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Background Sarcopenia and frailty influence clinical patients' outcomes. Low alanine aminotransferase (ALT) serum activity is a surrogate marker for sarcopenia and frailty. In-hospital hypoglycemia is associated, also with worse clinical outcomes. Aim We evaluated the association between low ALT, risk of in-hospital hypoglycemia and subsequent mortality. Design This was a retrospective cohort analysis. Methods We included patients hospitalized in a tertiary hospital between 2007 and 2019. Patients' data were retrieved from their electronic medical records. Results The cohort included 51 831 patients (average age 70.88). The rate of hypoglycemia was 10.8% (amongst diabetics 19.4% whereas in non-diabetics 8.3%). The rate of hypoglycemia was higher amongst patients with ALT < 10 IU/l in the whole cohort (14.3% vs. 10.4%, P  < 0.001) as well as amongst diabetics (24.6% vs. 18.8%, P  < 0.001). Both the overall and in-hospital mortality were higher in the low ALT group (57.7% vs. 39.1% P  < 0.001 and 4.3% vs. 3.2%, P  < 0.001). A propensity score matching, after which a regression model was performed, showed that patients with ALT levels < 10 IU/l had higher risk of overall mortality (HR = 1.21, CI 1.13–1.29, P  < 0.001). Conclusions Low ALT values amongst hospitalized patients are associated with increased risk of in-hospital hypoglycemia and overall mortality. [ABSTRACT FROM AUTHOR]

Background: COPD exacerbations have negative impact on patients' survival. Several risk factors for grave outcomes of such exacerbations have been descried. Muscle dysfunction and mass loss were shown to impact negatively on prognosis and survival. Low activity of the enzyme ALT (Alanine amino-transferase) in the blood is a known indicator for sarcopenia and frailty, however, no previous studies addressed the association of low ALT amongst patients hospitalized due to COPD exacerbation and long-term survival.Methods: This is a historic prospective cohort study of patients hospitalized due to acute COPD exacerbation.Results: Included were 232 consecutive COPD exacerbation patients. The median time of follow-up was 34.9 months (IQR 23.13-41.73 months). During this period 104 (44.8%) patients died. All patients were grouped to quartiles according to blood ALT levels (after exclusion of cases considered to have hepatic tissue damage (ALT > 40 IU)). The risk of long-term mortality increased, in a statistically significant manner, amongst patients with low ALT values: the median survival of patients with ALT < 11 IU was 18.5 months only while the median survival for the rest of the study group was not reached. For ALT < 11 IU; 12-16 IU; 17-20 IU and > 21 IU the mortality rates were 69%; 40.9%; 36.3 and 25% respectively (p <  0.001 for comparison of lower quartile with upper three quartiles). The crude hazard ratio for mortality amongst patients with ALT levels lower than 11 IU was 2.37 (95% CI; 1.6-3.5). This increased risk of mortality remained significant after adjustment for age, weight, creatinine, albumin concentration and cardiovascular diseases (HR = 1.83; 95% CI 1.08-3.1, p <  0.05).Conclusions: Low ALT values, a biomarker of sarcopenia and frailty, are associated with poor long-term survival amongst patients hospitalized due to COPD exacerbation. [ABSTRACT FROM AUTHOR]

We present the analysis of a total of 177 h of high-quality optical time-series photometry of the helium atmosphere pulsating white dwarf (DBV) EC 20058−5234. The bulk of the observations (135 h) were obtained during a WET campaign (XCOV15) in 1997 July that featured coordinated observing from four southern observatory sites over an 8-d period. The remaining data (42 h) were obtained in 2004 June at Mt John Observatory in NZ over a one-week observing period. This work significantly extends the discovery observations of this low-amplitude (few per cent) pulsator by increasing the number of detected frequencies from 8 to 18, and employs a simulation procedure to confirm the reality of these frequencies to a high level of significance (1 in 1000). The nature of the observed pulsation spectrum precludes identification of unique pulsation mode properties using any clearly discernable trends. However, we have used a global modelling procedure employing genetic algorithm techniques to identify the n, ℓ values of eight pulsation modes, and thereby obtain asteroseismic measurements of several model parameters, including the stellar mass and Teff (∼28 200 K). These values are consistent with those derived from published spectral fitting: and log g∼ 7.86. We also present persuasive evidence from apparent rotational mode splitting for two of the modes that indicates this compact object is a relatively rapid rotator with a period of 2 h. In direct analogy with the corresponding properties of the hydrogen (DAV) atmosphere pulsators, the stable low-amplitude pulsation behaviour of EC 20058 is entirely consistent with its inferred effective temperature, which indicates it is close to the blue edge of the DBV instability strip. Arguably, our most significant result from this work is the clear demonstration that EC 20058 is a very stable pulsator with several dominant pulsation modes that can be monitored for their long-term stability. [ABSTRACT FROM AUTHOR]

Photometric observations of V4633 Sgr (Nova Sagittarii 1998) during 1998–2005 reveal the presence of a stable photometric periodicity at which is probably the orbital period of the underlying binary system. A second period was present in the light curve of the object for 6 yr. Shortly after the nova eruption it was measured as . It has decreased monotonically in the following few years reaching the value in 2003. In 2004 it was no longer detectable. We suggest that the second periodicity is the spin of the magnetic white dwarf of this system that rotates nearly synchronously with the orbital revolution. According to our interpretation, the post-eruption evolution of Nova V4633 Sgr follows a track similar to the one taken by V1500 Cyg (Nova Cygni 1975) after that nova eruption, on a somewhat longer time-scale. The asynchronism is probably the result of the nova outburst that led to a considerable expansion of the white dwarf's photosphere. The increase in the moment of inertia of the star was associated with a corresponding decrease in its spin rate. Our observations have followed the spinning-up of the white dwarf resulting from the contraction of its outer envelope as the star is slowly returning to its pre-outburst state. It is thus the second known asynchronous polar classical nova. [ABSTRACT FROM AUTHOR]

The classical nova V4743 Sgr was observed with XMM–Newton for about 10 h on 2003 April 4, 6.5 months after optical maximum. At this time, this nova had become the brightest supersoft X-ray source ever observed. In this paper, we present the results of a time-series analysis performed on the X-ray light curve (LC) obtained in this observation, and in a previous shorter observation done with Chandra 16 d earlier. Intense variability, with amplitude as large as 40 per cent of the total flux, was observed both times. Similarities can be found between the two observations in the structure of the variations. Most of the variability is well represented as a combination of oscillations at a set of discrete frequencies lower than 1.7 mHz. At least five frequencies are constant over the 16 d time interval between the two observations. We suggest that a period in the power spectrum of both LCs at the frequency of 0.75 mHz and its first harmonic are related to the spin period of the white dwarf (WD) in the system, and that other observed frequencies are signatures of non-radial WD pulsations. A possible signal with a 24 000 s period is also found in the XMM–Newton LC: a cycle and a half are clearly identified. This period is consistent with the 24 278 s periodicity discovered in the optical LC of the source and thought to be the orbital period of the nova binary stellar system. [ABSTRACT FROM AUTHOR]

We analyse a light curve (LC) of the symbiotic star BF Cyg, covering 114 yr of its photometric history. The star had a major outburst around the year 1894. Since then the mean optical brightness of the system is in steady decline, reaching only in the last few years its pre-outburst value. Superposed on this general decline are some six less intense outbursts of 1–2 mag and duration of 2000–5000 d. We find a cycle of 6376 d, or possibly twice this period, in the occurrence of these outbursts. We suggest that the origin of the system outbursts is in some magnetic cycle in the outer layers of the giant star of the system, akin to the less intense 8000-d magnetic cycle of our Sun. We further find, that in addition to its well-known binary period of 757.3 d, BF Cyg possesses also another photometric period of 798.8 d. This could be the rotation period of the giant star of the system. If it is, the beat period of these two periodicities, 14 580 d, is the rotation period of a tidal wave on the surface of the giant. A fourth period of 4436 d, the beat period of the 14 580-d and the 6376-d cycles is possibly also present in the LC. We predict that BF Cyg will be at the peak of its next outburst around the month of May in the year 2007. The newly discovered 798.8-d period explains the disappearance of the orbital modulation at some epochs in the LC. The 757.3-d oscillations will be damped again around the year 2013. [ABSTRACT FROM AUTHOR]

We present the preliminary results of more than 160 h of time-series photometry on the subdwarf B pulsating star PG 1325+101 (Teff = 34 500 K log g = 6.1), obtained in March-April 2003 at nine different sites. The amplitude spectrum confirms the presence of the four frequencies found in the discovery run at the NOT in July 2001 (but with significantly lower amplitudes in two of them) and also shows at least two new low amplitude signals. Moreover, there is no sign of frequency splitting near the main peak at 7256 μHz, suggesting that this mode might be actually radial as indicated by the time-resolved spectroscopy (Østensen and Telting, 2004). [ABSTRACT FROM AUTHOR]

Time-resolved photometry of the long-period intermediate polar V1062 Tau confirmed the presence of the previously reported orbital and spin periods, and revealed the presence of a third one, corresponding to the beat of the two. While the orbital periodicity was present throughout our data, only one of the shorter periods was detectable at any given time. On a time-scale of ∼90 d, the short-period modulation in the light curve of the star changed three times between the spin period and the beat. On longer time-scales, we report two outbursts of V1062 Tau (the first to be recorded for this object) – both of which were probably short, low-amplitude bursts . Our data also suggest a brief low-state phase in 2002 January. Thus, this system joins two exclusive groups of intermediate polars: those undergoing short outbursts, and those having low states. We propose that the alternations between the short periods that modulate the light curve were caused by changes in the accretion mode, from disc-fed accretion to disc-overflow accretion. We further suggest that these changes may have been triggered by changes in mass-transfer rate, which were manifested by the low-state/outburst activity of the system. [ABSTRACT FROM AUTHOR]

We present results from a multisite (‘Whole Earth Telescope’) photometric campaign on PG 1336−018, the close eclipsing binary system containing a pulsating subdwarf B (sdB) star. The main part of the campaign (1999 April) resulted in ∼172 h of observations, representing a coverage of about 47 per cent, and additional data were obtained outside the core campaign. Periodogram analysis shows that the light variations are dominated by three frequencies near 5757, 5585 and 5369 μHz (∼174, 179 and 186 s, respectively), although many frequencies are present, particularly in the range 5000–6000 μHz (∼200–170 s). We identify, with some confidence, 28 frequencies down to a semi-amplitude of 0.0005 in fractional intensity (equivalent to about 0.5 mmag). It is clear that the pulsation frequencies of PG 1336−018 have changed substantially since the 1996 discovery observations were made, and that amplitude changes occur, at least in the dominant three frequencies, on relatively short time-scales (of the order of a day). On the assumption that the pulsating star is phase-locked in the binary system, we have searched for rotational splitting of frequencies near the orbital and half of the orbital period, but the results are confused by aliasing at those frequencies (due to the data gaps caused by the eclipses). A preliminary model qualitatively matches the distribution of frequencies in PG 1336−018, with some good individual correspondences, but cannot be considered adequate because geometric cancellation should hide some of the modes which are apparently detected. Analysis of the pulsations during eclipse recovers three of the strongest modes, but the limited eclipse data – which can, at best, be only about 9 per cent of the total – do not allow mode identification at this stage. Simulations indicate that an overall coverage of about 80 per cent would be required for this to be viable. An attempt was made to determine phase shifts in the pulsation frequencies as a way of directly measuring the size of the binary orbit, but the uncertainties in the method are comparable to the light travel time across the orbit (probably less than a second). [ABSTRACT FROM AUTHOR]

We report multisite observations devoted to the main-sequence δ Scuti star XX Pyx, conducted as the 17th run of the Delta Scuti Network. Over 125 nights a total of 550 h of usable time-series photometric B- and V-filter data were acquired involving both photoelectric and CCD measurements at eight observatories spread around the world, which represents the most extensive single time-series for any pulsating star other than the Sun obtained so far. We describe our observations and reduction methods, and present the frequency analysis of our new data. First, we detect six new pulsation and five new combination frequencies in the star's light curves. We also discover evidence for amplitude and/or frequency variations of some of the modes during the observations. These can occur on time-scales as short as 20 d and show quite diverse behaviour. To take them into account in the frequency analysis, a so-called non-linear frequency analysis method was developed, allowing us to quantify the temporal variability of the modes and to compensate for it. Following that we continue the frequency search and we also incorporate published multisite observations. In this way, we reveal three more pulsation and two more combination frequencies. In the end, we report a total of 30 significant frequencies – 22 of which correspond to independent pulsation modes. This is the largest number of independent modes ever detected in the light curves of a δ Scuti star. The frequencies of the modes show preferred separations as already suggested by previous work on this star; they are also arranged in clear patterns. These results lead to a refinement of the stellar mean density [equation] and to a new constraint on the rotation rate of XX Pyx (ν[sub rot]=1.1±0.3 d[sup -1]). However, our attempts to identify the modes by pattern recognition failed. Moreover, mode identification from multicolour photometry failed as well because the high pulsation frequencies make this method unfavourable. The diverse behaviour of the amplitude and frequency variations of some of the modes leaves resonances as the only presently known possibility for their explanation. [ABSTRACT FROM AUTHOR]

Copyright of Il Nuovo Cimento: A is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Il Nuovo Cimento: A is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Il Nuovo Cimento: B is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The interferon system of 20 children aged 2 to 11 years (mean 5 years), diagnosed as having transient synovitis of the hip by clinical criteria, was studied. The mean blood interferon concentration was significantly higher than that of normal children, and the incidence of an antiviral state of cells (in 78% of patients) was also significantly higher than in the control group. These findings are compatible with the hypothesis that the aetiology of transient synovitis is an acute, possibly unusual, viral infection. [ABSTRACT FROM AUTHOR]

After the initial discoveries fifteen years ago, over 200 extrasolar planets have now been detected. Most of them orbit main-sequence stars similar to our Sun, although a few planets orbiting red giant stars have been recently found. When the hydrogen in their cores runs out, main-sequence stars undergo an expansion into red-giant stars. This expansion can modify the orbits of planets and can easily reach and engulf the inner planets. The same will happen to the planets of our Solar System in about five billion years and the fate of the Earth is matter of debate. Here we report the discovery of a planetary-mass body (Msini = 3.2MJupiter) orbiting the star V 391 Pegasi at a distance of about 1.7 astronomical units (au), with a period of 3.2 years. This star is on the extreme horizontal branch of the Hertzsprung–Russell diagram, burning helium in its core and pulsating. The maximum radius of the red-giant precursor of V 391 Pegasi may have reached 0.7 au, while the orbital distance of the planet during the stellar main-sequence phase is estimated to be about 1 au. This detection of a planet orbiting a post-red-giant star demonstrates that planets with orbital distances of less than 2 au can survive the red-giant expansion of their parent stars. [ABSTRACT FROM AUTHOR]