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Background: Brachytherapy (BT) is routinely used in the treatment of various cancers. Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that may cause local traumas and lesions. Further, they suffer from inflexibility in where they can be placed and some sources reside permanently in the body, causing potential long-term discomfort. These issues can be circumvented through injectable sources, prepared as biodegradable materials containing radionuclides that form solid seeds after administration. The level of radioactivity contained in such seeds must be sufficient to achieve substantial local irradiation. In this report, we investigate two different strategies for biodegradable BT seeds. Results: The first strategy entails injectable seeds based on 103Pd-labeled palladium-gold alloy nanoparticles ([103Pd]PdAuNPs). These were prepared by combining [103Pd]PdH2Cl4 and AuHCl4, followed by lipophilic surface coating and dispersed in lactose octaisobutyrate and ethanol (LOIB:EtOH), in overall radiochemical yield (RCY) of 83%. With the second strategy, [103Pd]Pd-SSIB was prepared by conjugating the [16]aneS4 chelator with lipophilic sucrose septaisobutyrate (SSIB) followed by complexation with [103Pd]PdH2Cl4 (RCY = 99%) and mixed with LOIB:EtOH. [103Pd]Pd-SSIB was likewise formulated as injectable liquid forming seeds by mixing with LOIB. Both formulations reached activities of 1.0–1.5 GBq/mL and negligible release of radioactivity after injection of 100 µL (100–150 MBq) into aqueous buffer or mouse serum of less than 1% over one month. Conclusion: Both strategies for forming injectable BT seeds containing high 103Pd activity resulted in high radiolabeling yields, high activity per seed, and high activity retention. We consider both strategies suitable for BT, with the preferable strategy using a [16]aneS4 chelator due to its higher biodegradability. [ABSTRACT FROM AUTHOR]

Objective: Political attitudes are predicted by the key ideological variables of right‐wing authoritarianism (RWA) and social dominance orientation (SDO), as well as some of the Big Five personality traits. Past research indicates that personality and ideological traits are correlated for genetic reasons. A question that has yet to be tested concerns whether the genetic variation underlying the ideological traits of RWA and SDO has distinct contributions to political attitudes, or if genetic variation in political attitudes is subsumed under the genetic variation underlying standard Big Five personality traits. Method: We use data from a sample of 1987 Norwegian twins to assess the genetic and environmental relationships between the Big Five personality traits, RWA, SDO, and their separate contributions to political policy attitudes. Results: RWA and SDO exhibit very high genetic correlation (r = 0.78) with each other and some genetic overlap with the personality traits of openness and agreeableness. Importantly, they share a larger genetic substrate with political attitudes (e.g., deporting an ethnic minority) than do Big Five personality traits, a relationship that persists even when controlling for the genetic foundations underlying personality traits. Conclusion: Our results suggest that the genetic foundations of ideological traits and political attitudes are largely non‐overlapping with the genetic foundations of Big Five personality traits. [ABSTRACT FROM AUTHOR]

Corrections to the measured nuclear magnetic moments obtained from hyperfine structure measurements include the Breit–Rosenthal effect. In this paper, we present results from calculations on Bi using the GRASP2018 code. The results indicate that the Breit–Rosenthal effect is on the order of 0.1 % fm − 2 , the same order of magnitude as neighbouring elements, while some atomic states may have one order of magnitude smaller values. The ground state 6 p 3   S 3 / 2 o 4 is more sensitive to the Breit–Rosenthal effect, and hence the hyperfine anomaly, with a value of −0.25 % fm − 2 . [ABSTRACT FROM AUTHOR]

Sören Halldén's logic of nonsense is one of the most well-known many-valued logics available in the literature. In this paper, we discuss Peter Woodruff's as yet rather unexplored attempt to advance a version of such a logic built on the top of a constructive logical basis. We start by recalling the basics of Woodruff's system and by bringing to light some of its notable features. We then go on to elaborate on some of the difficulties attached to it; on our way to offer a possible solution to such difficulties, we discuss the relation between Woodruff's system and two-dimensional semantics for many-valued logics, as developed by Hans Herzberger. [ABSTRACT FROM AUTHOR]

Diseases caused by S. pneumoniae are the leading cause of child mortality. As antibiotic resistance of S. pneumoniae is rising, vaccination remains the most recommended solution. However, the existing pneumococcal polysaccharides vaccine (Pneumovax® 23) proved only to induce T-independent immunity, and strict cold chain dependence of the protein conjugate vaccine impedes its promotion in developing countries, where infections are most problematic. Affordable and efficient vaccines against pneumococcus are therefore in high demand. Here, we present an intranasal vaccine Lipo+CPS12F&αGC, containing the capsular polysaccharides of S. pneumoniae 12F and the iNKT agonist α-galactosylceramide in cationic liposomes. In BALB/cJRj mice, the vaccine effectively activates iNKT cells and promotes B cells maturation, stimulates affinity-matured IgA and IgG production in both the respiratory tract and systemic blood, and displays sufficient protection both in vivo and in vitro. The designed vaccine is a promising, cost-effective solution against pneumococcus, which can be expanded to cover more serotypes and pathogens. Intranasal immunization with capsular pneumococcal polysaccharides 12F and iNKT agonist α-galactosylceramide in cationic liposomes protects mice from S. pneumoniae 12F infection. [ABSTRACT FROM AUTHOR]

Cancer curing immune responses against heterogeneous solid cancers require that a coordinated immune activation is initiated in the antigen avid but immunosuppressive tumor microenvironment (TME). The plastic TME, and the poor systemic tolerability of immune activating drugs are, however, fundamental barriers to generating curative anticancer immune responses. Here, we introduce the CarboCell technology to overcome these barriers by forming an intratumoral sustained drug release depot that provides high payloads of immune stimulatory drugs selectively within the TME. The CarboCell thereby induces a hot spot for immune cell training and polarization and further drives and maintains the tumor-draining lymph nodes in an anticancer and immune activated state. Mechanistically, this transforms cancerous tissues, consequently generating systemic anticancer immunoreactivity. CarboCell can be injected through standard thin-needle technologies and has inherent imaging contrast which secure accurate intratumoral positioning. In particular, here we report the therapeutic performance for a dual-drug CarboCell providing sustained release of a Toll-like receptor 7/8 agonist and a transforming growth factor-β inhibitor in preclinical tumor models in female mice. Co-delivery of TLR7/8 agonists and TGF-β inhibitors (TGFβi) has the potential to overcome immunosuppression in the tumor microenvironment. Here the authors describe the application of the CarboCell technology for the sustained intratumoral release of a TLR7/8 agonist alone or in combination with a TGFβi, promoting anti-tumor immune responses in preclinical cancer models. [ABSTRACT FROM AUTHOR]

Objectives: Depressor anguli oris (DAO) excision can improve clinician‐graded, objective, and patient‐reported smile outcomes in patients with nonflaccid facial paralysis (NFFP). However, no prior research has studied changes in perceived emotions after surgery. This study quantifies changes in perceived emotions with smiling after DAO excision in the largest case series presented to date. Methods: Prospectively collected data from patients with NFFP who underwent DAO excision at a tertiary care facial nerve center were reviewed. Patient‐reported, clinician‐graded, and objective smile metrics were compared before and after surgery. Videos of faces at rest and while smiling were analyzed by artificial intelligence‐derived facial expression analysis software to quantify perceived emotions. Results: Sixty‐eight patients underwent isolated DAO excision between August 2021 and August 2023. Patients conveyed significantly more perceived happiness with smile and at rest after surgery (p < 0.001 and p = 0.012, respectively). DAO excision improved oral commissure excursion (p < 0.001), dental show (p < 0.001), and smile angle (p < 0.001) symmetry. Patients reported significant improvements in smiling and social function after surgery. Conclusions: This study demonstrates DAO excision increases perceived happiness conveyed by patients with NFFP while smiling and at rest. It confirms improved objective, clinician‐graded, and patient‐reported smile outcomes after surgery. Level of Evidence: 4 Laryngoscope, 134:4028–4035, 2024 [ABSTRACT FROM AUTHOR]

People tend to think of the prototypical person as a man more than as a woman, but this bias has primarily been observed in language-based tasks. Here, we investigated whether this bias is also present in the mental imagery of faces. A preregistered cross-cultural reverse-correlation study including participants from six WEIRD and non-WEIRD countries varying in gender equality (i.e., China, Ghana, Norway, Pakistan, Turkey, and the US; N = 645) unexpectedly suggested that people imagine the face of a generic "person" more as a woman than as a man. Replicating this unexpected result, a second preregistered study (N = 115) showed that U.S. participants imagine the face of a typical person as being more similar to their imagined face of a woman than of a man. We discuss explanations for these unexpected findings, including the possibility that the prototypical person is male-biased—consistent with previous work—but the default face may be female-biased. [ABSTRACT FROM AUTHOR]

Simple Summary: Understanding the diversity, distribution, and ecological roles of leaf-mining Lepidoptera across different biomes is both intriguing and important for advancing our knowledge of biodiversity and ecosystem functioning. Despite extensive studies on leaf-mining Nepticulidae in tropical environments, no one had previously explored trapping in completely dry deciduous forests, especially during the peak of the dry season when trees are bare and even grass is dried out. This paper reveals an unexpected and astonishing abundance of minuscule plant-mining Nepticulidae moths in such dry deciduous forests. Our study ecoregion, the tropical dry forests of Honduras, includes the Pacific coastal lowlands and premontane areas extending into low-altitude regions further inland, known for their rich biodiversity and high levels of endemism. In these tropical dry forests, we identified five species of pygmy moths belonging to the genus Acalyptris Meyrick, including three new species. These moths are characterized by their distinctive grey coloration and exceptionally small size, classified as "extremely small". Despite their similarities, they exhibit significant differences in genital structures and molecular profiles, indicating distinct species groups. Our research also uncovered novel atypical morphological traits in Nepticulidae from this ecoregion. These findings highlight the unique and highly specific nature of the Nepticulidae fauna in tropical dry forests. A key question arises regarding the presence of Nepticulidae adults during the dry season: could they be mining plant bark instead of leaves? This paper aims to stimulate further exploration of micromoths in other tropical dry forests, which, despite their limited and fragmented distribution, are found not only in Central America but also in other regions worldwide. Our investigation centered on the tropical dry forests along the Pacific coast of Honduras, aiming to elucidate the presence and abundance of minuscule grey moths during the dry season. Through specimen dissections and the taxonomic identification of the collected material, we have described three new species: Acalyptris podenasi sp. nov., A. palpiformis sp. nov., and A. tortoris sp. nov. Additionally, we documented two species previously known from neighboring countries, A. lascuevella Puplesis & Robinson and A. basicornis Remeikis & Stonis. The females of A. lascuevella were previously unknown and are documented here for the first time. Morphological examinations were complemented by DNA barcoding, particularly highlighting variation in A. lascuevella. The paper's primary significance lies not only in the description of new species but also in uncovering their taxonomic, morphological, and molecular importance. We found that these species are unique and indicative of the previously unstudied dry forests as a distinct ecosystem. Our findings revealed several novel atypical morphological traits within the studied Nepticulidae, including unusually large signum cells in the female genitalia, a dorso-ventrally divided uncus, and asymmetrical valvae in the male genitalia. These discoveries underscore the morphological diversity of Acalyptris Meyrick and their significance in evolutionary biology. Consequently, the paper addresses a previously unknown phenomenon of the occurrence and astonishing abundance of minuscule plant-mining micromoths in dry deciduous forests during the peak of the dry season. We hope that this paper will encourage Lepidoptera taxonomists to explore micromoths in other tropical dry forests, which, while limited in distribution, hold global importance. The paper is extensively illustrated with photographs of Acalyptris adults and their genitalia, along with maps, habitats, and molecular phylogenetic trees. [ABSTRACT FROM AUTHOR]

Objective: Investigate the feasibility of detecting early treatment-induced tumor tissue changes in patients with advanced lung adenocarcinoma using diffusion-weighted MRI-derived radiomics features. Methods: This prospective observational study included 144 patients receiving either tyrosine kinase inhibitors (TKI, n = 64) or platinum-based chemotherapy (PBC, n = 80) for the treatment of pulmonary adenocarcinoma. Patients underwent diffusion-weighted MRI the day prior to therapy (baseline, all patients), as well as either + 1 (PBC) or + 7 and + 14 (TKI) days after treatment initiation. One hundred ninety-seven radiomics features were extracted from manually delineated tumor volumes. Feature changes over time were analyzed for correlation with treatment response (TR) according to CT-derived RECIST after 2 months and progression-free survival (PFS). Results: Out of 14 selected delta-radiomics features, 6 showed significant correlations with PFS or TR. Most significant correlations were found after 14 days. Features quantifying ROI heterogeneity, such as short-run emphasis (p = 0.04(pfs)/0.005(tr)), gradient short-run emphasis (p = 0.06(pfs)/0.01(tr)), and zone percentage (p = 0.02(pfs)/0.01(tr)) increased in patients with overall better TR whereas patients with worse overall response showed an increase in features quantifying ROI homogeneity, such as normalized inverse difference (p = 0.01(pfs)/0.04(tr)). Clustering of these features allows stratification of patients into groups of longer and shorter survival. Conclusion: Two weeks after initiation of treatment, diffusion MRI of lung adenocarcinoma reveals quantifiable tissue-level insights that correlate well with future treatment (non-)response. Diffusion MRI-derived radiomics thus shows promise as an early, radiation-free decision-support to predict efficacy and potentially alter the treatment course early. Critical relevance statement: Delta-Radiomics texture features derived from diffusion-weighted MRI of lung adenocarcinoma, acquired as early as 2 weeks after initiation of treatment, are significantly correlated with RECIST TR and PFS as obtained through later morphological imaging. Key Points: Morphological imaging takes time to detect TR in lung cancer, diffusion-weighted MRI might identify response earlier. Several radiomics features are significantly correlated with TR and PFS. Radiomics of diffusion-weighted MRI may facilitate patient stratification and management. [ABSTRACT FROM AUTHOR]

In one of his papers, JC Beall advanced a new and interesting interpretation of Weak Kleene logic, in terms of on-topic/off-topic. In brief, Beall suggests to read the third value as off-topic, whereas the two classical values are read as true and on-topic and false and on-topic. Building on Beall's new interpretation, the aim of this paper is threefold. First, we discuss two motivations to enrich Beall's interpretation, and offer an alternative semantic framework that reflects our motivations. Second, by making use of our new framework, we will offer a new interpretation of the logic of Catuskoti which combines Beall's proposal of having FDE as the correct logic with the on-topic/off-topic divide. Finally, we will offer a general result that will allow us to make sense of a family of infectious logics in terms of Beall's on-topic/off-topic reading. [ABSTRACT FROM AUTHOR]

The attachment and caregiving domains maintain proximity and care-giving behavior between parents and offspring, in a way that has been argued to shape people's mental models of how relationships work, resulting in secure, anxious or avoidant interpersonal styles in adulthood. Several theorists have suggested that the attachment system is closely connected to orientations and behaviors in social and political domains, which should be grounded in the same set of familial experiences as are the different attachment styles. We use a sample of Norwegian twins (N = 1987) to assess the genetic and environmental relationship between attachment, trust, altruism, right-wing authoritarianism (RWA), and social dominance orientation (SDO). Results indicate no shared environmental overlap between attachment and ideology, nor even between the attachment styles or between the ideological traits, challenging conventional wisdom in developmental, social, and political psychology. Rather, evidence supports two functionally distinct systems, one for navigating intimate relationships (attachment) and one for navigating social hierarchies (RWA/SDO), with genetic overlap between traits within each system, and two distinct genetic linkages to trust and altruism. This is counter-posed to theoretical perspectives that link attachment, ideology, and interpersonal orientations through early relational experiences. [ABSTRACT FROM AUTHOR]

Previous research on group‐based hope has predominantly focused on positive intergroup outcomes, such as peace and harmony. In this paper, we demonstrate that hope experienced towards group‐centric political outcomes, such as a victory in a conflict and defeating the enemy, can be detrimental to peace. In Study 1, conducted among Israeli Jews, hope for victory over the Palestinians was uniquely associated with more support for extreme war policies, whereas hope for peace generally showed the opposite associations. In Study 2, we replicated these results among Muslim Pakistanis regarding the Pakistan–India dispute. Notably, in both Studies 1 and 2, only hope for victory significantly predicted personal violent extremist intentions. In Study 3, conducted with a representative sample of Israeli Jews, we found three latent profiles of hope: victory hopers, peace hopers, and dual hopers (hoping for both peace and victory). Finally, in preregistered Study 4, we longitudinally investigated how hopes for victory and peace changed from a relatively calm period in 2021 to the Israel–Hamas War of 2023, utilizing a Bivariate Latent Change Score analysis. Increases in hope for victory during the highly intense war explained the increase in support for violence. We discuss implications, limitations, and directions for future research. [ABSTRACT FROM AUTHOR]

We report on an unexpected reaction between ammonia and potassium ozonide dissolved in liq. NH3 resulting in the formation of peroxynitrite, [ONOO]−, which exclusively happens in the presence of a specific partially fluorinated aniline‐based ammonium cation. High‐resolution structural data of the peroxynitrite anion in cis‐conformation have been obtained. We further studied this molecule anion by single crystal Raman spectroscopy. The cis and trans isomers of peroxynitrite were analysed computationally with respect to their relative energies, the cis‐trans transition barrier and their decomposition pathways to the nitrate anion. By experimentally examining cations decorated with fluorine ligands to different degrees, we demonstrate that fluorine specific interactions play a crucial role in the unexpected formation of peroxynitrite and as a conspicuously structure directing factor for the underlying crystalline solid phases, exhibiting distinct micro‐separations of fluorine and hydrogen enriched regions. [ABSTRACT FROM AUTHOR]

This article provides a systematic literature review of existing strategic crisis management training research. The review explores practices on which strategic crisis management skills to prioritize and how to train these skills to be prepared when a crisis strikes. Our research question was: How is strategic crisis management trained, and is there a best practice? In all, we identified 538 articles from 3 databases and read the abstracts. From this, we selected 41 articles based on the defined inclusion criteria and read them as a whole. In the end, eight articles were a part of this analysis. A thematic analysis based on the categorization of repetitions of concepts was used to analyse the data. The analysis resulted in two main categories: what to train, which focuses on the outcome and skills, and how to train, which focuses on the process and pedagogy. The outcome (what to train) categories were (1) related to working together, (2) related to understanding the situation, (3) related to making adequate decisions in complex contexts, and (4) related to practicalities. The process (how to train) categories were (1) training methods and (2) learning theories. A model considering three main strategic crisis management training approaches, outcome‐focused training, process‐focused training, and learning‐focused training, was developed. The latter was concluded to be the desired option, as it is a balanced approach of both outcome and process focus. [ABSTRACT FROM AUTHOR]

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In the age of misinformation, conspiracy theories can have far-reaching consequences for individuals and society. Social and emotional experiences throughout the life course, such as loneliness, may be associated with a tendency to hold conspiracist worldviews. Here, we present results from a population-based sample of Norwegians followed for almost three decades, from adolescence into midlife (N = 2215). We examine participants’ life trajectories of loneliness using latent growth curve modeling. We show that people reporting high levels of loneliness in adolescence, and those who experience increasing loneliness over the life course, are more likely to endorse conspiracy worldviews in midlife. [ABSTRACT FROM AUTHOR]

Researchers have productively tested identity fusion theory, aiming to explain extreme pro-group orientations. However, the strength of effects, types of measurements, and study contexts have varied substantially. This first meta-analysis (90 studies from 55 reports, 106 effects, N = 36,880) supported four main conclusions based on the available literature: (1) identity fusion has a strong and positive but very heterogeneous relationship with extreme pro-group orientations; (2) its effect is significantly stronger than that of social identification; however, some evidence suggests that this difference is primarily observed in published rather than unpublished studies; (3) the verbal identity fusion scale has the best explanatory power; (4) identity fusion is most strongly associated with extreme collective action, followed by a willingness to sacrifice oneself, fight or die for the group, and outgroup hostility. We discuss the findings' implication for identity fusion theory. Based on the literature's limitations, we highlight avenues for future research. [ABSTRACT FROM AUTHOR]

Although the importance of temporal perspectives for understanding collective movements has been theoretically emphasised, they are rarely considered in research. Focusing on the mass protests against COVID‐19 policies in Germany, we investigated how protesters make use of temporal references in their protest narratives. Results from 11 multi‐site protest observations and 31 interviews showed that participants (a) drew historical perpetrator and victim analogies and imagined a dystopian future, bolstering perceptions of injustice, (b) drew on resistance narratives and imagined the ideal, utopian future society, increasing their perceived efficacy and (c) countered feelings of insignificance by identifying with past heroes. Protesters living in the East of Germany drew comparatively more resistance analogies than those living in the West, who often likened those complying with the COVID‐19 policies to the perpetrators of the past national‐socialist and communist dictatorships. The findings empirically underline the importance of integrating historical–cultural–future perspectives into models of collective action. [ABSTRACT FROM AUTHOR]

Background Social anxiety disorder (SAD) most commonly develops in adolescence—a period of life that includes a transition to upper secondary school. The aim of this study is to investigate the extent to which social anxiety in adolescence is associated with the completion of upper secondary school and progression to higher education. Methods This longitudinal study includes 8,192 adolescents aged 13–19 years who participated in the Norwegian Young-HUNT 3 population-based study. Social anxiety is measured employing (1) diagnostic interview screening questions (interview) and (2) a self-reported symptom index (questionnaire). Notably, we define the cohorts based on these two methods. Using national educational data (2008–2019), we follow educational attainment among the cohorts until they turn 25 years of age. Results We found that adolescents who screened positive (SP) for SAD had a predicted probability of upper secondary school completion at 21 years of age that was 14% points lower than those who screened negative (SN). Further, differences remained when looking at completion rates at age 25 years. Moreover, predicted probabilities for completion were inversely associated with increasing levels of self-reported social anxiety symptoms. Similarly, the proportion of the completers of an academic program in the SP group that were enrolled in higher education by 25 years of age, were lower than for the SN group (87 vs. 92%). Conclusion Social anxiety in adolescence, both self-reported symptoms and diagnostic screening, has long-term negative impact on upper secondary school completion and to some extent enrollment to higher education. [ABSTRACT FROM AUTHOR]

Simple Summary: While feeding, the larvae of pygmy moths (Nepticulidae) consume part of a leaf's photosynthetic tissue, thus causing damage to the host plant. Although these insects play a natural role in terrestrial ecosystems, they are perceived as pests in horticulture. This study investigates the identity of a potential Nepticulidae pest infesting plum trees in the Caucasus, initially presumed to be the widespread European Stigmella plagicolella (Stainton). Contrary to expectations, our detailed taxonomic analysis revealed a new species of pygmy moth with distinct male genitalia morphology and molecular differences from its European counterpart. This discovery challenges previous records and highlights the need for accurate pest identification. We hypothesize that the proximity of the Caucasus to Europe emphasizes the importance of monitoring and preventing unintentional pest spread, particularly given potential climate change impacts on the distribution and behavior of pests. Our findings contribute to both practical pest management and scientific understanding of evolutionary processes shaping the Caucasian and European biota. In instances of severe infestations, Nepticulidae larvae can inflict damage on cultivated plants. Previously, it was assumed that the Prunus-feeding Nepticulidae have continuous distribution from Europe to the neighboring Caucasus. During recent fieldwork in the Caucasus, leaf mines were found on plum trees that initially resembled those of Stigmella plagicolella (Stainton) in Europe. However, upon rearing the adults, significant differences emerged, leading to the hypothesis that a different Prunus-feeding species exists in the Caucasus; this challenges previous records in Western Asia. This paper presents the outcomes of our morphological, molecular, and statistical investigations, unveiling S. colchica sp. nov., a previously unknown potential plum-tree pest. Distinguished by male genitalia characteristics, the new species differs from S. plagicolella. The inter- and intraspecific divergences between S. colchica sp. nov. and S. plagicolella range from 3.5% to 6.02%. Moreover, the utilized delimitation algorithms reliably clustered two species separately, as does our mitotype network. A statistical analysis also shows a discernible trend between the leaf mines of S. colchica sp. nov. and S. plagicolella. This unexpected discovery not only documents a new potential pest, enhancing our understanding of the Caucasian fauna, but also contributes to the broader biological inventory. [ABSTRACT FROM AUTHOR]

Stochastic models of point patterns in space and time are widely used to issue forecasts or assess risk, and often they affect societally relevant decisions. We adapt the concept of consistent scoring functions and proper scoring rules, which are statistically principled tools for the comparative evaluation of predictive performance, to the point process setting, and place both new and existing methodology in this framework. With reference to earthquake likelihood model testing, we demonstrate that extant techniques apply in much broader contexts than previously thought. In particular, the Poisson log-likelihood can be used for theoretically principled comparative forecast evaluation in terms of cell expectations. We illustrate the approach in a simulation study and in a comparative evaluation of operational earthquake forecasts for Italy. [ABSTRACT FROM AUTHOR]

Recent advancements in studying long chains of unstable nuclei have revitalised interest in investigating the hyperfine anomaly. Hyperfine anomaly is particularly relevant for determining nuclear magnetic dipole moments using hyperfine structures where it limits the accuracy. This research paper focuses on the calculation of the differential Breit-Rosenthal effect for the 6 p 2 3 P 1 , 2 , 1 D 2 and 6 p 7 s 3 P 1 states in Pb, utilising the multi-configurational Dirac-Hartree-Fock code, GRASP2018. The findings show that the differential Breit-Rosenthal effect is typically less than 0.1 / f m 2 , which is often much smaller than the Bohr-Weisskopf effect. The differential Breit-Rosenthal effect for the 6 p 2 3 P 2 state is one order of magnitude smaller than the rest, which is why this state seems to be insensible to the hyperfine anomaly. [ABSTRACT FROM AUTHOR]

A taxonomic review of the Nepticulidae of Armenia is provided for the first time. Currently, the previously little-known fauna of the pygmy moths of Armenia consists of eight genera and 31 species, including seven new species described and illustrated in the current paper as follows: Stigmella armi Stonis, Dobrynina & Remeikis, sp. nov.; Stigmella garnica Stonis, Dobrynina & Remeikis, sp. nov.; Stigmella inopinoides Dobrynina, sp. nov.; Stigmella magicis Stonis & Dobrynina, sp. nov.; Stigmella ararati Stonis, Dobrynina & Remeikis, sp. nov.; Trifurcula vardenisi Stonis, Dobrynina & Remeikis, sp. nov.; and Etainia caucasi Remeikis, sp. nov. The most common Nepticulidae species in Armenia, Stigmella muricatella (Klimesch), still remains a taxonomic puzzle. However, the molecular sequences of the Armenian specimens and a specimen of S. muricatella from Greece were found to be similar, though clearly distinct from the widespread S. rolandi van Nieukerken due to numerous hypothetical mutational steps. Mitotype analysis revealed that the Ectoedemia specimens collected in Armenia do not belong to the expected widespread E. spinosella (Joannis) but are more similar to the less-known E. mahalebella (Klimesch). Moreover, some specimens from Armenia identified by us as Simplimorpha promissa (Staudinger) and Ectoedemia (Zimmermannia) longicaudella Klimesch may actually represent possible cryptic taxa, allopatric subspecies or species. However, from a practical point of view, the description of such difficult-to-diagnose taxa is inappropriate. Thus, we have refrained from describing such new taxa based solely on observed molecular differences. [ABSTRACT FROM AUTHOR]

The compounds [Me3N(C6H3(CF3)2)][BF4] and [Me3N(C6H3(CH3)2)][BF4] were synthesized from commercially available starting materials and fully characterized by single-crystal X-ray diffraction, NMR, IR and Raman spectroscopy, as well as mass spectrometry. Both ammonium cations show potential for applications in crystal engineering due to their structure directing properties in the solid state. [ABSTRACT FROM AUTHOR]

Nasal obstruction is a significant challenge greatly affecting individual quality of life. It is one of the most common presentations in the otolaryngology clinic, often persisting despite medical and, at times, surgical intervention. The butterfly graft has proven to be a veritable option addressing nasal valve collapse. Herein, we describe our most recent operative technique, highlight its application in ethnic rhinoplasty and revision cases, and discuss incorporation of dorsal preservation techniques in functional rhinoplasty. [ABSTRACT FROM AUTHOR]

The investigation of curved low-dimensional systems is a topic of great research interest. Such investigations include two-dimensional systems with cylindrical symmetry. In this work, we present a numerical study of the electronic transport properties of metallic nanotubes deviating from the cylindrical form either by having a bump or a depression, and under the influence of a magnetic field. Under these circumstances, it is found that the nanotube may be used as an energy high-pass filter for electrons. It is also shown that the device can be used to tune the angular momentum of transmitted electrons. [ABSTRACT FROM AUTHOR]

Background: Body relaxation and pain reduction are some of the reported benefits of flexibility training (through active stretching exercises), however their effects on posture and blood circulation are uncertain. We aimed to investigate the effects of flexibility training (through active stretching exercises) in combination with multicomponent training (MT) on blood pressure (BP), and the correlation with changes in body alignment and flexibility in physically inactive women. Methods: Women aged 60-70 years were into three groups: multicomponent training group (MT), multicomponent training plus flexibility training group (FT), and control group (CG). After randomization, the resting blood pressure was measured and the participants were reallocated into subgroups according to pressure values >130/80 mmHg (This classification is according to the American Heart Association (AHA), resulting in the subgroups: flexibility training (FT); flexibility training for hypertensive patients (FTSAH); multicomponent training (MT); multicomponent training for hypertensive patients (MTSAH); control group (CG); control group of hypertensive patients (CGSAH). The interventions lasted 14 weeks. Systolic (sBP) and diastolic (dBP) BP, range of motion (flexion and extension), and postural analysis by asymmetry in the frontal plane and asymmetry in the sagittal plane, displacement and the flexibility test were collected before (Pre) and after training (Post). In total, 141 women participated in the study (without SAH: FT = 23, MT = 20, and CG = 21; with SAH: FTSAH = 28, MTSAH = 23, and CGSAH = 26). Results: Systolic blood pressure, in the pre and post moments were: FT (116 ± 6.7 vs. 114 ± 4.7); FTSAH (144 ± 16.5 vs. 121 ± 10.1); MT: (120 ± 6.8 vs. 121 ± 7.3); MTSAH: (137 ± 10.6 vs. 126 ± 13.0); CG: (122 ± 5.3 vs. 133 ± 19.2); and CGSAH: (140 ± 9.7 vs. 143 ± 26.2), presenting an F value (p-value - group x time) of 12.00 (<0.001), with improvement in the groups who trained. The diastolic blood pressure in the pre and post moments were: FT (71 ± 4.7 vs. 74 ± 6.8); FTSAH (88 ± 9.6 vs. 70 ± 12.0); MT: (74 ± 4.5 vs. 77 ± 11.7); MTSAH: (76 ± 10.4 vs. 76 ± 10.2); CG: (69 ± 7.11 vs. 82 ± 11.4); and CGSAH: (76 ± 13.4 vs. 86.6 ± 7.7), presenting an F value (p-value - group x time) of 8.00 (p < 0.001), with improvement in the groups who trained. In the Elastic Net Regression, sBP was influenced by height (β: -0.044); hip flexion (β: 0.071); Shoulder extension (β: 0.104); low back flexion (β: 0.119) and dBP (β: 0.115). In the Elastic Net Regression, dBP was influenced by asymmetry in the sagittal plane variables (0.040); asymmetry in the frontal plane (β: 0.007); knee flexion (β: -0.398); BM (β: 0.007); Shoulder flexion (β: -0.142); Hip flexion (β: -0.004); sBP (β: 0.155) and Ankle Flexion (β: -0.001). Conclusion: The displacement of the asymmetry in the frontal plane and asymmetry in the sagittal plane, and the increase in the flexion position in the hip, lumbar, head, and knee regions, influenced the highest-pressure levels. Multicomponent training associated with flexibility training promoted improvement in body alignment, COM, and joint angles, and decreased blood pressure. [ABSTRACT FROM AUTHOR]

A systematic review was undertaken to investigate the involvement of hydration in heart rate (HR), HR variability (HRV) and diastolic (DBP) and systolic (SBP) blood pressure in response to exercise. Data synthesis: The EMBASE, MEDLINE, Cochrane Library, CINAHL, LILACS and Web of Science databases were searched. In total, 977 studies were recognized, but only 36 were included after final screening (33 studies in meta-analysis). This study includes randomized controlled trials (RCTs) and non-RCTs with subjects > 18 years old. The hydration group consumed water or isotonic drinks, while the control group did not ingest liquids. For the hydration protocol (before, during and after exercise), the HR values during the exercise were lower compared to the controls (−6.20 bpm, 95%CI: −8.69; −3.71). In the subgroup analysis, "water ingested before and during exercise" showed lower increases in HR during exercise (−6.20, 95%CI: 11.70 to −0.71), as did "water was ingested only during exercise" (−6.12, 95%CI: −9.35 to −2.89). Water intake during exercise only revealed a trend of avoiding greater increases in HR during exercise (−4,60, 95%CI: −9.41 to 0.22), although these values were not significantly different (p = 0.06) from those of the control. "Isotonic intake during exercise" showed lower HRs than the control (−7.23 bpm, 95% CI: −11.68 to −2.79). The HRV values following the exercise were higher in the hydration protocol (SMD = 0.48, 95%CI: 0.30 to 0.67). The values of the SBP were higher than those of the controls (2.25 mmHg, 95%CI: 0.08 to 4.42). Conclusions: Hydration-attenuated exercise-induced increases in HR during exercise, improved autonomic recovery via the acceleration of cardiac vagal modulation in response to exercise and caused a modest increase in SBP values, but did not exert effects on DBP following exercise. [ABSTRACT FROM AUTHOR]

Body condition, a measure for relative fat mass, is associated with primate health, fitness, and overall welfare. Body condition is often influenced by dietary factors, age, and/or sex, but several body condition measures (body weight, weight‐to‐height ratios, and so on) also show high heritability across primate species, indicating a role of genetic effects. Although different measures for body condition exist, many require direct handling of animals, which is invasive, time‐consuming, and expensive, making them impractical in wild and captive settings. Therefore, noninvasive visual body condition score (BCS) systems were developed for various animal species, including macaques and chimpanzees, to visually assess relative fat mass. Here we evaluate the utility of a visual BCS system in bonobos by assessing (1) inter‐rater reliability, (2) links with body mass, a traditional hands‐on measure of condition, and (3) the factors driving individual variation in BCS. We adapted the chimpanzee BCS system to rate 76 bonobos in 11 European zoos (92% of the adult population). Inter‐rater reliability was high (s* = 0.948), BCSs were positively associated with body mass (β = 0.075) and not predicted by diet, sex, or age, nor were they associated with a higher abundance of obesity‐related diseases. Instead, BCSs showed high levels of heritability (h2 = 0.637), indicating that a majority of body condition variation in bonobos is attributable to genetic similarity of the individuals. This is in line with reported h2‐values for traditional body condition measures in primates and provides support for the reliability of visual BCS systems in great apes. The results of this study emphasize an often unanticipated role of genetics in determining primate body fat and health that has implications for the management of captive primates. Application of this tool in wild populations would aid to unravel environmental from genetic drivers of body condition variation in primates. Research Highlights: We showed that the visual chimpanzee body condition score (BCS) system can reliably be used in bonobosWithin the entire European population of zoo‐housed bonobos, sex, age, and diet had no influence on body condition, and there was no link between BCS and obesity‐related diseasesWe found high heritability of body condition in bonobos (h2 = 0.637), emphasizing an often unanticipated role of genetics in determining the level of body fat in primates [ABSTRACT FROM AUTHOR]

Exercise increases muscle glucose uptake independently of insulin signaling and represents a cornerstone for the prevention of metabolic disorders. Pharmacological activation of the exercise-responsive AMPK in skeletal muscle has been proven successful as a therapeutic approach to treat metabolic disorders by improving glucose homeostasis through the regulation of muscle glucose uptake. However, conflicting observations cloud the proposed role of AMPK as a necessary regulator of muscle glucose uptake during exercise. We show that glucose uptake increases in human skeletal muscle in the absence of AMPK activation during exercise and that exercise-stimulated AMPKγ3 activity strongly correlates to muscle glucose uptake in the postexercise period. In AMPKγ3-deficient mice, muscle glucose uptake is normally regulated during exercise and contractions but impaired in the recovery period from these stimuli. Impaired glucose uptake in recovery from exercise and contractions is associated with a lower glucose extraction, which can be explained by a diminished permeability to glucose and abundance of GLUT4 at the muscle plasma membrane. As a result, AMPKγ3 deficiency impairs muscle glycogen resynthesis following exercise. These results identify a physiological function of the AMPKγ3 complex in human and rodent skeletal muscle that regulates glucose uptake in recovery from exercise to recapture muscle energy stores. Article Highlights: Exercise-induced activation of AMPK in skeletal muscle has been proposed to regulate muscle glucose uptake in recovery from exercise. This study investigated whether the muscle-specific AMPKγ3-associated heterotrimeric complex was involved in regulating muscle glucose metabolism in recovery from exercise. The findings support that exercise-induced activation of the AMPKγ3 complex in human and mouse skeletal muscle enhances glucose uptake in recovery from exercise via increased translocation of GLUT4 to the plasma membrane. This work uncovers the physiological role of the AMPKγ3 complex in regulating muscle glucose uptake that favors replenishment of the muscle cellular energy stores. [ABSTRACT FROM AUTHOR]

Recent research suggests that music can affect evaluations of other groups and cultures. However, little is known about the objective and subjective musical parameters that influence these evaluations. We aimed to fill this gap through two studies. Study 1 collected responses from 52 American participants who listened to 30 folk-song melodies from different parts of the world. Linear mixed-effects models tested the influence of objective and subjective musical parameters of these melodies on evaluations of the cultures from which they originated. Musical parameters consistently predicted cultural evaluations. The most prominent musical parameter was musical velocity, a measure of number of pitch onsets, predicting more cultural warmth, competence and evolvedness and less cultural threat. Next, with a sample of 212 American participants, Study 2 used a within-subjects experiment to alter the tempo and dissonance for a subset of six melody excerpts from Study 1, testing for causal effects. Linear mixed-effects models revealed that both dissonance and slow tempo predicted more negative cultural evaluations. Together, both studies demonstrate how musical parameters can influence cultural perceptions. Avenues for future research are discussed. [ABSTRACT FROM AUTHOR]

This paper presents and critically discusses the "logos approach to quantum mechanics" from the point of view of the current debates concerning the relation between metaphysics and science. Due to its alleged direct connection with quantum formalism, the logos approach presents itself as a better alternative for understanding quantum mechanics than other available views. However, we present metaphysical and methodological difficulties that seem to clearly point to a different conclusion: the logos approach is on an epistemic equal footing among alternative realist approaches to quantum mechanics. [ABSTRACT FROM AUTHOR]

In March 2020, the municipality of Oslo's Nursing Home Agency was hit by Norway's first COVID‐19 outbreak. Being responsible for a very vulnerable group, they had to deal with a situation never before encountered and of which they had very limited knowledge. In this study, we explored how situational awareness (SA) changed from a creeping to an urgent crisis. We undertook a case study of the Nursing Home Agency's top management during the initial period of the COVID‐19 pandemic (December 2019 through late March 2020). We conducted individual interviews with the management in charge of decisions. Thematic analysis yielded four main categories affecting SA: perception of event development, perception of available time, information, and cooperation and trust. We found that subjective experience of the geographical proximity of the crisis and subjective experience of time were essential in shaping SA. Perception of time was essential to the understanding of urgency, which was an important factor in reacting properly. Further, the perception of space was necessary for the crisis to be interpreted as critical. Time and space are objective factors but are perceived subjectively. Our model showed that the crisis must be perceived as urgent for proper actions to be decided upon. [ABSTRACT FROM AUTHOR]

This study aims to examine the association between baseline level and change of autonomic nervous function with subsequent development of arterial stiffness. Autonomic nervous function was assessed in 4901 participants of the Whitehall II occupational cohort by heart rate variability (HRV) indices and resting heart rate (rHR) three times between 1997 and 2009, while arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV) measured twice between 2007 and 2013. First, individual HRV/rHR levels and annual changes were estimated. Then, we modelled the development of PWV by HRV/rHR using linear mixed effect models. First, we adjusted for sex and ethnicity (model 1), and then for socioeconomic and lifestyle factors, various clinical measurements, and medications (model 2). A decrease in HRV and unchanged rHR was associated with subsequent higher levels of PWV, but the effect of a change in HRV was less pronounced at higher ages. A typical individual aged 65 years with a SDNN level of 30 ms and a 2% annual decrease in SDNN had 1.32 (0.95; 1.69) higher PWV compared to one with the same age and SDNN level but with a 1% annual decrease in SDNN. Further adjustment had no major effect on the results. People who experience a steeper decline in autonomic nervous function have higher levels of arterial stiffness. The association was stronger in younger people. [ABSTRACT FROM AUTHOR]

Change of logic is typically taken as requiring that the meanings of the connectives change too. As a result, it has been argued that legitimate rivalry between logics is under threat. This is, in a nutshell, the meaning‐variance argument, traditionally attributed to Quine. In this paper, we present a semantic framework that allows us to resist the meaning‐variance claim for an important class of systems: classical logic, the logic of paradox and strong Kleene logic. The major feature of the semantics is that the connectives have the same meanings in these systems, so that the meaning‐variance argument is straightforwardly blocked. We discuss the effects of this semantics for two uses of the argument of meaning variance, and also consider its impact on related issues. [ABSTRACT FROM AUTHOR]

How do English majority members' national culture maintenance and immigrant culture adoption (i.e., globalisation-based proximal-acculturation) predict their acculturation expectations (i.e., how they think immigrants should acculturate) and intergroup ideologies (i.e., how they think society should manage diversity)? Cross-sectional results (N = 220) supported hypothesised relationships using a variable- and person-centred approach: welcoming expectations/ideologies related positively to immigrant culture adoption (or an integration/assimilation strategy) and negatively to national culture maintenance (or a separation strategy), whilst the reverse was true for unwelcoming expectations/ideologies. Notably, colourblindness showed only weak correlations with/differences across acculturation orientations/strategies. In longitudinal analyses, adopting immigrants' cultures increased the intergroup ideologies polyculturalism and multiculturalism whilst reducing support for assimilation over time, whereas national culture maintenance had the opposite effect. Meanwhile, the expectation integration-transformation was especially related to higher odds of following an integration rather than separation strategy over time. Overall, results advance the psychological study of multiculturalism, providing first longitudinal insights on majority members' acculturation. [ABSTRACT FROM AUTHOR]

The parkinsonian gait disorder and freezing of gait are therapeutically demanding symptoms with considerable impact on quality of life. The aim of this study was to assess the role of subthalamic and nigral neurons in the parkinsonian gait control using intraoperative microelectrode recordings of basal ganglia neurons during a supine stepping task. Twelve male patients (56 ± 7 years) suffering from moderate idiopathic Parkinson's disease (disease duration 10 ± 3 years, Hoehn and Yahr stage 2), undergoing awake neurosurgery for deep brain stimulation, participated in the study. After 10 s resting, stepping at self-paced speed for 35 s was followed by short intervals of stepping in response to random 'start' and 'stop' cues. Single- and multi-unit activity was analysed offline in relation to different aspects of the stepping task (attentional 'start' and 'stop' cues, heel strikes, stepping irregularities) in terms of firing frequency, firing pattern and oscillatory activity. Subthalamic nucleus and substantia nigra neurons responded to different aspects of the stepping task. Of the subthalamic nucleus neurons, 24% exhibited movement-related activity modulation as an increase of the firing rate, suggesting a predominant role of the subthalamic nucleus in motor aspects of the task, while 8% of subthalamic nucleus neurons showed a modulation in response to the attentional cues. In contrast, responsive substantia nigra neurons showed activity changes exclusively associated with attentional aspects of the stepping task (15%). The firing pattern of subthalamic nucleus neurons revealed gait-related firing regularization and a drop of beta oscillations during the stepping performance. During freezing episodes instead, there was a rise of beta oscillatory activity. This study shows for the first time specific, task-related subthalamic nucleus and substantia nigra single-unit activity changes during gait-like movements in humans with differential roles in motor and attentional control of gait. The emergence of perturbed firing patterns in the subthalamic nucleus indicates a disrupted information transfer within the gait network, resulting in freezing of gait. [ABSTRACT FROM AUTHOR]

Understanding the psychological processes that drive violent extremism is a pressing global issue. Across six studies, we demonstrate that perceived cultural threats lead to violent extremism because they increase people’s need for cognitive closure (NFC). In general population samples (from Denmark, Afghanistan, Pakistan, France, and an international sample) and a sample of former Mujahideen in Afghanistan, single-level and multilevel mediation analyses revealed that NFC mediated the association between perceived cultural threats and violent extremist outcomes. Further, in comparisons between the sample of former Afghan Mujahideen and the general population sample from Afghanistan following the known-group paradigm, the former Mujahideen scored significantly higher on cultural threat, NFC, and violent extremist outcomes. Moreover, the proposed model successfully differentiated former Afghan Mujahideen participants from the general Afghan participants. Next, two preregistered experiments provided causal support for the model. Experimentally manipulating the predictor (cultural threat) in Pakistan led to higher scores on the mediator (NFC) and dependent variables (violent extremist outcomes). Finally, an experiment conducted in France demonstrated the causal effect of the mediator (NFC) on violent extremist outcomes. Two internal meta-analyses using state-of-the-art methods (i.e., meta-analytic structural equation modeling and pooled indirect effects analyses) further demonstrated the robustness of our results across the different extremist outcomes, designs, populations, and settings. Cultural threat perceptions seem to drive violent extremism by eliciting a need for cognitive closure. [ABSTRACT FROM AUTHOR]

Individual variation in complex social behavioral traits, like primate grooming, can be influenced by the characteristics of the individual and those of its social group. To better grasp this complexity, social network analysis can be used to quantify direct and indirect grooming relationships. However, multi-group social network studies remain rare, despite their importance to disentangle individual from group-level trait effects on grooming strategies. We applied social network analysis to grooming data of 22 groups of zoo-housed bonobos and investigated the impact of three individual (sex, age, and rearing-history) and two group-level traits (group size and sex ratio) on five social network measures (out-strength, in-strength, disparity, affinity, and eigenvector centrality). Our results showed age-effects on all investigated measures: for females, all measures except for affinity showed quadratic relationships with age, while in males, the effects of age were more variable depending on the network measure. Bonobos with atypical rearing histories showed lower out-strength and eigenvector centrality, while in-strength was only impacted by rearing history in males. Group size showed a negative association with disparity and eigenvector centrality, while sex ratio did not influence any of the investigated measures. Standardization for group size did not impact the effects of sex and age, indicating the robustness of these findings. Our study provides comprehensive insights into the complexity of grooming behavior in zoo-housed bonobos, and underlines the importance of multi-group analyses for the generalizability of social network analysis results for species as a whole. [ABSTRACT FROM AUTHOR]

Background: The repercussions on oxidative and inflammatory stress markers under the effects of arginine and citrulline in response to exercise are not fully reached. We completed a systematic review to investigate the effects of L-Citrulline or L-Arginine on oxidative stress and inflammatory biomarkers following exercise. EMBASE, MEDLINE (PubMed), Cochrane Library, CINAHL, LILACS, and Web of Science databases were used to record the trials. This study includes randomized controlled trials (RCTs) and non-RCTs with subjects over 18 years old. Those under the intervention protocol consumed L-Citrulline or L-Arginine, and the controls ingested placebo. We recognized 1080 studies, but only 7 were included (7 studies in meta-analysis). We observed no difference between pre- vs. post-exercise for oxidative stress (subtotal = −0.21 [CI: −0.56, 0.14], p = 0.24, and heterogeneity = 0%. In the sub-group "L-Arginine" we found a subtotal = −0.29 [−0.71, 0.12], p = 0.16, and heterogeneity = 0%. For the "L-Citrulline" subgroup we observed a subtotal = 0.00 [−0.67, 0.67], p = 1.00, and heterogeneity was not applicable. No differences were observed between groups (p = 0.47), and I² = 0%) or in antioxidant activity (subtotal = −0.28 [−1.65, 1.08], p = 0.68, and heterogeneity = 0%). In the "L-Arginine" sub-group, we found a subtotal = −3.90 [−14.18, 6.38], p = 0.46, and heterogeneity was not applicable. For the "L-Citrulline" subgroup, we reported a subtotal = −0.22 [−1.60, 1.16], p = 0.75, and heterogeneity was not applicable. No differences were observed between groups (p = 0.49), and I² = 0%), inflammatory markers (subtotal = 8.38 [−0.02, 16.78], p = 0.05, and heterogeneity = 93%. Tests for subgroup differences were not applicable, and anti-inflammatory markers (subtotal = −0.38 [−1.15, 0.39], p = 0.34 and heterogeneity = 15%; testing for subgroup differences was not applicable). In conclusion, our systematic review and meta-analysis found that L-Citrulline and L-Arginine did not influence inflammatory biomarkers and oxidative stress after exercise. [ABSTRACT FROM AUTHOR]

Objectives: To assess any benefit or harm, we conducted a systematic review of randomised clinical trials (RCTs) allocating adults to dexmedetomidine versus placebo/no intervention for the prevention of delirium in intensive care or post‐operative care units. Data Sources: We searched Medline, Embase, CENTRAL and other databases. The last search was 9 April 2022. Data Extraction: Literature screening, data extraction and risk of bias volume 2 assessments were performed independently and in duplicate. Primary outcomes were occurrences of serious adverse events (SAEs), delirium and all‐cause mortality. We used meta‐analysis, Trial Sequential Analysis, and GRADE (Grading Recommendations Assessment, Development and Evaluation). Data Synthesis: Eighty‐one RCTs (15,745 patients) provided data for our primary outcomes. Results from trials at low risk of bias showed that dexmedetomidine may reduce the occurrence of the most frequently reported SAEs (relative risk [RR] 0.69; 95% CI 0.43–1.09), cumulated SAEs (RR 0.70; 95% CI 0.52–0.95) and the occurrence of delirium (RR 0.62; 95% CI 0.43–0.89). The certainty of evidence was very low for delirium. Mortality was very low in trials at low risk of bias (0.4% in the dexmedetomidine groups and 1.0% in the control groups) and meta‐analysis did not provide conclusive evidence that dexmedetomidine may result in lower or higher all‐cause mortality (RR 0.47; 95% CI 0.18–1.21). There was a lack of information from trial results at low risk of bias for all primary outcomes. Conclusions: Trial results at low risk of bias showed that dexmedetomidine might reduce occurrences of SAEs and delirium, while no conclusive evidence was found for effects on all‐cause mortality. The certainty of evidence ranged from very low for occurrence of delirium to low for the remaining outcomes. [ABSTRACT FROM AUTHOR]

The question of why people become terrorists has preoccupied scholars and policy makers for decades. Yet, very little is known about how lay people perceive individuals at risk of becoming terrorists. In two studies conducted in the U.K., we aimed to fill this gap. Study 1 showed that Muslims and non-Muslims perceived a potential minority-group terrorist in terms of both structural (e.g., life-history, social) and individual risk factors (e.g., personality, psychopathology, ideology). In Study 2, Muslims and non-Muslims perceived a potential right-wing majority-group terrorist as having more individual predispositions to terrorism than a potential left-wing majority-group terrorist. Importantly, in both studies, individualist perceptions such as psychopathology were positively associated with support for stricter law enforcement, whereas structuralist perceptions such as adverse childhood experiences were positively associated with support for social interventions. Lay people seem to have multifactorial understandings of individuals at risk of becoming terrorists, which influence their counterterrorism policy support. [ABSTRACT FROM AUTHOR]

Many operational weather services use ensembles of forecasts to generate probabilistic predictions. Computational costs generally limit the size of the ensemble to fewer than 100 members, although the large number of degrees of freedom in the forecast model would suggest that a vastly larger ensemble would be required to represent the forecast probability distribution accurately. In this study, we use a computationally efficient idealised model that replicates key properties of the dynamics and statistics of cumulus convection to identify how the sampling uncertainty of statistical quantities converges with ensemble size. Convergence is quantified by computing the width of the 95% confidence interval of the sampling distribution of random variables, using bootstrapping on the ensemble distributions at individual time and grid points. Using ensemble sizes of up to 100,000 members, it was found that for all computed distribution properties, including mean, variance, skew, kurtosis, and several quantiles, the sampling uncertainty scaled as n−1/2 for sufficiently large ensemble size n. This behaviour is expected from the Central Limit Theorem, which further predicts that the magnitude of the uncertainty depends on the distribution shape, with a large uncertainty for statistics that depend on rare events. This prediction was also confirmed, with the additional observation that such statistics also required larger ensemble sizes before entering the asymptotic regime. By considering two methods for evaluating asymptotic behaviour in small ensembles, we show that the large‐n theory can be applied usefully for some forecast quantities even for the ensemble sizes in operational use today. [ABSTRACT FROM AUTHOR]