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The origin of propylitic fluids in intermediate sulfidation mineralization has not been investigated in detail. Here, we present an extensive petrographic, geochemical, and isotopic (O-H-Sr) study of propylitic epidote, chlorite, and calcite from the Zhengguang intermediate sulfidation epithermal Au-Zn deposit, NE China. Propylitic minerals can be divided into three main types based on their different textural occurrences, namely interstitial cement of clasts of hydrothermal breccia, replacement of primary plagioclase or hornblende, and vein infill of cracks, with late, minor calcite as amygdules in vesicles of andesite representing a fourth textural occurrence. The H-O isotope compositions and mass balance calculations suggest that most propylitic epidote records a dominant (> 50%) contribution of magmatic fluids. The decrease of the average δ18 O H 2 O values equilibrated with different types of epidote (cement 6.8 ± 0.7‰, replacement 5.1 ± 1.1‰, vein 4.5 ± 1.4‰, 1 SD), and the decreasing content of high-temperature elements (e.g., Cu-Mo) from cement, through replacement to vein epidote and chlorite, collectively indicates a decreasing role of magmatic fluids. Replacement epidote and chlorite are enriched in Sr-Mn-Y-Sb, whereas replacement epidote and calcite record similar (87Sr/86Sr)i values to the andesitic host rock, suggesting that replacement minerals inherit certain elements from plagioclase and hornblende, and the Sr isotope signature of the wall rocks. We highlight that propylitic alteration in epithermal deposits can involve significant proportions of magmatic fluids and texturally different alteration mineral types should be considered when using mineral isotopic or chemical compositions to track fluid sources or to vector towards the location of intrusive centers. [ABSTRACT FROM AUTHOR]

The Kulagangri Dome is located at the eastern part of the Himalayan metallogenic belt. Based on the 1 :50 000 mineral geological mapping and sparse surface engineering, the Gabo pegmatite-type lithium deposit was firstly found at the eastern part of the Kulagangri Dome. Ore-bearing spodumene pegmatite dikes are generally hosted by the marble in the middle unit of the dome, with length ranging from 1 m to 1 200 m, and width ranging from 0. 8 m to 40 m. The main lithium containing minerals in the spodumene pegmatite are spodumene, elbaite and lepidolite. At present, two main Li mineralization zones are controlled by 5 surface engineering. The mineralization zone I is about 2 km long, and includes 2 main orebodies (K1 and K2). The mineralization zone II is about 700 m long, and include one main orebody (K3). The K1 orebody is about 1 200 m long and 5 ~ 40 m thick, with an average thickness of about 20 m. The K2 and K3 orebodies occur as the large lenticular shape, with strike extension >100~600 m and thickness 15~50 m. The total thickness of K2 orebody is 45. 3 m. The average grade of Li2O, Rb2O and BeO is 1.11%, 0.064% and 0.047%, respectively. The newly discovered Gabo lithium deposit is dominated by Li, Be and Rb, associated with Nb, Ta, Cs, W and Sn. Based on the geological survey results, the Gabo lithium deposit is large in scale, and showing considerable potential for further prospecting in the area. The discovery of Gabo lithium deposit is another breakthrough in the exploration of rare metals in the Himalayan metallogenic belt, which is of great significant role in further understanding of the tectono-magmatic evolution and rare metal mineralization in the Cenozoic Himalaya, and further enriching the theory of collisional orogenesis and mineralization in the southern Qinghai-Tibet Plateau. [ABSTRACT FROM AUTHOR]

Background. Immunotherapy has been considered as a promising cancer treatment for hepatocellular carcinoma (HCC). However, due to the particular immune environment of the liver, identifying patients who could benefit from immunotherapy is critical in clinical practice. Methods. The pyroptosis gene expression database of 54 candidates from The Cancer Genome Atlas (TCGA) were collected to discover the critical prognostic-related pyroptosis genes. A novel pyroptosis gene model was established to calculate the risk score. Kaplan–Meier analysis and receiver operating characteristic curve (ROC) were used to verify its predictive ability. The International Cancer Genome Consortium (ICGC) data was collected as external validation data to verify the model's accuracy. We employed multiple bioinformatics tools and algorithms to evaluate the tumor immune microenvironment (TIME) and the response to immunotherapy. Results. Our study found that most pyroptosis genes were expressed differently in normal and tumor tissues and that their expression was associated with the prognosis. Then, a precise four-pyroptosis gene model was generated. The one-year area under the curves (AUCs) among the training, internal, and external validation patients were 0.901, 0.727, and 0.671, respectively. An analysis of survival data revealed that individuals had a worse prognosis than patients with low risk. The analysis of TIME revealed that the low-risk group had more antitumor cells, fewer immunosuppressive cells, stronger immune function, less immune checkpoint gene expression, and better immunotherapy response than the high-risk group. Immunophenoscore (IPS) analysis also demonstrated that the low-risk score was related to superior immune checkpoint inhibitors therapy. Conclusion. A nomogram based on the four-pyroptosis gene signature was a novel tool to predict the effectiveness of immunotherapy for HCC. Therefore, individualized treatment targeting the pyroptosis genes may influence TIME and play an essential role in improving the prognosis in HCC patients. [ABSTRACT FROM AUTHOR]

Background: Mesenchymal stem cells (MSCs) have important research value and broad application prospects in liver diseases. This study aims to comprehensively review the cooperation and influence of countries, institutions, authors, and journals in the field of MSCs in liver diseases from the perspective of bibliometrics, evaluate the clustering evolution of knowledge structure, and discover hot trends and emerging topics. Methods: The articles and reviews related to MSCs in liver diseases were retrieved from the Web of Science Core Collection using Topic Search. A bibliometric study was performed using CiteSpace and VOSviewer. Results: A total of 3404 articles and reviews were included over the period 2001-2021. The number of articles regarding MSCs in liver diseases showed an increasing trend. These publications mainly come from 3251 institutions in 113 countries led by China and the USA. Li L published the most papers among the publications, while Pittenger MF had the most co-citations. Analysis of the most productive journals shows that most are specialized in medical research, experimental medicine and cell biology, and cell & tissue engineering. The macroscopical sketch and micro-representation of the whole knowledge field are realized through co-citation analysis. Liver scaffold, MSC therapy, extracellular vesicle, and others are current and developing areas of the study. The keywords "machine perfusion", "liver transplantation", and "microRNAs" also may be the focus of new trends and future research. Conclusions: In this study, bibliometrics and visual methods were used to review the research of MSCs in liver diseases comprehensively. This paper will help scholars better understand the dynamic evolution of the application of MSCs in liver diseases and point out the direction for future research. [ABSTRACT FROM AUTHOR]

Background: The prognostic value of m6A-related genes in hepatocellular carcinoma (HCC) and its correlation with the immune microenvironment still requires further investigation. Methods: Consensus clustering by m6A related genes was used to classify 374 patients with HCC from The Cancer Genome Atlas (TCGA) database. Then we performed the least absolute shrinkage and selection operator (LASSO) to construct the m6A related genes model. The International Cancer Genome Consortium (ICGC) and Gene Expression Omnibus (GEO) datasets were used to verify and evaluate the model. ESTIMATE, CIBERSORTx, the expression levels of immune checkpoint genes, and TIDE were used to investigate the tumor microenvironment (TME) and the response to immunotherapy. Gene set enrichment analyses (GSEA), tumor-associated macrophages (TAMs), and gene-drug sensitivity were also analyzed. Results: By expression value and regression coefficient of five m6A related genes, we constructed the risk score of each patient. The patients with a higher risk score had a considerably poorer prognosis in the primary and validated cohort. For further discussing TME and the response to immunotherapy, we divided the entire set into two groups based on the risk score. Our findings implied that the tumor-infiltrating lymphocytes (TILs) were proportional to the risk scores, which seemed to contradict that patients with higher scores had a poor prognosis. Further, we found that the high-risk group had higher expression of PD-L1, CTLA-4, and PDCD1, indicating immune dysfunction, which may be a fundamental reason for poor prognosis. This was further reinforced by the fact that the low-risk group responded better than the high-risk group to monotherapy and combination therapy. Conclusion: The m6A related risk score is a new independent prognostic factor that correlates with immunotherapy response. It can provide a new therapeutic strategy for improving individual immunotherapy in HCC. [ABSTRACT FROM AUTHOR]

Background Few safety and effectiveness results have been published regarding the administration of tenofovir alafenamide fumarate (TAF) during pregnancy for the prevention of mother-to-child transmission (MTCT) of hepatitis B virus (HBV). Methods In this multicenter prospective observational study, pregnant women with HBV DNA levels higher than 200 000 IU/mL who received TAF or tenofovir disoproxil fumarate (TDF) from gestational weeks 24–35 to delivery were 1:1 enrolled and followed until postpartum month 6. Infants received immunoprophylaxis. The primary endpoint was the safety of mothers and infants. The secondary endpoint was the hepatitis B surface antigen (HBsAg)-positive rate at 7 months for infants. Results In total, 116 and 116 mothers were enrolled, and 117 and 116 infants were born, in the TAF and TDF groups, respectively. TAF was well tolerated during a mean treatment duration of 11.0 weeks. The most common maternal adverse event was nausea (19.0%). One (0.9%), 3 (2.6%), and 9 (7.8%) mothers had abnormal alanine aminotransferase levels at delivery and at postpartum months 3 and 6, respectively. The TDF group had safety profiles that were comparable to those of the TAF group. No infants had birth defects in either group. The infants' physical and neurological development at birth and at 7 months in the TAF group were comparable with those in the TDF group. The HBsAg positive rate was 0% at 7 months in all 233 infants. Conclusions Antiviral prophylaxis with TAF was determined to be generally safe for both mothers and infants and reduced the MTCT rate to 0%. [ABSTRACT FROM AUTHOR]

Background: Liver injuries have been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical role played by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Methods: In this multicentre, retrospective study, the parameters of liver function tests in COVID-19 inpatients were compared between various time-points in reference to SARS-CoV-2 shedding, and 3 to 7 days before the first detection of viral shedding was regarded as the reference baseline.Results: In total, 70 COVID-19 inpatients were enrolled. Twenty-two (31.4%) patients had a self-medication history after illness. At baseline, 10 (14.3%), 7 (10%), 9 (12.9%), 2 (2.9%), 15 (21.4%), and 4 (5.7%) patients already had abnormal alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin, and total bilirubin (TBIL) values, respectively. ALT and AST abnormal rates and levels did not show any significant dynamic changes during the full period of viral shedding (all p > 0.05). The GGT abnormal rate (p = 0.008) and level (p = 0.033) significantly increased on day 10 of viral shedding. Meanwhile, no simultaneous significant increases in abnormal ALP rates and levels were observed. TBIL abnormal rates and levels significantly increased on days 1 and 5 of viral shedding (all p < 0.05). Albumin abnormal decrease rates increased, and levels decreased consistently from baseline to SARS-CoV-2 clearance day (all p < 0.05). Thirteen (18.6%) patients had chronic liver disease, two of whom died. The ALT and AST abnormal rates and levels did not increase in patients with chronic liver disease during SARS-CoV-2 shedding.Conclusions: SARS-CoV-2 does not directly lead to elevations in ALT and AST but may result in elevations in GGT and TBIL; albumin decreased extraordinarily even when SARS-CoV-2 shedding ended. [ABSTRACT FROM AUTHOR]

aimed to discover the ceRNAs network in the pathophysiological development of human colorectal cancer (CRC) and to screen biomarkers for target therapy and prognosis by using integrated bioinformatics analysis. Methods: Data on gene expressions of mRNAs, miRNAs, and circRNAs and clinical information were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases, respectively. Differentially expressed mRNAs (DEmRNAs) were identified by using the DESeq2 package of R software. Functional enrichment analysis was conducted using the ClusterProfiler package of R software. The protein–protein interaction (PPI) network was shown by the STRING website. Survival analysis of hub genes was performed using the survival package in R software. Interactions among hub genes, differentially expressed miRNAs (DEmiRNAs), and differentially expressed circRNAs (DEcircRNAs) were used to construct the ceRNAs network. Results: A total of 412 DEmRNAs including 82 upregulated and 330 downregulated genes were screened out between 473 CRC and 41 normal samples. Two hundred and sixty DEcircRNAs including 253 upregulated and 7 downregulated genes were altered between 23 CRC and 23 normal samples. One hundred and ninety DEmiRNAs including 82 upregulated and 108 downregulated genes were obtained between 450 CRC and 8 normal samples. A ceRNAs and PPI network were successfully constructed, and TIMP1 associated with prognosis was employed. Conclusion: The present study identified a novel circRNAs-miRNAs-mRNA ceRNAs network, which implied that TIMP1 and related miRNAs, circRNAs were potential biomarkers underlying the development of CRC, providing new insights for survival predictions and therapeutic targets. [ABSTRACT FROM AUTHOR]

We present in‐situ zircon laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS) U–Pb ages, whole‐rock geochemistry, and Sr–Nd–Pb–Hf isotopes of the Mugagangri monzogranite in the southern margin of the Qiangtang Block, Tibet, western China. The zircons yield a U–Pb age of ca. 123 Ma. The hornblende‐bearing monzogranite shows metaluminous to weak peraluminous and high‐K calc‐alkaline characteristics exemplified by high silica (SiO2 = 67.57–70.57 wt%), high aluminium (Al2O3 = 14.68–15.78 wt%), high potassium (K2O = 4.00–5.14 wt%), high alkali (K2O + Na2O = 7.88–8.62 wt%), and low calcium contents (CaO = 1.72–2.17 wt%), with the aluminium saturation index (A/CNK) ranging from 0.98 to 1.09, suggesting that the Mugagangri monzogranite is a metaluminous to weak peraluminous I‐type high‐K calc‐alkaline granite. Geochemically, similar to the arc magmas, the monzogranite is enriched in large‐ion lithophile elements, and relatively depleted in high‐field‐strength elements. The monzogranite displays relatively high (87Sr/86Sr)i values (0.70972–0.71240), uniform εNd(t) values (−2.24 to −3.40), variable zircon εHf(t) values (−14.1 to +8.0), and high radiogenic Pb isotopic values (206Pb/204Pb = 18.588–18.790, 207Pb/204Pb = 15.616–15.642, and 208Pb/204Pb = 38.838–39.053). These geochemical characteristics indicate that the monzogranite was derived from a mixed source comprising ancient crustal and mantle materials, and experienced fractional crystallization during emplacement. We propose that the parental magma of the Mugagangri monzogranite was most likely generated during northward subduction of the Bangong Co‐Nujiang Meso‐Tethys Ocean. [ABSTRACT FROM AUTHOR]

Background: Chronic rejection characterized by chronic allograft vasculopathy (CAV) remains a major obstacle to long-term graft survival. Due to multiple complicated mechanisms involved, a novel therapy for CAV remains exploration. Although mesenchymal stromal cells (MSCs) have been ubiquitously applied to various refractory immune-related diseases, rare research makes a thorough inquiry in CAV. Meanwhile, melatonin (MT), a wide spectrum of immunomodulator, plays a non-negligible role in transplantation immunity. Here, we have investigated the synergistic effects of MT in combination with MSCs in attenuation of CAV. Methods: C57BL/6 (B6) mouse recipients receiving BALB/c mouse donor aorta transplantation have been treated with MT and/or adipose-derived MSCs. Graft pathological changes, intragraft immunocyte infiltration, splenic immune cell populations, circulating donor-specific antibodies levels, cytokine profiles were detected on post-operative day 40. The proliferation capacity of CD4+ and CD8+ T cells, populations of Th1, Th17, and Tregs were also assessed in vitro. Results: Grafts in untreated recipients developed a typical pathological feature of CAV characterized by intimal thickening 40 days after transplantation. Compared to untreated and monotherapy groups, MT in combination with MSCs effectively ameliorated pathological changes of aorta grafts indicated by markedly decreased levels of intimal hyperplasia and the infiltration of CD4+ cells, CD8+ cells, and macrophages, but elevated infiltration of Foxp3+ cells. MT either alone or in combination with MSCs effectively inhibited the proliferation of T cells, decreased populations of Th1 and Th17 cells, but increased the proportion of Tregs in vitro. MT synergized with MSCs displayed much fewer splenic populations of CD4+ and CD8+ T cells, Th1 cells, Th17 cells, CD4+ central memory T cells (Tcm), as well as effector memory T cells (Tem) in aorta transplant recipients. In addition, the percentage of splenic Tregs was substantially increased in the combination therapy group. Furthermore, MT combined with MSCs markedly reduced serum levels of circulating allospecific IgG and IgM, as well as decreased the levels of pro-inflammatory IFN-γ, TNF-α, IL-1β, IL-6, IL-17A, and MCP-1, but increased the level of IL-10 in the recipients. Conclusions: These data suggest that MT has synergy with MSCs to markedly attenuate CAV and provide a novel therapeutic strategy to improve the long-term allograft acceptance in transplant recipients. [ABSTRACT FROM AUTHOR]

This study investigates apatite and anhydrite inclusions in zircon from ore-forming intrusions in the Duolong porphyry Cu-Au deposit, central Tibet (Fig. 2 Geological characteristics (a) and cross sections (b, c) of the Duolong porphyry Cu-Au deposit, central Tibet, showing sample locations (Li et al. [21], [25]) The Duolong magmatic complex evolved from diorite to granodiorite porphyry and quartz diorite porphyry, the hosts of Cu-Au mineralization (Fig. Apatite inclusions ( I n i = 98) in zircon from the granodiorite porphyry and quartz diorite porphyry have F contents of 1.14-2.99 wt%, Cl of 0.16-2.51 wt%, and SO SB 3 sb of 0.04-1.38 wt%, with minor SiO SB 2 sb (0.05-1.39 wt%), MnO (0.12-0.93 wt%), Na SB 2 sb O (0-0.28 wt%), and FeO (0.01-0.64 wt%; Supplementary Table 1). Apatite and anhydrite were randomly enclosed by zircon crystals, which were later hosted in ore-forming porphyries One apatite inclusion coexisting with an anhydrite inclusion in a single zircon grain contains 0.69 wt% SO SB 3 sb with a low I X i SB F sb / I X i SB Cl sb ratio of ~ 1.2 (Fig. [Extracted from the article]

Imaging jamming of inverse synthetic aperture radar (ISAR) has been studied extensively in recent decades. Among them, the periodic interrupted sampling repeater jamming (P-ISRJ) technology can generate a series of false targets through matching filtering. However, with the rapid development of anti-jamming technology, it is necessary to improve the existing periodic sampling method to achieve better jamming effects. The latest research proposes that the two-dimensional square jamming strip can be generated based on the nonperiodic interrupted sampling repeater jamming (NP-ISRJ) to cover the target. In this article, the influence of NP-ISRJ on ISAR is studied with the model of escort free-flight. A linear weighted optimization method is proposed to improve the uneven energy distribution. The experimental results show that a square jamming strip with better blanket effects can be generated under the traditional range Doppler imaging method. While for the compressed sensing imaging method, the imaging fails because the sparse condition is no longer satisfied. The validity of the proposed blanket jamming method in different ISAR imaging reconstruction methods is verified. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to discover the ceRNAs network in the pathophysiological development of human colorectal cancer (CRC) and to screen biomarkers for target therapy and prognosis by using integrated bioinformatics analysis.Methods: Data on gene expressions of mRNAs, miRNAs, and circRNAs and clinical information were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases, respectively. Differentially expressed mRNAs (DEmRNAs) were identified by using the DESeq2 package of R software. Functional enrichment analysis was conducted using the ClusterProfiler package of R software. The protein-protein interaction (PPI) network was shown by the STRING website. Survival analysis of hub genes was performed using the survival package in R software. Interactions among hub genes, differentially expressed miRNAs (DEmiRNAs), and differentially expressed circRNAs (DEcircRNAs) were used to construct the ceRNAs network.Results: A total of 412 DEmRNAs including 82 upregulated and 330 downregulated genes were screened out between 473 CRC and 41 normal samples. Two hundred and sixty DEcircRNAs including 253 upregulated and 7 downregulated genes were altered between 23 CRC and 23 normal samples. One hundred and ninety DEmiRNAs including 82 upregulated and 108 downregulated genes were obtained between 450 CRC and 8 normal samples. A ceRNAs and PPI network were successfully constructed, and TIMP1 associated with prognosis was employed.Conclusion: The present study identified a novel circRNAs-miRNAs-mRNA ceRNAs network, which implied that TIMP1 and related miRNAs, circRNAs were potential biomarkers underlying the development of CRC, providing new insights for survival predictions and therapeutic targets. [ABSTRACT FROM AUTHOR]

Currently, COVID‐19 has been reported in nearly all countries globally. To date, little is known about the viral shedding duration, clinical course and treatment efficacy of COVID‐19 near Hubei Province, China. This multicentre, retrospective study was performed in 12 hospitals in Henan and Shaanxi Provinces from 20 January to 8 February 2020. Clinical outcomes were followed up until 26 March 2020. The viral shedding duration, full clinical course and treatment efficacy were analysed in different subgroups of patients. A total of 149 COVID‐19 patients were enrolled. The median age was 42 years, and 61.1% (91) were males. Of them, 133 (89.3%) had fever, 131 of 144 (91%) had pneumonia, 27 (18.1%) required intensive care unit (ICU) management, 3 (2%) were pregnant, and 3 (2%) died. Two premature newborns were negative for SARS‐CoV‐2. In total, the median SARS‐CoV‐2 shedding period and clinical course were 12 (IQR: 9–17; mean: 13.4, 95% CI: 12.5, 14.2) and 20 (IQR: 16–24; mean: 21.2, 95% CI: 20.1, 22.3) days, respectively, and ICU patients had longer median viral shedding periods (21 [17–24] versus 11 [9–15]) and clinical courses (30 [22–33] vs. 19 [15.8–22]) than non‐ICU patients (both p <.0001). SARS‐CoV‐2 clearances occurred at least 2 days before fatality in 3 non‐survivors. Current treatment with any anti‐viral agent or combination did not present the benefit of shortening viral shedding period and clinical course (all p >.05) in real‐life settings. In conclusion, the viral shedding duration and clinical course in Henan and Shaanxi Provinces were shorter than those in Hubei Province, and current anti‐viral therapies were ineffective for shortening viral shedding duration and clinical course in real‐world settings. These findings expand our knowledge of the SARS‐CoV‐2 infection and may be helpful for management of the epidemic outbreak of COVID‐19 worldwide. Further studies concerning effective anti‐viral agents and vaccines are urgently needed. [ABSTRACT FROM AUTHOR]

The Tibetan Plateau is characterized by the largest crustal thickness on Earth, although the timing of formation of the plateau remains debated. In this study, we present in situ laser ablation‐inductively coupled plasma‐mass spectrometry zircon U–Pb ages and Hf isotopes, and whole‐rock geochemical data on porphyritic granitoids of Sebuta in the central Lhasa block. Our zircon U–Pb data indicate that these rocks emplaced at ca. 89 Ma, in the early Late Cretaceous. Geochemically, the Sebuta biotite granite porphyry can be broadly divided into two subtypes, namely metaluminous porphyry and peraluminous porphyry. The metaluminous porphyry has high SiO2, Al2O3, Sr, low Y and Yb contents, and high Sr/Y and LaN/YbN ratios, showing adakitic features. These rocks have high K2O and Th contents, low Ti/Eu and Nd/Sm ratios, indicative of a continental crust affinity. Positive zircon εHf(t) values, along with high Mg#, Cr and Ni, imply that the Sebuta adakitic porphyry was most likely derived from partial melting of a delaminated thickened juvenile lower crust, and that the initial melts interacted with mantle peridotite during ascent. The field features, petrographic characteristics, formation age, ore‐bearing potential, and Hf isotope of the peraluminous porphyry are similar to those of the Sebuta adakitic porphyry, indicating that the peraluminous porphyry was likely formed by contamination with ancient crustal material and fractional crystallization from the same primary adakitic magmas which generated the Sebuta adakitic porphyry. Residual phases of amphibole + plagioclase + garnet + rutile in the source region, together with previous studies, suggest that the crust beneath the central‐northern Lhasa block experienced thickening during the early Late Cretaceous, and had already been thickened to more than 50 km by the Late Cretaceous (ca. 89 Ma). [ABSTRACT FROM AUTHOR]

Himalayan leucogranites are widely distributed in the North Himalayan gneiss dome (NHGD) and at the top of the Greater Himalayan Crystalline Complex (GHC) and are generally controlled by detachment faults. The ages of these prekinematic, synkinematic, and postkinematic leucogranites can be used to limit the activity of detachment structures (such as the South Tibetan Detachment System, STDS). Research on the STDS activity time in the eastern Himalayas is relatively sparse. In this study, the zircon and monazite U–Th–Pb geochronology of synkinematic and postkinematic leucogranites, which are affected by the STDS and NHGD, in four areas (Lhozhag, Kuju, Xiaozhan, and Cuonadong) in Shannan City, Tibet, China, was measured. The results show that the oldest synkinematic two‐mica granite from Lhozhag, which is affected by the STDS, is 24–25 Ma, so the time of STDS activity is at or slightly earlier than 25 Ma. The youngest synkinematic leucogranite is the garnet‐bearing muscovite granite in Cuonadong at 18.4 Ma. The oldest undeformed postkinematic leucogranite (not affected by the STDS) is the muscovite granite in Xiaozhan at 17.4 Ma. Therefore, the end of STDS activity can be limited to 18.4–17.4 Ma. The STDS includes three forms: detachment fault in the NHGD (northern extension of the STDS), the inner STDS between the GHC and Tethyan Himalayan Sequence, and the outer STDS at the bottoms of synformal klippes. In this paper, the active time limits of the above three kinds of detachment zones are comprehensively summarized. Based on this work, the northward extension (ductile deformation) time of the STDS in the region is considered to be 28–17 Ma. The exhumation of the GHC is mainly controlled by in‐sequence shearing: first, the South Tibet Thrust system (predecessor of the STDS) at the top of the GHC thrust southward at 45–28 Ma, then the High Himalayan Discontinuity fault in the middle of the GHC forms south‐vergent ductile thrusts at 28–17 Ma, and finally, the Main Central Thrust at the bottom of the GHC thrust southward at 17–9 Ma. [ABSTRACT FROM AUTHOR]

Currently, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported in almost all countries globally. No effective therapy has been documented for COVID-19, and the role of convalescent plasma therapy is unknown. In the current study, 6 patients with COVID-19 and respiratory failure received convalescent plasma a median of 21.5 days after viral shedding was first detected, all tested negative for SARS-CoV-2 RNA within 3 days after infusion, and 5 eventually died. In conclusion, convalescent plasma treatment can end SARS-CoV-2 shedding but cannot reduce the mortality rate in critically ill patients with end-stage COVID-19, and treatment should be initiated earlier. [ABSTRACT FROM AUTHOR]

Currently, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported in almost all countries globally. No effective therapy has been documented for COVID-19, and the role of convalescent plasma therapy is unknown. In the current study, 6 patients with COVID-19 and respiratory failure received convalescent plasma a median of 21.5 days after viral shedding was first detected, all tested negative for SARS-CoV-2 RNA within 3 days after infusion, and 5 eventually died. In conclusion, convalescent plasma treatment can end SARS-CoV-2 shedding but cannot reduce the mortality rate in critically ill patients with end-stage COVID-19, and treatment should be initiated earlier. [ABSTRACT FROM AUTHOR]

Miocene postcollisional potassic and adakitic rocks are widely distributed in the southern Lhasa terrane and western central Lhasa terrane. However, coeval potassic and adakitic rocks in eastern central Lhasa terrane were rarely recognized, and their origins and formation mechanism remain controversial. In this paper, we provide new geochronological and geochemical data for the Miocene postcollisional potassic and adakitic intrusions exposed in the Qingdu area, eastern central Lhasa terrane, southern Tibet. The Qingdu Miocene intrusions consist of quartz monzonite porphyry and biotite granite with coeval zircon U–Pb ages of 14.1 Ma and 14.0 Ma, respectively. They have high SiO2 (67.98–75.32 wt.%), Al2O3 (14.13–14.78 wt.%), and K2O (4.06–6.18 wt.%) and low MgO (0.25–1.46 wt.%) contents. They are both enriched in light rare earth elements (LREEs) and depleted in heavy rare earth elements (HREEs), with high (La/Yb)N (25.37–42.32) ratios. The biotite granite samples have low Y (7.10–9.96 ppm) and Yb (0.61–0.85 ppm) contents, and high Sr (229–384 ppm) contents and high Sr/Y (30–41) ratios, which show adakitic geochemical characteristics, whereas the quartz monzonite porphyry samples show potassic geochemical characteristics. They display initial (87Sr/86Sr)i ratios of 0.7083–0.7103, εHf(t) values of −6.7 to −0.1, εNd(t) values of −8.96 to −7.44, (208Pb/204Pb)i ratios of 39.028–39.110, (207Pb/204Pb)i ratios of 15.662–15.684, and (206Pb/204Pb)i ratios of 18.541–18.577. These signatures indicate that both the potassic and adakitic intrusions are more likely to originate from partial melting of a thickened lower crust, which were mainly the products of the binary mixing between the juvenile and ancient crust components. Based on the spatial distributions and isotopic features of the postcollisional potassic and adakitic rocks in the Lhasa terrane, we suggest that the differences of the lower crustal composition played a crucial role in causing the geochemical variations of the Miocene postcollisional adakitic and potassic rocks in Lhasa terrane. [ABSTRACT FROM AUTHOR]

Digital false-target image synthesizer (DIS) has been proposed as a deceptive jamming method against inverse synthetic aperture radar (ISAR). The DIS method based on sub-Nyquist sampling jamming has attracted increasing attention in recent years. However, multiple false-target images generated by sub-Nyquist sampling jamming are distributed in the down-range direction rather than the 2-D range-Doppler (RD) imaging plane. A novel DIS method is proposed in this letter. First, an additional phase controlled by polyphase code is added to the intercepted pulse, and the multiple false-target images will be induced regularly along the cross-range direction. Second, in order to generate false-target images both along the down-range and cross-range directions, the sub-Nyquist sampling theory is applied to the first step. The advantage of the proposed method is implementation simplicity. Experimental results verify the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

The electromagnetic (EM) vortex imaging has been found to have a great potential application prospect in the imaging radar field. However, current studies focus on the motionless target, which seriously limits its application in practice. Therefore, to achieve EM vortex imaging for the motion target, this study proposes a parametric sparse representation model for EM vortex imaging that takes into account a translational motion target and uses the stepped frequency signal. An iterative algorithm is developed based on the sparse Bayesian learning (SBL) algorithm to estimate the velocity, and accomplish the EM vortex imaging exploiting SBL algorithm. Simulation results demonstrate that the proposed algorithm can improve velocity estimate accuracy in terms of relative error and achieve EM vortex imaging for the motion target. [ABSTRACT FROM AUTHOR]

Two DMTCNQ (DMTCNQ = 2,5‐dimethyl‐7,7,8,8‐tetracyano‐p‐quinodimethane) and DETCNQ (DETCNQ = 2,5‐diethyl‐7,7,8,8‐tetracyano‐p‐quinodimethane) gadolinium complexes [Gd(DMTCNQ)2(CH3OH)(H2O)6][DMTCNQ]·4H2O (1) and [Gd(DETCNQ)(H2O)7][2DETCNQ] (2) were synthesized by reactions of GdCl3·6H2O with Li(DMTCNQ) or Li(DETCNQ). X‐ray diffraction analysis reveals that complexes 1 and 2 are discrete complexes. The central metal atom in 1 is coordinated by two DMTCNQ ligand radicals whereas that in 2 is coordinated by just one DETCNQ ligand radical. The adjacent molecules are connected by the intermolecular hydrogen bonds to form the two‐dimensional (2D) supramolecular layer structures, which are further packed into a three‐dimensional (3D) supramolecular architecture through the π–π interactions between ligand radicals in 1 and 2. Magnetic investigation indicates that the antiferromagnetic interactions between spin carriers exists in 1 and 2. [ABSTRACT FROM AUTHOR]

The Cuonadong Dome in southern Tibet is a newly discovered gneiss dome in the Tethys Himalaya. Here, we investigate the Late Cambrian augen gneiss (orthogneiss) within the core of this dome to address the controversy surrounding early Palaeozoic tectonic evolution of the northern margin of eastern Gondwana. We report new zircon laser ablation multicollector inductively coupled plasma mass spectrometry (LA‐(MC‐)ICP‐MS) U‐Pb ages, Lu‐Hf isotopes, whole‐rock major and trace element geochemistry, and Sr‐Nd‐Pb data on representative samples from the granitic gneiss. The weighted mean of 116 analyses of zircon grains yields an age of 498.2 ± 1.5 Ma (mean square weighted deviation [MSWD] = 1.2). Forty‐one spots analyses on these grains show consistent εHf (t) values of −2 to +4 (average = +1.1), corresponding to Hf crustal model age (TDM2) of 1.3 to 1.6 Ga (average = 1.39 Ga). The orthogneiss (metagranite) is characterized by high Si and K contents, with low Al, Mg, and Ti, and A/CNK values ranging from 0.87 to 0.98 with an average of 0.92, indicating a metaluminous composition and I‐type granitoid affinity. The granitoid displays significant enrichment in light rare earth elements (LREEs) and relatively flat high rare earth element (HREE) patterns, with strong negative Eu anomalies (Eu/Eu* = 0.26–0.31). The primitive mantle‐normalized trace elements show a relative enrichment in large‐ion lithophile elements, such as Rb, and high‐field strength elements, such as Th, U, Zr, and Hf, with depletion in Ba, Nb, Ta, Sr, P, and Ti. The rocks show high initial 87Sr/86Sr ratios (0.7221–0.7248) and low εNd (t) values (−8.9 to −7.3) with Nd model ages (TDM) of 1.79–1.91 Ga. Their radiogenic Pb isotopic compositions show (206Pb/204Pb)t = 18.804–19.110, (207Pb/204Pb)t = 15.730–15.768, and (208Pb/204Pb)t = 38.409–39.054, indicating an ancient upper middle continental crustal origin. Our study shows that the protolith of the metagranite was most likely derived from the partial melting of upper continental crust with a minor contribution of depleted mantle materials. Through integration of the regional information on early Palaeozoic magmatism and metamorphic events, we contend that the protolith of the Cuonadong granitic gneiss formed in an accretionary setting associated with the early Palaeozoic Proto‐Tethys Oceanic plate subduction beneath the Gondwana continent. [ABSTRACT FROM AUTHOR]

The Lhasa terrane is one of the major segments of the Tibetan Plateau, with widespread Mesozoic to Cenozoic magmatic and metallogenic records. Here, we investigate timing and characteristics of magmatism associated with the Lunggar Fe skarn deposit in Central Lhasa. We also present Sr–Nd–Pb and Hf (zircon) isotopic data on three associated intrusions to gain insights on the tectonic and metallogenic evolution of the region. Our data reveal at least two magmatic pulses in Lunggar represented by Early Cretaceous I‐type granodiorite (112.9 ± 1.5 Ma) and granite porphyry (112.6 ± 1.3 Ma) with magma generation related to slab break‐off associated with the Bangong–Nujiang Ocean during closure of the Meso‐Tethyan ocean at ~113 Ma. Iron skarn mineralization at Lunggar was contemporaneous with local Early Cretaceous intrusive activity. Following this, Late Cretaceous adakitic diorite (90.5 ± 1.5 Ma) formed from delaminated thickened crust at ~91 Ma related to the northern subduction of the Yarlung‐Zangbo oceanic plate. We also provide a comprehensive review of the Cretaceous tectonic evolution of Central Lhasa, which trace the tectonic evolution as follows: (a) 145–120 Ma: southward subduction of the Bangong–Nujiang oceanic plate under the Lhasa terrane; (b) 120–115 Ma: Lhasa‐Qiangtang continental collision; (c) 115–110 Ma: slab break‐off of the Bangong–Nujiang Ocean; (d) 110–95 Ma: crustal thickening of the Central Lhasa lower crust; (e) 95–80 Ma: delamination of lithospheric mantle; and (f) 80–65 Ma: northward subduction of the Yarlung‐Zangbo oceanic plate and subsequent slab rollback. The related metallogenic events in Central Lhasa include (a) ~115–110 Ma skarn Fe mineralization associated with slab break‐off; (b) ~90–80 Ma porphyry Cu–Au mineralization formed in delaminated thickened crust of Central Lhasa; and (c) ~65 Ma skarn Pb–Zn mineralization produced from slab rollback of the Yarlung‐Zangbo Ocean. [ABSTRACT FROM AUTHOR]

Frequency diverse array (FDA) has attracted much attention in recent years due to its range-angle-dependent beampattern. Multiple-input multiple-output (MIMO) radar can offer waveform diversity to increase the virtual aperture length for azimuth coherent focus processing in radar imaging. Combining the advantages of FDA and MIMO radar, FDA-MIMO radar can steer multiple beams to different targets in the same line of sight (LOS) of radar with different waveforms. In this paper, an improved FDA model with the logistic map is proposed to get the aperiodic and range-angle uncoupling beampattern. Based on the proposed FDA, combining the FDA-MIMO radar, the waveform and chirp rate jitter techniques are adopted to mainlobe jamming suppression. Simulation results show the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

Abstract: Reactions of N,N′‐bis (salicylidene)‐1,2‐cyclohexanediamine (H2L) with mixed lanthanide counterions of LnCl3·6H2O and Ln (NO3)3·6H2O afford six H2L lanthanide coordination polymers, e.g. {[Pr(H2L)2(NO3)2Cl]·2CH2Cl2}n (1); {[Ln(H2L)1.5(NO3)3]2·5CHCl3·mCH3OH}n [Ln = Sm (2), Eu (3), Gd (4), Tb (5) and Yb (6); m = 1 (2–5); m = 0 (6)]. X‐ray crystallographic analysis reveals that complex 1 exhibits three‐dimensional diamondoid topologic structure and complexes 2–6 are of two‐dimensional structure. Luminescent spectra show that complexes 1 and 6 have characteristic near‐infrared (NIR) emission of praseodymium (III) and ytterbium (III) ions and complexes 2–5 emit luminescence in the visible region. Complexes 3 and 6 reveal sensitive luminescence responses to formaldehyde. [ABSTRACT FROM AUTHOR]

Ru(ii) compounds are potential candidates for photodynamic therapy (PDT). In the present study, a Ru(ii) compound based on 3-(2-pyridyl)pyrazole (Hpypz) and 2,2′-bipyridine has been prepared and characterized. This compound can self-assemble to form nanoparticles (NPs) by nanoprecipitation in distilled water. These NPs with a mean size of 92 nm have good passive targeting by enhanced permeability and retention effect (EPR). In vitro studies on HeLa cells show that these NPs have high phototoxicity and a low IC50 (half-maximal inhibitory concentration) of only 8 μg mL−1 (12 μM), but they also have negligible dark toxicity. Moreover, such NPs can inhibit the migration of HeLa cells, indicating their potential to interfere with the transfer of tumors in vivo. Furthermore, in vivo investigations on nude mice demonstrate that such NPs can effectively inhibit the growth of the tumor. After treatment for 10 cycles, an obvious decrease in the tumor volume can be observed and in addition, the main organs (heart, liver, spleen, lung and kidney) suffer no damage, which indicates the high phototoxicity, low toxicity and excellent biocompatibility of these NPs. [ABSTRACT FROM AUTHOR]

Silver nanoparticles have good sterilization performance due to their small size and large specific surface area, while the small size also brings about reunification and reduces the sterilization activity. To resolve the problem, magnesium hydroxide [Mg(OH)] microsphere was designed as a supported material to load silver particles on its surface. Mg(OH) microspheres were successfully synthesized under the control of a biotemplate of eggshell membrane. X-ray diffraction, thermal gravimetric analysis/differential scanning calorimetry, and transmission electron microscopy were performed to characterize the Mg(OH) microspheres. The results indicate that the Mg(OH) microspheres of average size ~ 2 μm were formed from nanoflakes. The silver nanoparticles were loaded on the surface of Mg(OH) microspheres to form Mg(OH)/Ag nanocomposite, which exhibited enhanced antibacterial effect compared to that of silver nanoparticles. The enhanced antibacterial mechanism was investigated in detail. [ABSTRACT FROM AUTHOR]

Circular RNAs (circRNAs) exhibit a wide range of physiological and pathological activities. To uncover their role in hepatic steatosis, we investigated the expression profile of circRNAs in HepG2-based hepatic steatosis induced by high-fat stimulation. Differentially expressed circRNAs were subjected to validation using QPCR and functional analyses using principal component analysis, hierarchical clustering, target prediction, gene ontology (GO), and pathway annotation, respectively. Bioinformatic integration established the circRNA-miRNA-mRNA regulatory network so as to identify the mechanisms underlying circRNAs’ metabolic effect. Here we reported that hepatic steatosis was associated with a total of 357 circRNAs. Enrichment of transcription-related GOs, especially GO: 0006355, GO: 004589, GO: 0045944, GO: 0045892, and GO: 0000122, demonstrated their specific actions in transcriptional regulation. Lipin 1 (LPIN1) was recognized to mediate the transcriptional regulatory effect of circRNAs on metabolic pathways. circRNA-miRNA-mRNA network further identified the signaling cascade of circRNA_021412/miR-1972/LPIN1, which was characterized by decreased level of circRNA_021412 and miR-1972-based inhibition of LPIN1. LPIN1-induced downregulation of long chain acyl-CoA synthetases (ACSLs) expression finally resulted in the hepatosteatosis. These findings identify circRNAs to be important regulators of hepatic steatosis. Transcription-dependent modulation of metabolic pathways may underlie their effects, partially by the circRNA_021412/miR-1972/LPIN1 signaling. [ABSTRACT FROM AUTHOR]

The white-light emission of a triple-component lanthanide coordination polymer turns to blue and red upon adding Mn2+ and Ag+ ions, respectively. [ABSTRACT FROM AUTHOR]

A series of new isostructural lanthanide(iii) complexes are reported which are constructed from Schiff base and β-diketonate ligands, namely, [Ln2(DBM)6(L)] (Ln = Sm (1), Eu (2), Gd (3), Dy (4), Yb (5); L = N,N′-bis(pyridin-2-ylmethylene)ethane-1,2-diamine, DBM = dibenzoylmethanide). The structures of the isomorphous complexes 1–5 were determined by single-crystal X-ray crystallography. The two Ln(iii) ions in the molecules of 1–5 are bridged by a Schiff base ligand that displays a curved configuration. Complexes 1, 2 and 5 exhibit lanthanide ion-based luminescence not only in the solid state but also in methanol solution. The lifetimes and quantum yields of luminescence were also determined. The magnetic analysis reveals that complexes 4 and 5 exhibit field-induced single-molecule magnet behavior with energy barriers (Ueff/kB) of 46.8 and 23.0 K at direct current fields of 2000 Oe, respectively. [ABSTRACT FROM AUTHOR]

Reactions of LnCl3·6H2O (Ln = La, Ce, Pr, Nd, Gd and Lu), l-dibenzoyl tartaric acid (l-DBTA) and triethylamine in a methanol–water solution afford four complexes 1a–4a with 1D ladder chain structures, e.g. {[Ln2(l-DBTA)3(CH3OH)x(H2O)y]·zH2O}n (x = 3 or 4, y = 3 or 4, z = 2 or 5; Ln = La (1a), Ce (2a), Pr (3a) and Nd (4a)) and two complexes 5 and 6 with 1D linear chain structures, e.g. {Et3NH[Ln(l-DBTA)2(CH3OH)2(H2O)2]·2H2O}n (Ln = Gd (5) and Lu (6)). Accidentally, an in situ irreversible SCSC transformation from the kinetically stabilized 1D ladder chain structures of 1a–4a to thermodynamically stabilized 1D linear chain structures of 1–4 was observed, which was seldom reported for lanthanide coordination polymers. The coordination stability around a lanthanide cation was investigated to expatiate on the irreversible SCSC transformation. The solid-state NIR luminescence for complexes 3a, 3, 4a and 4 was also studied. [ABSTRACT FROM AUTHOR]

The Duolong porphyry Cu-Au deposit (5.4 Mt at 0.72% Cu, 41 t at 0.23 g/t Au) was recently discovered in the southern Qiangtang terrane, central Tibet. Here, new whole-rock elemental and Sr-Nd-Pb isotope and zircon Hf isotopic data of syn- and post-ore volcanic rocks and barren and ore-bearing granodiorite porphyries are presented for a reconstruction of magmas associated with Cu-Au mineralization. LA-ICP-MS zircon U-Pb dating yields mean ages of 117.0 ± 2.0 and 120.9 ± 1.7 Ma for ore-bearing granodiorite porphyry and 105.2 ± 1.3 Ma for post-ore basaltic andesite. All the samples show high-K calc-alkaline compositions, with enrichment of light rare earth elements (LREE) and large ion lithophile elements (LILE: Cs and Rb) and depletion of high field strength elements (HFSE: Nb and Ti), consistent with the geochemical characteristics of arc-type magmas. Syn- and post-ore volcanic rocks show initial Sr ratios of 0.7045-0.7055, εNd(t) values of −0.8 to 3.6, (206Pb/204Pb)t ratios of 18.408-18.642, (207Pb/204Pb)t of 15.584-15.672 and positive zircon εHf(t) values of 1.3-10.5, likely suggesting they dominantly were derived from metasomatized mantle wedge and contaminated by southern Qiangtang crust. Compared to mafic volcanic rocks, barren and ore-bearing granodiorite porphyries have relatively high initial Sr isotopic ratios (0.7054-0.7072), low εNd(t) values (−1.7 to −4.0), similar Pb and enriched zircon Hf isotopic compositions [εHf(t) of 1.5-9.7], possibly suggesting more contribution from southern Qiangtang crust. Duolong volcanic rocks and granodiorite porphyries likely formed in a continental arc setting during northward subduction of the Bangong-Nujiang ocean and evolved at the base of the lower crust by MASH (melting, assimilation, storage and homogenization) processes. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Magnesium hydroxide (Mg(OH)) assembly spheres were successfully synthesized by use of a facile bio-template method, with Mg(NO) and NaOH solution as reactants. The products were characterized by X-ray diffraction and transmission electron microscopy. The Mg(OH) nanomaterial obtained was assembled from nanoflakes and was approximately 2 μm in total size. Eggshell membrane was crucially important in the process of formation of the assembly spheres. The process and mechanism of assembly of the spheres are discussed. When the Mg(OH) assembly spheres were used to treat waste water containing heavy metals approximately 100 % of copper ions were removed. [ABSTRACT FROM AUTHOR]

A series of five l-di- p-toluoyl-tartaric acid ( l-DTTA) lanthanide coordination polymers, namely {[Ln4K4 L6(H2O)x]⋅yH2O}n, [Ln=Dy ( 1), x=24, y=12; Ln=Ho ( 2), x=23, y=12; Ln=Er ( 3), x=24, y=12; Ln=Yb ( 4), x=24, y=11; Ln=Lu ( 5), x=24, y=12] have been isolated by simple reactions of H2L (H2L= L-DTTA) with LnCl3⋅6 H2O at ambient temperature. X-ray crystallographic analysis reveals that complexes 1- 5 feature two-dimensional (2D) network structures in which the Ln3+ ions are bridged by carboxylate groups of ligands in two unique coordinated modes. Luminescent spectra demonstrate that complex 1 realizes single-component white-light emission, while complexes 2- 4 exhibit a characteristic near-infrared (NIR) luminescence in the solid state at room temperature. [ABSTRACT FROM AUTHOR]

New heteronuclear Zn2Ln2 clusters [Zn2L2Ln2(hfac)6] (Ln = Eu (1), Tb (2) and Dy (3)) have been synthesized based on a flexible Schiff base (H2L = N,N′-bis(salicylidene)-3,6-dioxa-1,8-diaminooctane) and β-diketonate ligand (hfac = hexafluoroacetylacetonate). The structures of the isomorphous complexes 1–3 were determined by single-crystal X-ray crystallography. Photophysical studies indicate that the short intramolecular distance of Zn…Ln allows energy transfer from the Zn2L2-based sensitizers to the Eu(iii) and Tb(iii) centres; the lanthanide luminescence is indeed “lighted up” by the excitation of the zinc complex. More interestingly, white light emission was realized by codoping Eu(iii) ion into the Dy(iii) complex for the first time. [ABSTRACT FROM AUTHOR]

To investigate the influence of POM species, temperature and counterions on the structures of POM-MOFs containing Cu-tda second building units (SBUs), six new complexes with various dimensionalities, e.g. three dimensional (3D) [Cu(H2tda)(H2O)2]4[SiW12O40]·12H2O (1), two dimensional (2D) [Cu2(H2tda)2(H2O)3]·[Cu(H2tda)(H2O)2]·[PMo12O40]·5H2O (2), H-bond 2D [Cu(H2tda)(H2O)2]3·[PMo12O40]·[Cu(Htda)(H2O)3]·8H2O (3), one dimensional (1D) [Cu2(H2tda)2(H2O)4]2·[Cu2(tda)2(H2O)4]·[HPW12O40]·5H2O (4), 1D [Cu2(H2tda)2(H2O)4][SiW12O40]·(TMA)2·3H2O (5), and zero dimensional (0D) [Cu(H2tda)(H2O)3][SiW12O40]·(TMA)3·H2O (6), were isolated depending on the reaction conditions. It is observed that the POM species, temperature and counterions exhibit an essential effect on the structures, which results in the formation of various dimensional POM-MOF complexes 1–6. In addition, photocatalytic degradation of RhB by complexes 1, 5 and 6 under UV irradiation was also investigated. [ABSTRACT FROM AUTHOR]

Activation of hepatic stellate cells (HSCs) depending on epithelial-to-mesenchymal transition (EMT) reflects the key event of liver fibrosis. Contrastively, mesenchymal-to-epithelial transition (MET) of HSCs facilitates the fibrosis resolution. Here we investigated the effect of Fuzheng Huayu (FZHY) recipe, a Chinese herbal decoction made of Radix Salviae Miltiorrhizae, Semen Persicae, Cordyceps sinensis, Pollen Pini, and Gynostemma pentaphyllum, on liver fibrosis concerning the balance of EMT and MET in HSCs. In contrast to the increased TGF-β1/BMP-7 ratio in activated HSCs, FZHY administration induced significant upregulation of BMP-7 and downregulation of TGF-β1 at both transcription and translation levels. Restoration of TGF-β1/BMP-7 ratio inhibited the expression of p38 MAPK and phosphorylated p38 MAPK, resulting in the reversal of epithelial-to-mesenchymal transition (EMT) to mesenchymal-to-epithelial transition (MET) as characterized by the abolishment of EMT markers (α-SMA and desmin) and reoccurrence of MET marker (E-cadherin). In vivo treatment of FZHY recipe also demonstrated the statistical reduction of activated HSCs with EMT phenotype, which attenuated the carbon tetrachloride- (CCl4-) induced liver fibrosis in a dose-dependent manner. These findings may highlight a novel antifibrotic role of FZHY recipe on the basis of rebalancing EMT and MET in HSCs. [ABSTRACT FROM AUTHOR]

Melatonin, mesenchymal stromal cells, mice, chronic allograft vasculopathy, aorta transplantation Keywords: chronic allograft vasculopathy; melatonin; mesenchymal stromal cells; aorta transplantation; mice EN chronic allograft vasculopathy melatonin mesenchymal stromal cells aorta transplantation mice 1 2 2 09/15/21 20210910 NES 210910 In the original article, there was a mistake in Figure 3A as published. [Extracted from the article]

Three new N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Cd(II) coordination polymers, namely, {[Cd(AMPPA)(HO)]·(NO)·HO} ( 1), {[Cd(AMPPA)(ipa)]·2HO} ( 2) and {[Cd(AMPPA)(Hbtc)]·2HO} ( 3) (AMPPA = N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine, Hipa = isophthalic acid and Hbtc = 1,3,5-benzenetricarboxylic acid) have been synthesized under hydrothermal conditions. X-ray diffraction analysis reveals that complex 1 exhibits one dimension (1D) coordination polymers when only the AMPPA ligand was employed. With the introduction of the building blocks (Hipa and Hbtc) into the reaction system of 1, complexes 2 with 2D layer and 3 with 3D networks were isolated, respectively. The effect of the building blocks in the construction of complexes 1- 3 has been discussed. In addition, all complexes display strong luminescence in the solid state. Graphical Abstract: Three N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine cadmium coordination polymers have been designed and isolated by the introduction of the building blocks of Hipa and Hbtc featuring 1D chain, 2D layer and 3D network with strong luminescence in the solid state.[Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

The Bangong- Nujiang suture ( BNS) between the Lhasa and Qiangtang terranes is an important boundary and its petrogenesis is controversial. Diabase from the accretionary prism in the southern Qiangtang terrane yields a zircon U- Pb age of 181.3 ± 1.4 Ma. All the diabases show tholeiitic basalt compositions, gentle enrichment patters of light rare earth elements ( REE), variable enrichment in incompatible element concentrations (e.g. Th and Rb), and no anomaly in high field strength elements (e.g. Nb and Ta), similar to that of enriched mid-ocean ridge basalt ( E- MORB). They have relatively homogeneous whole rock Nd (ε Nd(t) = 7.3-9.1) and zircon Hf- O isotopic compositions (ε Hf(t) = 14.8-16.1, and δ18 O = 4.57-6.12‰), possibly indicating melting of the depleted mantle and no significant crustal contamination during the petrogenesis. The element variations suggest that the diabases were formed by plume-ridge interaction at a mid-ocean ridge within the Bangong- Nujiang ocean. [ABSTRACT FROM AUTHOR]

MicroRNAs (miRNAs) regulate gene expression by inhibiting translation of target messenger RNAs (mRNAs) through pairing with miRNA recognition elements (MREs), usually in 3′-UTRs. miRNAs are involved in the pathogenesis of several types of cancers. Specifically, microRNA-32 (miR-32) is overexpressed in colorectal carcinoma, wherein accumulating evidence indicates that it functions as an oncogene. However, the function of miR-32 in hepatocellular carcinoma (HCC) has not been totally elucidated. In the present study, we found the expression of miR-32 was up-regulated in HCC tissue and cell lines, inversely the expression of phosphatase and tensin homolog (PTEN) decreased. Besides, miRNA-32 down-regulates PTEN through binding to 3′-UTR of PTEN mRNA from luciferase reporter assay, and the expression level of miR-32 could affect the proliferation, migration, and invasion of liver cancer cell lines via PTEN/Akt signaling pathway. Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation, migration, and invasion of liver cancer cells, suggesting that miR-32 could be a potential target for HCC treatment. [ABSTRACT FROM AUTHOR]

Two polyoxometalate-based coordination polymers (POMCPs) constructed form Keggin POMs and Ag+ with pyttz were synthesized: [Ag4(H2pyttz-I)(H2pyttz-II)(Hpyttz-II)][HSiW12O40]·4H2O (1) and [Ag4(H2pyttz-II)(Hpyttz-II)2][H2SiW12O40]·3H2O (2) (H2pyttz-I = 3-(pyrid-2-yl)-5-(1H-1,2,4-triazol-3-yl)-1,2,4-triazolyl; H2pyttz-II = 3-(pyrid-4-yl)-5-(1H-1,2,4-triazol-3-yl)-1,2,4-triazolyl). Both compounds have similar building units, similar stick-like units and similar 1D inorganic chains, but finally form the different motifs of tunnels (tunnel A in 1 and tunnel A&B in 2). By careful inspection of the structures of 1 and 2, it is believed that the isomerous pyttz molecules can precisely refine the structure of porous POMCPs without changing the underlying framework, which favors the study of the structure–activity relationship of POMCPs. Furthermore, the results of the photocatalytic activities show that compound 2 exhibits higher photocatalytic activity than that of compound 1, which is consistent with their structural characterization. [ABSTRACT FROM AUTHOR]

A general theoretical model is developed to investigate the sound radiation from an infinite orthogonally stiffened plate under point excitation force. The plate can be metallic or composite, and fluid loading is also considered in the research. The first order shear deformation theory is used to account for the transverse shear deformation. The motion of the equally spaced stiffeners is examined by considering their bending vibrations and torsional movements. Based on the periodic structure theory and the concepts of the equivalent dynamic flexibility of the plate, the generalized vibro-acoustic equation of the model is obtained by applying the Fourier transform method. The generalized model that can be solved numerically is validated by comparing model predictions with the existing results. Numerical calculations are performed to investigate the effects of the location of the excitation, the spacing of the stiffeners, the plate thickness, the strengthening form and the fiber orientation on the sound radiation characteristic of the orthogonally stiffened plate, and some practical conclusions are drawn from these parameter studies. [ABSTRACT FROM AUTHOR]

A series of novel organic–inorganic complexes based on trivalent lanthanides and 1,3-C6H4[CH2P(O)(OH)2]2 (H4L) formulated as Ln(HL)(H2O)2 (Ln = La, 1; Pr, 2; Nd, 3; Sm, 4; Eu, 5; Gd, 6; and Tb, 7) have been obtained as single phases by regulating the pH under hydrothermal conditions. Complexes are isostructural and feature a network in which the LnO7 polyhedra are interconnected by bridging CPO3 tetrahedra into inorganic layers. These layers are further stacked with the benzyl groups of ligands via C–H…π interaction into a laminar framework architecture. Luminescent measurements indicate that complexes 4, 5 and 7 show strong metal-centered emission bands in yellow, red and green light regions, respectively. Magnetic properties of 2 and 7 have also been studied. [ABSTRACT FROM AUTHOR]