established. © 2000 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Zooarchaeological collections from shell mounds in Rio de Janeiro (2,470-4,632 cal BP) contain a high prevalence of swollen fish bones belonging to the Atlantic spadefish ( Chaetodipterus faber), crevalle jack ( Caranx hippos) and fat snook ( Centropomus parallelus). Given the lack of knowledge of the bone degenerative process in senile fishes, this study analysed hyperostotic bone in zooarchaeological and modern specimens to obtain high-resolution morphology and microstructure reconstruction. We used micro CT as well as X-ray diffraction to characterize the crystallographic changes associated with fish senility. Our results showed that trabecular microstructures in hyperostotic bones were consistent with estimated values of the per cent bone volume-to-total volume ratio ( BV/ TV) and were greater than 60% in cortical bone. Hyperostotic bones indicated a high radiograph density, and X-ray diffractograms showed a decrease in hydroxyapatite [Ca10( PO4)6( OH)2] and calcite (Ca CO3) neocrystallization. These crystalline and density changes revealed an advanced stage of fish senile and indicate the vulnerability of ageing fish populations. [ABSTRACT FROM AUTHOR]

This paper aims to detect memory loss of the symmetry of blockades in ducts and how far the information on the asymmetry of the obstacles travels in the turbulent flow from computational simulations with OpenFOAM. From a practical point of view, it seeks alternatives to detect the formation of obstructions in pipelines. The numerical solutions of the Navier-Stokes equations were obtained through the solver PisoFOAM of the OpenFOAM library, using the large Eddy simulation (LES) for the turbulent model. Obstructions were placed near the duct inlet and, keeping the blockade ratio fixed, five combinations for the obstacles sizes were adopted. The results show that the information about the symmetry is preserved for a larger distance near the ducts wall than in mid-channel. For an inlet velocity of 5m/s near the walls the memory is kept up to distance 40 times the duct width, while in mid-channel this distance is reduced almost by half. The maximum distance in which the symmetry breaking memory is preserved shows sensitivity to Reynolds number variations in regions near the duct walls, while in the mid channel that variations do not cause relevant effects to the velocity distribution. [ABSTRACT FROM AUTHOR]

Aim To evaluate the effect of depth of insertion of an irrigation needle tip on the removal of hard-tissue debris using micro-computed tomographic (micro- CT) imaging. Methodology Twenty isthmus-containing mesial roots of mandibular molars were anatomically matched based on similar morphological dimensions using micro- CT evaluation and assigned to two groups ( n = 10), according to the depth of the irrigation needle tip during biomechanical preparation: 1 or 5 mm short of the working length ( WL). The preparation was performed with Reciproc R25 file (tip size 25, .08 taper) and 5.25% Na OCl as irrigant. The final rinse was 17% EDTA followed by bidistilled water. Then, specimens were scanned again, and the matched images of the canals, before and after preparation, were examined to quantify the amount of hard-tissue debris, expressed as the percentage volume of the initial root canal volume. Data were compared statistically using the Mann-Whitney U-test. Results None of the tested needle insertion depths yielded root canals completely free from hard-tissue debris. The insertion depth exerted a significant influence on debris removal, with a significant reduction in the percentage volume of hard-tissue debris when the needle was inserted 1 mm short of the WL ( P < 0.05). Conclusions The insertion depth of irrigation needles significantly influenced the removal of hard-tissue debris. A needle tip positioned 1 mm short of the WL resulted in percentage levels of hard-tissue debris removal almost three times higher than when positioned 5 mm from the WL. [ABSTRACT FROM AUTHOR]

Aim To evaluate, using a novel micro- CT approach, the solubility and dimensional changes of an MTA-based sealer inside the root canal system after a solubility challenge. The MTA-based material ( MTA Fillapex) was compared to a gold standard epoxy-based endodontic sealer ( AH Plus). Methodology Ten human mandibular premolars with a single canal were divided randomly into two groups ( n = 5) according to the sealer used. The canals were instrumented using the Reciproc System ( VDW) with a R40 file and filled with R40 gutta-percha cones and one of the sealers. The filled canals were immediately scanned in a micro- CT, and after that, the teeth were immersed in 20 mL phosphate-buffered saline ( PBS) at 37 °C for 7 days, when they were removed and rescanned. Final image stacks were registered against the initial stacks and the numerical difference between the initial and final volume of the filling material was obtained. Calculations were performed to identify dimensional changes of the filling material. All image stacks were 3D rendered to disclose areas of dislocation of the filling material inside or outside the root canal. The Shapiro-Wilk's test revealed that data were normally distributed; thus, the Student's t-test was used to detect statistically significant changes, assuming a 5% α-error. Results No significant changes were seen for the percentage volume of material lost after the solubility challenge for both AH Plus and MTA Fillapex groups (1.44% and 1.16%, respectively). A significant difference was, however, found for the volume of filling material which revealed dimensional changes after the solubility test (6.68% for MTA Fillapex and 1.09% for AH Plus). In fact, observation of 3D models disclosed that MTA Fillapex was associated with material extrusion through the foramen in all but one sample. In AH Plus filled samples, no material extrusion was detected. Conclusions Although the solubility of both sealers was similar using this novel micro- CT approach, MTA Fillapex was associated with significant dimensional changes related to material extrusion through the apex after PBS storage compared to AH Plus. [ABSTRACT FROM AUTHOR]

We calculate the power spectral density and velocity correlations for a turbulent flow of a fluid inside a duct. Turbulence is induced by obstructions placed near the entrance of the flow. The power spectral density is obtained for several points at cross-sections along the duct axis, and an analysis is made on the way the spectra changes according to the distance to the obstruction. We show that the differences on the power spectral density are important in the lower frequency range, while in the higher frequency range, the spectra are very similar to each other. Our results suggest the use of the changes on the low frequency power spectral density to identify the occurrence of obstructions in pipelines. Our results show some frequency regions where the power spectral density behaves according to the Kolmogorov hypothesis. At the same time, the calculation of the power spectral densities at increasing distances from the obstructions indicates an energy cascade where the spectra evolves in frequency space by spreading the frequency amplitude. [ABSTRACT FROM AUTHOR]

Copyright of Evidência is the property of Evidencia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Brazilian Journal of Soccer Science / Revista Brasileira de Futebol is the property of Revista Brasileira de Futebol and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Chemotherapy-induced mucositis is an important dose-limiting and costly side effect for which there is no definitive prophylaxis or treatment. This is due in part to the lack of understanding of its pathophysiology and impact on intestinal function. The objectives of this study were to investigate the small intestine barrier function and electrolyte and water transport in an experimental model of methotrexate-induced mucositis, and to correlate these alterations with histological damage. Wistar rats were treated with methotrexate (1.5-3.5 mg/kg) for 3 days to induce mucositis. Intestinal permeability was measured by the urinary excretion rate of lactulose and mannitol following administration by gavage. Intestinal perfusion was performed in vivo for evaluation of water and electrolyte transports. Methotrexate-treated rats lost a significant amount of weight and presented a marked reduction in food intake. Methotrexate induced significant and dose-dependent villous atrophy and elongation of crypts in duodenum, jejunum, and ileum. Methotrexate also induced an increase in sodium and potassium secretion and an important reduction of the mucosa absorptive surface area, shown by the decrease in the mannitol excretion ratio. In conclusion, methotrexate caused major changes in small bowel function by disrupting intestinal permeability and inducing electrolyte secretion in parallel with substantial histological damage. [ABSTRACT FROM AUTHOR]

Accurate projections of marine particle export production (EP) are crucial for predicting the response of the marine carbon cycle to climate change, yet models show a wide range in both global EP and their responses to climate change. This is, in part, due to EP being the net result of a series of processes, starting with net primary production (NPP) in the sunlit upper ocean, followed by the formation of particulate organic matter and the subsequent sinking and remineralization of these particles, with each of these processes responding differently to changes in environmental conditions. Here, we compare future projections in EP over the 21st century, generated by four marine ecosystem models under IPCC's high emission scenario RCP8.5, and determine the processes driving these changes. The models simulate small to modest decreases in global EP between -1 and -12%. Models differ greatly with regard to the drivers causing these changes. Among them, the formation of particles is the most uncertain process with models not agreeing on either magnitude or the direction of change. The removal of the sinking particles by remineralization is simulated to increase in the low and intermediate latitudes in three models, driven by either warming-induced increases in remineralization or slower particle sinking, and show insignificant changes in the remaining model. Changes in ecosystem structure, particularly the relative role of diatoms matters as well, as diatoms produce larger and denser particles that sink faster and are partly protected from remineralization. Also this controlling factor is afflicted with high uncertainties, particularly since the models differ already substantially with regard to both the initial (present-day) distribution of diatoms (between 11-94% in the Southern Ocean) and the diatom contribution to particle formation (0.6-3.8 times lower/higher than their contribution to biomass). As a consequence, changes in diatom concentration are a strong driver for EP changes in some models but of low significance in others. Observational and experimental constraints on ecosystem structure and how the fixed carbon is routed through the ecosystem to produce export production are urgently needed in order to improve current generation ecosystem models and their ability to project future changes. [ABSTRACT FROM AUTHOR]

Past model studies have projected a global decrease in marine net primary production (NPP) over the 21st century, but these studies focused on the multi-model mean rather than on the large inter-model differences. Here, we analyze model-simulated changes in NPP for the 21st century under IPCC's high-emission scenario RCP8.5. We use a suite of nine coupled carbon-climate Earth system models with embedded marine ecosystem models and focus on the spread between the different models and the underlying reasons. Globally, NPP decreases in five out of the nine models over the course of the 21st century, while three show no significant trend and one even simulates an increase. The largest model spread occurs in the low latitudes (between 30° S and 30° N), with individual models simulating relative changes between -25 and +40 %. Of the seven models diagnosing a net decrease in NPP in the low latitudes, only three simulate this to be a consequence of the classical interpretation, i.e., a stronger nutrient limitation due to increased stratification leading to reduced phytoplankton growth. In the other four, warming-induced increases in phytoplankton growth outbalance the stronger nutrient limitation. However, temperaturedriven increases in grazing and other loss processes cause a net decrease in phytoplankton biomass and reduce NPP despite higher growth rates. One model projects a strong increase in NPP in the low latitudes, caused by an intensification of the microbial loop, while NPP in the remaining model changes by less than 0.5 %. While models consistently project increases NPP in the Southern Ocean, the regional inter-model range is also very substantial. In most models, this increase in NPP is driven by temperature, but it is also modulated by changes in light, macronutrients and iron as well as grazing. Overall, current projections of future changes in global marine NPP are subject to large uncertainties and necessitate a dedicated and sustained effort to improve the models and the concepts and data that guide their development. [ABSTRACT FROM AUTHOR]

We use an eddy-resolving, regional ocean biogeochemical model to investigate the main variables and processes responsible for the climatological spatio-temporal variability of pCO2 and the air-sea CO2 fluxes in the southwestern Atlantic Ocean. Overall, the region acts as sink of atmospheric CO2 south of 30° S, and is close to equilibrium with the atmospheric CO2 to the north. On the shelves, the ocean acts as a weak source of CO2, except for the mid/outer shelves of Patagonia, which act as sinks. In contrast, the inner shelves and the low latitude open ocean of the southwestern Atlantic represent source regions. Observed nearshore-to-offshore and meridional pCO2 gradients are well represented by our simulation. A sensitivity analysis shows the importance of the counteracting effects of temperature and dissolved inorganic carbon (DIC) in controlling the seasonal variability of pCO2. Biological production and solubility are the main processes regulating pCO2, with biological production being particularly important on the shelf regions. The role of mixing/stratification in modulating DIC, and therefore surface pCO2 is shown in a vertical profile at the location of the Ocean Observatories Initiative (OOI) site in the Argentine Basin (42° S, 42° W). [ABSTRACT FROM AUTHOR]

We use an eddy-resolving, regional ocean biogeochemical model to investigate the main variables and processes responsible for the climatological spatio-temporal variability of pCO2 and the air-sea CO2 fluxes in the southwestern Atlantic Ocean. Overall, the region acts as a sink of atmospheric CO2 south of 30 S, and is close to equilibrium with the atmospheric CO2 to the north. On the shelves, the ocean acts as a weak source of CO2, except for the mid/outer shelves of Patagonia, which act as sinks. In contrast, the inner shelves and the low latitude open ocean of the southwestern Atlantic represent source regions. Observed nearshoreto- offshore and meridional pCO2 gradients are well represented by our simulation. A sensitivity analysis shows the importance of the counteracting effects of temperature and dissolved inorganic carbon (DIC) in controlling the seasonal variability of pCO2. Biological production and solubility are the main processes regulating pCO2, with biological production being particularly important on the shelves. The role of mixing/stratification in modulating DIC, and therefore surface pCO2, is shown in a vertical profile at the location of the Ocean Observatories Initiative (OOI) site in the Argentine Basin (42° S, 42° W). [ABSTRACT FROM AUTHOR]

Background Type 1 narcolepsy is a neurological disorder characterized by excessive daytime sleepiness and cataplexy associated with the HLA allele DQB1*06:02. Genetic predisposition along with external triggering factors may drive autoimmune responses, ultimately leading to the selective loss of hypocretin-positive neurons. Objective The aim of this study was to investigate potential aetiological factors in Swedish cases of postvaccination (Pandemrix) narcolepsy defined by interferon-gamma ( IFNγ) production from immune cells in response to molecularly defined targets. Methods Cellular reactivity defined by IFNγ production was examined in blood from 38 ( HLA- DQB1*06:02+) Pandemrix-vaccinated narcolepsy cases and 76 (23 HLA- DQB1*06:02+ and 53 HLA- DQB1*06:02−) control subjects, matched for age, sex and exposure, using a variety of different antigens: β-haemolytic group A streptococcal ( GAS) antigens (M5, M6 and streptodornase B), influenza (the pandemic A/H1N1/California/7/09 NYMC X-179A and A/H1N1/California/7/09 NYMC X-181 vaccine antigens, previous Flu-A and -B vaccine targets, A/H1N1/Brisbane/59/2007, A/H1N1/Solomon Islands/3/2006, A/H3N2/Uruguay/716/2007, A/H3N2/Wisconsin/67/2005, A/H5N1/Vietnam/1203/2004 and B/Malaysia/2506/2004), noninfluenza viral targets ( CMVpp65, EBNA-1 and EBNA-3) and auto-antigens (hypocretin peptide, Tribbles homolog 2 peptide cocktail and extract from rat hypothalamus tissue). Results IFN-γ production was significantly increased in whole blood from narcolepsy cases in response to streptococcus serotype M6 ( P = 0.0065) and streptodornase B protein ( P = 0.0050). T-cell recognition of M6 and streptodornase B was confirmed at the single-cell level by intracellular cytokine ( IL-2, IFNγ, tumour necrosis factor-alpha and IL-17) production after stimulation with synthetic M6 or streptodornase B peptides. Significantly, higher ( P = 0.02) titres of serum antistreptolysin O were observed in narcolepsy cases, compared to vaccinated controls. Conclusion β-haemolytic GAS may be involved in triggering autoimmune responses in patients who developed narcolepsy symptoms after vaccination with Pandemrix in Sweden, characterized by a Streptococcus pyogenes M-type-specific IFN-γ cellular immune response. [ABSTRACT FROM AUTHOR]

We use a suite of eight ocean biogeochemical/ecological general circulation models from the Marine Ecosystem Model Intercomparison Project and Coupled Model Intercomparison Project Phase 5 archives to explore the relative roles of changes in winds (positive trend of Southern Annular Mode, SAM) and in warming- and freshening-driven trends of upper ocean stratification in altering export production and CO2 uptake in the Southern Ocean at the end of the 21st century. The investigated models simulate a broad range of responses to climate change, with no agreement on a dominance of either the SAM or the warming signal south of 44°S. In the southernmost zone, i.e., south of 58°S, they concur on an increase of biological export production, while between 44 and 58°S the models lack consensus on the sign of change in export. Yet in both regions, the models show an enhanced CO2 uptake during spring and summer. This is due to a larger CO2(aq) drawdown by the same amount of summer export production at a higher Revelle factor at the end of the 21st century. This strongly increases the importance of the biological carbon pump in the entire Southern Ocean. In the temperate zone, between 30 and 44°S, all models show a predominance of the warming signal and a nutrient-driven reduction of export production. As a consequence, the share of the regions south of 44°S to the total uptake of the Southern Ocean south of 30°S is projected to increase at the end of the 21st century from 47 to 66% with a commensurable decrease to the north. Despite this major reorganization of the meridional distribution of the major regions of uptake, the total uptake increases largely in line with the rising atmospheric CO2. Simulations with the MITgcm-REcoM2 model show that this is mostly driven by the strong increase of atmospheric CO2, with the climate-driven changes of natural CO2 exchange offsetting that trend only to a limited degree (∼10%) and with negligible impact of climate effects on anthropogenic CO2 uptake when integrated over a full annual cycle south of 30°S. [ABSTRACT FROM AUTHOR]

Current global inventories of ammonia emissions identify the ocean as the largest natural source. This source depends on seawater pH, temperature, and the concentration of total seawater ammonia (NH x(sw)), which reflects a balance between remineralization of organic matter, uptake by plankton, and nitrification. Here we compare [NH x(sw)] from two global ocean biogeochemical models (BEC and COBALT) against extensive ocean observations. Simulated [NH x(sw)] are generally biased high. Improved simulation can be achieved in COBALT by increasing the plankton affinity for NH x within observed ranges. The resulting global ocean emissions is 2.5 TgN a−1, much lower than current literature values (7-23 TgN a−1), including the widely used Global Emissions InitiAtive (GEIA) inventory (8 TgN a−1). Such a weak ocean source implies that continental sources contribute more than half of atmospheric NH x over most of the ocean in the Northern Hemisphere. Ammonia emitted from oceanic sources is insufficient to neutralize sulfate aerosol acidity, consistent with observations. There is evidence over the Equatorial Pacific for a missing source of atmospheric ammonia that could be due to photolysis of marine organic nitrogen at the ocean surface or in the atmosphere. Accommodating this possible missing source yields a global ocean emission of ammonia in the range 2-5 TgN a−1, comparable in magnitude to other natural sources from open fires and soils. [ABSTRACT FROM AUTHOR]

We use an eddy-resolving, regional ocean biogeochemical model to investigate the main variables and processes responsible for the climatological spatio-temporal variability of pCO2 and the air--sea CO2 fluxes in the southwestern Atlantic Ocean. Overall, the region acts as sink of atmospheric CO2 south of 30° S, and is close to equilibrium with the atmospheric CO2 to the north. On the shelves, the ocean acts as a weak source of CO2, except for the mid/outer shelves of Patagonia, which act as sinks. In contrast, the inner shelves and the low latitude open ocean of the southwestern Atlantic represent source regions. Observed nearshore-to-offshore and meridional pCO2 gradients are well represented by our simulation. A sensitivity analysis shows the importance of the counteracting effects of temperature and dissolved inorganic carbon (DIC) in controlling the seasonal variability of pCO2. Biological production and solubility are the main processes regulating pCO2, with biological production being particularly important on the shelf regions. The role of mixing/stratification in modulating DIC, and therefore surface pCO2 is shown in a vertical profile at the location of the Ocean Observatories Initiative (OOI) site in the Argentine Basin (42° S, 42° W). [ABSTRACT FROM AUTHOR]