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Background: In Brazil, the most relevant scorpions for public health are species of the genus Tityus: T. serrulatus, T. bahiensis, T. obscurus and T. stigmurus, the latter occurring mainly in Ceará, showing that severe cases affect more the population at risk, children under 14 years old. Objectives: The survey aims to identify what are the clinical and laboratory changes in children and teenagers affected by scorpion bites, as well as predictive factors in severe cases. Methods: This is an observational, retrospective and quantitative study of poisoning by scorpion accidents attended and notified by the Toxicological Assistance Center of Fortaleza (CIATOX / CE) from January to December 2019. Results: 820 records were diverted, in which 425 (51.83%) women were killed, of which only 3 (0.37%) were pregnant. Regarding the age group, 1-3 years old is more frequent, 183 (22.32%). The species T. stigmurus 534 cases, (65.12%), the feet region 271 cases (33.04%); the origin of the municipality of Fortaleza 773 (94.15%) and the regional II 122 cases (15.78%) had higher occurrences. Of the 820 cases, only 12 underwent laboratory tests, showing changes such as leukocytosis leukocytosis (72.7%), platelets (63.6%), hyperglycemia (83.3%), TGO (100%), LDH (100%), CK - MB (100%) and Amylase (30%). Conclusion: It was found that the epidemiological, clinical and laboratory profile of children and adolescentes is associated with the severity of scorpionism, which indicates an emergency characteristic, especially when it affects children. [ABSTRACT FROM AUTHOR]

Gastroesophageal Reflux Disease (GRD) is the most common form of esophagitis, where proton pump inhibitors are the most widely used drugs. This study aimed to perform a literature review about the clinical use and adverse reactions of proton pump inhibitors (PPIs). Treatment of GRD evolved in the 1970s, when the first PPI, timoprazole, was discovered and in 1979, omeprazole originated, with a high action on the proton bomb. The most potent drugs in gastric suppression are proton pump inhibitors where they act irreversibly in the proton pump H+, K+, - ATPase, the suppression of acid secretion lasts for 24-48 hr. PPIs with prolonged use are associated with changes in the intestinal microbiota, which can be compared to changes seen with antimicrobials, in addition to altering the absorption of iron and Vitamin B12 and the metabolism of calcium and magnesium. The population most susceptible to the appearance of the side effects of PPIs is the elderly, age is a factor that predisposes to the appearance of various pathologies and it is necessary to use many medications thus constituting a polypharmacy, in addition, may increase the risks of drug toxicity due to the hepatic metabolism of the elderly being compromised, this is a worrying condition, as it can cause, in addition to the side effects of PPIs, drug interactions, making pharmacotherapeutic follow-up essential, thus being able to make dose adjustments and assess possible drug-related problems and adverse drug reactions. [ABSTRACT FROM AUTHOR]