106 results on '"Killgore, William D. S."'
Search Results
2. Neighborhood-level sleep health and childhood opportunities.
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Gorovoy, Suzanne, Phan, Sydney, Begay, Tommy K., Valencia, Dora, Hale, Lauren, Robbins, Rebecca, Killgore, William D. S., Williamson, Ariel A., and Grandner, Michael
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- 2024
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3. Functional connectivity of the default mode network predicts subsequent polysomnographically measured sleep in people with symptoms of insomnia.
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Killgore, William D. S., Jankowski, Samantha, Henderson-Arredondo, Kymberly, Lucas, Daniel A., Patel, Salma I., Hildebrand, Lindsey L., Huskey, Alisa, and Dailey, Natalie S.
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- 2023
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4. Development and validation of an online emotional intelligence training program.
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Durham, Michelle R. Persich, Smith, Ryan, Cloonan, Sara, Hildebrand, Lindsey L., Woods-Lubert, Rebecca, Skalamera, Jeff, Berryhill, Sarah M., Weihs, Karen L., Lane, Richard D., Allen, John J. B., Dailey, Natalie S., Alkozei, Anna, Vanuk, John R., and Killgore, William D. S.
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ONLINE education ,EMOTIONAL intelligence ,EMOTIONS ,WELL-being - Abstract
Introduction: Emotional intelligence (EI) is associated with a range of positive health, wellbeing, and behavioral outcomes. The present article describes the development and validation of an online training program for increasing EI abilities in adults. The training program was based on theoretical models of emotional functioning and empirical literature on successful approaches for training socioemotional skills and resilience. Methods: After an initial design, programming, and refinement process, the completed online program was tested for efficacy in a sample of 326 participants (72% female) from the general population. Participants were randomly assigned to complete either the EI training program (n = 168) or a matched placebo control training program (n = 158). Each program involved 10-12 hours of engaging online content and was completed during either a 1-week (n = 175) or 3-week (n = 151) period. Results: Participants who completed the EI training program showed increased scores from pre- to post-training on standard self-report (i.e., trait) measures of EI (relative to placebo), indicating self-perceived improvements in recognizing emotions, understanding emotions, and managing the emotions of others. Moreover, those in the EI training also showed increased scores in standard performance-based (i.e., ability) EI measures, demonstrating an increased ability to strategically use and manage emotions relative to placebo. Improvements to performance measures also remained significantly higher than baseline when measured six months after completing the training. The training was also wellreceived and described as helpful and engaging. Discussion: Following a rigorous iterative development process, we created a comprehensive and empirically based online training program that is wellreceived and engaging. The program reliably improves both trait and ability EI outcomes and gains are sustained up to six months post-training. This program could provide an easy and scalable method for building emotional intelligence in a variety of settings. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Reduced anhedonia following internet-based cognitive-behavioral therapy for depression is mediated by enhanced reward circuit activation.
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Hanuka, Shir, Olson, Elizabeth A., Admon, Roee, Webb, Christian A., Killgore, William D. S., Rauch, Scott L., Rosso, Isabelle M., and Pizzagalli, Diego A.
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ANHEDONIA ,INTERNET ,MEDICAL care ,MAGNETIC resonance imaging ,MENTAL depression ,ATTENTION ,DESCRIPTIVE statistics ,STATISTICAL sampling ,COGNITIVE therapy - Abstract
Background: Major depressive disorder (MDD) is a highly prevalent psychiatric condition, yet many patients do not receive adequate treatment. Novel and highly scalable interventions such as internet-based cognitive-behavioral-therapy (iCBT) may help to address this treatment gap. Anhedonia, a hallmark symptom of MDD that refers to diminished interest and ability to experience pleasure, has been associated with reduced reactivity in a neural reward circuit that includes medial prefrontal and striatal brain regions. Whether iCBT can reduce anhedonia severity in MDD patients, and whether these therapeutic effects are accompanied by enhanced reward circuit reactivity has yet to be examined. Methods: Fifty-two MDD patients were randomly assigned to either 10-week iCBT (n = 26) or monitored attention control (MAC, n = 26) programs. All patients completed pre- and post-treatment assessments of anhedonia (Snaith–Hamilton Pleasure Scale; SHAPS) and reward circuit reactivity [monetary incentive delay (MID) task during functional magnetic resonance imaging (fMRI)]. Healthy control participants (n = 42) also underwent two fMRI scans while completing the MID task 10 weeks apart. Results: Both iCBT and MAC groups exhibited a reduction in anhedonia severity post-treatment. Nevertheless, only the iCBT group exhibited enhanced nucleus accumbens (Nacc) and subgenual anterior cingulate cortex (sgACC) activation and functional connectivity from pre- to post-treatment in response to reward feedback. Enhanced Nacc and sgACC activations were associated with reduced anhedonia severity following iCBT treatment, with enhanced Nacc activation also mediating the reduction in anhedonia severity post-treatment. Conclusions: These findings suggest that increased reward circuit reactivity may contribute to a reduction in anhedonia severity following iCBT treatment for depression. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Associations between Insomnia Symptoms and Anxiety Symptoms in Adults in a Community Sample of Southeastern Pennsylvania, USA.
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Ghani, Sadia B., Kapoor, Ashna, Tubbs, Andrew S., Wills, Chloe C. A., Karp, Jordan F., Perlis, Michael L., Killgore, William D. S., Fernandez, Fabian-Xosé, and Grandner, Michael A.
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GENERALIZED anxiety disorder ,INSOMNIA ,ANXIETY ,SYMPTOMS ,ADULTS - Abstract
Although insomnia is reliably associated with anxiety symptoms, aspects of insomnia may differentially relate to one anxiety symptom versus another. Therefore, treatment for insomnia comorbidity with anxiety might be individually tailored to optimize treatment response. Working from this hypothesis, we analyzed data from a survey of 1007 community-dwelling adults. Insomnia was measured using the Insomnia Severity Index (ISI), categorizing items as nighttime disturbances, daytime dysfunction, or self-perceived dissatisfaction. Anxiety symptoms were measured with the Generalized Anxiety Disorder 7-item questionnaire (GAD-7). Linear and binomial logistic regression were used and adjusted for covariates. Post hoc forward stepwise analyses determined which components of the insomnia contributed to individual anxiety symptoms. Significant associations between nighttime disturbance (β = 0.88 [0.44, 1.3]), daytime dysfunction (β = 1.30 [0.81, 1.80]), dissatisfaction (β = 1.20 [0.60, 1.7]) and total GAD-7 score were maintained after adjusting for covariates. Nighttime disturbance was associated with excess worrying, restlessness, irritability, and fear of catastrophe. Daytime dysfunction was associated with all symptoms except for fear of catastrophe, and self-perceived dissatisfaction was associated with all symptoms except irritability. Stepwise analyses revealed that daytime dysfunction and dissatisfaction were most consistently related to anxiety symptoms. Greater attention should be paid to daytime dysfunction in patients with insomnia and anxiety, as improving daytime functioning may improve anxiety. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Sleep loss suicidal ideation: the role of trait extraversion.
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Killgore, William D. S., Grandner, Michael A., Tubbs, Andrew S., Fernandez, Fabian-Xosé, Doty, Tracy Jill, Capaldi II, Vincent F., and Dailey, Natalie S.
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EXTRAVERSION ,SUICIDAL ideation ,SLEEP interruptions ,PERSONALITY assessment ,SLEEP deprivation ,SLEEP - Abstract
Background: It is known that sleep disturbance is associated with increased suicidal thinking. Moreover, completed suicides, when adjusted for the proportion of the populace that is awake at a given time, are more probable during the late night/early morning hours. Despite these concerns, no studies have examined the role of trait-like individual differences in vulnerability to suicidal ideation during sleep deprivation or insomnia. In two separate studies, we examined whether the trait of extraversion is predictive of changes in suicidal thinking following two nights of sleep deprivation and among individuals meeting the criteria for insomnia. Methods: Study 1: Twenty-five healthy military personnel (20 males), ages 20-35 completed the NEO-PI-R Extraversion scale and the Suicidal Ideation (SUI) scale of the Personality Assessment Inventory (PAI). Participants completed 77 h of continuous sleep deprivation. After 56 h of sleep deprivation, participants completed the SUI scale a second time. We predicted a change in SUI scores from baseline extraversion. Study 2: 2,061 adults aged 18-79 (900 males) were divided into two groups based on the clinical threshold (≥10) on the Insomnia Severity Index (ISI) and completed measures of extraversion and depression, including the suicide item of the Patient Health Questionnaire-9 (PHQ9). Results: Study 1: After controlling for the caffeine group and changes in PAI Depression, Extraversion scores were used to predict changes in SUI scores using stepwise multiple linear regression. Higher Extraversion was significantly associated with increased non-clinical suicidal ideation following sleep loss, β = 0.463, partial r = 0.512, p = 0.013. Study 2: After controlling for depression, the effect of insomnia on suicidal ideation was moderated by trait extraversion (p < 0.0001). Overall, the presence or absence of insomnia had little effect on individuals low in trait extraversion (i.e., introverts), but insomnia was associated with significantly higher suicidal ideation among high trait extraverted individuals. Conclusions: Higher trait extraversion was associated with increased vulnerability to suicidal ideation between rested baseline and total sleep deprivation and was associated with greater suicidal ideation among those meeting criteria for clinically severe insomnia. These findings point to a potential trait-like vulnerability factor that may further our understanding of sleep disruption in the phenomenology of suicide. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Development and Initial Validation of the Assessment of Sleep Environment (ASE): Describing and Quantifying the Impact of Subjective Environmental Factors on Sleep.
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Grandner, Michael A., Valencia, Dora Y., Seixas, Azizi A., Oliviér, Kayla, Gallagher, Rebecca A., Killgore, William D. S., Hale, Lauren, Branas, Charles, and Alfonso-Miller, Pamela
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- 2022
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9. Effects of docosahexaenoic acid and eicosapentaoic acid supplementation on white matter integrity after repetitive sub-concussive head impacts during American football: Exploratory neuroimaging findings from a pilot RCT.
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Raikes, Adam C., Hernandez, Gerson D., Mullins, Veronica A., Yiwei Wang, Lopez, Claudia, Killgore, William D. S., Chilton, Floyd H., and Brinton, Roberta D.
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FOOTBALL ,DOCOSAHEXAENOIC acid ,WHITE matter (Nerve tissue) ,HEAD injuries ,DIETARY supplements - Abstract
Context: Repetitive sub-concussive head impacts (RSHIs) are common in American football and result in changes to the microstructural integrity of white matter. Both docosahexaenoic acid (DHA) and eicosapentaoic acid (EPA) supplementation exerted neuroprotective effects against RSHIs in animal models and in a prior study in football players supplemented with DHA alone. Objective: Here, we present exploratory neuroimaging outcomes from a randomized controlled trial of DHA + EPA supplementation in American football players. We hypothesized that supplementation would result in less white matter integrity loss on diffusion weighted imaging over the season. Design, setting, participants: We conducted a double-blind placebo-controlled trial in 38 American football players between June 2019 and January 2020. Intervention: Participants were randomized to the treatment (2.442 g/day DHA and 1.020 g/day EPA) or placebo group for five times-per-week supplementation for 7 months. Of these, 27 participants were included in the neuroimaging data analysis (n = 16 placebo; n = 11 DHA + EPA). Exploratory outcome measures: Changes in white matter integrity were quantified using both voxelwise diffusion kurtosis scalars and deterministic tractography at baseline and end of season. Additional neuroimaging outcomes included changes in regional gray matter volume as well as intra-regional, edge-wise, and network level functional connectivity. Serum neurofilament light (NfL) provided a peripheral biomarker of axonal damage. Results: No voxel-wise between-group differences were identified on diffusion tensor metrics. Deterministic tractography using quantitative anisotropy (QA) revealed increased structural connectivity in ascending corticostriatal fibers and decreased connectivity in long association and commissural fibers in the DHA+EPA group compared to the placebo group. Serum NfL increases were correlated with increased mean (ρ = 0.47), axial (ρ = 0.44), and radial (ρ = 0.51) diffusivity and decreased QA (ρ = -0.52) in the corpus callosum and bilateral corona radiata irrespective of treatment group. DHA + EPA supplementation did preserve default mode/frontoparietal control network connectivity (g = 0.96, p = 0.024). Conclusions: These exploratory findings did not provide strong evidence that DHA + EPA prevented or protected against axonal damage as quantified via neuroimaging. Neuroprotective effects on functional connectivity were observed despite whitematter damage. Further studies with larger samples are needed to fully establish the relationship between omega-3 supplementation, RSHIs, and neuroimaging biomarkers. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Treatment with morning blue light increases left amygdala volume and sleep duration among individuals with posttraumatic stress disorder.
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Killgore, William D. S., Vanuk, John R., and Dailey, Natalie S.
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POST-traumatic stress disorder ,BLUE light ,AMYGDALOID body ,SLEEP quality ,VOXEL-based morphometry - Abstract
Background: Posttraumatic stress disorder (PTSD) is associated with numerous cognitive, affective, and psychophysiological outcomes, including problems with sleep and circadian rhythms. We tested the effectiveness of a daily morning blue-light exposure treatment (BLT) versus a matched amber light treatment (ALT) to regulate sleep in individuals diagnosed with PTSD. Moreover, PTSD is also associated with reliable findings on structural neuroimaging scans, including reduced amygdala volumes and other differences in cortical gray matter volume (GMV) that may be indicative of underlying neurobehavioral dysfunctions. We examined the effect of BLT versus ALT on GMV and its association with sleep outcomes. Methods: Seventy-six individuals (25 male; 51 female) meeting DSM-V criteria for PTSD (Age = 31.45 years, SD = 8.83) completed sleep assessments and structural neuroimaging scans, followed by random assignment one of two light groups, including BLT (469 nm; n = 39) or placebo ALT (578 nm; n = 37) light therapy daily for 30-min over 6-weeks. Participants wore a wrist actigraph for the duration of the study. After treatment, participants returned to complete sleep assessments and a structural neuroimaging scan. Neuroimaging data were analyzed using the Computational Anatomy Toolbox (CAT12) and Voxel-Based Morphometry (VBM) modules within the Statistical Parametric Mapping (SPM12) software. Results: The BLT condition produced significant increases in total time in bed and total sleep time from actigraphy compared to the ALT condition, while ALT improved wake after sleep onset and sleep efficiency compared to BLT. Additionally, BLT led to an increase in left amygdala volume compared to ALT but did not affect hypothesized medial prefrontal regions. Finally, within group correlations showed that improvements in sleep quality and nightmare severity were correlated with increases in left amygdala volume over the course of treatment for the BLT group but not the ALT group. Conclusion: In individuals with PTSD, daily exposure to morning blue light treatment was associated with improvements in objective sleep duration and increased volume of the left amygdala compared to amber placebo light treatment, and changes in amygdala volume correlated with subjective improvement in sleep. These findings suggest that daily morning BLT may provide an important non-pharmacologic adjunctive approach for facilitating sleep and neurobehavioral recovery from PTSD. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Morning blue light treatment improves sleep complaints, symptom severity, and retention of fear extinction memory in post-traumatic stress disorder.
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Vanuk, John R., Pace-Schott, Edward F., Bullock, Ayla, Esbit, Simon, Dailey, Natalie S., and Killgore, William D. S.
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EXPOSURE therapy ,POST-traumatic stress disorder ,BLUE light ,FUNCTIONAL magnetic resonance imaging ,SLEEP interruptions ,GALVANIC skin response - Abstract
Disrupted sleep is a major feature in numerous clinical disorders and is related to decrements in affective memory processing. The prevalence of sleep disruption in post-traumatic stress disorder (PTSD) is suggested to be a key feature that exacerbates the impaired ability to recall extinction memories during experimental fear conditioning. We hypothesized that an intervention employing blue-wavelength light therapy (BLT) to regulate sleep and stabilize circadian rhythms in patients with PTSD (i.e., via regulated morning exposure) would be associated with PTSD symptom improvement, decreased sleep-related complaints, as well as improved consolidation and retention of extinction memories relative to a fear conditioning/extinction paradigm. Eighty-two individuals with PTSD underwent a well-validated fear conditioning/extinction protocol with subsequent assignment to receive morning BLUE (BLT) or placebo AMBER (ALT) light therapy daily for 30-min over 6-weeks. Participants returned after the intervention for post-treatment extinction recall, comprised of exposure to the previously conditioned stimuli, with the difference in skin conductance response between the "extinguished" and the "never-extinguished" stimuli at follow-up. Participants also viewed previously conditioned stimuli in a novel context during a functional magnetic resonance imaging (fMRI) scan. BLUE light therapy was associated with improvements relative to correlated decreases between PTSD symptoms and sleep-related complaints. Participants receiving BLT also sustained retention of the extinction memory, while those in the placebo amber light treatment group showed impairment, characterized by the restoration of the extinguished fear response after 6-weeks. Participants in the ALT also demonstrated greater reactivity in the left insula when viewing the previously extinguished fear-conditioned stimuli in a novel context. Daily BLUE-wavelength morning light exposure was associated with greater retention of extinction learning in patients with PTSD when compared to ALT, as supported by both autonomic and neurobiological reactivity. We speculate that improved sleep facilitated by a stabilized circadian rhythm, after fear-learning, led to greater consolidation of the fear extinction memory, decreased PTSD symptom presentation, and associated decreases in sleeprelated complaints. Prominent exposure treatments for PTSD incorporate principles of fear extinction, and our findings suggest that blue light treatment may facilitate treatment gains by promoting the consolidation of extinction memories via improved sleep. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Higher emotional awareness is associated with greater domain-general reflective tendencies.
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Smith, Ryan, Persich, Michelle, Lane, Richard D., and Killgore, William D. S.
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AWARENESS ,MENTAL health ,SIGNAL processing ,COGNITION ,INFORMATION processing - Abstract
The tendency to reflect on the emotions of self and others is a key aspect of emotional awareness (EA)—a trait widely recognized as relevant to mental health. However, the degree to which EA draws on general reflective cognition vs. specialized socio-emotional mechanisms remains unclear. Based on a synthesis of work in neuroscience and psychology, we recently proposed that EA is best understood as a learned application of domain-general cognitive processes to socio-emotional information. In this paper, we report a study in which we tested this hypothesis in 448 (125 male) individuals who completed measures of EA and both general reflective cognition and socio-emotional performance. As predicted, we observed a significant relationship between EA measures and both general reflectiveness and socio-emotional measures, with the strongest contribution from measures of the general tendency to engage in effortful, reflective cognition. This is consistent with the hypothesis that EA corresponds to the application of general reflective cognitive processes to socio-emotional signals. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Nightmare content during the COVID‐19 pandemic: Influence of COVID‐related stress and sleep disruption in the United States.
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Kennedy, Kathryn E. R., Bastien, Célyne H., Ruby, Perrine M., Killgore, William D. S., Wills, Chloe C. A., and Grandner, Michael A.
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NIGHTMARES ,SLEEP interruptions ,ACUTE stress disorder ,COVID-19 pandemic ,LOGISTIC regression analysis ,DOMESTIC violence - Abstract
Nightmares are often associated with psychiatric disorders and acute stress. This study explores how the COVID‐19 pandemic may have influenced the content of nightmares. A sample of N = 419 US adults completed online surveys about sleep and COVID‐19 experiences. Participants were asked about the degree to which they agreed with statements linking greater general stress, worse overall sleep and more middle‐of‐the‐night insomnia with the COVID‐19 pandemic. They were also asked if, during the pandemic, they experienced nightmares related to various themes. Logistic regression analyses examined each nightmare content as outcome and increased stress, worse sleep and more middle‐of‐the‐night insomnia as predictors, adjusted for age, sex and race/ethnicity. Those who reported greater general COVID‐related stress were more likely to have nightmares about confinement, failure, helplessness, anxiety, war, separation, totalitarianism, sickness, death, COVID and an apocalypse. Those who reported worsened sleep were more likely to have nightmares about confinement, oppression, failure, helplessness, disaster, anxiety, evil forces, war, domestic abuse, separation, totalitarianism, sickness, death, COVID and an apocalypse. Those who reported worsened middle‐of‐the‐night insomnia were more likely to have nightmares about confinement, oppression, failure, helplessness, disaster, anxiety, war, domestic abuse, separation, totalitarianism, sickness, death, COVID and an apocalypse. These results suggest that increased pandemic‐related stress may induce negatively‐toned dreams of specific themes. Future investigation might determine whether (and when) this symptom indicates an emotion regulation mechanism at play, or the failure of such a mechanism. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Menstrual regularity and bleeding is associated with sleep duration, sleep quality and fatigue in a community sample.
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Kennedy, Kathryn E. R., Onyeonwu, Chidera, Nowakowski, Sara, Hale, Lauren, Branas, Charles C., Killgore, William D. S., Wills, Chloe C. A., and Grandner, Michael A.
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MENSTRUAL cycle ,MENSTRUATION ,MENORRHAGIA ,SLEEP ,EPWORTH Sleepiness Scale ,BODY mass index ,ODDS ratio ,ETHNICITY - Abstract
Summary: Female menstrual health and its relationship with sleep is an understudied subject. The aim of this investigation was to determine the association between the two in a community sample. Data were obtained from n = 579 menstruating females who participated in the Sleep and Health Activity, Diet, Environment, and Socialization (SHADES) study, a community‐based sample of adults aged 22–60 years. Participants were asked, "How regular is your period?", with response choices of "very regular", "mostly regular", "fairly regular" and "not regular". They were also asked, "How much bleeding do you usually experience during your period?" Response choices were: "very heavy", "heavy", "medium", "light" or "very light". These were evaluated as ordinal outcomes. Sleep‐related predictors included sleep duration (in hr; ≤ 6 [short], 7–9 [normal] and ≥ 9 [long]), Insomnia Severity Index score, Pittsburgh Sleep Quality Index score, Epworth Sleepiness Scale score and Fatigue Severity Scale score. Covariates included age, education, income, race/ethnicity and body mass index. Short sleep duration was associated with heavier bleeding (odds ratio = 1.46, p = 0.026) and greater cycle irregularity (odds ratio = 1.44, p = 0.031) as compared with normal sleep. Higher Pittsburgh Sleep Quality Index score was associated with greater cycle irregularity (odds ratio = 1.05, p = 0.022). Higher Fatigue Severity Scale score was associated with heavier bleeding (odds ratio = 1.02, p = 0.003) and greater cycle irregularity (odds ratio = 1.02, p = 0.008). Long sleep, Insomnia Severity Index and Epworth Sleepiness Scale were not associated with either outcome. These results demonstrate an association between short sleep duration, poor sleep quality, fatigue, stress and depression with heavier bleeding and menstrual cycle irregularity, highlighting the need for further studies to improve treatment options. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Lower Levels of Directed Exploration and Reflective Thinking Are Associated With Greater Anxiety and Depression.
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Smith, Ryan, Taylor, Samuel, Wilson, Robert C., Chuning, Anne E., Persich, Michelle R., Wang, Siyu, and Killgore, William D. S.
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CRITICAL thinking ,INFORMATION-seeking behavior ,ANXIETY ,MENTAL depression ,AFFECTIVE disorders - Abstract
Anxiety and depression are often associated with strong beliefs that entering specific situations will lead to aversive outcomes – even when these situations are objectively safe and avoiding them reduces well-being. A possible mechanism underlying this maladaptive avoidance behavior is a failure to reflect on: (1) appropriate levels of uncertainty about the situation, and (2) how this uncertainty could be reduced by seeking further information (i.e., exploration). To test this hypothesis, we asked a community sample of 416 individuals to complete measures of reflective cognition, exploration, and symptoms of anxiety and depression. Consistent with our hypotheses, we found significant associations between each of these measures in expected directions (i.e., positive relationships between reflective cognition and strategic information-seeking behavior or "directed exploration", and negative relationships between these measures and anxiety/depression symptoms). Further analyses suggested that the relationship between directed exploration and depression/anxiety was due in part to an ambiguity aversion promoting exploration in conditions where information-seeking was not beneficial (as opposed to only being due to under-exploration when more information would aid future choices). In contrast, reflectiveness was associated with greater exploration in appropriate settings and separately accounted for differences in reaction times, decision noise, and choice accuracy in expected directions. These results shed light on the mechanisms underlying information-seeking behavior and how they may contribute to symptoms of emotional disorders. They also highlight the potential clinical relevance of individual differences in reflectiveness and exploration and should motivate future research on their possible contributions to vulnerability and/or maintenance of affective disorders. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Emotional intelligence training as a protective factor for mental health during the COVID‐19 pandemic.
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Persich, Michelle R., Smith, Ryan, Cloonan, Sara A., Woods‐Lubbert, Rebecca, Strong, Michael, and Killgore, William D. S.
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COVID-19 pandemic ,EMOTIONAL intelligence ,MENTAL health ,ONLINE education ,SUICIDAL ideation - Abstract
Introduction: The COVID‐19 pandemic has presented a major challenge to mental health and emotional wellbeing. The present study examined whether training in emotional intelligence (EI) skills, provided before the pandemic, would serve as a protective factor for sustaining mental health during the COVID‐19 crisis. Methods: Data came from a longitudinal study (N = 89) that was initially designed to test the effectiveness of an EI training program versus a non‐emotion‐focused placebo program. The design and timing of the study were such that baseline and posttraining assessments of depression and anxiety had been completed before the pandemic, and planned 6‐month follow‐ups were serendipitously scheduled to occur after the onset of the COVID‐19 crisis. This provided us with an unexpected real‐world opportunity to investigate whether EI training would bolster emotional resilience to the challenges posed by the COVID‐19 pandemic. Results: Although mental health concerns generally increased after the start of the pandemic, individuals who completed the EI training program scored lower on depression, suicidal ideation, and state anxiety relative to individuals who had been assigned to the placebo training program. Conclusion: Online EI training appears to be effective at sustaining critical aspects of mental health during a subsequent real‐life crisis. [ABSTRACT FROM AUTHOR]
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- 2021
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17. 40 Sex Differences in Emotional Intelligence Ability and Risk-Taking Behavior.
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Hildebrand, Lindsey and Killgore, William D. S.
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RISK-taking behavior ,EMOTIONAL intelligence ,PEARSON correlation (Statistics) ,PERSONALITY ,INTELLIGENCE tests ,STATISTICAL power analysis - Abstract
Objective: People differ in their propensity to engage in risky behaviors. Numerous factors such as cognition and personality have been utilized in predicting risk-taking, but little is known about the influence of stable emotional competencies, such as Emotional Intelligence (EI), in risk-taking. EI is defined as the ability and capacity to understand, perceive, and manage one's own, as well as others', emotions. However there has been little published research on the effect of ability emotional intelligence in engaging in risk- taking behavior. We hypothesized that those with higher emotional intelligence ability scores would demonstrate higher and more optimal risk-taking propensity. Furthermore, as prior research has demonstrated that males engage in more risk-taking behaviors, we accounted for sex differences within our analysis. Participants and Methods: One-hundred and twelve healthy adults completed this study, including 56 females (Mage=21.7, SD=5.8) and 56 males (Mage=21.5, SD=3.2). The Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) was used to assess total EI ability while the Balloon Analog Risk Task (BART) was used to assess risk-taking propensity. We specifically analyzed adjusted number of pumps on unexploded balloons throughout the BART to account for the increased risk. We conducted Pearson correlations and a multiple regression to assess the if ability emotional intelligence and gender significantly predicted risk-taking propensity. Results: There was a significant correlation between total emotional intelligence ability score and adjusted number of pumps on the BART for females, r(55)=.362, p =.006, but not for males r(55)=.053, p=.701, suggesting that females who score higher in emotional intelligence ability also had a higher risk-taking propensity. Due to these findings, we conducted a multiple regression to assess if ability emotional intelligence and gender significantly predict risk-taking propensity on the BART. The results of the regression indicated the two predictors explained 9.0% of the variance (R
2 =.09, F(2,108)=5.32, p<.01). However, it was found that ability emotional intelligence significantly predicted risk-taking propensity (β =.23, p<.05), but not sex (β = -.17, p=.06). There was no sex x EI interaction. Conclusions: Higher ability emotional intelligence was significantly related to greater risk-taking propensity, but this was only observed for females. However, the lack of significance of sex in significantly predicting risk-taking may just be due to lower statistical power in the study. Importantly, the adjusted number of pumps for the participants in this sample was generally far below the mid-point for popping balloons, suggesting that the higher scores observed here represent more optimal decision performance rather than just greater risk. Thus, greater EI may reflect greater capacity to learn from reward and punishment feedback and apply that learning to optimize performance. Future research should look at the effect of emotional intelligence training in improving optimal risk-taking, particularly for populations known for engaging in risky behaviors such as those with mTBI. [ABSTRACT FROM AUTHOR]- Published
- 2023
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18. 79 Continuous Theta Burst Stimulation (cTBS) over the Inferior Parietal Cortex Decreases Default Mode Connectivity and Improves Overnight Sleep in People with Insomnia.
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Killgore, William D. S., Jankowski, Samantha, Henderson-Arredondo, Kymberly, Trapani, Christopher, Elledge, Heidi, Lucas, Daniel, Le, Andrew, Suckow, Emmett, Hildebrand, Lindsey, Persich, Michelle, Zahorecz, Brianna, Salazar, Cohelly, Watson, Tyler, Wellman, Camryn, Reign, Deva, Chen, Yu-Chin, Chou, Ying-Hui, and Dailey, Natalie S.
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PARIETAL lobe ,SLEEP duration ,FUNCTIONAL magnetic resonance imaging ,DEFAULT mode network ,TRANSCRANIAL magnetic stimulation ,SLEEP - Abstract
Objective: Chronic insomnia is a highly prevalent disorder affecting approximately one-in-three Americans. Insomnia is associated with increased cognitive and brain arousal. Compared to healthy individuals, those with insomnia tend to show greater activation/connectivity within the default mode network (DMN) of the brain, consistent with the hyperarousal theory. We investigated whether it would be possible to suppress activation of the DMN to improve sleep using a type of repetitive transcranial magnetic stimulation (rTMS) known as continuous theta burst stimulation (cTBS). Participants and Methods: Participants (n=9, 6 female; age=25.4, SD=5.9 years) meeting criteria for insomnia/sleep disorder on standardized scales completed a counterbalanced sham-controlled crossover design in which they served as their own controls on two separate nights of laboratory monitored sleep on separate weeks. Each session included two resting state functional magnetic resonance imaging (fMRI) sessions separated by a brief rTMS session. Stimulation involved a 40 second cTBS stimulation train applied over an easily accessible cortical surface node of the DMN located at the left inferior parietal lobe. After scanning/stimulation, the participant was escorted to an isolated sleep laboratory bedroom, fitted with polysomnography (PSG) electrodes, and allowed an 8-hour sleep opportunity from 2300 to 0700. PSG was monitored continuously and scored for standard outcomes, including total sleep time (TST), percentage of time various sleep stages, and number of arousals. Results: Consistent with our hypothesis, a single session of active cTBS produced a significant reduction of functional connectivity (p <.05, FDR corrected) within the DMN. In contrast, the sham condition produced no changes in functional connectivity from pre- to post-treatment. Furthermore, after controlling for age, we also found that the active treatment was associated with meaningful trends toward greater overnight improvements in sleep compared to the sham condition. First, the active cTBS condition was associated with significantly greater TST compared to sham (F(1,7)=14.19, p=.007, partial eta-squared=.67). Overall, individuals obtained 26.5 minutes more sleep on the nights that they received the active cTBS compared to the sham condition. Moreover, the active cTBS condition was associated with a significant increase in the percentage of time in rapid eye movement (REM%) sleep compared to the sham condition (F(1,7)=7.05, p=.033, partial eta-squared=.50), which was significant after controlling for age. Overall, active treatment was associated with an increase of 6.76% more of total sleep time in REM compared to sham treatment. Finally, active cTBS was associated with fewer arousals from sleep (t(8) = -1.84, p =.051, d =.61), with an average of 15.1 fewer arousals throughout the night than sham. Conclusions: Overall, these findings suggest that this simple and brief cTBS approach can alter DMN brain functioning in the expected direction and was associated with trends toward improved objectively measured sleep, including increased TST and REM% and fewer arousals during the night following stimulation. These findings emerged after only a single 40-second treatment, and it remains to be seen whether multiple treatments over several days or weeks can sustain or even improve upon these outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Chronotype and social support among student athletes: impact on depressive symptoms.
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Wills, Chloe, Ghani, Sadia, Tubbs, Andrew, Fernandez, Fabian-Xosé, Athey, Amy, Turner, Robert, Robbins, Rebecca, Patterson, Freda, Warlick, Chloe, Alfonso-Miller, Pamela, Killgore, William D. S., and Grandner, Michael A.
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SOCIAL support ,MENTAL depression ,YOUNG adults ,SOCIAL isolation ,COLLEGE athletes ,SOCIAL networks - Abstract
Previous studies have shown individuals with evening chronotype to have a greater likelihood for depression (self-reported and clinical ratings), especially in young adults. However, the mechanisms for this relationship remain unknown. Low levels of social support may be a plausible mechanism: young adults with evening chronotypes are awake when others are sleeping, which may lead to feelings of isolation or low support. This study examined links between chronotype, depression, and social support in relationship subtypes within a group of university student athletes. Data were obtained from 189 NCAA Division-I student athletes across all sports. Chronotype was assessed with the Circadian Energy Scale and ranged from −2 (definitely morning type) to +2 (definitely evening type). Depressive symptoms were assessed with Center for Epidemiological Studies Depression scale. Social support was assessed with the Multidimensional Scale of Perceived Social Support, which included subscales for Family, Friends, and Significant Other. A subscale for Team was created using the items from the Friends subscale (changing the word "friends" to "teammates"). Regression analyses adjusted for age, sex, and minority status. More evening chronotype was associated with higher reported depressive symptoms (p =.018), lower overall perceived social support (p =.001), and lower perceived social support specifically provided by family (p <.0001), friends (p <.0001), and teammates (p =.014). However, more evening chronotype was associated with higher depressive symptoms for higher, but not lower perceived social support from significant other. Moreover, chronotype-by-support interactions on depressive symptoms were observed; the statistical relationship between chronotype and depression was evident only in those with low (but not high) social support from friends and teammates. These data suggest that having a more evening chronotype may be associated with social isolation, and decreased opportunities for interactions with friends and teammates. This may contribute to the long-standing circadian association seen with depression in college student-athletes. Interventions aimed at increasing university support networks may reduce the impact of depression in students self-identifying with later chronotypes and sleep schedules. [ABSTRACT FROM AUTHOR]
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- 2021
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20. Culturally-consistent diet among individuals of Mexican descent at the US-Mexico border is associated with sleep duration and snoring.
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Ghani, Sadia B., Taneja, Krishna, Wills, Chloe C. A., Tubbs, Andrew S., Delgadillo, Marcos E., Valencia, Dora, Halane, Mohamed, Killgore, William D. S., and Grandner, Michael A.
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SNORING ,FOOD consumption ,HEART metabolism disorders ,SLEEP physiology ,HEALTH equity - Abstract
Background: Existing studies show that consuming food consistent with one's culture reduces cardiometabolic risk. However, few studies have assessed whether these dietary choices influence sleep health. Accordingly, this study assessed how Mexican food consumption by individuals of Mexican descent residing at the US-Mexico border, was associated with various measures of sleep, after accounting for acculturation. Methods: Data were provided by 100 adults between the ages of 18–60, in the city of Nogales, AZ. Questionnaires were provided in either Spanish or English. Acculturation was assessed with the Acculturation Scale for Mexican-Americans (ARSMA-II), with an additional question, asking how often "my family cooks Mexican foods." Frequency of cooking Mexican food was coded as either "yes" or "no." Sleep was assessed, using validated measures that include the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI), and sleep duration with the item "how many hours of actual sleep did you get at night?" Regression models estimated the associations between sleep health variables as outcomes and consumption of Mexican food as the independent variable. Covariates included age, sex, and acculturation scores. Parental education level was also included, as an indicator of childhood socioeconomic status and since food culture likely involves parents. Result: We found that among individuals who identified as Mexican-Americans who consumed culturally-consistent foods, was associated with, on average, 1.41 more hours of sleep (95% CI 0.19, 2.62; p = 0.024) and were less likely to report snoring (OR: 0.25; 95% CI 0.07, 0.93; p = 0.039). Consuming Mexican food was not associated with sleep quality, insomnia severity or sleepiness. Conclusion: Individuals of Mexican descent residing at the US-Mexico border who regularly consumed Mexican food, reported more sleep and less snoring. Mexican acculturation has been shown previously to improve sleep health. This is likely due to consumption of a culturally- consistent diet. Future studies should examine the role of acculturation in sleep health, dietary choices, and subsequent cardiometabolic risk. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Mental Health in Student Athletes: Associations With Sleep Duration, Sleep Quality, Insomnia, Fatigue, and Sleep Apnea Symptoms.
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Grandner, Michael A., Hall, Christine, Jaszewski, Anjelica, Alfonso-Miller, Pamela, Gehrels, Jo-Ann, Killgore, William D. S., and Athey, Amy
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INSOMNIA risk factors ,FATIGUE risk factors ,WELL-being ,FRIENDSHIP ,AFFINITY groups ,COLLEGE athletes ,SOCIAL support ,TIME ,MENTAL health ,FAMILIES ,SLEEP ,RISK assessment ,PSYCHOSOCIAL factors ,SLEEP apnea syndromes ,SLEEP deprivation ,MENTAL depression ,ANXIETY ,MENTAL illness ,PSYCHOLOGICAL stress ,DISEASE risk factors - Abstract
Purpose: To quantify the relationship between sleep difficulties and poor mental health among student athletes using validated measures. Methods: Data were collected from 190 National Collegiate Athletic Association Division I student athletes. Sleep assessments included measures of sleep duration, sleep quality, insomnia, fatigue, and sleep apnea symptoms. Mental well-being was assessed as depression, anxiety, mental health days, stress, and social support from family, friends, significant other, and teammates. Results: Shorter sleep duration, poor sleep quality, insomnia, and fatigue were consistently and independently associated with stress, depression, anxiety, mental health days, and social support. Sleep apnea symptoms were associated with stress, depression, and social support. Conclusions: Short sleep duration, poor sleep quality, and daytime fatigue in student athletes are all associated with depression, anxiety, stress, poor mental health days, and decreased social support. These associations are not accounted for solely by stress. [Athletic Training & Sports Health Care. 2021;13(4):e159–e167.] [ABSTRACT FROM AUTHOR]
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- 2021
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22. Mental Health During the First Weeks of the COVID-19 Pandemic in the United States.
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Killgore, William D. S., Cloonan, Sara A., Taylor, Emily C., and Dailey, Natalie S.
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COVID-19 pandemic ,MENTAL health ,STAY-at-home orders ,LAYOFFS ,ACUTE stress disorder ,ALCOHOL drinking ,COVID-19 - Abstract
Background: By March 2020, the World Health Organization declared the COVID-19 crisis as a worldwide pandemic and many local governments instituted stay-at-home orders and closed non-essential businesses. Within the United States, tens of millions of workers lost their jobs and financial security during the first few weeks of the national response, in an attempt to slow the global pandemic. Because of the enormity of the pandemic and its potential impact on mental health, the objective of the present study was to document the prevalence of mental health problems and their association with pandemic-related job loss during the third week of the nationwide shutdown. Methods: Mental health was assessed via online questionnaires among a representative sample of 1,013 U.S. adults on April 9–10, 2020. Rates of clinically significant mental health outcomes were compared between participants who lost their job as a result of COVID-19 restrictions (17.4%) vs. those who did not (82.6%). Bivariate multiple logistic regression identified factors that were predictive of, and protective against, mental health problems. Results: The prevalence of clinically significant symptoms was significantly higher than prior population estimates, ranging from 27 to 32% for depression, 30 to 46% for anxiety disorders, 15 to 18% for acute/post-traumatic stress, 25% for insomnia, and 18% for suicidal ideation. Prevalence estimates were 1.5–1.7 times higher for those who reported job loss due to COVID-19 restrictions than those who did not. Mental health problems were predicted by worry over financial instability, insomnia, social isolation, and alcohol consumption, while getting outside more often, perceived social support, and older age were protective against these problems. Conclusions: During the first 3 weeks of lockdowns/stay-at-home restrictions, mental health problems, including depression, anxiety, insomnia, and acute stress reactions were notably elevated relative to prior population estimates. Job loss related to the nationwide shutdown was particularly associated with poorer mental health. These findings provide a baseline of mental health functioning during the first weeks of the national emergency and lockdown orders in response to COVID-19. [ABSTRACT FROM AUTHOR]
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- 2021
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23. Exposure to Blue Wavelength Light Is Associated With Increases in Bidirectional Amygdala-DLPFC Connectivity at Rest.
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Alkozei, Anna, Dailey, Natalie S., Bajaj, Sahil, Vanuk, John R., Raikes, Adam C., and Killgore, William D. S.
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BLUE light ,FUNCTIONAL connectivity ,PREFRONTAL cortex ,AFFECTIVE disorders - Abstract
Blue wavelength light has been used successfully as a treatment method for certain mood disorders, but, the underlying mechanisms behind the mood enhancing effects of light remain poorly understood. We investigated the effects of a single dose of 30 min of blue wavelength light (n = 17) vs. amber wavelength light (n = 12) exposure in a sample of healthy adults on subsequent resting-state functional and directed connectivity, and associations with changes in state affect. Individuals who received blue vs. amber wavelength light showed greater positive connectivity between the right amygdala and a region within the left dorsolateral prefrontal cortex (DLPFC). In addition, using granger causality, the findings showed that individuals who received blue wavelength light displayed greater bidirectional information flow between these two regions relative to amber light. Furthermore, the strength of amygdala-DLPFC functional connectivity was associated with greater decreases in negative mood for the blue, but not the amber light condition. Blue light exposure may positively influence mood by modulating greater information flow between the amygdala and the DLPFC, which may result in greater engagement of cognitive control strategies that are needed to perceive and regulate arousal and mood. [ABSTRACT FROM AUTHOR]
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- 2021
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24. Daily Morning Blue Light Therapy for Post-mTBI Sleep Disruption: Effects on Brain Structure and Function.
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Raikes, Adam C., Dailey, Natalie S., Forbeck, Brittany, Alkozei, Anna, and Killgore, William D. S.
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PHOTOTHERAPY ,BLUE light ,FUNCTIONAL magnetic resonance imaging ,BRAIN injuries ,COGNITIVE ability ,SLEEP interruptions ,MORNINGNESS-Eveningness Questionnaire - Abstract
Background: Mild traumatic brain injuries (mTBIs) are associated with novel or worsened sleep disruption. Several studies indicate that daily morning blue light therapy (BLT) is effective for reducing post-mTBI daytime sleepiness and fatigue. Studies demonstrating changes in brain structure and function following BLT are limited. The present study's purpose is to identify the effect of daily morning BLT on brain structure and functional connectivity and the association between these changes and self-reported change in post-mTBI daytime sleepiness. Methods: A total of 62 individuals recovering from a mTBI were recruited from two US cities to participate in a double-blind placebo-controlled trial. Eligible individuals were randomly assigned to undergo 6 weeks of 30 min daily morning blue or placebo amber light therapy (ALT). Prior to and following treatment all individuals completed a comprehensive battery that included the Epworth Sleepiness Scale as a measure of self-reported daytime sleepiness. All individuals underwent a multimodal neuroimaging battery that included anatomical and resting-state functional magnetic resonance imaging. Atlas-based regional change in gray matter volume (GMV) and region-to-region functional connectivity from baseline to post-treatment were the primary endpoints for this study. Results: After adjusting for pre-treatment GMV, individuals receiving BLT had greater GMV than those receiving amber light in 15 regions of interest, including the right thalamus and bilateral prefrontal and orbitofrontal cortices. Improved daytime sleepiness was associated with greater GMV in 74 ROIs, covering many of the same general regions. Likewise, BLT was associated with increased functional connectivity between the thalamus and both prefrontal and orbitofrontal cortices. Improved daytime sleepiness was associated with increased functional connectivity between attention and cognitive control networks as well as decreased connectivity between visual, motor, and attention networks (all FDR corrected p < 0.05). Conclusions: Following daily morning BLT, moderate to large increases in both gray matter volume and functional connectivity were observed in areas and networks previously associated with both sleep regulation and daytime cognitive function, alertness, and attention. Additionally, these findings were associated with improvements in self-reported daytime sleepiness. Further work is needed to identify the personal characteristics that may selectively identify individuals recovering from a mTBI for whom BLT may be optimally beneficial. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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25. Sex differences in limbic network and risk‐taking propensity in healthy individuals.
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Bajaj, Sahil and Killgore, William D. S.
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- 2020
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26. The Mediating Role of Interpretation Bias on the Relationship Between Trait Gratitude and Depressive Symptoms.
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Alkozei, Anna, Smith, Ryan, Waugaman, Debby L., Kotzin, Megan D., Bajaj, Sahil, and Killgore, William D. S.
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- 2019
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27. The Role of Prefrontal Cortical Surface Area and Volume in Preclinical Suicidal Ideation in a Non-Clinical Sample.
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Bajaj, Sahil, Raikes, Adam C., Smith, Ryan, Vanuk, John R., and Killgore, William D. S.
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SUICIDAL ideation ,SURFACE area ,PERSONALITY assessment ,POPULATION ,PSYCHIATRIC diagnosis - Abstract
Suicidal ideation (SUI) can occur in the absence of concomitant psychiatric diagnoses, and even normal levels can be problematic among individuals experiencing excess stress or lack of social support. The objective of this study was to investigate the neuroanatomical basis of SUI in non-clinical human populations who are within the normal limits of SUI, after accounting for elevated stress and perceived lack of social support. Neuroanatomical data were collected from 55 healthy individuals (mean age 30.9 ± 8.1 years, 27 females) whose depression severity levels were below the Diagnostic and Statistical Manual of Mental Disorders criteria. Measures of SUI, aggression, stress, non-support, and treatment rejection were collected from the treatment-consideration scales (TCS) of the Personality Assessment Inventory (PAI). Correlations between standardized SUI scores and three brain morphometry measures, including vertex wise cortical thickness (CT), cortical surface area (CSA), and cortical volume (CV), were estimated for each participant, controlling for age, sex, intracranial volume, and the remaining TCS measures. We observed a significant negative association between scores on SUI and both CSA and CV (cluster-forming threshold of p < 0.005, clusterwise threshold of p < 0.05, FDR corrected for multiple comparisons) within the left rostral middle frontal gyrus. Our findings suggest that greater CSA and CV within the dorsolateral prefrontal cortex are associated with reduced SUI in a non-clinical population with mild levels of stress and perceived lack of social support. Because the dorsolateral prefrontal cortex has been broadly linked to cognitive reappraisal, self-critical thoughts, and emotional regulation, greater CSA and CV within these regions may lead to better mental health by protecting healthy individuals from engaging in SUI during periods of stress and perceived insufficient social support. As our data consisted of only healthy individuals with non-clinical levels of SUI, further investigation will be necessary to explore the neural basis of SUI in populations who may be at greater risk of future suicidal behavior [ABSTRACT FROM AUTHOR]
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- 2019
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28. Ability-Based Emotional Intelligence Is Associated With Greater Cardiac Vagal Control and Reactivity.
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Vanuk, John R., Alkozei, Anna, Raikes, Adam C., Allen, John J. B., and Killgore, William D. S.
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EMOTIONAL intelligence ,HEART beat ,VAGAL tone ,VISCERA abnormalities ,STRESS management - Abstract
Several distinct models of emotional intelligence (EI) have been developed over the past two decades. The ability model conceptualizes EI as a narrow set of interconnected, objectively measured, cognitive-emotional abilities, including the ability to perceive, manage, facilitate, and understand the emotions of the self and others. By contrast, trait or mixed models focus on subjective ratings of emotional/social competencies. Theoretically, EI is associated with neurobiological processes involved in emotional regulation and reactivity. The neurovisceral integration (NVI) model proposes a positive relationship between cardiac vagal control (CVC) and cognitive-emotional abilities similar to those encompassed by EI. The current study examined the association between CVC and EI. Because ability EI is directly tied to actual performance on emotional tasks, we hypothesized that individuals with higher ability-based EI scores would show greater levels of CVC at rest, and in response to a stressful task. Because mixed-models of EI are not linked directly to observable emotional behavior, we predicted no association with CVC. Consistent with expectations, individuals with higher levels of ability EI, but not mixed EI, had higher levels of CVC. We also found that individuals with greater levels of CVC who demonstrated reactivity to a stress induction had significantly higher EI compared to individuals that did not respond to the stress induction. Our findings support the theoretically expected overlap between constructs within the NVI model and ability EI model, however, the observed effect size was small, and the associations between EI and CVC should not be taken to indicate a causal connection. Results suggest that variance in the ability to understand emotional processes in oneself and to reason about one's visceral experience may facilitate better CVC. Future work manipulating either CVC or EI may prove informative in teasing apart the causal role driving their observed relationship. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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29. Increases in Emotional Intelligence After an Online Training Program Are Associated With Better Decision-Making on the Iowa Gambling Task.
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Demers, Lauren A., Weber, Mareen, Berryhill, Sarah M., Killgore, William D. S., Alkozei, Anna, and Smith, Ryan
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EMOTIONAL intelligence ,IMPLICIT learning ,ONLINE education ,INTELLIGENCE tests ,GAMBLING ,INTELLIGENCE levels - Abstract
Higher levels of emotional intelligence have been associated with better inter and intrapersonal functioning. In the present study, 59 healthy men and women were randomized into either a three-week online training program targeted to improve emotional intelligence (n = 29), or a placebo control training program targeted to improve awareness of nonemotional aspects of the environment (n = 30). Compared to placebo, participants in the emotional intelligence training group showed increased performance on the total emotional intelligence score of the Mayer–Salovey–Caruso Emotional Intelligence Test, a performance measure of emotional intelligence, as well as subscales of perceiving emotions and facilitating thought. Moreover, after emotional intelligence training, but not after placebo training, individuals displayed the ability to arrive at optimal performance faster (i.e., they showed a faster learning rate) during an emotion-guided decision-making task (i.e., the Iowa Gambling Task). More specifically, although both groups showed similar performance at the start of the Iowa Gambling Task from pre- to posttraining, the participants in the emotional intelligence training group learned to choose more advantageous than disadvantageous decks than those in the placebo training group by the time they reached the "hunch" period of the task (i.e., the point in the task when implicit task learning is thought to have occurred). Greater total improvements in performance on the Iowa Gambling Task from pre- to posttraining in the emotional intelligence training group were also positively correlated with pre- to posttraining changes in Mayer–Salovey–Caruso Emotional Intelligence Test scores, in particular with changes in the ability to perceive emotions. The present study provides preliminary evidence that emotional intelligence can be trained with the help of an online training program targeted at adults; it also suggests that changes in emotional intelligence, as a result of such a program, can lead to improved emotion-guided decision-making. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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30. Parameters as Trait Indicators: Exploring a Complementary Neurocomputational Approach to Conceptualizing and Measuring Trait Differences in Emotional Intelligence.
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Smith, Ryan, Alkozei, Anna, and Killgore, William D. S.
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EMOTIONAL intelligence ,COGNITIVE neuroscience ,REINFORCEMENT learning ,COMPUTATIONAL neuroscience ,SELF-control - Abstract
Current assessments of trait emotional intelligence (EI) rely on self-report inventories. While this approach has seen considerable success, a complementary approach allowing objective assessment of EI-relevant traits would provide some potential advantages. Among others, one potential advantage is that it would aid in emerging efforts to assess the brain basis of trait EI, where self-reported competency levels do not always match real-world behavior. In this paper, we review recent experimental paradigms in computational cognitive neuroscience (CCN), which allow behavioral estimates of individual differences in range of parameter values within computational models of neurocognitive processes. Based on this review, we illustrate how several of these parameters appear to correspond well to EI-relevant traits (i.e., differences in mood stability, stress vulnerability, self-control, and flexibility, among others). In contrast, although estimated objectively, these parameters do not correspond well to the optimal performance abilities assessed within competing "ability models" of EI. We suggest that adapting this approach from CCN—by treating parameter value estimates as objective trait EI measures—could (1) provide novel research directions, (2) aid in characterizing the neural basis of trait EI, and (3) offer a promising complementary assessment method. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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31. Rested-Baseline Responsivity of the Ventral Striatum Is Associated With Caloric and Macronutrient Intake During One Night of Sleep Deprivation.
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Satterfield, Brieann C., Raikes, Adam C., and Killgore, William D. S.
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SLEEP deprivation ,OBESITY ,NEUROENDOCRINE system ,FUNCTIONAL magnetic resonance imaging ,NEURAL circuitry - Abstract
Background: Sleep loss contributes to obesity through a variety of mechanisms, including neuroendocrine functioning, increased hunger, and increased food intake. Additionally, sleep loss alters functional activation within brain regions associated with reward and behavioral control. However, it remains unknown whether individual differences in baseline neural functioning can predict eating behaviors during total sleep deprivation (TSD). We used functional magnetic resonance imaging (fMRI) to test the hypothesis that individuals with increased baseline responsiveness within reward regions are more vulnerable to TSD-induced overeating. Methods: N = 45 subjects completed several fMRI scans during a single pre-TSD session that included performance on the Multi-Source Interference Task (MSIT) and the n- back task. Subjects returned to the laboratory for an overnight TSD session, during which they were given ad libitum access to 10,900 kcal of food. Leftover food and packaging were collected every 6 h (00:00, 06:00, and 12:00) to measure total food consumption. Subjects reported sleepiness every hour and performed a food rating task every 3 h. Results: Functional activation within the ventral striatum during the MSIT and n -back positively correlated with total caloric and carbohydrate intake during the final 6 h (06:00–12:00) of TSD. Activation within the middle and superior temporal gyri during the MSIT also correlated with total carbohydrates consumed. Food consumption did not correlate with subjective sleepiness, hunger, or food desire. Conclusions: Individual differences in neural activity of reward processing areas (i.e., nucleus accumbens) prior to sleep deprivation are associated with an individual's propensity to overeat during subsequent sleep deprivation. This suggests that individual differences within reward processing pathways are potential key factors in sleep loss related overeating. Sleep loss and obesity are tightly linked. Both phenomena have been associated with increased neural activation in regions associated with reward, inhibitory control, and disrupted dopamine signaling. Elevated baseline reward sensitivity in the ventral striatum appears to be further compounded by sleep deprivation induced dysfunction in the reward neurocircuitry, increasing the likelihood of overeating. Our findings suggest that large individual differences in baseline responsiveness of hedonic reward pathways may modulate the association between sleep loss and obesity. [ABSTRACT FROM AUTHOR]
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- 2019
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32. The Association Between Trait Gratitude and Self-Reported Sleep Quality Is Mediated by Depressive Mood State.
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Alkozei, Anna, Smith, Ryan, Kotzin, Megan D., Waugaman, Debby L., and Killgore, William D. S.
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GRATITUDE ,SLEEP ,MENTAL depression ,MOOD (Psychology) ,RESENTMENT ,THOUGHT & thinking ,FATIGUE (Physiology) - Abstract
Background: It has been shown that higher levels of trait gratitude are associated with better self-reported sleep quality, possibly due to differences in presleep cognitions. However previous studies have not taken into account the role of depressive symptoms in this relationship. Participants and Methods: In this study, 88 nonclinical 18-29-year-olds completed the Gratitude Resentment and Appreciation Test (GRAT) as a measure of trait gratitude. The Glasgow Content of Thought Inventory (GCTI) was used to measure the intrusiveness of cognitions prior to sleep onset, the Motivation and Energy Inventory (MEI) assessed daytime fatigue, and the Pittsburgh Sleep Quality Index (PSQI) was used to assess self-reported sleep quality. The BDI-II assessed self-reported depressive symptoms. Results: Consistent with previous work, GRAT scores were positively associated with higher daytime energy and greater number of hours of sleep per night. Importantly, however, we further observed that depressive symptoms mediated the relationships between gratitude scores and sleep metrics. Conclusions: Depressive mood state appears to mediate the association between gratitude and self-reported sleep quality metrics. We suggest, as one plausible model of these phenomena, that highly grateful individuals have lower symptoms of depression, which in turn leads to fewer presleep worries, resulting in better perceived sleep quality. Future work should aim to disentangle the causal nature of these relationships in order to better understand how these important variables interact. [ABSTRACT FROM AUTHOR]
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- 2019
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33. Resting-state functional connectivity as a biomarker of aggression in mild traumatic brain injury.
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Dailey, Natalie S., Smith, Ryan, Vanuk, John R., Raikes, Adam C., and Killgore, William D. S.
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- 2018
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34. Lightening the mood: evidence for blue light exposure in the treatment of post-concussion depression.
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Killgore, William D. S.
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- 2020
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35. In‐season docosahexaenoic acid supplementation does not prevent white matter damage during a single American football season: Implications for neurodegeneration prevention.
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Raikes, Adam C., Hernandez, Gerson D, Mullins, Veronica A., Wang, Yiwei, Lopez, Claudia M, Killgore, William D. S., Chilton, Floyd, and Brinton, Roberta Diaz
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- 2022
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36. Common and Unique Neural Systems Underlying the Working Memory Maintenance of Emotional vs. Bodily Reactions to Affective Stimuli: The Moderating Role of Trait Emotional Awareness.
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Smith, Ryan, Lane, Richard D., Sanova, Anna, Alkozei, Anna, Smith, Courtney, and Killgore, William D. S.
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BIOLOGICAL neural networks ,EMOTIONS ,INTEROCEPTION ,PROPRIOCEPTION ,SHORT-term memory ,PREFRONTAL cortex - Abstract
Many leading theories suggest that the neural processes underlying the experience of one's own emotional reactions partially overlap with those underlying bodily perception (i.e., interoception, somatosensation, and proprioception). However, the goal-directed maintenance of one's own emotions in working memory (EWM) has not yet been compared to WM maintenance of one's own bodily reactions (BWM). In this study, we contrasted WM maintenance of emotional vs. bodily reactions to affective stimuli in 26 healthy individuals while they underwent functional magnetic resonance imaging. Specifically, we examined the a priori hypothesis that individual differences in trait emotional awareness (tEA) would lead to greater differences between these two WM conditions within medial prefrontal cortex (MPFC). We observed that MPFC activation during EWM (relative to BWM) was positively associated with tEA. Whole-brain analyses otherwise suggested considerable similarity in the neural activation patterns associated with EWM and BWM. In conjunction with previous literature, our findings not only support a central role of body state representation/maintenance in EWM, but also suggest greater engagement of MPFC-mediated conceptualization processes during EWM in those with higher tEA. [ABSTRACT FROM AUTHOR]
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- 2018
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37. Higher levels of trait emotional awareness are associated with more efficient global information integration throughout the brain: a graph-theoretic analysis of resting state functional connectivity.
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Smith, Ryan, Sanova, Anna, Alkozei, Anna, Lane, Richard D, and Killgore, William D S
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INTELLIGENCE levels ,GRAPH theory ,FUNCTIONAL magnetic resonance imaging ,INFORMATION sharing ,GENERAL factor (Psychology) - Abstract
Previous studies have suggested that trait differences in emotional awareness (tEA) are clinically relevant, and associated with differences in neural structure/function. While multiple leading theories suggest that conscious awareness requires widespread information integration across the brain, no study has yet tested the hypothesis that higher tEA corresponds to more efficient brain-wide information exchange. Twenty-six healthy volunteers (13 females) underwent a resting state functional magnetic resonance imaging scan, and completed the Levels of Emotional Awareness Scale (LEAS; a measure of tEA) and the Wechsler Abbreviated Scale of Intelligence (WASI-II; a measure of general intelligence quotient [IQ]). Using a whole-brain (functionally defined) region of interest (ROI) atlas, we computed several graph theory metrics to assess the efficiency of brain-wide information exchange. After statistically controlling for differences in age, gender and IQ, we first observed a significant relationship between higher LEAS scores and greater average degree (i.e. overall whole-brain network density). When controlling for average degree, we found that higher LEAS scores were also associated with shorter average path lengths across the collective network of all included ROIs. These results jointly suggest that individuals with higher tEA display more efficient global information exchange throughout the brain. This is consistent with the idea that conscious awareness requires global accessibility of represented information. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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38. Chronic sleep restriction differentially affects implicit biases toward food among men and women: preliminary evidence.
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Alkozei, Anna, Killgore, William D. S., Smith, Ryan, Dailey, Natalie S., Bajaj, Sahil, Raikes, Adam C., and Haack, Monika
- Subjects
SLEEP deprivation & health ,FOOD preferences ,LOW-calorie diet ,HIGH-calorie diet ,WEIGHT gain ,FATIGUE (Physiology) - Abstract
Summary: Chronic sleep restriction and obesity are two major public health concerns. This study investigated how chronic sleep restriction changes implicit attitudes towards low‐ and high‐calorie foods. In a randomized, counterbalanced cross‐over design, 17 participants (eight females, nine males) underwent two laboratory testing sessions where they were either sleep‐restricted for 3 weeks (i.e. underwent three weekly cycles of 5 nights of 4 h of sleep followed by 2 nights of 8 h of sleep opportunity) or received 3 weeks of control sleep (i.e. 8 h of sleep opportunity per night for 3 weeks). There was evidence for a significant sleep condition x sex interaction (F
(1, 20) = 4.60, P = 0.04). After chronic sleep restriction, men showed a trend towards a significant decrease in their implicit attitudes favouring low‐calorie foods (P = 0.08), whereas women did not show a significant change (P = 0.16). Men may be at increased risk of weight gain when sleep‐deprived due to a reduced bias towards low‐calorie foods. [ABSTRACT FROM AUTHOR]- Published
- 2018
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39. Elevated Aggression and Reduced White Matter Integrity in Mild Traumatic Brain Injury: A DTI Study.
- Author
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Dailey, Natalie S., Smith, Ryan, Bajaj, Sahil, Alkozei, Anna, Gottschlich, Melissa K., Raikes, Adam C., Satterfield, Brieann C., and Killgore, William D. S.
- Subjects
AGGRESSION (Psychology) ,WHITE matter (Nerve tissue) ,BRAIN injuries ,HEAD injuries ,COGNITION disorders ,DIFFUSION tensor imaging - Abstract
Mild traumatic brain injury (mTBI) remains the most commonly reported head injury in the United States, and is associated with a wide range of post-concussive symptoms including physical, cognitive and affective impairments. Elevated aggression has been documented in mTBI; however, the neural mechanisms associated with aggression at the chronic stage of recovery remain poorly understood. In the present study, we investigated the association between white matter integrity and aggression in mTBI using diffusion tensor imaging (DTI). Twenty-six age-matched adults participated in the study, including 16 healthy controls (HCs) and 10 individuals in the chronic stage of recovery (either 6-months or 12 months post-mTBI). Psychological measures of aggression included the Buss-Perry Aggression Questionnaire and the Personality Assessment Inventory (PAI). Axonal pathways implicated in affective processing were studied, including the corpus callosum, anterior thalamic radiation, cingulum and uncinate fasciculus, and measures of white matter integrity included fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). We found that adults with mTBI in the chronic stage of recovery had higher levels aggression. Individuals with mTBI also had greater RD in the corpus callosum compared to HCs, indicating reduced fiber integrity. Furthermore, we observed a significant association between reduced white matter integrity in the corpus callosum and greater aggression. Our findings provide additional evidence for underlying neuroanatomical mechanisms of aggression, although future research will be necessary to characterize the specific relationship between aggression and the white matter pathways we identified. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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40. Diffusion Tensor Imaging (DTI) Correlates of Self-Reported Sleep Quality and Depression Following Mild Traumatic Brain Injury.
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Raikes, Adam C., Bajaj, Sahil, Dailey, Natalie S., Smith, Ryan S., Alkozei, Anna, Satterfield, Brieann C., and Killgore, William D. S.
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BRAIN imaging ,DIFFUSION tensor imaging ,BRAIN injuries - Abstract
Background: Mild traumatic brain injuries (mTBIs) are a significant social, sport, and military health issue. In spite of advances in the clinical management of these injuries, the underlying pathophysiology is not well-understood. There is a critical need to advance objective biomarkers, allowing the identification and tracking of the long-term evolution of changes resulting from mTBI. Diffusion-weighted imaging (DWI) allows for the assessment of white-matter properties in the brain and shows promise as a suitable biomarker of mTBI pathophysiology.Methods: 34 individuals within a year of an mTBI (age: 24.4 ± 7.4) and 18 individuals with no history of mTBI (age: 23.2 ± 3.4) participated in this study. Participants completed self-report measures related to functional outcomes, psychological health, post-injury symptoms, and sleep, and underwent a neuroimaging session that included DWI. Whole-brain white matter was skeletonized using tract-based spatial statistics (TBSS) and compared between groups as well as correlated within-group with the self-report measures.Results: There were no statistically significant anatomical differences between the two groups. After controlling for time since injury, fractional anisotropy (FA) demonstrated a negative correlation with sleep quality scores (higher FA was associated with better sleep quality) and increasing depressive symptoms in the mTBI participants. Conversely, mean (MD) and radial diffusivity (RD) demonstrated positive correlations with sleep quality scores (higher RD was associated with worse sleep quality) and increasing depressive symptoms. These correlations were observed bilaterally in the internal capsule (anterior and posterior limbs), corona radiata (anterior and superior), fornix, and superior fronto-occipital fasciculi.Conclusion: The results of this study indicate that the clinical presentation of mTBI, particularly with respect to depression and sleep, is associated with reduced white-matter integrity in multiple areas of the brain, even after controlling for time since injury. These areas are generally associated not only with sleep and emotion regulation but also cognition. Consequently, the onset of depression and sleep dysfunction as well as cognitive impairments following mTBI may be closely related to each other and to white-matter integrity throughout the brain. [ABSTRACT FROM AUTHOR]- Published
- 2018
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41. Conflict-related dorsomedial frontal cortex activation during healthy food decisions is associated with increased cravings for high-fat foods.
- Author
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Smith, Ryan, Alkozei, Anna, and Killgore, William D. S.
- Abstract
Previous studies suggest obesity is associated with altered function within the insula and dorsomedial frontal cortex (including dorsal anterior cingulate cortex; DMFC/dACC), reflecting abnormal reward processing and reduced sensitivity to feelings of satiety. Given the proposed roles of DMFC/dACC in monitoring response conflict and reward-based decision making, the present study examined DMFC/dACC activation, and functional connectivity between the DMFC/dACC and the anterior insula (AI), during food-related decision-making. Twenty participants recruited from the general population (10 Female) performed a decision task while undergoing functional magnetic resonance imaging. They were instructed to "choose the healthier option" when simultaneously shown pairs of images of different foods. Significant DMFC/dACC activation was observed during food-related decision-making, and activation levels also positively correlated with self-reported cravings for high-fat foods (r = 0.57, p = 0.009) and self-reported desire to eat the high-fat foods depicted in the images (r = 0.48, p = 0.032). Negative functional connectivity estimates between the right AI and DMFC/dACC were also associated with self-reported control over eating (r = -0.50, p = 0.025). These results suggest that (1) more intense cravings for unhealthy foods are associated with greater response conflict when deciding between healthy and unhealthy food options, and (2) lack of eating-related control may involve a reduced influence of insula-mediated bodily signals on decision-making. This task may offer a neuroimaging-based probe for identifying individuals vulnerable to eating-related disorders and should be replicated in clinical populations. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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42. Gratitude and Subjective Wellbeing: A Proposal of Two Causal Frameworks.
- Author
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Alkozei, Anna, Smith, Ryan, and Killgore, William D. S.
- Subjects
GRATITUDE ,SUBJECTIVE well-being (Psychology) ,PATHOLOGICAL psychology ,INTERPERSONAL relations ,HEALTH - Abstract
Gratitude, the experience of appreciating the positive aspects in life, has been associated with increased subjective wellbeing (SWB). This paper proposes two causal frameworks (i.e., a cognitive and a psycho-social framework) that highlight the possible mechanisms by which gratitude influences SWB. This paper provides support for these two frameworks by reviewing research conducted to date on the relationship between the experience of gratitude and SWB, in terms of reduced symptoms of psychopathology, better interpersonal relationships, and improved physical health. In addition, the promising potential of gratitude interventions to improve SWB in healthy individuals and those with symptoms of psychopathology are reviewed. While gratitude interventions represent a relatively new approach, the limited evidence suggests that they may eventually provide an effective form of intervention that can be used to complement current therapy aprroaches for improving SWB. Therefore its potential application in clinical populations and the underlying mechanisms that might be driving the positive effects of gratitude interventions in improving SWB deserve further research attention. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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43. Time‐dependent differences in cortical measures and their associations with behavioral measures following mild traumatic brain injury.
- Author
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Bajaj, Sahil, Dailey, Natalie S., Rosso, Isabelle M., Rauch, Scott L., and Killgore, William D. S.
- Abstract
Abstract: There is currently a critical need to establish an improved understanding of time‐dependent differences in brain structure following mild traumatic brain injury (mTBI). We compared differences in brain structure, specifically cortical thickness (CT), cortical volume (CV), and cortical surface area (CSA) in 54 individuals who sustained a recent mTBI and 33 healthy controls (HCs). Individuals with mTBI were split into three groups, depending on their time since injury. By comparing structural measures between mTBI and HC groups, differences in CT reflected cortical thickening within several areas following 0–3 (time‐point, TP1) and 3–6 months (TP2) post‐mTBI. Compared with the HC group, the mTBI group at TP2 showed lower CSA within several areas. Compared with the mTBI group at TP2, the mTBI group during the most chronic stage (TP3: 6–18 months post‐mTBI) showed significantly higher CSA in several areas. All the above reported differences in CT and CSA were significant at a cluster‐forming
p < .01 (corrected for multiple comparisons). We also found that in the mTBI group at TP2, CT within two clusters (i.e., the left rostral middle frontal gyrus (L. RMFG) and the right postcentral gyrus (R. PostCG)) was negatively correlated with basic attention abilities (L. RMFG:r = −.41,p = .05 and R. PostCG:r = −.44,p = .03). Our findings suggest that alterations in CT and associated neuropsychological assessments may be more prominent during the early stages of mTBI. However, alterations in CSA may reflect compensatory structural recovery during the chronic stages of mTBI. [ABSTRACT FROM AUTHOR]- Published
- 2018
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44. Changes in morning salivary melatonin correlate with prefrontal responses during working memory performance.
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Killgore, William D. S., Kent, Haley C., Knight, Sara A., and Alkozei, Anna
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- 2018
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45. Successful Goal-Directed Memory Suppression is Associated With Increased Inter-Hemispheric Coordination Between Right and Left Frontoparietal Control Networks.
- Author
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Smith, Ryan, Alkozei, Anna, Bao, Jennifer, and Killgore, William D. S.
- Subjects
CONSCIOUSNESS ,MEMORY ,EMOTIONS ,PSYCHOSOMATIC medicine ,MAGNETIC resonance imaging ,PSYCHOLOGY - Abstract
The neural basis of suppressing conscious access to one’s own memories has recently received considerable attention, with several studies suggesting this process engages frontal-parietal cognitive control regions. However, researchers to date have not examined the way right and left hemisphere cognitive control networks coordinate with one another to accomplish this. We had 48 participants (25 female) complete a Think/No Think (T/NT) task for memories of emotionally unpleasant visual scenes while undergoing functional magnetic resonance imaging. We used generalized psychophysiologic interaction analyses to examine functional connectivity between right and left hemisphere frontal-parietal regions during memory suppression. Participants who were better at memory suppression, as assessed by greater numbers of forgotten memories in the NT than T conditions, also showed greater functional connectivity between multiple right and left hemisphere control regions. This suggests that individual differences in memory suppression ability may be partially explained by differences in task-specific inter-hemispheric coordination. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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46. Brain Aging: Uncovering Cortical Characteristics of Healthy Aging in Young Adults.
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Bajaj, Sahil, Alkozei, Anna, Dailey, Natalie S., and Killgore, William D. S.
- Subjects
AGING ,BRAIN ,CEREBRAL arteriosclerosis ,HEALTH of adults ,NEUROSCIENCES ,BRAIN diseases - Abstract
Despite extensive research in the field of aging neuroscience, it still remains unclear whether age related cortical changes can be detected in different functional networks of younger adults and whether these networks respond identically to healthy aging. We collected high-resolution brain anatomical data from 56 young healthy adults (mean age D 30.8 ± 8.1 years, 29 males). We performed whole brain parcellation into seven functional networks, including visual, somatomotor, dorsal attention, ventral attention, limbic, frontoparietal and default mode networks. We estimated intracranial volume (ICV) and averaged cortical thickness (CT), cortical surface area (CSA) and cortical volume (CV) over each hemisphere as well as for each network. Averaged cortical measures over each hemisphere, especially CT and CV, were significantly lower in older individuals compared to younger ones (one-way ANOVA, p < 0.05, corrected for multiple comparisons). There were negative correlations between age and averaged CT and CV over each hemisphere (p < 0.05, corrected for multiple comparisons) as well as between age and ICV (p D 0.05). Network level analysis showed that age was negatively correlated with CT for all functional networks (p < 0.05, corrected for multiple comparisons), apart from the limbic network. While age was unrelated to CSA, it was negatively correlated with CV across several functional networks (p < 0.05, corrected for multiple comparisons). We also showed positive associations between CV and CT and between CV and CSA for all networks (p < 0.05, corrected for multiple comparisons). We interpret the lack of association between age and CT of the limbic network as evidence that the limbic system may be particularly resistant to age-related declines during this period of life, whereas the significant age-related declines in averaged CT over each hemisphere as well as in all other six networks suggests that CT may serve as a reliable biomarker to capture the effect of normal aging. Due to the simultaneous dependence of CV on CT and CSA, CV was unable to identify such effects of normal aging consistently for the other six networks, but there were negative associations observed between age and averaged CV over each hemisphere as well as between age and ICV. Our findings suggest that the identification of early cortical changes within various functional networks during normal aging might be useful for predicting the effect of aging on the efficiency of functional performance even during early adulthood. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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47. Blue-light Therapy following Mild Traumatic Brain injury: effects on White Matter Water Diffusion in the Brain.
- Author
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Bajaj, Sahil, Vanuk, John R., Smith, Ryan, Dailey, Natalie S., and Killgore, William D. S.
- Subjects
BLUE light ,BRAIN injuries ,WHITE matter (Nerve tissue) - Abstract
Mild traumatic brain injury (mTBI) is a common and often inconspicuous wound that is frequently associated with chronic low-grade symptoms and cognitive dysfunction. Previous evidence suggests that daily blue wavelength light therapy may be effective at reducing fatigue and improving sleep in patients recovering from mTBI. However, the effects of light therapy on recovering brain structure remain unexplored. In this study, we analyzed white matter diffusion properties, including generalized fractional anisotropy, and the quantity of water diffusion in isotropic (i.e., isotropic diffusion) and anisotropic fashion (i.e., quantitative anisotropy, QA) for fibers crossing 11 brain areas known to be significantly affected following mTBI. Specifically, we investigated how 6 weeks of daily morning blue light exposure therapy (compared to an amber-light placebo condition) impacted changes in white matter diffusion in individuals with mTBI. We observed a significant impact of the blue light treatment (relative to the placebo) on the amount of water diffusion (QA) for multiple brain areas, including the corpus callosum, anterior corona radiata, and thalamus. Moreover, many of these changes were associated with improvements in sleep latency and delayed memory. These findings suggest that blue wavelength light exposure may serve as one of the potential non-pharmacological treatments for facilitating structural and functional recovery following mTBI; they also support the use of QA as a reliable neuro-biomarker for mTBI therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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48. Emotional intelligence is associated with connectivity within and between resting state networks.
- Author
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Killgore, William D. S., Smith, Ryan, Olson, Elizabeth A., Weber, Mareen, Rauch, Scott L., and Nickerson, Lisa D.
- Subjects
EMOTIONAL intelligence ,EMOTIONS ,MENTAL health ,NEURAL circuitry ,REGRESSION (Psychology) - Abstract
Emotional intelligence (EI) is defined as an individual's capacity to accurately perceive, understand, reason about, and regulate emotions, and to apply that information to facilitate thought and achieve goals. Although EI plays an important role in mental health and success in academic, professional and social realms, the neurocircuitry underlying this capacity remains poorly characterized, and no study to date has yet examined the relationship between EI and intrinsic neural network function. Here, in a sample of 54 healthy individuals (28 women, 26 men), we apply independent components analysis (ICA) with dual regression to functional magnetic resonance imaging (fMRI) data acquired while subjects were resting in the scanner to investigate brain circuits (intrinsic resting state networks) whose activity is associated with greater self-reported (i.e. Trait) and objectively measured (i.e. Ability) EI. We show that higher Ability EI, but not Trait EI, is associated with stronger negatively correlated spontaneous fMRI signals between the basal ganglia/limbic network (BGN) and posterior default mode network (DMN), and regions involved in emotional processing and regulation. Importantly, these findings suggest that the functional connectivity within and between intrinsic networks associated with mentation, affective regulation, emotion processing, and reward are strongly related to ability EI. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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49. Acute exposure to blue wavelength light during memory consolidation improves verbal memory performance.
- Author
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Alkozei, Anna, Smith, Ryan, Dailey, Natalie S., Bajaj, Sahil, and Killgore, William D. S.
- Subjects
VERBAL memory ,VISIBLE spectra ,BLUE light ,MEMORY testing ,GENERAL factor (Psychology) - Abstract
Acute exposure to light within the blue wavelengths has been shown to enhance alertness and vigilance, and lead to improved speed on reaction time tasks, possibly due to activation of the noradrenergic system. It remains unclear, however, whether the effects of blue light extend beyond simple alertness processes to also enhance other aspects of cognition, such as memory performance. The aim of this study was to investigate the effects of a thirty minute pulse of blue light versus placebo (amber light) exposure in healthy normally rested individuals in the morning during verbal memory consolidation (i.e., 1.5 hours after memory acquisition) using an abbreviated version of the California Verbal Learning Test (CVLT-II). At delayed recall, individuals who received blue light (n = 12) during the consolidation period showed significantly better long-delay verbal recall than individuals who received amber light exposure (n = 18), while controlling for the effects of general intelligence, depressive symptoms and habitual wake time. These findings extend previous work demonstrating the effect of blue light on brain activation and alertness to further demonstrate its effectiveness at facilitating better memory consolidation and subsequent retention of verbal material. Although preliminary, these findings point to a potential application of blue wavelength light to optimize memory performance in healthy populations. It remains to be determined whether blue light exposure may also enhance performance in clinical populations with memory deficits. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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- View/download PDF
50. Contributions of self-report and performance-based individual differences measures of social cognitive ability to large-scale neural network functioning.
- Author
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Smith, Ryan, Alkozei, Anna, Killgore, William, and Killgore, William D S
- Subjects
BRAIN physiology ,BRAIN ,BRAIN mapping ,COGNITION ,SOCIAL dominance ,INDIVIDUALITY ,JUDGMENT (Psychology) ,MAGNETIC resonance imaging ,NEUROPSYCHOLOGICAL tests ,SENSORY perception ,SELF-perception ,EMOTIONAL intelligence ,NEURAL pathways ,PHYSIOLOGY - Abstract
Adaptive social behavior appears to require flexible interaction between multiple large-scale brain networks, including the executive control network (ECN), the default mode network (DMN), and the salience network (SN), as well as interactions with the perceptual processing systems these networks function to modulate. Highly connected cortical "hub" regions are also thought to facilitate interactions between these networks, including the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), anterior cingulate cortex (ACC), and anterior insula (AI). However, less is presently known about the relationship between these network functions and individual differences in social-cognitive abilities. In the present study, 23 healthy adults (12 female) underwent functional magnetic resonance imaging (fMRI) while performing a visually based social judgment task (requiring the evaluation of social dominance in faces). Participants also completed both self-report and performance-based measures of emotional intelligence (EI), as well as measures of personality and facial perception ability. During scanning, social judgment, relative to a control condition involving simple perceptual judgment of facial features in the same stimuli, activated hub regions associated with each of the networks mentioned above (observed clusters included: bilateral DLPFC, DMPFC/ACC, AI, and ventral visual cortex). Interestingly, self-reported and performance-based measures of social-cognitive ability showed opposing associations with these patterns of activation. Specifically, lower self-reported EI and lower openness in personality both independently predicted greater activation within hub regions of the SN, DMN, and ECN (i.e., the DLPFC, DMPFC/ACC, and AI clusters); in contrast, in the same analyses greater scores on performance-based EI measures and on facial perception tasks independently predicted greater activation within hub regions of the SN and ECN (the DLPFC and AI clusters), and also in the ventral visual cortex. These findings suggest that lower confidence in one's own social-cognitive abilities may promote the allocation of greater cognitive resources to, and improve the performance of, social-cognitive functions. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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