1. Coronary flow reserve after <span style="font-variant:small-caps">l</span> -thyroxine therapy in Hashimotoâs thyroiditis patients with subclinical and overt hypothyroidism.
- Author
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Huseyin Oflaz, Ramazan Kurt, Fatma Sen, Imran Onur, Arif Cimen, Ali Elitok, Kultigin Turkmen, Burak Pamukcu, Erdem Kasikcioglu, Zehra Bugra, Fehmi Mercanoglu, and Nese Ozbey
- Abstract
Abstract  Backgound/Aims Overt and subclinical hypothyroidism are reported to be associated with increased cardiovascular disease risk. We have used coronary flow reserve (CFR) measurement by trans-thoracic Doppler echocardiography (TTDE) to determine coronary microvascular function in Hashimotoâs thyroiditis patients with overt and subclinical hypothyroidism and to evaluate effects of l-thyroxine replacement on coronary endothelial function. Methods In total, 10 overt hypothyroid patients, 10 subclinical hypothyroid patients, and 10 controls were enrolled. FT4, TSH, anti-thyroid antibodies, lipid profile, insulin, glucose, HOMA-IR, physical parameters, and CFR measured by TTDE were recorded before and after 6 months of l-thyroxine replacement in all groups. Results CFR values of all hypothyroid patients at baseline were significantly lower than those in controls. After l-thyroxine, CFR increased significantly in overt and subclinical hypothyroidism with respect to the baseline measurements (P r = 0.31, P = 0.01) and negatively correlated with TSH and HOMA-IR (r = â0.38, P = 0.002 and r = â0.42, P Conclusion Subclinical as well as overt hypothyroid patients have impaired coronary microvascular function which improved after l-thyroxine therapy. Treatment of Hashimotoâs thyroiditis patients with subclinical hypothyroidism should be considered to improve cardiovascular disease risk. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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