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Routine measurements of carbonaceous species in PM2.5 inculidng organic carbon (OC), elemental carbon (EC), water-soluble organic carbon (WSOC), and humiclike- substance carbon (HULIS-C) in PM2.5 were performed at Anmyeon Island (AI) to clarify the seasonal variation and carbonaceous aerosol concentrations at a background site in Korea between 2015 and 2016. The annual average OC and EC concentrations were 4.52±3.25 µg/m3 and 0.46±0.28 µg/m3, respectively, and there were no clear seasonal variations in OC and EC concentrations. The average concentrations of WSOC and waterinsoluble organic carbon (WISOC) were 2.56±1.95 µg/m3 and 1.96±1.45 µg/m3, respectively, and their composition in OC showed high temporal variations. A low correlation between WISOC and EC was observed, while WSOC concentrations were highly correlated with secondary organic carbon concentrations, which were estimated using the EC tracer method. The results indicate that the formation of secondary organic aerosols is a major factor for the determination of WSOC concentrations in this region. HULIS-C was the major component of WSOC, accounting for 39-99% of WSOC and the average concentration was 1.88±1.52 µg/m3. Two distinct periods with high carbonaceous speciess in PM2.5 were observed and characterized by their OC/EC ratios. The high concentration of OC with high ratio of OC/EC was due to the influence of a mixture of emissions from biomass burning and secondary formation transported from outside AI. While, the high concentrations of OC and EC with low OC/EC ratio were related to local vehicular emissions. [ABSTRACT FROM AUTHOR]

Background: Co-existence or subsequent isolation of multiple nontuberculous mycobacteria (NTM) species in same patient has been reported. However, clinical significance of these observations is unclear. The aim of this study was to determine clinical implications of changes of NTM species during or after treatment in patients with NTM lung disease.Methods: Patients with NTM lung disease, who experienced changes of NTM species during treatment or within 2 years of treatment completion between January 1, 2009 and December 31, 2015, were included in the analysis. Demographic, clinical, microbiological, and radiographic data were reviewed and analyzed.Results: During the study period, 473 patients were newly diagnosed with NTM lung disease. Treatment was started in 164 patients (34.6%). Among these 164 patients, 16 experienced changes of NTM species during or within 2 years of treatment completion. Seven showed changes from M. avium complex (MAC) to M. abscessus subspecies abscessus (MAA) and five patients displayed changes from M. abscessus subspecies massiliense (MAM) to MAC. With isolation of new NTM species, 6 out of 7 patients with change from MAC to MAA reported worsening of symptoms, whereas none of the five patients with change from MAM to MAC reported worsening of symptoms. All MAA isolated during or after treatment for MAC lung diseases showed inducible resistance to clarithromycin.Conclusions: Change of NTM species may occur during or after treatment for NTM lung disease. Especially, changes from MAC to MAA is accompanied by symptomatic and radiographic worsening as well as inducible resistance to clarithromycin. [ABSTRACT FROM AUTHOR]

The 26S proteasome, composed of the 20S core and the 19S regulatory complex, plays a central role in ubiquitin-dependent proteolysis by catalyzing degradation of polyubiquitinated proteins. In a search for proteins involved in regulation of the proteasome, we affinity purified the 19S regulatory complex from HeLa cells and identified a novel protein of 43 kDa in size as an associated protein. Immunoprecipitation analyses suggested that this protein specifically interacted with the proteasomal ATPases. Hence the protein was named proteasomal ATPase-associated factor 1 (PAAF1). Immunoaffinity purification of PAAF1 confirmed its interaction with the 19S regulatory complex and further showed that the 19S regulatory complex bound with PAAF1 was not stably associated with the 20S core. Overexpression of PAAF1 in HeLa cells decreased the level of the 20S core associated with the 19S complex in a dose-dependent fashion, suggesting that PAAF1 binding to proteasomal ATPases inhibited the assembly of the 26S proteasome. Proteasomal degradation assays using reporters based on green fluorescent protein revealed that overexpression of PAAF1 inhibited the proteasome activity in vivo. Furthermore, the suppression of PAAF1 expression that is mediated by small inhibitory RNA enhanced the proteasome activity. These results suggest that PAAF1 functions as a negative regulator of the proteasome by controlling the assembly/disassembly of the proteasome. [ABSTRACT FROM AUTHOR]

This article presents the design and development of a satellite cluster system that supports an interfederation communication in High Level Architecture (HLA)-compliant distributed simulation. The interfederation communication enables the execution of a complex, large-scale cluster system of distributed satellites that share the dispersed data assets among satellite components collaboratively. After a brief review of the HLA bridge for interfederation communication, the authors discuss the design issues related to a satellite cluster system that provides cluster management, interfederation communication, and communication data management. They analyze system performance and scalability for centralized and decentralized configurations. The empirical results on the heterogeneous OS distributed system indicate that the satellite cluster system is effective and scalable due to the use of interfederation communication and the reduction of data transmission. [ABSTRACT FROM AUTHOR]

A 1.8-V 2-Gb NAND flash memory has been successfully developed on a 90-nm CMOS STI process technology, resulting in a 141-mm² die size and a 0.044-µm² effective cell. For the higher level integration, critical layers are patterned with KrF photolithography. The device has three notable differences from previous generations. 1) The cells are organized in a single (16K+512) column and 128K row array by adopting a one-sided row decoder in order to minimize the die size. 2) The bitline precharge level is set to 0.9 V in order to increase on-cell current. 3) During the program operations, the string select line, which connects the NAND cell strings to the bitlines, is biased with sub-V[sub CC] in order to avoid program disturbance issues. [ABSTRACT FROM AUTHOR]

Reports on the fabrication of a high-performance one-gigabit NAND flash memory with 0.12–micrometer complementary metal oxide semiconductor STI technology. Application of a 32-cell NAND structure; Voltage generated by the pseudo-four-phase charge pump circuit; Provision of the copy-back function for on-chip garbage collection; Attainment of a measured disturbance free-window.

Internal auditory canal (IAC) metastasis due to leptomeningeal carcinomatosis (LMC) from gastric cancer (GC) has rarely been reported. Early manifestation of symptoms, such as hearing loss, vertigo and facial paralysis, in cases of IAC metastasis due to LMC may facilitate the early detection of brain metastasis. To the best of our knowledge, the present study is the first to report IAC metastasis due to LMC in human epidermal growth factor receptor 2 (Her2)-positive GC. This study reports a case of an Her2-positive GC patient with LMC including IAC metastasis, who presented with acute sensorineural hearing loss, ipsilateral facial paralysis and vertigo during trastuzumab containing chemotherapy. The current study also discusses the early diagnosis and management of this complicated condition, demonstrating that clinical suspicion is key for a prompt diagnosis and proper management of LMC including IAC metastasis in Her2-positive GC. [ABSTRACT FROM AUTHOR]

This study objectives to investigate a range of Partin table and several machine learning methods for pathological stage prediction and assess them with respect to their predictive model performance based on Koreans data. The data was used SPCDB and gathered records from 944 patients treated with tertiary hospital. Partin table has low accuracy (65.68%) when applied on SPCDB dataset for comparison on patients with OCD and NOCD conditions. SVM (75%) represents a promising alternative to Partin table from which pathology staging can benefit [ABSTRACT FROM AUTHOR]