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Background: Familial adenomatous polyposis (FAP) predisposes individuals to duodenal adenomas. This study describes the histopathological features of endoscopic and surgical specimens from the duodenum, as well as genotype-phenotype associations. Methods: All known FAP patients were included from the Danish Polyposis Register. FAP patients were defined as having more than 100 cumulative colorectal adenomas and/or having a known germline pathogenic variant in the APC gene. Endoscopic procedures, histopathology, and genetics were evaluated. Results: Of 500 FAP patients, 70.6% underwent esophagogastroduodenoscopy (EGD) at least once. Of these, 59.2% presented with detectable duodenal adenomas. The most severe morphology was tubular in 62.7% patients, tubulovillous in 25.4%, and villous in 12.0%, while the most severe dysplasia was low-grade in 67.5% patients, high-grade in 25.4%, and 6.7% had adenocarcinoma. In 6.2% of FAP patients, duodenal resection was recommended, including 29% with duodenal adenocarcinoma. The risk of duodenal surgery was 1.31 per 1,000 person-years (median age: 53 years). The predominant reason for surgery was extensive polyposis (67.7%). Of the patients who underwent duodenal resection, a median of six (IQR: 4–8) EGDs were performed within five years prior to surgery, but 67.6% and 83.9% never underwent a duodenal polypectomy or endoscopic mucosa resection, respectively. Of note, seventeen of 500 patients (3.4%) developed duodenal adenocarcinoma, of which 47% were advanced at diagnosis. Genetic evaluations revealed various pathogenic variants in the APC gene, with no strong genotype-phenotype association. Conclusions: The prevalence of duodenal adenomas and cancer in FAP warrants vigilant endoscopic surveillance. Nevertheless, the need for duodenal surgery persists and should together with endoscopic practice be monitored in national registers. [ABSTRACT FROM AUTHOR]

Background: The use of digital tools such as electronic patient portals in different health care disciplines and settings has been increasing, but the rate of implementation in clinical practice still lags behind expectations. While studies have linked the use of electronic patient portals to positive health outcomes for patients, studies addressing the viewpoints of healthcare providers are rare. Methods: We performed an online survey of attitudes of healthcare providers towards an electronic patient portal for mental health hospitals. The portal was developed by five communal providers of mental health care in different regions in Germany. The survey was carried out during the early phase of implementation of the portal. Results: Twenty project leaders and 37 clinicians from five different mental health hospitals answered the questionnaire (response rate: 45% and 28%). Overall, acceptance of online applications among respondents was high. The healthcare providers mentioned perceived benefits (e.g. accessibility of new patient groups, use of therapy-free periods) as well as a number of technical, structural, organizational and staffing barriers for successful implementation in hospital settings (e.g. workload of healthcare providers and lack of staff, limited digital competences, unstable WLAN). Conclusion: The perceived barriers and facilitators of the implementation of online applications and electronic patient portals in mental health hospitals identified by healthcare providers may be taken into account. Improving commitment of the healthcare providers to implementation and use of digital interventions may help foster digitalisation in mental health hospitals. [ABSTRACT FROM AUTHOR]

A study published in Acta Neuropathologica explores the use of targeted whole-viral genome sequencing from formalin-fixed paraffin-embedded (FFPE) neuropathology specimens. The researchers conducted a proof-of-concept study using a viral nucleic acid enrichment protocol on 23 FFPE samples with confirmed viral infections. They found that the viral enrichment panel led to a significant enrichment of viral sequences, resulting in a high genome coverage and improved detection of viral integration sites. The study demonstrates that metagenomic sequencing of virus-enriched libraries from FFPE specimens is a valuable method for viral whole-genome sequencing, even in low-quality and low-biomass samples. [Extracted from the article]

This paper presents the development and application of a deep learning-based method for inverting CO2 atmospheric plumes from power plants using satellite imagery of the CO2 total column mixing ratios (XCO2). We present an end-to-end CNN approach, processing the satellite XCO2 images to derive estimates of the power plant emissions, that is resilient to missing data in the images due to clouds or to the partial view of the plume due to the limited extent of the satellite swath. The CNN is trained and validated exclusively on CO2 simulations from 8 power plants in Germany in 2015. The evaluation on this synthetic dataset shows an excellent CNN performance with relative errors close to 20 %, which is only significantly affected by substantial cloud cover. The method is then applied to 39 images of the XCO2 plumes from 9 power plants, acquired by the Orbiting Carbon Observatory-3 Snapshot Area Maps (OCO3-SAMs), and the predictions are compared to average annual reported emissions. The results are very promising, showing a relative difference of the predictions to reported emissions only slightly higher than the relative error diagnosed from the experiments with synthetic images. Furthermore, the analysis of the area of the images in which the CNN-based inversion extract the information for the quantification of the emissions, based on integrated gradient techniques, demonstrates that the CNN effectively identifies the location of the plumes in the OCO-3 SAM images. This study demonstrates the feasibility of applying neural networks that have been trained on synthetic datasets for the inversion of atmospheric plumes in real satellite imagery of XCO2, and provides the tools for future applications. [ABSTRACT FROM AUTHOR]

Benign tumors, but rarely cancer, are common in patients with tuberous sclerosis complex (TSC). Blood samples from patients undergoing treatment for TSC at our institution were analyzed for their individual sensitivity to ionizing radiation. Blood samples were collected from 13 adult patients with TSC. The samples were irradiated ex vivo and analyzed by 3-color fluorescence in situ hybridization. In each patient, aberrations were analyzed in 200 metaphases of chromosomes 1, 2, and 4 and scored as breaks. Radiosensitivity was determined by mean breaks per metaphase (B/M) and compared to both healthy donors and oncologic patients. The radiosensitivity (B/M) of the TSC patient cohort (n = 13; female: 46.2%, B/M: 0.48 ± 0.11) was clearly increased compared to healthy individuals of similar age (n = 90; female: 54.4%; B/M: 0.40 ± 0.09; p = 0.001). There was no difference compared to age-matched oncological patients (n = 78; female: 67.9%; B/M 0.49 ± 0.14; p = 0.246). Similarly, the proportion of radiosensitive (B/M > 0.5) and distinctly radiosensitive individuals (B/M > 0.6) was increased in the TSC and oncological patient cohorts (TSC: 30.8% and 7.7%, oncological patients: 46.2% and 14.1%) compared to the healthy individuals (11.1% and 2.2%). Although patients with TSC develop mostly benign and rarely malignant tumors, they are similarly sensitive to radiation as patients with malignant tumors. [ABSTRACT FROM AUTHOR]

Cyanobacteria, commonly known as blue-green algae, are prevalent in freshwater systems and have gained interest for their potential in medical applications, particularly in skin regeneration. Among these, Synechococcus sp. strain PCC 7002 stands out because of its rapid proliferation and capacity to be genetically modified to produce growth factors. This study investigates the safety of Synechococcus sp. PCC 7002 when used in scaffolds for skin regeneration, focusing on systemic inflammatory responses in a murine model. We evaluated the following three groups: scaffolds colonized with genetically engineered bacteria producing hyaluronic acid, scaffolds with wild-type bacteria, and control scaffolds without bacteria. After seven days, we assessed systemic inflammation by measuring changes in cytokine profiles and lymphatic organ sizes. The results showed no significant differences in spleen, thymus, and lymph node weights, indicating a lack of overt systemic toxicity. Blood cytokine analysis revealed elevated levels of IL-6 and IL-1β in scaffolds with bacteria, suggesting a systemic inflammatory response, while TNF-α levels remained unaffected. Proteome profiling identified distinct cytokine patterns associated with bacterial colonization, including elevated inflammatory proteins and products, indicative of acute inflammation. Conversely, control scaffolds exhibited protein profiles suggestive of a rejection response, characterized by increased levels of cytokines involved in T and B cell activation. Our findings suggest that Synechococcus sp. PCC 7002 does not appear to cause significant systemic toxicity, supporting its potential use in biomedical applications. Further research is necessary to explore the long-term effects and clinical implications of these responses. [ABSTRACT FROM AUTHOR]

Egø Engsø is an artificial Danish suburban lake created in 2006, primarily for nutrient retention and flood control. Expanding submerged macrophyte cover (dominated by Stoneworts Chara spp. and Pondweeds Potamogeton spp.) attracted moulting concentrations of 600 mute swans Cygnus olor, 1100 greylag geese Anser anser and 280 Canada geese Branta canadensis. These unexpected additions to the avifauna benefit from reliable food supplies and effective protection from recreational disturbance on and near the water surface. Egø Engsø is a model of enabling intense human activity at a waterbird moulting site, and confirming appropriate planning can accommodate multiple functional objectives following wetland creation. [ABSTRACT FROM AUTHOR]

Multinomial processing tree (MPT) models are a broad class of statistical models used to test sophisticated psychological theories. The research questions derived from these theories often go beyond simple condition effects on parameters and involve ordinal expectations (e.g., the same-direction effect on the memory parameter is stronger in one experimental condition than another) or disordinal expectations (e.g., the effect reverses in one experimental condition). Here, we argue that by refining common modeling practices, Bayesian hierarchical models are well suited to estimate and test these expectations. Concretely, we show that the default priors proposed in the literature lead to nonsensical predictions for individuals and the population distribution, leading to problems not only in model comparison but also in parameter estimation. Rather than relying on these priors, we argue that MPT modelers should determine priors that are consistent with their theoretical knowledge. In addition, we demonstrate how Bayesian model comparison may be used to test ordinal and disordinal interactions by means of Bayes factors. We apply the techniques discussed to empirical data from Bell et al. Journal of Experimental Psychology: Learning, Memory, and Cognition, 41, 456–472 (2015). [ABSTRACT FROM AUTHOR]

The chemical UV filter 2-ethylhexyl salicylate (EHS) is used in various personal-care products. The dermal and oral metabolism of EHS have already been targeted by different studies. However, toxicokinetic data after a single dermal exposure to EHS was missing. In our study, three volunteers were dermally exposed to a commercial EHS-containing sunscreen for 9 h with an application dose of 2 mg sunscreen per cm2 body surface area. The exposure was performed indoors, and sunscreen was applied on about 75% of the total skin area. Complete urine voids were collected over 72 h and eight blood samples were drawn from each subject. Urine samples were analyzed for EHS and seven known metabolites (5OH-EHS, 4OH-EHS, 2OH-EHS, 6OH-EHS, 4oxo-EHS, 5oxo-EHS, and 5cx-EPS) by online-SPE UPLC MS/MS. The peaks of urinary elimination occurred 10–11 h after application. The elimination half-lives (Phase 1) were between 6.6 and 9.7 h. The dominant urinary biomarkers were EHS itself, followed by 5OH-EHS, 5cx-EPS, 5oxo-EHS, and 4OH-EHS. 2OH-EHS, 6OH-EHS, and 4oxo-EHS were detected only in minor amounts. An enhanced analysis of conjugation species revealed marginal amounts of unconjugated metabolites and up to 40% share of sulfate conjugates for 5OH-EHS, 5oxo-EHS, and 5cx-EPS. The results demonstrated a delayed systemic resorption of EHS via the dermal route. Despite an extensive metabolism, the parent compound occurred as main urinary parameter. The delayed dermal resorption as well as the slow elimination of EHS indicate an accumulation up to toxicological relevant doses during daily repeated dermal application to large skin areas. [ABSTRACT FROM AUTHOR]

Even highly motivated undergraduates drift off their STEM career pathways. In large introductory STEM classes, instructors struggle to identify and support these students. To address these issues, we developed co‐redesign methods in partnership with disciplinary experts to create high‐structure STEM courses that better support students and produce informative digital event data. To those data, we applied theory‐ and context‐relevant labels to reflect active and self‐regulated learning processes involving LMS‐hosted course materials, formative assessments, and help‐seeking tools. We illustrate the predictive benefits of this process across two cycles of model creation and reapplication. In cycle 1, we used theory‐relevant features from 3 weeks of data to inform a prediction model that accurately identified struggling students and sustained its accuracy when reapplied in future semesters. In cycle 2, we refit a model with temporally contextualized features that achieved superior accuracy using data from just two class meetings. This modelling approach can produce durable learning analytics solutions that afford scaled and sustained prediction and intervention opportunities that involve explainable artificial intelligence products. Those same products that inform prediction can also guide intervention approaches and inform future instructional design and delivery.Practitioner notesWhat is already known about this topicLearning analytics includes an evolving collection of methods for tracing and understanding student learning through their engagements with learning technologies.Prediction models based on demographic data can perpetuate systemic biases.Prediction models based on behavioural event data can produce accurate predictions of academic success, and validation efforts can enrich those data to reflect students' self‐regulated learning processes within learning tasks.What this paper addsLearning analytics can be successfully applied to predict performance in an authentic postsecondary STEM context, and the use of context and theory as guides for feature engineering can ensure sustained predictive accuracy upon reapplication.The consistent types of learning resources and cyclical nature of their provisioning from lesson to lesson are hallmarks of high‐structure active learning designs that are known to benefit learners. These designs also provide opportunities for observing and modelling contextually grounded, theory‐aligned and temporally positioned learning events that informed prediction models that accurately classified students upon initial and later reapplications in subsequent semesters.Co‐design relationships where researchers and instructors work together toward pedagogical implementation and course instrumentation are essential to developing unique insights for feature engineering and producing explainable artificial intelligence approaches to predictive modelling.Implications for practice and/or policyHigh‐structure course designs can scaffold student engagement with course materials to make learning more effective and products of feature engineering more explainable.Learning analytics initiatives can avoid perpetuation of systemic biases when methods prioritize theory‐informed behavioural data that reflect learning processes, sensitivity to instructional context and development of explainable predictors of success rather than relying on students' demographic characteristics as predictors.Prioritizing behaviours as predictors improves explainability in ways that can inform the redesign of courses and design of learning supports, which further informs the refinement of learning theories and their applications. [ABSTRACT FROM AUTHOR]

We analysed whether temporal heterogeneity of ctDNA encodes evolutionary patterns in ovarian cancer. Targeted sequencing of 275 cancer-associated genes was performed in a primary tumor biopsy and in ctDNA of six longitudinal plasma samples from 15 patients, using the Illumina platform. While there was low overall concordance between the mutational spectrum of the primary tumor biopsies vs. ctDNA, TP53 variants were the most commonly shared somatic alterations. Up to three variant clusters were detected in each tumor biopsy, likely representing predominant clones of the primary tumor, most of them harbouring a TP53 variant. By tracing these clusters in ctDNA, we propose that liquid biopsy may allow to assess the contribution of ancestral clones of the tumor to relapsed abdominal masses, revealing two evolutionary patterns. In pattern#1, clusters detected in the primary tumor biopsy were likely relapse seeding clones, as they contributed a major share to ctDNA at relapse. In pattern#2, similar clusters were present in tumors and ctDNA; however, they were entirely cleared from liquid biopsy after chemotherapy and were undetectable at relapse. ctDNA private variants were present among both patterns, with some of them mirroring subclonal expansions after chemotherapy. We demonstrate that tracing the temporal heterogeneity of ctDNA, even below exome scale resolution, deciphers evolutionary trajectories in ovarian cancer. Furthermore, we describe two evolutionary patterns that may help to identify relapse seeding clones for targeted therapy. [ABSTRACT FROM AUTHOR]

Background: Currently, multiple tools exist to teach and learn anatomy, but finding an adequate activity is challenging. However, it can be achieved through haptic experiences, where motivation is the means of a significant learning process. This study aimed to evaluate a haptic experience to determine if a tactile and painting with color marker interactive experience, established a better learning process in comparison to the traditional 2D workshop on printed paper with photographs. Methods: Plaster bone models of the scapulae, humerus and clavicle were elaborated from a computerized scan tomography. Second year undergraduate medical students were invited to participate, where subjects were randomly assigned to the traditional 2D method or the 3D plaster bone model. A third group decided not to join any workshop. Following, all three groups were evaluated on bone landmarks and view, laterality, muscle insertions and functions. 2D and 3D workshop students were asked their opinion in a focus group and answered a survey regarding the overall perception and learning experience. Evaluation grades are presented as mean ± standard deviation, and answers from the survey are presented as percentages. Results: The survey demonstrated the students in the 3D model graded the experience as outstanding, and in five out of the six questions, answers were very good or excellent. In contrast, for students participating in the 2D workshop the most common answers were fair or good. The exception was the answer regarding the quiz, where both groups considered it good, despite the average among all groups not being a passing grade. Conclusions: To learn the anatomy of the shoulder, the conventional methodology was compared with a haptic experience, where plaster bone models were used, enabling students to touch and paint on them. Based on the focus group and survey this study revealed the 3D workshop was an interactive experience where, the sense of touch and painting greatly contributed to their learning process. Even though this activity was useful in terms of learning bone landmarks, view muscle insertions, and establish relations, further activities must be developed to increase their understanding regarding their function, and its relevance in a clinical setting. [ABSTRACT FROM AUTHOR]

The drug efflux transporter P-glycoprotein, encoded by the ABCB1 gene, promotes acquired chemoresistance. We explored the presence and clinical relevance of circulating cell-free ABCB1 transcripts (cfABCB1tx) in ovarian cancer patients (173 longitudinal serum samples from 79 cancer patients) using digital droplet PCR. cfABCB1tx were readily detectable at primary diagnosis (median 354 mRNA copies/20 µl serum), paralleled FIGO-stage and predicted surgical outcome (p = 0.023, p=0.022, respectively). Increased cfABCB1tx levels at primary diagnosis indicated poor PFS (HR = 2.329, 95%CI:1.374–3.947, p = 0.0017) and OS (HR = 2.074, 95%CI:1.194–3.601, p = 0.0096). cfABCB1tx induction under platinum-based chemotherapy was an independent predictor for poor OS (HR = 2.597, 95%CI: 1.218–5.538, p = 0.013) and paralelled a micrometastatic phenotype, shaped by the presence of disseminated tumor cells in the bone marrow. A strong correlation was observed between cfABCB1tx and circulating transcripts of the metastasis-inducer MACC1, which is the transcriptional activator of ABCB1. Combined assessment of cfABCB1tx and circulating cell-free MACC1 transcripts (cfMACC1tx) resulted in an improved prognostic prediction, with the cfABCB1tx-high/cfMACC1tx-high phenotype bearing the highest risk for relapse and death. Conclusively, we provide proof of principle, that ABCB1 transcripts are readily traceable in the liquid-biopsy of ovarian cancer patients, advancing a new dimension for systemic monitoring of ABCB1/P-glycoprotein expression dynamics. [ABSTRACT FROM AUTHOR]

Background: The use of free gracilis muscle flaps in reconstructive surgery of the lower leg is common practice to cover defects. However, there is still a lack of understanding of the morphometric changes that occur in the transferred muscle and area of interest over time, particularly the characteristic volume decrease that is observed over the course of the first year. This study aimed to assess volume changes in patients with free gracilis muscle flap reconstruction following infection, trauma, or malignancies of the lower extremity. Methods: Three-dimensional surface imaging was performed intraoperatively after 2 weeks, 6 months, and 12 months with the Vectra H2 system. A total of 31 patients were included in this study and analyzed. Results: There was an average volume increase of 146.67 ± 29.66% 2 weeks after reconstruction. Compared to this volume increase, there was a reduction of 108.44 ± 13.62% after 12 months (p < 0.05). Overall, we found a shrinkage to 85.53 ± 20.14% of the intraoperative baseline volume after 12 months. Conclusions: The use of non-invasive 3D surface imaging is a valuable tool for volume monitoring after free flap reconstruction of the lower extremity. The free gracilis muscle flap undergoes different phases of volume change over the first year, with the greatest influence on overall change being the development and decongestion of edema. Precise initial surgical tailoring is crucial for optimal long-term functional and cosmetic results. [ABSTRACT FROM AUTHOR]

Background: Acute abdominal pain (AAP) is a major driver for capacity-use in emergency departments (EDs) worldwide. Yet, the health care utilization of patients with AAP before and after the ED remains unclear. The primary objective of this study was to describe adult patients presenting to the ED with AAP and their outpatient care (OC) use before and after the ED. Secondary objectives included description of hospitalization rates, in-hospital mortality, ED re-visits, and exploration of potential risk factors for hospitalization and ED re-visits. Methods: For the analysis, we combined routine hospital data from patients who visited 15 EDs in Germany in 2016 with their statutory health insurance OC claims data from 2014 to 2017. Adult patients were included based on a chief complaint or an ED diagnosis indicating unspecific AAP or the Manchester Triage System indicator "Abdominal pain in adults". Baseline characteristics, ED diagnosis, frequency and reason of hospitalization, frequency and type of prior-OC (prOC) use up to 3 days before and of post-OC use up to 30 days after the ED visit. Main results: We identified 28,085 adults aged ≥ 20 years with AAP. 39.8% were hospitalized, 33.9% sought prOC before the ED visit (48.6% of them were hospitalized) and 62.7% sought post-OC up to 30 days after the ED visit. Hospitalization was significantly more likely for elderly patients (aged 65 and above vs. younger; adjusted OR 3.05 [95% CI 2.87; 3.25]), prOC users (1.71 [1.61; 1.90]) and men (1.44 [1.37; 1.52]). In-hospital mortality rate was 3.1% overall. Re-visiting the ED within 30 days was more likely for elderly patients (1.32 [1.13; 1.55) and less likely for those with prOC use (0.37 [0.31; 0.44]). Conclusions: prOC use was associated with more frequent hospitalizations but fewer ED re-visits. ED visits by prOC patients without subsequent hospitalization may indicate difficulties of OC resources to meet the complex diagnostic requirements and expectations of this patient population. Fewer ED re-visits in prOC users indicate effective care in this subgroup. [ABSTRACT FROM AUTHOR]

Timber–concrete composite (TCC) structural systems are characterized by the combination of timber and concrete, which are connected to transmit shear forces between the two elements. In addition, to achieve an efficient connection, the slip between the two materials should be limited. Therefore, the load-carrying capacity, the stiffness, and the failure mode of TCC connections are important for the behavior of the composite element. This work aims to investigate the influence of test conditions on TCC connections using shear tests to determine the mechanical properties of connections. Therefore, it is essential to understand the influence of the configuration of the specimens (symmetric as push-out tests or asymmetric as inclined tests), the type of interface between the timber and concrete, and the test procedure (static or cyclic load protocol) on the resulting load-carrying capacity, stiffness, and failure modes. This paper reviews experimental tests conducted on TCC shear connection specimens, using various configurations to assess the influence of the test specimen configuration, material interface, and testing protocol on the determination of the mechanical properties. [ABSTRACT FROM AUTHOR]

Objectives: We have recently described a predictive/prognostic model for ovarian cancer, exploiting commonly available clinico-pathological parameters and the ovarian serum biomarkers mesothelin (MSL), human epididymis protein 4 (HE4) and cancer-antigen 125 (CA125). Considering urine as a prototype non- invasive sample, we investigated whether serum levels of these biomarkers are mirrored in urine and compared their clinical relevance in matched serum vs. urine samples. Methods: MSL, HE4 and CA125 were quantified in urinary (n=172) and matched serum samples (n=188) from ovarian cancer patients (n=192) using the Lumipulse ® G chemiluminescent enzyme immunoassay (Fujirebio). Results: While absolute concentrations of MSL or CA125 were higher in serum than in matched urine samples, HE4 concentrations were considerably higher in urine than in serum. Nonetheless, the levels of all three biomarkers strongly correlated between matched serum vs. urine samples and were unrelated to BRCA1/2 mutational status. Consequently, prediction of surgical outcome or relapse/death by MSL, HE4 or CA125 was similarly efficient among urinary- vs. serum-based detection. HE4 provided the highest capacity to predict surgical outcome or relapse/death among both body fluids (urine: AUC=0.854; serum: AUC=0.750, respectively). All clinically relevant findings regarding the investigated urinary biomarkers were equally reproducible among raw vs. creatinine-normalized datasets, suggesting that normalization may have subordinate priority for urine-based analysis of these biomarkers. Conclusion: We report that the capacity of MSL, HE4 and CA125 to predict surgical outcome and relapse/death is equivalent between serum vs. urine-based detection. Urinary biomarkers, in particular HE4, may provide an additional dimension for prognostic modeling in ovarian cancer. [ABSTRACT FROM AUTHOR]

The potential of Si and SiGe-based devices for the scaling of quantum circuits is tainted by device variability. Each device needs to be tuned to operation conditions and each device realisation requires a different tuning protocol. We demonstrate that it is possible to automate the tuning of a 4-gate Si FinFET, a 5-gate GeSi nanowire and a 7-gate Ge/SiGe heterostructure double quantum dot device from scratch with the same algorithm. We achieve tuning times of 30, 10, and 92 min, respectively. The algorithm also provides insight into the parameter space landscape for each of these devices, allowing for the characterization of the regions where double quantum dot regimes are found. These results show that overarching solutions for the tuning of quantum devices are enabled by machine learning. [ABSTRACT FROM AUTHOR]

Background: Postoperative delirium (POD) in the oral and maxillofacial settings has gained more attention in recent decades. Due to advances in medical technology, treatment possibilities have expanded treatment for elderly and frail patients. This scoping review explores the correlation between POD and oral and maxillofacial surgery, summarizing screening and management protocols and identifying risk factors in this surgical field. Methods: This review follows the Scoping Review extension of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-ScR). A comprehensive literature search was performed using multiple databases, focusing on articles published from 2002 to 2023 that discuss delirium in oral and maxillofacial surgery settings. The review was registered beforehand in the Open Science Framework (https://osf.io/r2ebc). Results: From the initial 644 articles, 68 met the inclusion criteria. These studies highlighted the significant heterogeneity in POD diagnosis methods. The review identifies multiple risk factors across the preoperative, intraoperative, and postoperative phases that influence the occurrence of POD. Significant and independent risk factors in multiple regression analysis were highlighted, creating a clinical prediction list for the occurrence of POD. Conclusion: It is crucial to preoperatively identify patients at risk for POD and actively modify these risks throughout the patient's hospital stay. Implementing nonpharmacological preventive measures for at-risk patients is recommended to decrease the incidence of POD. Future research should focus on creating standardized specialty-specific protocols incorporating validated assessment tools and addressing the full spectrum of risk factors associated with POD. [ABSTRACT FROM AUTHOR]

This study investigates the impact of acetylsalicylic acid (ASA), also known as aspirin, on adipose tissue-derived stem cells (ASCs), aiming to elucidate its dose-dependent effects on morphology, viability, proliferation, and osteogenic differentiation. Isolated and characterized human ASCs were exposed to 0 µM, 100 µM, 200 µM, 400 µM, 800 µM, 1000 µM, 10,000 µM, and 16,000 µM of ASA in vitro. Cell morphology, viability, and proliferation were evaluated with fluorescent live/dead staining, alamarBlue viability reagent, and CyQUANT® cell proliferation assay, respectively. Osteogenic differentiation under stimulation with 400 µM or 1000 µM of ASA was assessed with alizarin red staining and qPCR of selected osteogenic differentiation markers (RUNX2, SPP1, ALPL, BGLAP) over a 3- and 21-day-period. ASA doses ≤ 1000 µM showed no significant impact on cell viability and proliferation. Live/dead staining revealed a visible reduction in viable cell confluency for ASA concentrations ≥ 1000 µM. Doses of 10,000 µM and 16,000 µM of ASA exhibited a strong cytotoxic and anti-proliferative effect in ASCs. Alizarin red staining revealed enhanced calcium accretion under the influence of ASA, which was macro- and microscopically visible and significant for 1000 µM of ASA (p = 0.0092) in quantification if compared to osteogenic differentiation without ASA addition over a 21-day-period. This enhancement correlated with a more pronounced upregulation of osteogenic markers under ASA exposure (ns). Our results indicate a stimulatory effect of 1000 µM of ASA on the osteogenic differentiation of ASCs. Further research is needed to elucidate the precise molecular mechanisms underlying this effect; however, this discovery suggests promising opportunities for enhancing bone tissue engineering with ASCs as cell source. [ABSTRACT FROM AUTHOR]

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Nitrogen oxides (NOx = NO + NO2) are air pollutants which are co-emitted with CO2 during high-temperature combustion processes. Monitoring NOx emissions is crucial for assessing air quality and for providing proxy estimates of CO2 emissions. Satellite observations, such as those from the TROPOspheric Monitoring Instrument (TROPOMI) on board the Sentinel-5P satellite, provide global coverage at high temporal resolution. However, satellites measure only NO2 , necessitating a conversion to NOx. Previous studies have applied a constant NO2 -to- NOx conversion factor. In this paper, we develop a more realistic model for NO2 -to- NOx conversion and apply it to TROPOMI data of 2020 and 2021. To achieve this, we analysed plume-resolving simulations from the MicroHH large-eddy simulation model with chemistry for the Bełchatów (PL), Jänschwalde (DE), Matimba (ZA) and Medupi (ZA) power plants, as well as a metallurgical plant in Lipetsk (RU). We used the cross-sectional flux method to calculate NO , NO2 and NOx line densities from simulated NO and NO2 columns and derived NO2 -to- NOx conversion factors as a function of the time since emission. Since the method of converting NO2 to NOx presented in this paper assumes steady-state conditions and that the conversion factors can be modelled by a negative exponential function, we validated the conversion factors using the same MicroHH data. Finally, we applied the derived conversion factors to TROPOMI NO2 observations of the same sources. The validation of the NO2 -to- NOx conversion factors shows that they can account for the NOx chemistry in plumes, in particular for the conversion between NO and NO2 near the source and for the chemical loss of NOx further downstream. When applying these time-since-emission-dependent conversion factors, biases in NOx emissions estimated from TROPOMI NO2 images are greatly reduced from between - 50 % and - 42 % to between only - 9.5 % and - 0.5 % in comparison with reported emissions. Single-overpass estimates can be quantified with an uncertainty of 20 %–27 %, while annual NOx emission estimates have uncertainties in the range of 4 %–21 % but are highly dependent on the number of successful retrievals. Although more simulations covering a wider range of meteorological and trace gas background conditions will be needed to generalise the approach, this study marks an important step towards a consistent, uniform, high-resolution and near-real-time estimation of NOx emissions – especially with regard to upcoming NO2 -monitoring satellites such as Sentinel-4, Sentinel-5 and CO2M. [ABSTRACT FROM AUTHOR]

For n, d ∈ ℕ, the cone 퓟n+1,2d of positive semidefinite real forms in n + 1 variables of degree 2d contains the subcone Σn+1,2d of those representable as finite sums of squares of real forms. Hilbert [11] proved that these cones coincide exactly in the Hilbert cases (n + 1, 2d) with n + 1 = 2 or 2d = 2 or (n + 1, 2d) = (3, 4). In this paper, we induce a filtration of intermediate cones between Σn+1,2d and 퓟n+1,2d via the Gram matrix approach in [4] on a filtration of irreducible projective varieties Vk−n ⊊ ... ⊊ Vn ⊊ ... ⊊ V0 containing the Veronese variety. Here, k is the dimension of the vector space of real forms in n + 1 variables of degree d. By showing that V0, ..., Vn (and Vn+1 when n = 2) are varieties of minimal degree, we demonstrate that the corresponding intermediate cones coincide with Σn+1,2d. We moreover prove that, in the non-Hilbert cases of (n + 1)-ary quartics for n ≥ 3 and (n + 1)-ary sextics for n ≥ 2, all the remaining cone inclusions are strict. [ABSTRACT FROM AUTHOR]

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The divergence method, a lightweight approach for estimating emission fluxes from satellite images, rests on a few implicit assumptions. This paper explicitly outlines these assumptions by deriving the method from first principles. The assumptions are: the enhanced mass flux is dominated by advection, normal fluxes vanish at the top and bottom of the atmosphere, steady‐state conditions apply, sources are multiplications of temporal and spatial functions, sinks are described as first‐order reactions, and effective wind fields are concentration‐weighted wind fields. No such assumptions have to be made for the background field. A "topography correction term" does not follow from the theory, but is rather shown to be a practical correction for topography‐dependent effective wind speed errors. The cross‐sectional flux method follows naturally from the derived theory, and the methods are compared. Effects of discrete pixels and finite‐difference operations are explored, leading to recommendations, primarily the recommendation to integrate over small regions only to minimize the influence of noise. Numerical examples featuring Gaussian plumes and COSMO‐GHG simulated plumes are provided. The Gaussian plume example suggests that the divergence method might underestimate emissions when assuming only advection in the presence of cross‐wind diffusion. Conversely, the cross‐sectional flux method remains unaffected, provided fluxes are integrated across the entire plume. The COSMO‐GHG example reveals frequent violations of the steady‐state assumption, although the assumption remains valid proximal to the source (<20 km in this example). It is the hope that this paper provides a solid theoretical foundation for the divergence and cross‐sectional flux methods. Plain Language Summary: Power plants, megacities, and other regions can be places where considerable amounts of gases are emitted into the atmosphere. Satellite data is capable of recording the enhanced concentrations in the atmosphere due to these sources. How does one estimate emissions of these sources based on this data? Typically by running an atmospheric inverse model; but one computationally lightweight method gaining popularity is the "divergence method." With this method, one applies a simple mathematical operation to the satellite image multiplied by the horizontal wind speeds—the result of which is related to the emissions. The method has been used before, but here we systematically state the assumptions involved; factors like how gases are transported horizontally and over time, and what happens when we apply the method on pixelated data (such as satellite images). We find that some other analyses in the literature may be partially incorrect. Another popular method (the "cross‐sectional flux") is easily derived from the same theory. Synthetic examples are used to illustrate that various assumptions are not met in realistic data; although the examples also show that one can work around these limitations by a careful application of the methods, and by acquiring more estimates over many days. Key Points: The divergence method for estimating emissions from satellite images is derived from first principlesAssumptions made on the way are made explicit, highlighting discrepancies with existing literatureA comparison is made against the cross‐sectional flux method which follows from the same theory [ABSTRACT FROM AUTHOR]

Non-photochemical quenching (NPQ) is a protective mechanism for dissipating excess energy generated during photosynthesis in the form of heat. The accelerated relaxation of the NPQ in fluctuating light can lead to an increase in the yield and dry matter productivity of crops. Since the measurement of NPQ is time-consuming and requires specific light conditions, theoretical NPQ (NPQ(T)) was introduced for rapid estimation, which could be suitable for High-throughput Phenotyping. We investigated the potential of NPQ(T) to be used for testing plant genetic resources of chickpea under drought stress with non-invasive High-throughput Phenotyping complemented with yield traits. Besides a high correlation between the hundred-seed-weight and the Estimated Biovolume, significant differences were observed between the two types of chickpea desi and kabuli for Estimated Biovolume and NPQ(T). Desi was able to maintain the Estimated Biovolume significantly better under drought stress. One reason could be the effective dissipation of excess excitation energy in photosystem II, which can be efficiently measured as NPQ(T). Screening of plant genetic resources for photosynthetic performance could take pre-breeding to a higher level and can be implemented in a variety of studies, such as here with drought stress or under fluctuating light in a High-throughput Phenotyping manner using NPQ(T). [ABSTRACT FROM AUTHOR]

Atmospheric emissions from anthropogenic hotspots, i.e., cities, power plants and industrial facilities, can be determined from remote sensing images obtained from airborne and space-based imaging spectrometers. In this paper, we present a Python library for data-driven emission quantification (ddeq) that implements various computationally light methods such as the Gaussian plume inversion, cross-sectional flux method, integrated mass enhancement method and divergence method. The library provides a shared interface for data input and output and tools for pre- and post-processing of data. The shared interface makes it possible to easily compare and benchmark the different methods. The paper describes the theoretical basis of the different emission quantification methods and their implementation in the ddeq library. The application of the methods is demonstrated using Jupyter notebooks included in the library, for example, for NO 2 images from the Sentinel-5P/TROPOMI satellite and for synthetic CO 2 and NO 2 images from the Copernicus CO 2 Monitoring (CO2M) satellite constellation. The library can be easily extended for new datasets and methods, providing a powerful community tool for users and developers interested in emission monitoring using remote sensing images. [ABSTRACT FROM AUTHOR]

Menstrual hygiene management (MHM) among female students is a neglected public health issue in the U.S. This study documented period product insecurity, school absenteeism, and use of school resources to obtain period products among high-school students in St. Louis, MO. Female students completed an anonymous, self-administered survey in English (n = 119). Descriptive statistics were used to determine the prevalence of period product need, resources used to obtain period products, and period-related absenteeism. The mean age of participants was 15.78 ± 1.28. Nearly two-thirds (64.4% (95% CI 55.1%-73.0%)) reported period product insecurity. Two-thirds (66.9% (95% CI 57.7%-75.3%)) reported using at least one of the school's resources to obtain period products. One-third of the participants (33.6% (95% CI 25.0%-43.1%)) reported missing school due to a lack of period products. School nurses need to be cognizant of how MHM affects their students' attendance at school and what measures they can take to help reduce menstruation-related absenteeism. [ABSTRACT FROM AUTHOR]

(1) Head and neck squamous cell carcinoma (HNSCC) is common, while treatment is difficult, and mortality is high. Kinase inhibitors are promising to enhance the effects of radiotherapy. We compared the effects of the PARP inhibitors talazoparib and niraparib and that of the DNA-PKcs inhibitor AZD7648, combined with ionizing radiation. (2) Seven HNSCC cell lines, including Cal33, CLS-354, Detroit 562, HSC4, RPMI2650 (HPV-negative), UD-SCC-2 and UM-SCC-47 (HPV-positive), and two healthy fibroblast cell lines, SBLF8 and SBLF9, were studied. Flow cytometry was used to analyze apoptosis and necrosis induction (AnnexinV/7AAD) and cell cycle distribution (Hoechst). Cell inactivation was studied by the colony-forming assay. (3) AZD7648 had the strongest effects, radiosensitizing all HNSCC cell lines, almost always in a supra-additive manner. Talazoparib and niraparib were effective in both HPV-positive cell lines but only consistently in one and two HPV-negative cell lines, respectively. Healthy fibroblasts were not affected by any combined treatment in apoptosis and necrosis induction or G2/M-phase arrest. AZD7648 alone was not toxic to healthy fibroblasts, while the combination with ionizing radiation reduced clonogenicity. (4) In conclusion, talazoparib, niraparib and, most potently, AZD7648 could improve radiation therapy in HNSCC. Healthy fibroblasts tolerated AZD7648 alone extremely well, but irradiation-induced effects might occur. Our results justify in vivo studies. [ABSTRACT FROM AUTHOR]

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The aim of this paper is to compare the power measurement capabilities in millimetre- and sub-millimetre-wave frequency bands of several national metrology institutes and one research institute. The first comparison, in WR-6.5 waveguide (110 GHz to 170 GHz), involved NPL, TUBITAK UME and PTB. The second comparison, in WR-1.5 waveguide (500 GHz to 750 GHz), involved NPL, METAS, TUBITAK UME, LNE, WAT, GUM and VDI. Two types of travelling standards were used for these comparisons: a thermoelectric power sensor in the WR-6.5 band and a calorimetric power sensor in the WR-6.5 and WR-1.5 bands. The thermoelectric power sensor was characterised by the participants against their own standards and a generalised effective efficiency was calculated. The calorimetric power sensor operating in the WR-6.5 band was measured to observe its behaviour during the comparison and was also measured in the WR-1.5 band after being fitted with a suitable waveguide taper and used in conjunction with a frequency multiplier. The participants measured the output of the calorimetric power sensor and their own power sensor standard. A normalised power ratio method was used as a comparison parameter for the WR-1.5 band measurements. In addition, a pyroelectric power standard was used by METAS to measure absolute power, and a frequency of 650 GHz was used as a link between the absolute power and the power ratios. Finally, all but two of the measurement points compared between the participants achieved agreement in terms of E n scores less than 1. For the first time, an interlaboratory comparison of power measurements at sub-millimetre frequencies has been performed and, overall, good agreement was achieved between the different laboratories. [ABSTRACT FROM AUTHOR]

Previous research on whether source memory is enhanced for emotionally valenced sources yielded inconclusive results. To identify potential boundary conditions, we tested whether encoding instructions that promote affective versus different types of non-affective item-source-processing foster versus hamper source-valence effects. In both experiments, we used neutral words as items superimposed on emotional (positive & negative) or neutral pictures as sources. Source pictures were selected based on valence and arousal ratings collected in a pre-study such that only valence varied across sources. Source memory was measured via multinomial modelling. In Experiment 1, we applied an affective, item-focused orienting task (OT; i.e. word-pleasantness ratings) during item-source encoding and found enhanced source memory for emotionally valenced (positive & negative) compared to neutral sources. In Experiment 2, we systematically manipulated encoding instructions and again found enhanced source memory for emotionally valenced sources with an affective OT. No such effects occurred in the non-affective conditions, where participants were instructed to integrate item and source (item-source-fit judgments), to focus on the item (living-non-living judgments), or to encode the items only, respectively. With intentional item encoding, however, source memory was surprisingly better for positive than negative sources. We conclude that source-valence effects might unfold only under affective processing. [ABSTRACT FROM AUTHOR]

Purpose of Review: Chronic pancreatitis (CP), a condition marked by severe pain, necessitates precise pain assessment for effective treatment. This review explores recent advances in CP pain assessment, including CP-specific tools, quantitative sensory testing (QST), and the emerging use of wearable devices. Recent Findings: Unidimensional pain assessment tools are constrained in capturing the multifaceted nature of CP pain. CP-specific tools, such as the Comprehensive Pain Assessment Tool (COMPAT) and its briefer variant, COMPAT-SF, exhibit promise but may necessitate further validation for broader adoption. QST provides a semi-objective method for characterizing pain profiles, and the P-QST consortium is refining QST for CP patients. Additionally, technology is opening new avenues for objective pain assessment. Wearable devices, like smartwatches, can monitor vital signs, activity levels, and sleep quality. While they hold promise for improving pain assessment, their effectiveness requires further validation. Summary: Accurate pain assessment is critical for managing CP. Recent developments include tools like COMPAT and COMPAT-SF, QST for characterizing pain profiles, and the potential of wearable devices. These advances can potentially enhance pain assessment and guide personalized treatment strategies. Integration into clinical practice and rigorous validation will be instrumental in improving CP pain assessment and raising the level of patient care. [ABSTRACT FROM AUTHOR]

In the period of political repression up to the revolution of 1848–1849, private societies (Vereine) functioned as a surrogate for public life. The Gustav-Adolf-Verein, created to support diaspora communities, united protestants of different convictions, including clergy and believers who considered the traditional structures of the Prussian church insufficient to answer the needs of modern society. Among them were rationalists deemed heretics by King Friedrich Wilhelm IV. By means of his Patent of Toleration issued in 1847, the king attempted to squeeze the rationalists, called 'Lichtfreunde', out of his church, arguing that they were free to form new congregations (freie Gemeinden). Their training in public debate made several of the rationalist clergymen obvious candidates for the parliamentary bodies that came into life during the revolution of 1848–1849. Most of them were considered to be "democrats". [ABSTRACT FROM AUTHOR]

An editorial is presented on administrative sciences pioneers the navigation of complex governmental landscapes. Topics include demand for innovative approaches to public administration becomes increasingly evident; and guided the journal through periods of transition and growth, ensuring its continued relevance and impact in an ever-evolving academic landscape.

Objectives: Independent internal and external validation of three previously published CT-based radiomics models to predict local tumor progression (LTP) after thermal ablation of colorectal liver metastases (CRLM). Materials and methods: Patients with CRLM treated with thermal ablation were collected from two institutions to collect a new independent internal and external validation cohort. Ablation zones (AZ) were delineated on portal venous phase CT 2–8 weeks post-ablation. Radiomics features were extracted from the AZ and a 10 mm peri-ablational rim (PAR) of liver parenchyma around the AZ. Three previously published prediction models (clinical, radiomics, combined) were tested without retraining. LTP was defined as new tumor foci appearing next to the AZ up to 24 months post-ablation. Results: The internal cohort included 39 patients with 68 CRLM and the external cohort 52 patients with 78 CRLM. 34/146 CRLM developed LTP after a median follow-up of 24 months (range 5–139). The median time to LTP was 8 months (range 2–22). The combined clinical-radiomics model yielded a c-statistic of 0.47 (95%CI 0.30–0.64) in the internal cohort and 0.50 (95%CI 0.38–0.62) in the external cohort, compared to 0.78 (95%CI 0.65–0.87) in the previously published original cohort. The radiomics model yielded c-statistics of 0.46 (95%CI 0.29–0.63) and 0.39 (95%CI 0.28–0.52), and the clinical model 0.51 (95%CI 0.34–0.68) and 0.51 (95%CI 0.39–0.63) in the internal and external cohort, respectively. Conclusion: The previously published results for prediction of LTP after thermal ablation of CRLM using clinical and radiomics models were not reproducible in independent internal and external validation. Clinical relevance statement: Local tumour progression after thermal ablation of CRLM cannot yet be predicted with the use of CT radiomics of the ablation zone and peri-ablational rim. These results underline the importance of validation of radiomics results to test for reproducibility in independent cohorts. Key Points: • Previous research suggests CT radiomics models have the potential to predict local tumour progression after thermal ablation in colorectal liver metastases, but independent validation is lacking. • In internal and external validation, the previously published models were not able to predict local tumour progression after ablation. • Radiomics prediction models should be investigated in independent validation cohorts to check for reproducibility. [ABSTRACT FROM AUTHOR]

The HD-ZIP class I transcription factor Homeobox 1 (HvHOX1), also known as Vulgare Row-type Spike 1 (VRS1) or Six-rowed Spike 1, regulates lateral spikelet fertility in barley (Hordeum vulgare L.). It was shown that HvHOX1 has a high expression only in lateral spikelets, while its paralog HvHOX2 was found to be expressed in different plant organs. Yet, the mechanistic functions of HvHOX1 and HvHOX2 during spikelet development are still fragmentary. Here, we show that compared with HvHOX1 , HvHOX2 is more highly conserved across different barley genotypes and Hordeum species, hinting at a possibly vital but still unclarified biological role. Using bimolecular fluorescence complementation, DNA-binding, and transactivation assays, we validate that HvHOX1 and HvHOX2 are bona fide transcriptional activators that may potentially heterodimerize. Accordingly, both genes exhibit similar spatiotemporal expression patterns during spike development and growth, albeit their mRNA levels differ quantitatively. We show that HvHOX1 delays the lateral spikelet meristem differentiation and affects fertility by aborting the reproductive organs. Interestingly, the ancestral relationship of the two genes inferred from their co-expressed gene networks suggested that HvHOX1 and HvHOX2 might play a similar role during barley spikelet development. However, CRISPR-derived mutants of HvHOX1 and HvHOX2 demonstrated the suppressive role of HvHOX1 on lateral spikelets, while the loss of HvHOX2 does not influence spikelet development. Collectively, our study shows that through the suppression of reproductive organs, lateral spikelet fertility is regulated by HvHOX1, whereas HvHOX2 is dispensable for spikelet development in barley. [ABSTRACT FROM AUTHOR]

Aging affects all cell types in the CNS and plays an important role in CNS diseases. However, the underlying molecular mechanisms driving these age-associated changes and their contribution to diseases are only poorly understood. The white matter in the aging brain as well as in diseases, such as Multiple sclerosis is characterized by subtle abnormalities in myelin sheaths and paranodes, suggesting that oligodendrocytes, the myelin-maintaining cells of the CNS, lose the capacity to preserve a proper myelin structure and potentially function in age and certain diseases. Here, we made use of directly converted oligodendrocytes (dchiOL) from young, adult and old human donors to study age-associated changes. dchiOL from all three age groups differentiated in an comparable manner into O4 + immature oligodendrocytes, but the proportion of MBP + mature dchiOL decreased with increasing donor age. This was associated with an increased ROS production and upregulation of cellular senescence markers such as CDKN1A, CDKN2A in old dchiOL. Comparison of the transcriptomic profiles of dchiOL from adult and old donors revealed 1324 differentially regulated genes with limited overlap with transcriptomic profiles of the donors' fibroblasts or published data sets from directly converted human neurons or primary rodent oligodendroglial lineage cells. Methylome analyses of dchiOL and human white matter tissue samples demonstrate that chronological and epigenetic age correlate in CNS white matter as well as in dchiOL and resulted in the identification of an age-specific epigenetic signature. Furthermore, we observed an accelerated epigenetic aging of the myelinated, normal appearing white matter of multiple sclerosis (MS) patients compared to healthy individuals. Impaired differentiation and upregulation of cellular senescence markers could be induced in young dchiOL in vitro using supernatants from pro-inflammatory microglia. In summary, our data suggest that physiological aging as well as inflammation-induced cellular senescence contribute to oligodendroglial pathology in inflammatory demyelinating diseases such as MS. [ABSTRACT FROM AUTHOR]

Short headed studs used in grouted joints with precast concrete elements are currently not sufficiently covered by EN 1994‐1‐1. Therefore, three test series have been realised to define the load‐bearing capacity under these special conditions. These are characterised by short headed studs of height hsc=65 mm in combination with a high‐strength grout. For a more in‐depth analysis of the load‐bearing and deformation behaviour, a finite element model has been developed and validated on the conducted push‐out tests. Based on subsequent numerical studies – varying geometric and material parameters – recommendations of analytical model equations are given for headed studs of short length. [ABSTRACT FROM AUTHOR]