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Exoskeleton-based support for patients requires the learning of individual machine-learning models to recognize movement intentions of patients based on the electroencephalogram (EEG). A major issue in EEG-based movement intention recognition is the long calibration time required to train a model. In this paper, we propose a transfer learning approach that eliminates the need for a calibration session. This approach is validated on healthy subjects in this study. We will use the proposed approach in our future rehabilitation application, where the movement intention of the affected arm of a patient can be inferred from the EEG data recorded during bilateral arm movements enabled by the exoskeleton mirroring arm movements from the unaffected to the affected arm. For the initial evaluation, we compared two trained models for predicting unilateral and bilateral movement intentions without applying a classifier transfer. For the main evaluation, we predicted unilateral movement intentions without a calibration session by transferring the classifier trained on data from bilateral movement intentions. Our results showed that the classification performance for the transfer case was comparable to that in the non-transfer case, even with only 4 or 8 EEG channels. Our results contribute to robotic rehabilitation by eliminating the need for a calibration session, since EEG data for training is recorded during the rehabilitation session, and only a small number of EEG channels are required for model training. [ABSTRACT FROM AUTHOR]

Background: Transitional care is an integrated service to ensure coordination and continuity of patients' healthcare. Many models are being developed and implemented for this care. This study aims to identify the facilitators and obstacles of project performance through the experiences of the coordinator in charge of the Community Linkage Program for Discharge Patients (CLDP), a representative transitional care program in Korea. Method: Forty-one coordinators (nurses and social workers) from 21 hospitals were interviewed using a semi-structured questionnaire, and thematic analysis was performed. Result: Three themes were found as factors that facilitate or hinder CLDP: Formation and maintenance of cooperative relationships; Communication and information sharing system for patient care; and interaction among program, regional, and individual capabilities. These themes were similar regardless of the size of the hospitals. Conclusion: A well-implemented transitional care model requires a program to prevent duplication and form a cooperative relationship, common computing platform to share patient information between institutions, and institutional assistance to set long-term directions focused on patient needs and support coordinators' capabilities. [ABSTRACT FROM AUTHOR]

This study aimed to verify the effects of client-centered occupational therapy on individuals with dementia. Twenty participants were randomly assigned to an experimental group (client-centered occupational therapy) and a control group (general occupational therapy). A pretest, post-test, and follow-up tests were used to compare the effects of the intervention. The experimental group had significant changes in all variables, and the control group showed significant differences in verbal social interaction, quality of life, and burden of caregivers (p < 0.05). As a result of repeated measurement variance analysis, it was found that there was a significant effect within the group except for the NPI-Q distress items (p < 0.05), but the effect was not verified in all areas between the groups. Client-centered customized occupational therapy can be more effective than general occupational therapy in problem behavior, social interaction, quality of life, caregiver burden, and occupational performance of individuals with dementia. [ABSTRACT FROM AUTHOR]

We investigated the effects of biofloc and artificial substrates (net and brush) on the growth and immunology of the postlarvae of Marsupenaeus japonicus (Spence Bate, 1888) reared for 30 days. The mRNA expressions of innate immune-related genes (prophenoloxidase, masquerade-like serine proteinase, and lysozyme) in the postlarvae were analyzed using quantitative reverse transcription PCR (qRT-PCR). The highest specific growth rate of larvae (3.66 ± 0.02% d–1, 3.75 ± 0.02% d–1) were shown in the net and control groups. The highest survival rate (90 ± 7.1%) was observed in the brush group (P < 0.05). The net yield was significantly higher in the artificial substrate groups (brush 36.60 ± 6.19 g m–2, net 36.46 ± 2.36 g m–2) than in the control (33.79 ± 0.16 g m–2) (P < 0.05). Total suspended, volatile suspended, and suspended solids were significantly lower in the brush group than in the other groups. The immune-related genes showed significantly higher expressions in the artificial substrate groups than in the control. These results support the benefits of artificial substrate in M. japonicus nursery culture to mitigate space competition and suppress cannibalism, with a positive effect on survival. The additional surface area provided by the biofloc, which the larvae can graze on, enhanced the expression of immune-related genes in individuals. [ABSTRACT FROM AUTHOR]

We investigated the effects of biofloc and artificial substrates (net and brush) on the growth and immunology of the postlarvae of Marsupenaeus japonicus (Spence Bate, 1888) reared for 30 days. The mRNA expressions of innate immune-related genes (prophenoloxidase, masquerade-like serine proteinase, and lysozyme) in the postlarvae were analyzed using quantitative reverse transcription PCR (qRT-PCR). The highest specific growth rate of larvae (3.66 ± 0.02% d–1, 3.75 ± 0.02% d–1) were shown in the net and control groups. The highest survival rate (90 ± 7.1%) was observed in the brush group (P < 0.05). The net yield was significantly higher in the artificial substrate groups (brush 36.60 ± 6.19 g m–2, net 36.46 ± 2.36 g m–2) than in the control (33.79 ± 0.16 g m–2) (P < 0.05). Total suspended, volatile suspended, and suspended solids were significantly lower in the brush group than in the other groups. The immune-related genes showed significantly higher expressions in the artificial substrate groups than in the control. These results support the benefits of artificial substrate in M. japonicus nursery culture to mitigate space competition and suppress cannibalism, with a positive effect on survival. The additional surface area provided by the biofloc, which the larvae can graze on, enhanced the expression of immune-related genes in individuals. [ABSTRACT FROM AUTHOR]

This study investigates the production technology of black burnished pottery from the royal fortress and tombs in the Hanseong period of Baekje (fourth to fifth century AD), Ancient Korea. This pottery can be classified into two types based on the form of the black layer on the cross-section: a thick, progressing layer (smudging black (SB)-type) and a thin and fine layer on the surface (coating black (CB)-type). Raman spectroscopy detected combustion carbon with an amorphous structure in the black portion of the SB-type (surface/core/inner surface) and CB-type (outer surface/inner surface). Micro Fourier transform infrared spectroscopy (micro-FT-IR) and time-of-flight secondary-ion mass spectrometry (ToF–SIMS) results showed that urushiol, the main component of lacquer, was found on the outer surface of pottery. Results showed that SB-type is a pottery in which combustion carbon is smudged inside the pottery using plant ash, and the outermost surface is lacquered for gloss. In CB-type pottery, a thin combustion carbon layer is formed using a lacquer after firing the pottery body. X-ray diffraction studies showed that most of the pottery may have been fired at 550–850 °C. This study identified the colouring component of black pottery and presented examples of the lacquer usage in pottery. [ABSTRACT FROM AUTHOR]

The purpose of this study was to investigate the effect of assistive technology-based occupational therapy on occupational performance, satisfaction, and psychosocial impacts of community-dwelling people recovering from stroke. A total of eleven community-dwelling people recovering from stroke participated in an occupational therapy intervention based on the core concepts of the Human Activity Assistive Technology (HAAT) model. The intervention involved the adoption of assistive technology devices (ATDs) to perform individual goal activities in the daily lives of people recovering from stroke. The intervention was conducted weekly as a 30-min session for a total of 4 weeks, in the home where each participant actually resided. All participants in the intervention showed statistically significant improvements in occupational performance, satisfaction, and goal attainment level with regard to the individually meaningful activities, between pretest, posttest, and follow-up. User satisfaction with the ATDs and associated services was generally 'satisfactory,' and the mean score significantly increased from post-intervention to follow-up. The psychosocial impact of assistive technologies significantly improved from post-intervention to follow-up evaluation. Interventions involving concepts, processes, and strategies based on the HAAT model should be continuously performed to select and adopt appropriate interventions involving assistive technologies. [ABSTRACT FROM AUTHOR]

Diabetic retinopathy is currently treated by highly invasive repeated therapeutic injections and surgical interventions without complete vision recovery. Here, a noninvasive smart wireless far red/near‐infrared (NIR) light emitting contact lens developed successfully for the repeated treatment of diabetic retinopathy with significantly improved compliance. A far red/NIR light emitting diode (LED) is connected with an application‐specific integrated circuit chip, wireless power, and communication systems on a PET film, which is embedded in a silicone elastomer contact lens by thermal crosslinking. After in vitro characterization, it is confirmed that the retinal vascular hyper‐permeability induced by diabetic retinopathy in rabbits is reduced to a statistically significant level by simply repeated wearing of smart far red/NIR LED contact lens for 8 weeks with 120 µW light irradiation for 15 min thrice a week. Histological analysis exhibits the safety and feasibility of LED contact lenses for treating diabetic retinopathy. This platform technology for smart LED contact lens would be harnessed for various biomedical photonic applications. [ABSTRACT FROM AUTHOR]

Optimal stocking density of the marine red alga Agarophyton vermiculophyllum was determined to maximize the productivity and nitrogen removal in biofloc effluent. Agarophyton vermiculophyllum was cultured at 0.2, 2, 4 and 8 g L−1 (FW) stocking densities, 160 ± 10 μmol photons m−2 s−1 and 12:12 L:D photoperiod for 20 days. Agarophyton vermiculophyllum was cultured in effluent from a juvenile Paralichthys biofloc tank culture system and von Stosch–enriched (VSE) medium at 20 °C. The total nitrogen and phosphorus concentration of VSE medium was adjusted to the biofloc level, 1000 μmol L−1 and 33 μmol L−1, respectively. Specific growth rate was significantly higher at 0.2, 2, 4 and 8 g L−1 in both media. However, the productivity was significantly higher at 8 than 0.2 g L−1 in both media. Tissue carbon contents were not significantly influenced by the medium at 8 g L−1 (34.9% in VSE and 34.0% in biofloc). However, tissue nitrogen content was significantly higher at VSE medium than at biofloc medium at 8 g L−1 (3.7% in VSE and 3.4% in biofloc). The carbon removal rate was highest at the highest stocking density, 1.98 mgC g−1 DW day−1 (VSE) and 1.89 mgC g−1 DW day−1 (biofloc), respectively. Also, the nitrogen removal rate was highest at the highest stocking density, 0.21 mgN g−1 DW day−1 (VSE) and 0.19 mgN g−1 DW day−1 (biofloc), respectively. The nutrient removal was not significantly influenced by medium at 4 and 8 g L−1. These results show that A. vermiculophyllum can grow and have the potential to remove nutrients in the biofloc medium at high nitrogen concentrations. [ABSTRACT FROM AUTHOR]

This article presents a controller IC for smart contact lens (SCL). For wireless telemetry, we propose a transmitter supporting dual-mode operations with a single external loop antenna. In the wireless-powered backscattering load-shift keying (LSK) mode, the transmitter is configured to use the antenna as an ${L}$ for magnetic resonance coupling. The transmitter switches its configuration to be an active LC oscillator circuit in the RF-radiated transmission mode. To suppress the average power consumption, a 0.2% duty cycling is applied with a controlled timing schedule while minimizing static power consumption in the sleep mode. To reduce the effect of instantaneous discharging, the period of data transmission is shortened by transmitting data with a higher rate. The designed IC is fabricated using 0.18- $\mu \text{m}$ CMOS. For in vitro verifications in both modes, an SCL is implemented by integrating the IC, a glucose sensor, a thin-film battery, a loop antenna, and a supply-regulating capacitor. The IC achieves a power consumption of 143 nW with an input dynamic range of 89 dB. [ABSTRACT FROM AUTHOR]

Abstract: The diagnosis of liver diseases is generally carried out via ultrasound imaging, computed tomography, and magnetic resonance imaging. The emerging photoacoustic imaging is an attractive alternative to diagnose even early stage of liver diseases providing high‐resolution anatomical and functional information in deep tissue noninvasively. However, the liver has insufficient photoacoustic contrast due to low optical absorbance in the near‐infrared windows. Here, a new hyaluronate–silica nanoparticle (HA–SiNP) conjugate for liver‐specific delivery and imaging for the diagnosis of liver diseases is developed. The HA–SiNP conjugates show high liver‐specific targeting efficiency, strong optical absorbance near‐infrared windows, excellent biocompatibility, and biodegradability. The liver‐specific targeting efficiency is verified by in vitro cellular uptake test, and in vivo and ex vivo photoacoustic imaging. In vivo photoacoustic imaging shows that photoacoustic amplitude in the liver injected with HA–SiNP conjugates is 4.4 times higher than that of the liver injected with SiNP. The biocompatibility and biodegradability of HA–SiNP conjugates are verified by cell viability test, optical spectrum analysis of urine, and inductively coupled plasma‐mass spectroscopy (ICP‐MS) analysis. Taken together, HA–SiNP conjugates may be developed as a promising liver targeted photoacoustic imaging contrast agent and liver‐targeted drug delivery agent. [ABSTRACT FROM AUTHOR]

Event-related potentials (ERPs) are often used in brain-computer interfaces (BCIs) for communication or system control for enhancing or regaining control for motor-disabled persons. Especially results from single-trial EEG classification approaches for BCIs support correlations between single-trial ERP detection performance and ERP expression. Hence, BCIs can be considered as a paradigm shift contributing to new methods with strong influence on both neuroscience and clinical applications. Here, we investigate the relevance of the choice of training data and classifier transfer for the interpretability of results from single-trial ERP detection. In our experiments, subjects performed a visual-motor oddball task with motor-task relevant infrequent (targets), motor-task irrelevant infrequent (deviants), and motor-task irrelevant frequent (standards) stimuli. Under dual-task condition, a secondary senso-motor task was performed, compared to the simple-task condition. For evaluation, average ERP analysis and single-trial detection analysis with different numbers of electrodes were performed. Further, classifier transfer was investigated between simple and dual task. Parietal positive ERPs evoked by target stimuli (but not by deviants) were expressed stronger under dual-task condition, which is discussed as an increase of task emphasis and brain processes involved in task coordination and change of task set. Highest classification performance was found for targets irrespective whether all 62, 6 or 2 parietal electrodes were used. Further, higher detection performance of targets compared to standards was achieved under dual-task compared to simple-task condition in case of training on data from 2 parietal electrodes corresponding to results of ERP average analysis. Classifier transfer between tasks improves classification performance in case that training took place on more varying examples (from dual task). In summary, we showed that P300 and overlaying parietal positive ERPs can successfully be detected while subjects are performing additional ongoing motor activity. This supports single-trial detection of ERPs evoked by target events to, e.g., infer a patient's attentional state during therapeutic intervention. [ABSTRACT FROM AUTHOR]

A feeding trial was carried out to determine the effects of bioflocs on dietary protein requirement in juvenile whiteleg shrimp, Litopenaeus vannamei. Four bioflocs treatments ( BFT) and one control group were managed: BFT fed diets 25% of crude protein ( CP) ( BFT-25%), 30% CP ( BFT-30%), 35% CP ( BFT-35%) and 40% CP ( BFT-40%), and clear water control without bioflocs fed with 40% CP ( CW-40%). Triplicate groups of shrimp (initial body weight, 1.3 g) were fed one of the test diets at a ratio of 7% body weight daily for 8 weeks. At the end of the feeding trial, significantly ( P < 0.05) higher weight gain and specific growth rate were obtained in shrimp fed BFT-35% and BFT-40% compared to BFT-25% and BFT-30%. Shrimp fed BFT-35% exhibited the lowest feed conversion ratio. Significantly higher muscle nucleic acid indices were also recorded such as DNA content in BFT-30%, RNA content in BFT-35% and RNA/ DNA ratio than that of shrimp fed control. Total protein level in the haemolymph of shrimp fed BFT-40% was significantly higher than those of shrimp fed BFT-25% and BFT-30%. Therefore, the present results demonstrated that, when L. vannamei juveniles were reared in bioflocs-based tanks, dietary protein level could be reduced from 40% to 35% without any adverse effect on shrimp growth performance, body composition and haemolymph characteristics. [Correction added on 20 May 2015, after first online publication: sentence modified to clarify the reduction in dietary protein level.]. [ABSTRACT FROM AUTHOR]

This paper proposes an application oriented approach that enables to transfer a classifier trained within an experimental scenario into a more complex application scenario or a specific rehabilitation situation which do not allow to collect sufficient training data within a reasonable amount of time. The proposed transfer approach is not limited to be applied to the same type of event-related potential. We show that a classifier trained to detect a certain brain pattern can be used successfully to detect another brain pattern, which is expected to be similar to the first one. In particular a classifier is transferred between two different types of error-related potentials (ErrPs) within the same subject. The classifier trained on observation ErrPs is used to detect interaction ErrPs, since twice as much training data is collected for observation ErrPs compared to interaction ErrPs during the same calibration time. Our results show that the proposed transfer approach is feasible and outperforms another approach, in which a classifier is transferred between different subjects but the same type of ErrP is used to train and test the classifier. The proposed approach is a promising way to handle few training data and to reduce calibration time in ErrP-based brain-computer interfaces. [ABSTRACT FROM AUTHOR]

Goal: Current brain–computer interfaces (BCIs) are usually based on various, often supervised, signal processing methods. The disadvantage of supervised methods is the requirement to calibrate them with recently acquired subject-specific training data. Here, we present a novel algorithm for dimensionality reduction (spatial filter), that is ideally suited for single-trial detection of event-related potentials (ERPs) and can be adapted online to a new subject to minimize or avoid calibration time. Methods: The algorithm is based on the well-known xDAWN filter, but uses generalized eigendecomposition to allow an incremental training by recursive least squares (RLS) updates of the filter coefficients. We analyze the effectiveness of the spatial filter in different transfer scenarios and combinations with adaptive classifiers. Results: The results show that it can compensate changes due to switching between different users, and therefore allows to reuse training data that has been previously recorded from other subjects. Conclusions: The presented approach allows to reduce or completely avoid a calibration phase and to instantly use the BCI system with only a minor decrease of performance. Significance: The novel filter can adapt a precomputed spatial filter to a new subject and make a BCI system user independent. [ABSTRACT FROM PUBLISHER]

The bioflocs technology ( BFT) for shrimp production has been proposed as a sustainable practice capable of reducing environmental impacts and preventing pathogen introduction. The microbial community associated with BFT not only detoxifies nutrients, but also can improve feed utilization and animal growth. Biofloc system contains abundant number of bacteria of which cell wall consists of various components such as bacterial lipopolysaccharide, peptidoglycan and β-1, 3-glucans, and is known as stimulating nonspecific immune activity of shrimp. Bioflocs, therefore, are assumed to enhance shrimp immunity because they consume the bioflocs as additional food source. Although there are benefits for having an in situ microbial community in BFT systems, better understanding on these microorganisms, in particular molecular level, is needed. A fourteen-day culture trial was conducted with postlarvae of Litopenaeus vannamei in the presence and absence of bioflocs. To determine mRNA expression levels of shrimp, we selected six genes (prophenoloxidase1, prophenoloxidase2, prophenoloxidase activation enzyme, serine proteinase1, masquerade-like proteinase, and ras-related nuclear protein) which are involved in a series of responses known as the prophenoloxidase (proPO) cascade, one of the major innate immune responses in crustaceans. Significant differences in shrimp survival and final body weights were found between the clear water and in the biofloc treatments. m RNA expression levels were significantly higher in the biofloc treatment than the clear water control. These results suggest that the presence of bioflocs in the culture medium gives positive effect on growth and immune-related genes expression in L.vannamei postlarvae. [ABSTRACT FROM AUTHOR]

The ability of today's robots to autonomously support humans in their daily activities is still limited. To improve this, predictive human-machine interfaces (HMIs) can be applied to better support future interaction between human and machine. To infer upcoming context-based behavior relevant brain states of the human have to be detected. This is achieved by brain reading (BR), a passive approach for single trial EEG analysis that makes use of supervised machine learning (ML) methods. In this work we propose that BR is able to detect concrete states of the interacting human. To support this, we show that BR detects patterns in the electroencephalogram (EEG) that can be related to event-related activity in the EEG like the P300, which are indicators of concrete states or brain processes like target recognition processes. Further, we improve the robustness and applicability of BR in application-oriented scenarios by identifying and combining most relevant training data for single trial classification and by applying classifier transfer. We show that training and testing, i.e., application of the classifier, can be carried out on different classes, if the samples of both classes miss a relevant pattern. Classifier transfer is important for the usage of BR in application scenarios, where only small amounts of training examples are available. Finally, we demonstrate a dual BR application in an experimental setup that requires similar behavior as performed during the teleoperation of a robotic arm. Here, target recognition processes and movement preparation processes are detected simultaneously. In summary, our findings contribute to the development of robust and stable predictive HMIs that enable the simultaneous support of different interaction behaviors. [ABSTRACT FROM AUTHOR]

The goal of this study was to analyze the human ability of external force discrimination while actively moving the arm. With the approach presented here, we give an overview for the whole arm of the just-noticeable differences (JNDs) for controlled movements separately executed for the wrist, elbow, and shoulder joints. The work was originally motivated in the design phase of the actuation system of a wearable exoskeleton, which is used in a teleoperation scenario where force feedback should be provided to the subject. The amount of this force feedback has to be calibrated according to the human force discrimination abilities. In the experiments presented here, 10 subjects performed a series of movements facing an opposing force from a commercial haptic interface. Force changes had to be detected in a two-alternative forced choice task. For each of the three joints tested, perceptual thresholds were measured as absolute thresholds (no reference force) and three JNDs corresponding to three reference forces chosen. For this, we used the outcome of the QUEST procedure after 70 trials. Using these four measurements we computed the Weber fraction. Our results demonstrate that different Weber fractions can be measured with respect to the joint. These were 0.11, 0.13, and 0.08 for wrist, elbow, and shoulder, respectively. It is discussed that force perception may be affected by the number of muscles involved and the reproducibility of the movement itself. The minimum perceivable force, on average, was 0.04 N for all three joints. [ABSTRACT FROM PUBLISHER]