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The application of metaverse technology in the field of civil engineering has the potential to improve project efficiency and accuracy. Nevertheless, the pervasive adoption and effective integration of metaverses are contingent on a number of crucial factors. This study investigates the critical factors underlying the successful implementation of metaverse technology within a business context. This research employs a comprehensive mixed-method approach comprised of exploratory factor analysis (EFA) and structural equation modelling (SEM) to examine survey responses gathered from seasoned professionals in the architecture, engineering, and construction (AEC) sectors in Bangladesh. In areas such as communication and collaboration, design visualization, and monitoring and maintenance, the construction industry has made extraordinary strides. As imperatives for managerial consideration strategic investment in resources, targeted training initiatives, heightened awareness campaigns, and prudent deployment of cost-effective and efficient metaverse-based solutions emerge, future investigations should include a larger sample size and an evaluation of the lasting effects over extended time periods. The key to unleashing the full potential of the metaverse within the architecture, engineering, and construction industries lies in addressing these identified success determinants, thereby ushering in enhanced project outcomes and enhanced efficiency within the constructed environment. The combination of these initiatives is expected to pave the way for a new era in the AEC landscape. [ABSTRACT FROM AUTHOR]

Although the retinoblastoma susceptibility gene RB1 is inactivated in a wide range of human tumours, overexpression in colonic carcinomas has been linked to the antiapoptotic function of the protein. In the current study we show that the Retinoblastoma susceptibility protein (Rb) protein interacts with Bag-1, an apoptotic regulator, in human colonic adenoma- and carcinoma-derived cell lines. Coimmunoprecipitation demonstrated that endogenous Rb and Bag-1 interact in both adenoma- and carcinoma-derived cell lines. The specificity of the interaction was demonstrated by expression of human Papillomavirus E7 oncoprotein, an inhibitor of Rb protein interactions, which disrupted the Rb/Bag-1 complex. We report that Bag-1 is predominantly localised in the nucleus of colorectal adenoma- and carcinoma-derived epithelial cells. Disruption of the Rb/Bag-1 complex through expression of E7 changes the subcellular distribution of Bag-1, decreasing nuclear localised Bag-1. Our work establishes that the Rb protein interacts with the Bag-1 apoptotic regulator protein, and introduces a novel function for Rb, involving modulation of the subcellular localisation of Bag-1 in human colonic epithelial cells. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]