1. Survival benefit of overweight patients undergoing MitraClip® procedure in comparison to normal‐weight patients.
- Author
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Keller, Karsten, Geyer, Martin, Hobohm, Lukas, Tamm, Alexander R., Kreidel, Felix, Ruf, Tobias F., Hell, Michaela, Schmitt, Volker H., Bachmann, Kevin, Born, Sonja, Schulz, Eberhard, Münzel, Thomas, and von Bardeleben, Ralph S.
- Subjects
SURVIVAL analysis (Biometry) ,MITRAL valve ,MITRAL valve insufficiency ,OBESITY ,OVERALL survival - Abstract
Background: The number of MitraClip® implantations increased significantly in recent years. Data regarding the impact of weight class on survival are sparse. Hypothesis: We hypothesized that weight class influences survival of patients treated with MitraClip® implantation. Methods: We investigated in‐hospital, 1‐year, 3‐year, and long‐term survival of patients successfully treated with isolated MitraClip® implantation for mitral valve regurgitation (MR) (June 2010–March 2018). Patients were categorized by weight classes, and the impact of weight classes on survival was analyzed. Results: Of 617 patients (aged 79.2 years; 47.3% females) treated with MitraClip® implantation (June 2010–March 2018), 12 patients were underweight (2.2%), 220 normal weight (40.1%), 237 overweight (43.2%), and 64 obesity class I (11.7%), 12 class II (2.2%), and 4 class III (0.7%). Preprocedural Logistic EuroScore (21.1 points [IQR 14.0–37.1]; 26.0 [18.5–38.5]; 26.0 [18.4–39.9]; 24.8 [16.8–33.8]; 33.0 [25.9–49.2]; 31.6 [13.1–47.6]; p =.291) was comparable between groups. Weight class had no impact on in‐hospital death (0.0%; 4.1%; 1.5%; 0.0%; 7.7%; 0.0%; p =.189), 1‐year survival (75.0%; 72.0%; 76.9%; 75.0%; 75.0%; 33.3%; p =.542), and 3‐year survival (40.0%; 36.8%; 38.2%; 48.6%; 20.0%; 33.3%; p =.661). Compared to normal weight, underweight (hazard ratio [HR]: 1.35 [95% confidence interval [CI]: 0.65–2.79], p =.419), obesity‐class I (HR: 0.93 [95% CI: 0.65–1.34], p =.705), class II (HR: 0.39 [95% CI: 0.12–1.24], p =.112), and class III (HR: 1.28 [95% CI: 0.32–5.21], p =.726) did not affect long‐term survival. In contrast, overweight was associated with better survival (HR: 1.32 [95% CI: 1.04–1.68], p =.023). Conclusion: Overweight affected the long‐term survival of patients undergoing MitraClip® implantation beneficially compared to normal weight. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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