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Although often viewed as detrimental, fluctuations carry valuable information about the physical system from which they emerge. Femtosecond noise correlation spectroscopy (FemNoC) has recently been established to probe the ultrafast fluctuation dynamics of thermally populated magnons by measurement of their amplitude autocorrelation. Subharmonic lock-in detection is the key technique in this method, allowing us to extract the pulse-to-pulse polarization fluctuations of two femtosecond optical pulse trains transmitted through a magnetic sample. Here, we present a thorough technical description of the subharmonic demodulation technique and the FemNoC measurement system. We mathematically model the data acquisition process and identify the essential parameters that critically influence the signal-to-noise ratio of the signals. Comparing the model calculations to real datasets allows validating the predicted parameter dependences and provides a means to optimize FemNoC experiments. [ABSTRACT FROM AUTHOR]

Owing to their high magnon frequencies, antiferromagnets are key materials for future high-speed spintronics. Picosecond switching of antiferromagnetic spin systems has been viewed a milestone for decades and pursued only by using ultrafast external perturbations. Here, we show that picosecond spin switching occurs spontaneously due to thermal fluctuations in the antiferromagnetic orthoferrite Sm0.7Er0.3FeO3. By analysing the correlation between the pulse-to-pulse polarisation fluctuations of two femtosecond optical probes, we extract the autocorrelation of incoherent magnon fluctuations. We observe a strong enhancement of the magnon fluctuation amplitude and the coherence time around the critical temperature of the spin reorientation transition. The spectrum shows two distinct features, one corresponding to the quasi-ferromagnetic mode and another one which has not been previously reported in pump-probe experiments. Comparison to a stochastic spin dynamics simulation reveals this new mode as smoking gun of ultrafast spontaneous spin switching within the double-well anisotropy potential. Antiferromagnets exhibit high frequency magnons, in the THz regime, a point potentially useful for applications, however, it has meant that detecting spin-fluctuations in antiferromagnets is typically too fast for current experimental approaches. Here Weiss et al use femtosecond noise correlation spectroscopy to observe magnon fluctuations in Sm0.7Er0.3FeO3. [ABSTRACT FROM AUTHOR]

Summary: In patients with postmenopausal osteoporosis, prior osteoporosis treatment affected the bone mineral density increase of following treatment with 12 months of romosozumab, although it did not affect that of following treatment with 12 months of denosumab after romosozumab. Purpose: To investigate the effects of prior osteoporosis treatment on the response to treatment with romosozumab (ROMO) followed by denosumab (DMAb) in patients with postmenopausal osteoporosis. Methods: In this prospective, observational, multicenter study, treatment-naïve patients (Naïve; n = 55) or patients previously treated with bisphosphonates (BP; n = 37), DMAb (DMAb; n = 45) or teriparatide (TPTD; n = 17) (mean age, 74.6 years; T-scores of the lumbar spine [LS] − 3.2 and total hip [TH] − 2.6) were switched to ROMO for 12 months, followed by DMAb for 12 months. Bone mineral density (BMD) and serum bone turnover markers were evaluated for 24 months. Results: A BMD increase was observed at 12 and 24 months in the following patients: Naïve (18.2% and 22.0%), BP (10.2% and 12.1%), DMAb (6.6% and 9.7%), and TPTD (10.8% and 15.0%) (P < 0.001 between the groups at both 12 and 24 months) in LS and Naïve (5.5% and 8.3%), BP (2.9% and 4.1%), DMAb (0.6% and 2.2%), and TPTD (4.3% and 5.4%) (P < 0.01 between the groups at 12 months and P < 0.001 at 24 months) in TH, respectively. The BMD increase in LS from 12 to 24 months was negatively associated with the levels of bone resorption marker at 24 months. Incidences of major fragility fractures for the respective groups were as follows: Naïve (5.5%), BP (16.2%), DMAb (11.1%), and TPTD (5.9%). Conclusions: Previous treatment affected the BMD increase of following treatment with ROMO, although it did not affect that of following treatment with DMAb after ROMO. [ABSTRACT FROM AUTHOR]

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Hydrogen peroxide (H2O2) and lignin induced by acibenzolar‐S‐methyl (ASM) during the expression of systemic acquired resistance (SAR) of cucumber plants against the fungus Colletotrichum orbiculare was analysed with electron microscopy and energy‐filtering electron microscopy (EFEM). ASM pretreatment consistently led to the blockage of appressorial penetration pegs into leaves at early stages after inoculation, whereas the fungus was able to grow into the vascular tissue after distilled water pretreatment. The blocked pegs, seen frequently at epidermal pectin layers in leaves of ASM‐treated plants, were surrounded by abundant electron‐dense amorphous material and dots. These were identified as lignin, based on their appearance and high reactivity with KMnO4. Lignin first appeared as an amorphous material at pectin layers, and then as dots in some areas of the material. The results showed that ASM caused SAR in leaves via faster formation of lignin within 1 day after inoculation. After CeCl3 treatment to detect H2O2, H2O2‐reactive products (cerium perhydroxides) were seen near ASM‐induced lignin formation sites in pectin layers. EFEM analysis showed that Ce and O were located at the same sites as the lignin dots, suggesting that lignin was associated with sources of H2O2 generation. The results indicate that the faster H2O2 generation and lignification induced by ASM were the potential causes of SAR. [ABSTRACT FROM AUTHOR]

Nonlinear refractive index and absorption coefficient are measured for common semiconductor material such as silicon and organic molecule such as lactose in the terahertz (THz) spectral regime extending from 0.1 to 3 THz. Terahertz pulses with field strengths in excess of 4.4 MV/cm have been employed. Transmittance and the transmitted spectrum were measured with Z-scan and single shot noncollinear electro-optic pump-probe techniques. The THz-induced change in the refractive index (Δn) shows frequency-dependence and a maximum change of −0.128 at 1.37 THz in lactose and up to +0.169 at 0.15 THz in silicon was measured for a peak incident THz intensity of 26 GW/cm2. Furthermore, the refractive index variation shows a quadratic dependence on the incident THz field, implying the dominance of third-order nonlinearity. [ABSTRACT FROM AUTHOR]

Applications of high-field terahertz pulses are attractive in physics and terahertz technology. In this study, two applications related to high-intensity terahertz pulses are demonstrated. The field enhancement effect by subwavelength metallic microstructures is utilized for terahertz excitation measurement. The spin precession dynamics in magnetic materials was induced by a terahertz magnetic field. Spin precession was amplified by one order of magnitude in amplitude by the enhanced magnetic terahertz field in orthoferrite ErFeO with metal microstructures. The induced spin dynamics was analyzed and explained by LLG-LCR model. Moreover, a detection method for terahertz pulses was developed using a cholesteric liquid crystal at room temperature without any electronic devices. The beam profile of terahertz pulses was visualized and compared to other methods such as the knife edge method using pyroelectric detector and micro-bolometer array. The liquid crystal terahertz imager is very simple and has good applicability as a portable terahertz-sensing card. [ABSTRACT FROM AUTHOR]

The blistering problem due to high power proton irradiation is a crucial issue for any neutron generation target. When a proton beam irradiates a metal, the protons stopped inside capture free electrons in the metal to form a hydrogen gas. Eventually, blisters and/or flakes appear on the surface as the pressure of the hydrogen gas rises enough to cause ruptures. An experimental setup for observation of the metal surface that would have high sensitivity and high spatial resolution was proposed, designed and implemented. The system observes light-polarization and reflectivity and has successfully detected blistering surface dynamics. [ABSTRACT FROM AUTHOR]

Neutropenia during chemotherapy has been reported to be a predictor of better survival in patients with several types of cancer, although there are no reports on stage III colorectal cancer ( CRC). The purpose of this study was to examine the association between neutropenia and prognosis in stage III CRC patients receiving adjuvant chemotherapy consisting of oral uracil and tegafur ( UFT) plus leucovorin ( LV). We retrospectively analysed 123 patients with stage III CRC who received UFT/ LV as adjuvant chemotherapy. The end-point was disease-free survival ( DFS). Survival curves of the two categories (neutropenia absent vs. present) were estimated using the Kaplan- Meier method and compared by the log-rank test. We estimated the hazard ratio ( HR) for DFS according to neutropenia after adjustment for covariates by multivariate analyses using Cox's regression analysis. A total of 33 (26.8%) patients experienced neutropenia. Patients without neutropenia showed a significantly lower DFS than those with neutropenia (3-year DFS 57.3% vs. 81.2%, P = 0.0213). By multivariate analysis, neutropenia and histological type were independent prognostic factors, with HR of 0.410 (neutropenia absent vs. present, P = 0.045) and 4.793 (well to moderately differentiated vs. poorly differentiated, P = 0.004) respectively. We demonstrated that neutropenia occurring during adjuvant chemotherapy consisting of UFT/ LV may be a prognostic factor of recurrence in stage III CRC patients. [ABSTRACT FROM AUTHOR]

The purpose of our study is to investigate the training effect of the prevention program for anterior cruciate ligament injuries. Nine female college basketball players participated in our study. This training program took nine months to complete in all the subjects. Three-dimensional motion analysis and force plate data were used to compare the kinetics and kinematics of single-leg landing before and after this training. Therefore isokonetic knee extension/flexion, single leg squat and isometric hip muscle strength were measured before and after this training. Initial knee flexion, maximum hip and knee flexion angle increased after this training. Maximum knee extension moment and hip abduction moment also decreased. The maximum ground reaction force also decreased. Concerning lower muscular strength, knee extension/flexion, hip abduction and external rotation increased after this training. This training program can potentially lower the risk of noncontact anterior cruciate ligament injuries at the time of landing. [ABSTRACT FROM AUTHOR]

Background: Intramuscular water movement is expected to be affected by the mechanical changes of the muscle fibers. However, the effect of changes in fiber length (FL) and pennation angle (PA) on the water movement has not been sufficiently investigated in human skeletal muscles. Purpose: To determine the relationship between intramuscular water movement and the mechanical changes in human muscle fibers. Material and Methods: Axial magnetic resonance diffusion-weighted images of the right leg (eight men) were taken using a 1.5-Tesla device with the ankle joint maximally dorsiflexed and maximally plantar flexed. The apparent diffusion coefficient (ADC) values of both the dorsiflexors (the superficial and deep parts of the tibialis anterior) and the plantar flexors (medial gastrocnemius and soleus) were calculated along three orthogonal axes (S-I: superior-to-inferior, A-P: anterior-to-posterior, and R-L: right-to-left). FL and PA of both muscle groups were also calculated from longitudinal B-mode ultrasound images with the ankle joint maximally dorsiflexed and plantar flexed. Results: There was a significant increase in the ADC in superficial (P < 0.05) and deep (P < 0.05) parts of the dorsiflexors in the S-I direction when the ankle was plantar flexed and in the A-P and R-L directions when the ankle was dorsiflexed (P < 0.05). The plantar flexors showed significantly elevated ADC in the S-I direction when the ankle was dorsiflexed (P < 0.05), and in the A-P and R-L directions when the ankle was plantar flexed (P < 0.05). The dorsiflexors also showed significantly increased PA and decreased FL values when the ankle was dorsiflexed (P < 0.05). The plantar flexors displayed similar morphological changes when the ankle was plantar flexed (P < 0.05). Conclusion: Water diffusion is affected by structural changes in the long axis of the muscle fibers, namely the changes in PA and FL. [ABSTRACT FROM AUTHOR]

Extremely low levels of serum hepatitis C virus (HCV) RNA can be detected by COBAS TaqMan HCV test. To investigate whether the COBAS TaqMan HCV test is useful for measuring rapid virological response (RVR) and early virological response (EVR) to predict sustained virological response (SVR), we compared the virological response to PEG-IFN-alfa 2a plus RBV in 76 patients infected with HCV genotype 1 when undetectable HCV RNA by the COBAS TaqMan HCV test was used, with those when below 1.7 log IU/mL HCV RNA by COBAS TaqMan HCV test was used, which corresponded to the use of traditional methods. Among the 76 patients, 28 (36.8%) had SVR, 13 (17.1%) relapsed, 19 (25.0%) did not respond, and 16 (21.0%) discontinued the treatment due to side effects. The positive predictive values for SVR based on undetectable HCV RNA by COBAS TaqMan HCV test at 24 weeks after the end of treatment [10/10 (100%) at week 4, 21/23 (91.3%) at week 8 and 26/33 (78.7%) at week 12] were superior to those based on <1.7 log IU/mL HCV RNA [17/19 (89.4%) at week 4, 27/38 (71.0%) at week 8, and 27/43 (62.7%) at week 12]. The negative predictive values for SVR based on <1.7 log IU/mL HCV RNA by COBAS TaqMan HCV test [46/57 (80.7%) at week 4, 37/38 (97.3%) at week 8, and 32/33 (96.9%) at week 12] were superior to those based on undetectable HCV RNA [48/66 (72.7%) at week 4, 46/53 (86.7%) at week 8, and 41/43 (95.3%) at week 12]. The utilization of both undetectable RNA and <1.7 log IU/mL HCV RNA by COBAS TaqMan HCV test is useful and could predict SVR and non-SVR patients with greater accuracy. [ABSTRACT FROM AUTHOR]

Exposure to unaccustomed eccentric exercise causes muscle damage. Popping sarcomere theory [1] has been proposed and assumed that eccentric contraction-induced muscle damage predominantly occurs at muscle length on the descending limb of the force-length relationship. This study investigated changes in the mechanical properties following maximum effort eccentric exercise at systematically different muscle lengths for the human ankle dorsiflexors. The results of this study showed that the eccentric exercise of the ankle dorsiflexors decreased the peak torque, shifted the optimal joint angle towards longer muscle length without changes in the level of muscle activation. However, no difference in the shift of the optimal ankle joint angle was observed between the groups that performed eccentric exercise at long muscle length (ECC_L) and at short muscle length (ECC_S). In conclusion, the muscle length at which the eccentric exercise was performed did not produce differential effects on the neuro-mechanical properties of in-vivo human ankle dorsiflexors, and thus the popping sarcomere theory might not be the sole mechanism to account for the eccentric contraction-induced optimal muscle length change. [ABSTRACT FROM AUTHOR]

Diabetic retinopathy is a progressive neurodegenerative disease, but the underlying mechanism is still obscure. Here, we focused on oxidative stress in the retina, and analysed its influence on retinal neurodegeneration, using an antioxidant, lutein. C57BL/6 mice with streptozotocin-induced diabetes were constantly fed either a lutein-supplemented diet or a control diet from the onset of diabetes, and their metabolic data were recorded. In 1-month-diabetic mice, reactive oxygen species (ROS) in the retina were measured using dihydroethidium and visual function was evaluated by electroretinograms. Levels of activated extracellular signal-regulated kinase (ERK), synaptophysin and brain-derived neurotrophic factor (BDNF) were also measured by immunoblotting in the retina of 1-month-diabetic mice. In the retinal sections of 4-month-diabetic mice, histological changes, cleaved caspase-3 and TUNEL staining were analysed. Lutein did not affect the metabolic status of the diabetic mice, but it prevented ROS generation in the retina and the visual impairment induced by diabetes. ERK activation, the subsequent synaptophysin reduction, and the BDNF depletion in the diabetic retina were all prevented by lutein. Later, in 4-month-diabetic mice, a decrease in the thickness of the inner plexiform and nuclear layers, and ganglion cell number, together with increase in cleaved caspase-3- and TUNEL-positive cells, were avoided in the retina of lutein-fed mice. The results indicated that local oxidative stress that has a neurodegenerative influence in the diabetic retina is prevented by constant intake of a lutein-supplemented diet. The antioxidant, lutein may be a potential therapeutic approach to protect visual function in diabetes. [ABSTRACT FROM AUTHOR]