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[ Objectives] To find out a suitable cultivation technique of Wangu 098 in Nanyang area, speed up the popularization, demonstration and application of Wangu 098, and provide a theoretical and practical basis for adjusting the planting structure and realizing the matching of improved varieties and methods. [Methods] The new self-bred millet variety Wangu 098 was used a the material, and the two-factor split zone experimental design was adopted. The effects of different sowing dates and densities on the yield, growth period and agronomic characters of millet were studied. [ Results] The interaction of seeding date and density had a great effect on the yield and plant traits of millet. Millet yield was significantly and positively correlated with plant height, panicle length, singe panicle weight, panicle gain weight and tiller number. [ Conclusions] The reasonable combination of seeding date and density could give full play to the yield potential of millet. According to the experimental results and cultivation experience, the suitable seeding date of millet in Nanyang area is in the first and middle ten days of June, and the best density is about 750 000 plants/ha. However, after June 30, the seeding millet did not tiller, so the density should be increased to more than 900 000 plants/ha to obtain higher yield. In terms of cultivation and management, timely seeding, reasonable close planting, and coordination of vegetative growth and reproductive growth can make the plant tall and strong, panicle long and thick, and improve the yield of millet. [ABSTRACT FROM AUTHOR]

The present work explored the use of solid waste fine blue-coke as a feedstock for the preparation of activated blue-coke and its adsorption property of Cr(VI). Chemical activation of this precursor, using KOH as activating agent, was adopted. The properties of activated blue-coke were characterized by N2 adsorption isotherms. The results show that the iodine number is 1202 mg/g, the Brunauer- Emmett-Teller (BET) surface area is 1368.18 m2/g and the total pore volume is 0.6745 cm3/g, when the activated blue-coke prepared at the optimized conditions: KOH/fine blue-coke ratio at 4, 800°C activated temperature, 60 min activated time. The adsorption properties of activated coke on Cr(VI) were discussed. The regression results show that the adsorption kinetics is more accurately expressed as a pseudo second order model. The linear correlation coefficients of the Langmuir and Freundlich isotherms were determined and the results reveal that the Freundlich isotherm fits the experimental results better. [ABSTRACT FROM AUTHOR]

Colorectal cancer (CRC) is one of the most common malignancies worldwide with substantial mortality and morbidity. Alisertib (ALS) is a selective Aurora kinase A (AURKA) inhibitor with unclear effect and molecular interactome on CRC. This study aimed to evaluate the molecular interactome and anticancer effect of ALS and explore the underlying mechanisms in HT29 and Caco-2 cells. ALS markedly arrested cells in G2/M phase in both cell lines, accompanied by remarkable alterations in the expression level of key cell cycle regulators. ALS induced apoptosis in HT29 and Caco-2 cells through mitochondrial and death receptor pathways. ALS also induced autophagy in HT29 and Caco-2 cells, with the suppression of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), but activation of 51 AMP-activated protein kinase (AMPK) signaling pathways. There was a differential modulating effect of ALS on p38 MAPK signaling pathway in both cell lines. Moreover, induction or inhibition of autophagy modulated basal and ALS-induced apoptosis in both cell lines. ALS potently suppressed epithelial to mesenchymal transition (EMT) in HT29 and Caco-2 cells. Collectively, it suggests that induction of cell cycle arrest, promotion of apoptosis and autophagy, and suppression of EMT involving mitochondrial, death receptor, PI3K/Akt/mTOR, p38 MAPK, and AMPK signaling pathways contribute to the cancer cell killing effect of ALS on CRC cells. [ABSTRACT FROM AUTHOR]