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The article addresses how to create inductance-free plasma and use it to excite soft x-ray lasers. The method employs a bifilar phenomenon in which one part of the pulsed current flows via the plasma column while the other part runs in the opposite direction via the closely placed external conductor. The electromagnetic fields formed by the plasma and return conductor are adjusted by lowering the distance between them to neutralize the magnetic field of the bifilar. Because the net transient magnetic field is drastically reduced, the plasma-conductor mutual inductance is near zero during current rise and decay. The inductance-free (L ∼ 2 nH) 35 cm-long Z pinches in a 3.1 mm-diameter argon-filled alumina capillary with current rise and decay times of 15 ns, dI/dt > 1012 A/s, and amplitudes up to 17 kA were predicted, realized, and verified to be suitable for pumping soft x-ray Ar+8 lasers. Without the bifilar phenomenon, the 35 cm Z pinches obey a 200 nH inductance that restricts the rise and decay durations of currents to 150 ns. The 35 cm Z pinches with 2 nH inductance generated 46.9 nm laser pulses with up to 4 μJ of energy and a beam divergence of 2 mrad at a low operating voltage of 35–45 kV, compared to 0.1–0.8 MV for similar lasers. The bifilar method could find applications in many research and technological fields, where the rise and decay times of discharge currents play a key role. [ABSTRACT FROM AUTHOR]

We consider an inverse problem for Schrödinger operators on a connected equilateral graph G with standard matching conditions. The graph G consists of at least two odd cycles glued together at a common vertex. We prove an Ambarzumian-type result, i.e., if a specific part of the spectrum is the same as in the case of zero potential, then the potential must be equal to zero. [ABSTRACT FROM AUTHOR]

The Reynolds–Orr equation predicts the unconditional stability limit of a flow. Although this seems to be a desirable aim in engineering applications, the predicted critical Reynolds numbers are one magnitude below the experimental observations. In this paper, an attempt is made to reduce this gap for incompressible shear flows. It is known that the Navier–Stokes equation has no regular solution at the initial time if the initial velocity field does not fulfill the compatibility condition. However, the original solution of the Reynolds–Orr equation, the critical perturbation, does not necessarily fulfill this condition. Therefore, the condition is added to the original problem as a non-linear constraint. This requires the use of a discrete functional, introduced in the paper. Two different formulations are implemented and discussed. The solution is assumed in a waveform. The augmented problem is solved in the cases of planar Poiseuille and the Couette flow. The result shows that adding the constraint increases the critical Reynolds number significantly in the case of a streamwise perturbation but only slightly in the case of a spanwise one. It was demonstrated using numerical simulations that the single waveform assumption was unreasonably strict. The usage of the compatibility condition without assuming the single waveform has a negligible effect on the critical Reynolds number. However, the presented methods can be used for adding other reasonable and complicated constraints to the variational problem. [ABSTRACT FROM AUTHOR]

In order to reveal cationic site preference in β-FeSi2, Co-substituted samples synthesized by various techniques such as molecular beam epitaxy, ion implantation, and chemical vapor transport were investigated by 57Fe conversion electron Mössbauer (CEM) as well as 57Co Mössbauer emission (ME) spectroscopy. Literature on the structure of β-FeSi2 is somewhat contradictory, especially on the point of the population of the two iron sites in the orthorhombic structure. 57Co ME and 57Fe CEM spectra both showed two quadrupole split spectral components in the crystalline phase. Hyperfine parameters indicate that Co atoms substitute Fe in both Fe positions in the orthorhombic lattice. The aim of the present study was to get reliable results on the relative population of the two iron sites and determine the substitution of the iron sites by Co atoms in the β-FeSi2 lattice. The relative intensities of the two components in the absorption and emission Mössbauer spectra were found to be very similar for the samples prepared by different techniques, indicating a homogeneous distribution of Co on both Fe sites. [ABSTRACT FROM AUTHOR]

Lepidoptera is one of the most diverse orders of insects, their larvae are very abundant in many habitats, and frequent prey of various predators. To decrease predation risk, caterpillars developed several means of defence, among them timing their activity to avoid predators (seeking enemy-free time). Although the enemy-free time hypothesis is often invoked to explain caterpillar behaviour, empirical evidence for it is scarce. We tested whether such enemy-free time exists in a temperate forest by comparing predation pressure on artificial caterpillars during day and night on the ground in forest fragments in Denmark. We found a high predation rate, 23.9%d-1, and higher predation rate at night (30.9%d-0.5) than during the day (17.0%d-0.5), both by invertebrate (23.3%d-0.5 vs. 12.4%d-0.5) and vertebrate (8.5%d-0.5 vs. 3.3%d-0.5) predators. The most important predators were chewing insects (73.4% of all attacks) and small mammals (19.0%). Attack rates on red caterpillars were higher (30.0%d-1) than on green ones (19.5%d-1). Overall, these data do not support the idea that night activity can provide enemy-free time for solitary caterpillars on the temperate forest floor. [ABSTRACT FROM AUTHOR]

We consider an inverse eigenvalue problem for Dirac operators on finite intervals. We show that if for a $${\mu\in\mathbb{C}}$$ the system $${\{\exp{2i\lambda_nx}}$$ , $${\exp{2i\mu x}\}}$$ is closed in $${L^p[-\pi,\pi]}$$ , then there is at most one $${L^p}$$ -potential with the eigenvalues $${\lambda_n}$$ . The result corresponds to the case of Schrödinger operators. [ABSTRACT FROM AUTHOR]

The most accurate models of the capillary Z-pinches used for excitation of soft X-ray lasers and photolithography XUV sources currently are based on the magnetohydrodynamics theory (MHD). The output of MHD-based models greatly depends on details in the mathematical description, such as initial and boundary conditions, approximations of plasma parameters, etc. Small experimental groups who develop soft X-ray/XUV sources often use the simplest Z-pinch models for analysis of their experimental results, despite of these models are inconsistent with the MHD equations. In the present study, keeping only the essential terms in the MHD equations, we obtained a simplified MHD model of cylindrically symmetric capillary Z-pinch. The model gives accurate results compared to experiments with argon plasmas, and provides simple analysis of temporal evolution of main plasma parameters. The results clarify the influence of viscosity, heat flux and approximations of plasma conductivity on the dynamics of capillary Z-pinch plasmas. The model can be useful for researchers, especially experimentalists, who develop the soft X-ray/XUV sources. (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]

Infrasound measurements are used to detect seismic waves and a large effort is devoted to eliminating the turbulence-related infrasound signal, usually considered as noise. Here we take a complementary approach, investigating whether infrasound can provide information on atmospheric turbulence. Microphone measurements of infrasound from an experimental campaign in Hungary in 2013 are used, together with data from a nearby sonic anemometer and a sodar. The comparison of infrasound integrated spectral energy to turbulent kinetic energy from the sonic provides a good match when turbulence is present near the ground. Moreover, on stable nights when the surface layer is strongly stratified and with turbulence absent, microphones sometimes recorded infrasound when the sodar showed a low-level jet above the surface inversion, indicating that microphones may be used as detectors of elevated turbulence. [ABSTRACT FROM AUTHOR]

In the 50 years since the advent of X-ray astronomy there have been many scientific advances due to the development of new experimental techniques for detecting and characterising X-rays. Observations of X-ray polarisation have, however, not undergone a similar development. This is a shortcoming since a plethora of open questions related to the nature of X-ray sources could be resolved through measurements of the linear polarisation of emitted X-rays. The PoGOLite Pathfinder is a balloon-borne hard X-ray polarimeter operating in the 25-240 keV energy band from a stabilised observation platform. Polarisation is determined using coincident energy deposits in a segmented array of plastic scintillators surrounded by a BGO anticoincidence system and a polyethylene neutron shield. The PoGOLite Pathfinder was launched from the SSC Esrange Space Centre in July 2013. A near-circumpolar flight was achieved with a duration of approximately two weeks. The flight performance of the Pathfinder design is discussed for the three Crab observations conducted. The signal-to-background ratio for the observations is shown to be 0.25 ±0.03 and the Minimum Detectable Polarisation (99 % C.L.) is (28.4 ±2.2) %. A strategy for the continuation of the PoGOLite programme is outlined based on experience gained during the 2013 maiden flight. [ABSTRACT FROM AUTHOR]

The continuous expansion of built-up areas in the urban environment at the expense of green spaces brings up numerous environmental problems, for which accurate and efficient solutions should be found. The assessment of ecosystem services developed within the field of landscape ecology is playing an ever more important role in environmental sciences and thus may offer suitable answers. Such assessments can be carried out by developing indicators. Accordingly, in the case of urban trees, an accurate quantitative characterization of their services (such as e.g. carbon sequestration, pollutant removal and microclimate regulation) is also needed. The aim of this study is to establish a generally applicable method based on indicator development, using widely available data. In the case of urban green spaces there are several services for which the development of proper indicators and evaluation methods requires a delineation of tree crowns, or at least the crown projection area. Accordingly, in our work, we map the crown projection area of a large and popular urban park of Szeged, Széchenyi square, using object-based image analysis on UltraCamD digital orthophotos. Following a multiresolution segmentation the classification of the resulting objects was carried out, using the eCognition image analysis software. Besides fulfilling the policy objectives related to the evaluation of urban ecosystem services, the produced crown base can also be used in several other types of urban ecological and urban climatological studies (e.g. urban climate modelling, human-comfort assessment). In this paper the first results are presented. [ABSTRACT FROM AUTHOR]

Studying the published values of Maxwellian-averaged neutron capture cross sections, we found simple phenomenological rules obeyed by the cross sections as a function of proton and neutron numbers. We use these rules to make predictions for cross sections of neutron capture on nuclei with proton number above 83, where very few MACS data are available. These predictions may be useful in certain models of nucleosynthesis of heavy nuclei in stars. [ABSTRACT FROM AUTHOR]

The present study is focused on the demonstration of the most critical parameters of the pumping scheme of a table-top Ar+8-laser excited by discharges with relatively low current and voltage ( I ≤ 20 kA, U ≤ 200 kV) in long ( L ∼ 0.5 m) capillaries. The most critical parameters of the pumping scheme were analyzed and then adjusted experimentally. The table-top size is attributed to the use of a low-inductance co-axial discharge configuration that decreases the voltage and current necessary for laser excitation. Low inductance is achieved by using a capillary, water-capacitor and water spark-gap placed into a chamber filled with deionized water. The capillary z-pinch is produced by the water capacitor, which is pulse-charged by a six-stage Marx generator, optimized for the low-inductance discharge configuration. Optimization is performed by adjusting the value of the charging inductance and the peak charging voltage with a water spark-gap. At the optimal conditions laser pulses with a Gaussian-like intensity distribution and divergence angle ∼ 1 mrad and energy ∼ 10 μJ are generated. The physical method for generation of a laser beam with such parameters is based on the use of a long ( L = 0.45 m) capillary plasma (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]

We investigate the relationship between intradaily HUF/EUR exchange rate on the one hand and news announcements and order flow on the other hand. We extend the existing literature on foreign exchange market microstructure by considering a small open transition economy. We find that the intradaily exchange rate depends on both news announcements and order flow. We conclude that news on the HUF/EUR market are transmitted directly via immediate reactions to news announcements as well as indirectly via order flow. We decompose the total effect of news on exchange rate and find that order flow accounts for approximately three quarters, compared with one quarter for direct news impact. Although the HUF is pegged to the EUR, the exchange rate shows similar characteristics as reported in the literature for major currencies. It does, however, differ in quantitative terms: the importance of indirect news transmission is remarkably higher on the HUF/EUR market. Furthermore, we extend the commonly used set of news by communication of central bankers and significantly improve the explanatory power of the estimates. Thus, central bank communication can be regarded as an important determinant for the HUF/EUR rate. Copyright © 2010 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

This study compared measurements of upper body aerobic fitness in elite (EC; n = 7) and intermediate rock climbers (1C; n = 7), and a control group (C; n = 7). Subjects underwent an upper limb incremental test on hand cycle ergometer, with increments of 23 W-min"1, until exhaustion. Ventilation (VE) data were smoothed to 10 s averages and plotted against time for the visual determination of the first ( VT1 ) and second (VT2) ventilatory thresholds. Peak power output was not different among groups [EC= 130.9 (±11.8) W; 1C=122.1 (±28.4) W; C = 115.4 (±15.1) W], but time to exhaustion was significantly higher in EC than 1C and C. VO2Peai< was significantly higher in EC [36.8 (±5.7) mLkg-1.min-1] and IC [35.5 (±5.2) mLkg-'.mirT1] than C [28.8 (±5.0) mL.kg-1.min-1], but there was no difference between EC and IC. VT1 was significantly higher inECthanC[EC=69.0(±9.4)W;lC = 62.4(±13.0) W; C = 52.1 (±11.8) W], but no significant difference was observed in VT2 [EC = 103.5 (±18.8) W; IC = 92.0 (±22.0) W; C=85.6 (±19.7) W]. These results show that elite indoor rock climbers elicit higher aerobic fitness profile than control subjects when measured with an upper body test. [ABSTRACT FROM AUTHOR]

The objective of this study was to propose an alternative method (MAODALT) to estimate the maximal accumulated oxygen deficit (MAOD) using only one supramaximal exhaustive test. Nine participants performed the following tests: (a) a maximal incremental exercise test, (b) six submaximal constant workload tests, and (c) a supramaximal constant workload test. Traditional MAOD was determined by calculating the difference between predicted O2 demand and accumulated O2 uptake during the supramaximal test. MAODALT was established by summing the fast component of excess post-exercise oxygen consumption and the O2 equivalent for energy provided by blood lactate accumulation, both of which were measured during the supramaximal test. There was no significant difference between MAOD (2.82 ± 0.45 L) and MAODALT (2.77 ± 0.37 L) (p=0.60). The correlation between MAOD and MAODALT was also high (r=0.78; p=0.014). These data indicate that the MAODALT can be used to estimate the MAOD. [ABSTRACT FROM AUTHOR]

Our objective was to evaluate the frequency of antinucleosome antibodies (anti-Ncs) in juvenile systemic lupus erythematosus (JSLE) comparing it to that observed for anti-DNA and to correlate the presence of these antibodies with clinical manifestations and disease activity. Anti-Ncs and anti-DNA were detected by ELISA in 74 patients with JSLE and 64 normal controls. Clinical records were reviewed. Disease activity was assessed by SLEDAI score. Anti-Ncs and anti-DNA showed sensitivity of 52.7% and 54% and specificity of 98.4% and 95.3%, respectively. Disagreement between the two assays was found in 25.7% of the cases: isolated positive Anti-Ncs in nine cases (12.2%) and isolated positive anti-DNA in 10 cases (13.5%). Agreement was found in 74.3%: both positive antibodies in 30 cases and both negative in 25. The presence of anti-Ncs was significantly associated with malar erythema, hemolytic anemia, anti-DNA and low complement levels, but not with renal manifestations. The presence of anti-Ncs was associated with a higher SLEDAI median (P < 0.001) and its titers correlated with the SLEDAI score (r = 0.504; P < 0.001). The frequency, sensitivity and specificity values were similar between anti-Ncs and anti-DNA antibodies in patients with JSLE. Nevertheless, the discordance of 25.7% between the two assays suggests that both antibodies may have a complementary diagnostic role. The association and correlation between anti-Ncs and several disease activity parameters demonstrated its usufulness in the follow-up of these patients. [ABSTRACT FROM AUTHOR]

Abstract: Pemphigus erythematosus, initially described as a combination of pemphigus with lupus erythematosus, and pemphigus foliaceus are now frequently considered localized and generalized variants of superficial pemphigus. Yet diagnostic criteria for pemphigus erythematosus remain controversial. Distinct from pemphigus foliaceus, pemphigus erythematosus displays immune depositions at the dermal-epidermal junction, which suggests additional immunopathological mechanisms. We present three patients with clinical and histopathologic signs of superficial pemphigus, who all exhibited an immunomorphology characteristic of pemphigus erythematosus. Complement depositions in a granular-linear fashion were consistently found at the dermal-epidermal junction besides in vivo bound and circulating antikeratinocyte cell-surface autoantibodies. Histopathology showed subcorneal acantholysis, and all sera contained antidesmoglein 1 but not antidesmoglein 3 autoantibodies detected by enzyme-linked immunosorbent assays (ELISA). Additional autoantibodies against a 230-kDa protein and against a 190-kDa protein comigrating with bullous pemphigoid antigen 1 (BP230) and periplakin, respectively, were present in all the patients' sera. As two sera specifically reacted with BP230 by ELISA, the presence of BP230-specific autoantibodies could be associated with dermal-epidermal immune staining in these patients. In pemphigus erythematosus, dermal–epidermal immune staining is generally attributed to the deposition of immune complexes, while the presence of BP230-specific autoantibodies has not been reported in this disease previously. Perhaps, the unique autoantibody profile of the patients in the study permits discrimination between patients with superficial pemphigus that display additional dermal-epidermal immune staining from those with conventional pemphigus foliaceus on a molecular basis. Further studies will be required to substantiate the frequency of this occurrence and to unravel its pathogenic significance. [ABSTRACT FROM AUTHOR]

Differential scanning calorimetry and electron paramagnetic resonance experiments were performed on glycerinated skeletal muscle fibres to study the effect of the binding of nucleotides and nucleotide analogues to myosin. The thermal unfolding of muscle fibres in rigor showed three discrete domain regions with thermal stability of 52.2, 58.8 and 67.8°C. AMP.PNP and ATP plus AlF3 or BeF2 affected markedly the transitions, which implies the strong interaction between AMP.PNP or nucleotide analogues and catalytic domain of myosin, and a partial dissociation of heads from actin. ADP.BeFx and states model the transition states of the ATP hydrolysis cycle which precede the powerstroke of the muscle fibres. Spectrum deconvolution on isothiocyanate-labelled fibres in AMP.PNP-state resulted in two populations; 50% of labels was highly ordered with respect to fibre axis, whereas the other 50% of labels was randomly oriented. The myosin heads which showed high degree of order were in the strongly binding ADP-state. The spectra in - and ADP.BeFx state reflected random orientation of labels with increased rotational mobility in comparison with rigor. The results suggest that myosin in muscle fibres in ADP.BeFx state exists in two forms. [ABSTRACT FROM AUTHOR]

Thermal stability and internal dynamics of myosin head in psoas muscle fibres of rabbit in the intermediate state AM.ADP.Pi - mimicked by AM.ADP.Vi - of the ATP hydrolysis cycle was studied by differential scanning calorimetry and spin label electron paramagnetic resonance spectroscopy. Three overlapping endotherms were detected in rigor, in strongly binding ADP and weakly binding AM.ADP.Vi state of myosin to actin. The transition at 54.0°C can be assigned to the 50 k actin-binding domain. The transition at highest temperature (67.3°C) represents the unfolding of actin and the contributions arising from the nucleotide-myosin head interaction. The transition at 58.4°C reflects the melting of the large rod part of myosin. Nucleotide binding (ADP, ATP plus orthovanadate) induced shifts of the melting temperatures and produced changes in the calorimetric enthalpies. The changes of the EPR parameters indicated local rearrangements of the internal structure in myosin heads in agreement with DSC findings. [ABSTRACT FROM AUTHOR]

The article focuses on the instrumentation, mechanism and applicability of Diffraction Enhanced Imaging (DEI) in soft tissue imaging. It offers brief information on principles and concepts of DEI including the preparation of an imaging beam, the refraction and extinction as two sources of image contrast to radiography, and the stages of scanning. It also explores the DEI imaging in breast, cartilage, and lungs.

The effect of free radicals obtained in hydroxyl and cerium(IV)-nitrilotriacetic acid free radical generating systems on contractile proteins (actin, myosin and their complexes in glycerinated muscle fibres) was studied using differential scanning calorimetry and spin trapping electron paramagnetic resonance technique. The analysis of spectra showed that selective attack of thiol groups – Cys-257 and Cys-374 residues of actin, and among others Cys-707 residue of myosin – and random attack of sidechains of the main proteins of muscle tissue produced structural and functional changes, which affected the ATP hydrolysis cycle and very likely the dynamics of actin. The melting curves obtained on protein systems support the view that global conformational changes accompany the local damage of free radicals. [ABSTRACT FROM AUTHOR]

Objective: Dithranol is highly effective in the treatment of psoriasis, however its mode of action is still not well known. Since interleukin-8 and interleukin-10 are involved in the pathogenesis of psoriasis, the aim of our study was to investigate the effect of dithranol on interleukin-8, interleukin-10 mRNA production and interleukin-10 receptor expression of the HaCaT keratinocyte cell line which is commonly used in experiments examining the effects of therapeutic drugs on keratinocytes.¶ Materials and Methods: Cultured HaCaT cells were treated with 0.1-0.5 μg/ml dithranol for 30 minutes. After 2 and 4 h total cellular RNA isolated from HaCaT cells was reverse transcribed (RT) to cDNA which was subjected to polymerase chain reaction (PCR) with specific primer pairs for interleukin-8, interleukin-10 and interleukin-10 receptor. For immunohistochemistry cultured HaCaT cells were stained with a monoclonal antibody against the human interleukin-10 receptor.¶ Results: Our results showed that dithranol treatment did not change the highly elevated level of interleukin-8 mRNA of HaCaT cells. Interleukin-10 mRNA signal with RT-PCR could not be detected in HaCaT cells. Depending on the concentration dithranol increased the mRNA production of interleukin-10 receptors in HaCaT cells. This dithranol induced dose dependent upregulation of IL-10 receptors in HaCaT cells was also observed on the protein level using immunohistochemistry.¶ Conclusions: Since the interleukin-10 receptor expression of keratinocytes in psoriatic lesional skin is downregulated, the dithranol induced upregulation of the receptor in our model system might help to reveal the therapeutic action of the drug.¶ [ABSTRACT FROM AUTHOR]

Presents a letter to the editor regarding human herpesvirus 8 DNA sequences in angiosarcoma of the face, previously published in "British Journal of Dermatology."

A 43-year-old woman developed annular and pustular cutaneous lesions preceded by tiny yellow pustules coating the surface of the oral mucosa. The clinical, histological and immunopathological evidence clearly showed that the patient had pyodermatitis-pyostomatitis vegetans, it is suggested that this disease is a distinct entity which should be differentiated from pemphigus vegetans. [ABSTRACT FROM AUTHOR]

We report five patients with moyamoya associated with arterial anomalies, including five aneurysms, one with ectasia of the parent artery, a basilar artery fenestration and an arteriovenous malformation. Possible pathogenetic factors for moyamoya are discussed, and a prenatal origin is suggested. [ABSTRACT FROM AUTHOR]

Background. The etiology of cold contact urticaria is unknown and the therapy is therefore usually rather disappointing. Methods. This study reports therapeutic data on 42 patients with cold urticaria treated with a combination of terbutaline (3 × 5 mg a week, later 3 × 2.5 mg) and aminophylline-containing drugs (3 × 150 mg). Results. Complete remission of the urticarial response was achieved in 37 of the 42 patients. Conclusions. The therapy was tolerated relatively well and the results are promising. [ABSTRACT FROM AUTHOR]

Background Merkel cell carcinoma (MCC) is a rare, aggressive tumour for which an increasing incidence has been reported. A new human polyomavirus, Merkel cell polyomavirus (MCV), was recently isolated from these tumours by applying digital transcriptome subtraction methodology. Objectives To detect the presence or absence of MCV in MCCs and other, randomly selected neoplasms. Methods Nine primary or recurrent MCCs from seven patients were examined; 29 other tumours (squamous cell, basal cell and basosquamous carcinomas and malignant melanomas) were examined for comparative purposes. Viral large T protein (LT1 and LT3), and viral capsid protein (VP1) were detected by primer-directed amplification, using a polymerase chain reaction (PCR)-based method, and the amplified PCR products were analysed by agarose gel electrophoresis and subsequent sequence analysis. Results The presence of viral T antigen and/or viral capsid DNA sequences was demonstrated in seven of the eight MCC lesions. None of the comparative samples contained MCV DNA. Conclusions Our findings strongly support the hypothesis that MCV infection may well be specific for MCC, and MCV may play a role in the pathogenesis of MCC. [ABSTRACT FROM AUTHOR]

Summary We determined the prevalence of antineutrophil cytoplasmic antibodies (ANCAs) in patients with systemic lupus erythematosus (SLE) and evaluated the correlation between ANCA positivity and clinical features. Forty-one patients with SLE and two control groups were examined. One of the control groups consisted of 15 patients with systemic vasculitis, and the other of 12 healthy blood donors. A quantitative enzyme-linked immunosorbent assay technique was used to measure the serum cytoplasmic ANCA (cANCA) and perinuclear ANCA (pANCA) levels. cANCA positivity was found in three patient samples, and pANCA positivity in 10 SLE patients. The occurrence and titres of both ANCA types in SLE patients were similar to those in healthy controls and significantly lower than those in patients with systemic vasculitis. The clinical picture and antibody profile were similar in ANCA-positive and ANCA-negative SLE patients. We conclude that measurement of ANCAs does not provide any additional diagnostic or prognostic data in SLE. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented in response to the article "Therapy-Resistant Leg Ulcer Caused by Multiple Myeloma" in September 2005 issue.