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7 results on '"Joseph, John M"'

2. Chronic neutrophilic leukemia presenting as secondary gout: Report of a rare myeloproliferative disorder.

Author

Sugandha, Kakkar, Naveen, and Joseph John, M

Subjects
MYELOPROLIFERATIVE neoplasms, CHRONIC leukemia, LEUCOCYTES, GOUT, LEUKOCYTE count, SYMPTOMS, CHRONIC myeloid leukemia, DISEASE complications
Abstract

Chronic neutrophilic leukemia is a rare leukemia seen in middle aged and elderly people, characterized by neutrophilic leukocytosis with no significant increase in granulocytic precursors. The chief criteria for diagnosis include total leukocyte count ≥25 × 109/L, >80% of white blood cells being mature neutrophils (segmented and band forms), immature granulocytic precursors ≥10% in the peripheral blood, and hypercellular marrow. In addition to this, there must be no evidence of dysplasia, monocytosis or BCR-ABL1, PDGFR-A, PDGFR-B, or FGRF-1 rearrangements. Moreover, the cause of neutrophilia should not be attributed to any other myeloproliferative disorders or to physiologic neutrophilia.We present two patients with this rare disorder who presented with gout as the initial symptom. [ABSTRACT FROM AUTHOR]

Published
2020
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3. High speed, direct detection 1k Frame-Store CCD sensor for synchrotron radiation.

Author

Doering, Dionisio, Andresen, Nord, Contarato, Devis, Denes, Peter, Joseph, John M., McVittie, Patrick, Walder, Jean-Pierre, Weizeorick, John, and Zheng, Bob

Abstract

This work presents the development of a high speed, direct detection, 1k Frame Store CCD camera for synchrotron radiation. We review the research and development of this detector from small scale prototypes to a megapixel sensor, highlighting design challenges and solutions, and reporting on the achieved imaging performance. Further, we report on performance improvements obtained by implementing a second-generation fast readout integrated circuit manufactured in 0.25µm CMOS technology, as well as a voltage buffer chip manufactured in high voltage 0.35µm CMOS technology. The camera presented in this paper is high vacuum-compatible to allow for soft X-ray detection. [ABSTRACT FROM PUBLISHER]

Published
2011
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