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Real-world evidence on the impact of monoclonal antibodies as first-line treatment in Spain is limited. This observational, retrospective and prospective, multicenter, descriptive study included 117 transplant-ineligible newly diagnosed multiple myeloma (TIE-NDMM) patients divided into Group A, who received no daratumumab standard regimens, and the DVMP group (daratumumab, bortezomib, melphalan, and prednisone treatment). More than 90% of the patients in Group A received bortezomib, lenalidomide, or a combination of them. The median follow-up time for Group A was 38.2 months in comparison to 25.8 months for the DVMP group (p < 0.0001). The rate of DVMP patients that experienced disease progression or death from any cause was 36.8%, compared to 67.3% of Group A patients at 36 months of follow-up. The DVMP group had a higher 36-month progression-free survival (PFS) rate (52.9% vs. 31.7%). During the retrospective period, 73.0% of patients reported adverse drug reactions, while in the prospective period, 40.5% experienced adverse events, with no clinical differences between groups. The study supports the use of daratumumab regimens in frontline therapy based on real-world data. The findings provide valuable insights into the clinical outcomes of daratumumab therapy, which can help physicians make informed decisions regarding the optimal treatment approach for this patient population. [ABSTRACT FROM AUTHOR]

The biostratigraphic analysis of the Paleozoic sedimentary successions in Mexico is crucial for understanding their age, depositional setting, and paleogeographic implications. This study examined conodonts and microfacies of calcareous strata within the Del Monte Formation of the Tamatán Group in northeastern Mexico. Field observations have led to the identification of three units within the Del Monte Formation: Unit 1, characterized by calcareous sandstone, bioclastic limestone, shale, occasional conglomerate, and dolomitized beds; Unit 2, consisting of conglomerate and/or breccia associated with debris flows; and Unit 3 including turbiditic sandstone and shale. Conodonts were only recognized in Unit 1, with such genera as Idiognathoides, Neognathodus, Idiognathodus and less frequently, Streptognathodus, Adetognathus, and Diplognathodus. The faunal associations include Idiognathoides cf. Id. corrugatus Harris & Hollingsworth, 1933, Idiognathoides sulcatus sulcatus Higgins & Bouckaert, 1968, Idiognathoides convexus (Ellison & Graves, 1941), Idiognathoides asiaticus Nigmadganov & Nemyrovskaya, 1992, Neognathodus cf. N. atokaensis Grayson, 1984, Neognathodus aff. bothrops Merrill, 1972, Neognathodus nataliae Alekseev & Gerelzezeg, 2001 (in Alekseev & Goreva 2001), Streptognathodus parvus Dunn, 1966, Idiognathodus incurvus Dunn, 1966, and Idiognathodus aff. delicatus Gunnell, 1931, suggesting Morrowan and Atokan (Pennsylvanian) ages for the dolomitic limestone and grainstone beds. Five types of microfacies (MF) and several marine facies zone (FZ) have been detected: MF1-bioclastic grainstone and MF2-wackestone deposited at the platform margin (FZ 6 and FZ 7), MF3-dolomitized wackestone representing an inner restricted platform (FZ 8), MF4-mudstone from a deeper water zone (FZ 4), and MF5-siliciclastic beds with bioclasts indicating a high-energy barrier associated with a platform margin (FZ 6). The findings confirm a shallow to deep platform and imply a connection among Mexican peri-Gondwanan basins, including the Tamatán Basin, indicating similarities in sedimentary facies and/or depositional environments linked to the Rheic Ocean during the Early to Middle Pennsylvanian. [ABSTRACT FROM AUTHOR]

Carotenoids constitute compounds of significant biological interest due to their multiple biological activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and antioxidant properties. Metabolic syndrome (MetS) comprehends a series of metabolic abnormalities (e.g., hypertension, obesity, and atherogenic dyslipidemia) that can affect children, adolescents, and the elderly. The treatment of MetS involves numerous medications, which, despite their efficacy, pose challenges due to prolonged use, high costs, and various side effects. Carotenoids and their derivatives have been proposed as alternative treatments to MetS because they reduce serum triglyceride concentrations, promote insulin response, inhibit adipogenesis, and downregulate angiotensin-converting enzyme activity. However, carotenoids are notably sensitive to pH, light exposure, and temperature. This review addresses the activity of carotenoids such as lycopene, lutein, fucoxanthin, astaxanthin, crocin, and β-carotene towards MetS. It includes a discussion of sources, extraction methods, and characterization techniques for analyzing carotenoids. Encapsulation approaches are critically reviewed as alternatives to prevent degradation and improve the biological performance of carotenoids. A brief overview of the physiopathology and epidemiology of the diseases, including MetS, is also provided. [ABSTRACT FROM AUTHOR]

The Cenozoic Sierra de San Carlos-Cruillas (SSCC) magmatic complex belongs to the Eastern Mexican Alkaline Province (EMAP). The SSCC mainly consists of plutonic and subvolcanic bodies displaying diverse lithological compositions. These rocks exhibit both OIB- and arc-like geochemical characteristics. In this contribution, we present new petrographic, geochemical, isotopic, and geochronological data of the Rincón Murillo Gabbro (RMG), situated in the southern part of the SSCC. The RMG is nepheline normative and displays an OIB-like intraplate character. Laser ablation ICP-MS U-Pb analyses on titanites yielded Oligocene (Rupelian) crystallization ages of 31.8 ± 1.8 and 31.0 ± 1.7 Ma. The 87Sr/86Sr(i) (0.703400–0.704159) and 143Nd/144Nd(i) (0.512732–0.512815) ratios indicate a mantle origin. Trace element data indicate the participation of different enriched mantle components in the source. One component is related to previous subduction processes, generating the HFSE-depleted arc-like magmas of San José Gabbro in the northern part of SSCC. The second component is related to deep mantle melts with a slightly carbonatitic signal and HFSE-enriched fluids derived from the subducted Hess conjugate plateau generating different enriched sources in the upper mantle under the SSCC. The passage, eclogitization, detachment and foundering of the Hess plateau gave rise to an asthenospheric upwelling that triggered the low to moderate partial melting degrees (3–15%) of an amphibole-bearing garnet peridotite, generating the OIB-like parental magmas of RMG, located in the southern part of SSCC. Two-component mixing, and AFC models indicate that variable degrees of crystal fractionation and minor crustal assimilation are involved in the evolution of Rincón Murillo Gabbro. [ABSTRACT FROM AUTHOR]

Neotectonic activity in the western margin of the Sierra Madre Oriental in northeastern Mexico was evaluated using geomorphological, geological, structural, and seismological analyses. We evaluated recent tectonic evidence in the basin of the Potosí Valley related to the Santo Domingo Fault System (SDFS), which is one of the largest active extensional fault zones documented so far in the transition zone between the Basin and Range and the Sierra Madre Oriental provinces. Two indices were used in the geomorphological analysis: transverse topographic basin asymmetry (T) and mountain front sinuosity (Smf). The results show that the studied basin is slightly tilted to the WSW, consistent with the typical basin deformation pattern in the Basin and Range province. Structural data collected in the field unveil a NW–SE striking fault system, geometrically and kinematically similar to the Cenozoic lineaments of the Basin and Range province. The local stress tensor calculated in this study indicates an extensional tectonic regime, suggesting S V > S NW > S NE . Analysis defines an azimuth trend of 298° and 036° for σ 2 (S Hmax) and σ 3 S hmin , respectively. According to the results, the SDFS is well orientated for possible future reactivation as a normal fault system. We estimate that a segmented rupture of the SDFS could produce seismic events on the order of magnitude 5 < Mw < 6. Considering a continuous rupture (~ 42 km) of the SDFS in a single event, an earthquake of Mw 7.0 could be expected. The results are essential to estimate seismic hazards in northeastern Mexico, including important urban areas, such as Monterrey, Nuevo León, and Saltillo, Coahuila. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Derecho Politico is the property of Editorial UNED and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The main objective was to evaluate differences in the clinical, motor, or functional variables in patients with Early Osteoarthritis (EOA) and individuals at risk of developing osteoarthritis (OA). Methods: A cross-sectional study was performed. All the participants were divided into two groups: EOA patients and healthy subjects (HS) at risk of developing OA. The main outcomes were clinical tests, such as those of knee morphology, instability, or proprioception; motor and functional variables, such as knee strength, range of motion, walking speed, and the sit-to-stand test; pain and disability, assessed through the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and Knee injury and Osteoarthritis Outcome Score (KOOS) scales; and knee alignment and leg length inequality, assessed via X-ray images. Results: A total of 97 participants were included (54 EOA and 43 HS). Patients with EOA showed a greater presence of knee pain (p < 0.01). In addition, more EOA patients showed instability both in the left (p < 0.01) and right legs (p < 0.05). Regarding the knee alignment variable, significant differences were found (p < 0.04), with more patients with EOA diagnosed as possessing a varus alignment. In addition, EOA patients showed lower knee strength, since statistically significant differences were found regarding flexion and extension strength in the left leg (Mean Difference (MD): 12.92; p = 0.03; d = −0.46 and MD:7.81; p = 0.04; d = −0.39). Differences were found for the sit-to-stand test scores, showing lower results for the EOA group (MD: −1.91; p < 0.01; d = 0.54). Conclusions: The results of this research show statistically significant differences between patients with EOA and HS at risk of developing OA with respect to pain, disability, instability, knee strength, and the sit-to-stand test. Our results suggest that the evaluation of clinical, motor, and functional features could contribute to an early management of knee OA. [ABSTRACT FROM AUTHOR]

The origin of the Eastern Mexican Alkaline Province has been explained by landward arc migration and subsequent asthenospheric upwelling after slab roll-back of the Farallon Plate. In this work, we present new petrographic, mineral chemical, geochemical, and geochronological data of the Sierra de San Carlos-Cruillas (SSCC), one of the most important complexes in the province. This information, together with published data, helped us to reinterpret the tectonic processes operating during the generation of this province, as well as the mantle sources involved in the partial melting process. Detailed geochemical analysis suggests the participation of two types of metasomatized mantle regions: a lithospheric source modified by past subduction processes and an asthenospheric source slightly affected by carbonatite-related metasomatism. Variations in the partial melting degrees controlled the extent of magma enrichment in the latter. Major and trace element geochemistry, together with geochronological data and field relations, evinced an older post-orogenic setting related to the arc-like rocks (Eocene) and a younger intraplate extensional environment associated with all enriched igneous rocks (Oligocene-Miocene). Bivariate diagrams of SiO2-trace element ratios and multi-element patterns indicate that magmas from the SSCC complex dominantly evolved through fractional crystallization with a limited crustal contribution. Petrographic and mineral chemistry features suggest that some of these magmas experienced open-system processes (e.g. recharge events) in a complex and dynamic magmatic feeding system. In contrast to the traditional petrotectonic model, we propound that the passage and subsequent foundering of the Hess conjugate under northeastern Mexico resulted in its eclogitization and triggered slab tearing and succeeding detachment. This latter process occasioned mantle upwelling and the partial melting of the two recognized metasomatized mantle sources, thus generating the San Carlos-Cruillas magmatism. [ABSTRACT FROM AUTHOR]

Considering the U–Pb ages of detrital zircons grains contained in Holocene sands from the Chachalacas beach as reported by Armstrong‐Altrin, Ramos‐Vázquez, Hermenegildo‐Ruiz, and Madhavaraju (2020) it is possible to track a wide‐ranging record of the most important magmatic and tectonothermal events preserved along NE to SE of Mexico. These zircon‐forming events include those responsible for the development of its Proterozoic basement, the Palaeozoic and Mesozoic magmatic arcs, as well as the Cenozoic arc and intraplate magmatism. The proposed sources for the studied zircon crystals are Oaxaquia, Maya Block, the Peregrina‐Mochonian arc, the Tamatán Group of the Ciudad Victoria Block, the Nazas Arc, the Cretaceous Mexican Arc, the foreland basins of the Sierra Madre Oriental, the Eastern Alkaline Province, and the Trans‐Mexican Volcanic Belt. [ABSTRACT FROM AUTHOR]

The study of the pre-Mesozoic geological history of NE Mexico offers the opportunity to reconstruct the processes that occurred at the NW margin of Gondwana. The Huizachal–Peregrina Anticlinorium, which is located west of Ciudad Victoria (Tamaulipas) is a regional structure produced during the Cretaceous–Palaeogene Laramide Orogeny. Its eroded core exposes Precambrian and Palaeozoic units that together comprise the Sierra Madre Oriental basement. These units are the Neoproterozoic metamorphic Novillo Complex, the Ordovician Peregrina Tonalite, the metamorphic Pennsylvanian Granjeno Complex, and the sedimentary Silurian–Permian Tamatán Group. Aserradero Rhyolite belongs to the Tamatán Group, occurring between the siliciclastic deposits of the Early Mississippian Vicente Guerrero and the Pennsylvanian Del Monte Formations. The studied rhyolites display geochemical characteristics corresponding to high-K, low-Sr, and S-type granitoid rocks that may have been produced by upper-crustal anatexis from a source similar to that of the Novillo Complex. New LA-ICP-MS U–Pb geochronological analysis on zircons separated from the Aserradero Rhyolite yielded Early to Middle Mississippian crystallisation ages of 347.8 ± 2.7 Ma and 340.7 ± 3.6 Ma, confirming that this acidic unit is in its original stratigraphic position despite the pervasive deformation of the Tamatán Group. Based on the correlation with other Carboniferous–Early Permian magmatic complexes in Mexico and Central America, it is suggested that the Aserradero Rhyolite represents an early stage of a precollisional Carboniferous–Permian peri-Gondwanan arc, occurring also in the Las Delicias, Oaxaquia, the Acatlán Complex, the Maya Block, as well as in the buried crystalline basement along the Western Gulf of Mexico. The assembly of the Precambrian and Palaeozoic basement units from the Huizachal–Peregrina Anticlinorium were integrated with the Ciudad Victoria Block, which was dismembered from Oaxaquia and their peripheral units during the Upper-Jurassic Gulf of Mexico opening. [ABSTRACT FROM AUTHOR]

Aims: The objective of this study is to analyze how the impact of Diabetes Mellitus [DM] in patients with COVID-19 varies according to altitudinal gradient. Methods: We obtained 1,280,806 records from adult patients with COVID-19 and DM to analyze the probability of COVID-19, development of COVID-19 pneumonia, hospitalization, intubation, admission to the Intensive Care Unit [ICU] and case-fatality rates [CFR]. Variables were controlled by age, sex and altitude of residence to calculate adjusted prevalence and prevalence ratios. Results: Patients with DM had a 21.8% higher prevalence of COVID-19 and an additional 120.2% higher prevalence of COVID-19 pneumonia. The adjusted prevalence was also higher for these outcomes as well as for hospitalization, intubation and ICU admission. COVID-19 and pneumonia patients with DM had a 97.0% and 19.4% higher CFR, respectively. With increasing altitudes, the probability of being a confirmed COVID-19 case and the development of pneumonia decreased along CFR for patients with and without DM. However, COVID-19 patients with DM were more likely to require intubation when residing at high altitude. Conclusions: The study suggests that patients with DM have a higher probability of being a confirmed COVID-19 case and developing pneumonia. Higher altitude had a protective relationship against SARS-CoV-2 infection; however, it may be associated with more severe cases in patients with and without DM. High altitude decreases CFR for all COVID-19 patients. Our work also shows that women are less affected than men regardless of altitude. [ABSTRACT FROM AUTHOR]

Background: During COVID-19 pandemic, elective invasive cardiac procedures (ICP) have been frequently cancelled or postponed. Consequences may be more evident in patients with diabetes. Objectives: The objective was to identify the peculiarities of patients with DM among those in whom ICP were cancelled or postponed due to the COVID-19 pandemic, as well as to identify subgroups in which the influence of DM has higher impact on the clinical outcome. Methods: We included 2,158 patients in whom an elective ICP was cancelled or postponed during COVID-19 pandemic in 37 hospitals in Spain. Among them, 700 (32.4%) were diabetics. Patients with and without diabetes were compared. Results: Patients with diabetes were older and had a higher prevalence of other cardiovascular risk factors, previous cardiovascular history and co-morbidities. Diabetics had a higher mortality (3.0% vs. 1.0%; p = 0.001) and cardiovascular mortality (1.9% vs. 0.4%; p = 0.001). Differences were especially important in patients with valvular heart disease (mortality 6.9% vs 1.7% [p < 0.001] and cardiovascular mortality 4.9% vs 0.9% [p = 0.002] in patients with and without diabetes, respectively). In the multivariable analysis, diabetes remained as an independent risk factor both for overall and cardiovascular mortality. No significant interaction was found with other clinical variables. Conclusion: Among patients in whom an elective invasive cardiac procedure is cancelled or postponed during COVID-19 pandemic, mortality and cardiovascular mortality is higher in patients with diabetes, irrespectively on other clinical conditions. These procedures should not be cancelled in patients with diabetes. [ABSTRACT FROM AUTHOR]

Background: A Demographic and Family Health Survey (ENDES, for Encuesta Demográfica y de Salud Familiar in Spanish) is carried out annually in Peru. Based on it, the anemia prevalence was 43.6% in 2016 and 43.8% in 2017 using the WHO cutoff value of 11 g/dL and the altitude-correction equation. Objective: To assess factors contributing to anemia and to determine its prevalence in Peruvian children 6 to 35 months old. Methods: We used the MEASURE DHS-based ENDES survey to obtain representative data for11364 children from 6 to 35 months old on hemoglobin and health determinants. To evaluate normal hemoglobin levels, we used the original WHO criterion of the 5th percentile in children without chronic malnutrition and then applied it to the overall population. Relationships between hemoglobin and altitude levels, usage of cleaning methods to sanitize water safe to drink, usage of solid fuels and poverty status were tested using methodology for complex survey data. Percentile curves were made for altitude intervals by plotting hemoglobin compared to age. The new anemia rates are presented in graphs by Peruvian political regions according to the degree of public health significance. Results: Hemoglobin increased as age and altitude of residence increased. Using the 5th percentile, anemia prevalence was 7.3% in 2016 and 2017. Children from low altitudes had higher anemia prevalence (8.5%) than those from high altitudes (1.2%, p<0.0001). In the rainforest area of Peru, anemia prevalence was highest (13.5%), while in the highlands it was lowest (3.3%, p<0.0001). With access to safe drinking water and without chronic malnutrition, anemia rates could be reduced in the rainforest by 45% and 33%, respectively. Conclusion: Anemia prevalence in Peruvian children from 6 to 35 months old was 7.3% in 2016 and 2017. [ABSTRACT FROM AUTHOR]

The Huizachal–Peregrina Anticlinorium basement of the Sierra Madre Oriental in north-eastern (NE) Mexico comprises a wide variety of Precambrian and Paleozoic units. A granitic unit, described in this work as the Peregrina Tonalite (PTo), intruded the Neoproterozoic Novillo Gneiss, which is the northernmost expression of the Oaxaquia microcontinent. In contrast, the PTo's contact with the Carboniferous Granjeno Schist is tectonic along vertical faults with a strike-slip component. This Paleozoic lithodeme is part of the Granjeno–Acatlán Belt. The PTo has been described as an orphaned block associated with an enigmatic Carboniferous magmatic arc located along the north-western (NW) margin of Gondwana. In this study, new U–Pb LA–ICP–MS data from PTo zircons included a youngest Late Ordovician (Katian stage) population at 448.8 ± 2.9 Ma, interpreted as the crystallisation age, and an oldest Grenvillian population interpreted as the potential age of its protolith. Additionally, major and trace element concentrations and ratios indicate a link to a continental arc that developed along the NW margin of Gondwana. Given this proposed arc's age and position, a comprehensive model for the development of the NE Mexican basement without the involvement of exotic or orphaned terranes is now proposed. The PTo outcropping near Ciudad Victoria, Tamaulipas, is interpreted to be part of a previously unreported magmatic arc in NE Mexico established during the Late Ordovician, herein described as the Peregrina–Mochonian Orogeny. It represents an extension of the South American Famatinian arc into Mexico. [ABSTRACT FROM AUTHOR]

The geochemistry of the metavolcanic rocks from the Granjeno Schist in northeastern Mexico indicates an origin in different tectonic environments: mid-ocean ridge and ocean island. High ratios of Hf/Th and Th/Nb (4.4-14 and 0.08-0.15), low ratios of LaN/YbN and LaN/SmN (0.74-1.7 and 0.60-1.4) and depleted LREE patterns in metabasalt display mid-ocean ridge characteristics. In contrast, the pattern of trace-element ratios and REEs in metabasalt and metapillow lava 60 km to the west indicates a magma source with ocean-island basalt characteristics. Both areas were metamorphosed during the Late Carboniferous (300 ± 4 Ma). Estimated metamorphic conditions deduced from white mica and chlorite compositions, distinguish greenschist facies (350 °C and 4 kbar) for the mid-ocean ridge basalt, and prehnite-pumpellyite facies (250 °C and 2.5 kbar) for the ocean-island-type basalt. This metamorphism took place at an active continental margin during Pennsylvanian time. Our new tectonic model, which differs from earlier models, suggests that the origin of the Granjeno Schist is related to a subduction zone located at the western margin of Pangaea, active after Laurentia-Gondwana collision. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

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Copyright of Politica y Sociedad is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract  In this work we study the behavior of a time discrete multiregional stochastic model for a population structured in age classes and spread out in different spatial patches between which individuals can migrate. The dynamics of the population is controlled both by reproduction-survival and by migration. These processes take place at different time scales in the sense of the latter being much faster than the former. We incorporate the effect of demographic stochasticity into the population, which results in both dynamics being modelled by multitype Bienaymé–Galton–Watson branching processes. We present a multitype global model that incorporates the effect of both processes and, making use of the existence of different time scales for demography and migration, build a reduced model in which the variables correspond to the total population in each age class. We extend previous results that relate the behavior of the original and the reduced model showing that, given a large enough separation of time scales between demography and migration, we can obtain information about the behavior of the multitype global model through the study of the simpler reduced model. We concentrate on the case where the two systems are supercritical and therefore the expected number of individuals grows to infinity, and show that we can approximate the asymptotic structure of the population vector and the asymptotic population size of the original system through the study of the reduced model. [ABSTRACT FROM AUTHOR]

Copyright of Anuario de Psicología Jurídica is the property of Colegio Oficial de Psicologos de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Dispersing individuals can use conspecifics as indicators of habitat quality and aggregate at traditionally occupied sites, leaving other favourable patches unoccupied. Here we test the predictions of the conspecific-based habitat selection hypothesis on a Spanish great bustard (Otis tarda) metapopulation, currently fragmented due to recent human-induced habitat changes. The number of birds had increased by 23% between 1988 and 1998, but not consistently among leks. Leks that were large in 1988 increased, while those that were small decreased, which suggests that dispersing individuals used the numbers of conspecifics as cues for breeding-site selection. Moreover, leks with high productivity increased, while those with low productivity decreased. Finally, lek distribution was markedly stable throughout the decade, with no establishment of new leks, and suitable habitat patches remained unoccupied, as predicted by the conspecific attraction hypothesis. These results were corroborated by a simulation model which incorporated natal dispersal rates between leks as obtained through radio-tracking of 15 birds that survived throughout their 4-year dispersal period. In conclusion, in spite of the apparent increase in total numbers throughout the decade, both conspecific attraction and local differences in reproductive success contributed to a more aggregated distribution, increasing the species' vulnerability to local catastrophes, and the risks of reduced genetic diversity and extinction of small leks. [ABSTRACT FROM AUTHOR]

Copyright of Siglo Cero is the property of Siglo Cero and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Discusses the clinical evolution and management of cystic adenomatoid malformation of the lung (CAML). Type of neoplasms related to CAML; Potential of pleuropulmonary blastoma (PPB); Absence of a proven link between CAML and PPB.