Search

There are few cerebrotendineous xanthomatosis (CTX) case series and observational studies including a significant number of Latin American patients. We describe a multicenter Brazilian cohort of patients with CTX highlighting their clinical phenotype, recurrent variants and assessing possible genotype–phenotype correlations. We analyzed data from all patients with clinical and molecular or biochemical diagnosis of CTX regularly followed at six genetics reference centers in Brazil between March 2020 and August 2023. We evaluated 38 CTX patients from 26 families, originating from 4 different geographical regions in Brazil. Genetic analysis identified 13 variants in the CYP27A1 gene within our population, including 3 variants that had not been previously described. The most frequent initial symptom of CTX in Brazil was cataract (27%), followed by xanthomas (24%), chronic diarrhea (13.5%), and developmental delay (13.5%). We observed that the median age at loss of ambulation correlates with the age of onset of neurological symptoms, with an average interval of 10 years (interquartile range 6.9 to 11 years). This study represents the largest CTX case series ever reported in South America. We describe phenotypic characteristics and report three new pathogenic or likely pathogenic variants. [ABSTRACT FROM AUTHOR]

This work investigates the material extrusion‐based additive manufacturing (AM) process chain of a pure alumina‐based oxide ceramic matrix composite, starting from material selection, large‐scale compounding to pellets, the AM process itself, debinding and sintering as well as microstructural and mechanical characterization. The compounded pellets have a volume share of 50% binder (polyvinyl butyral [PVB], polyethylene glycol [PEG], and stearic acid) and 50% alumina (Al2O3, alumina powder, and Nextel 610 alumina fibers) with an aimed fiber volume share of 40% after sintering. The material is compounded on an industrial scale with approximately 10 kg/h and the material extrusion‐based AM process reaches speeds of up to 1000 mm/s. A variation of the feed rate leads to a significant increase in surface roughness and an increase in mass of 30%, in thickness of 12% and in width of 25%. The flexural behavior in the four‐point‐bending test can be described by a fast first peak and reaching higher flexural strength after the first crack subsequent with averages of 23.8 ± 3.6 MPa below.1% elongation. The fracture surfaces show the expected failure mechanisms like pull‐out and crack deflection. The resulting fiber length in the printed samples is 140 µm in average. [ABSTRACT FROM AUTHOR]

We present Einstein coefficient spectra and a detailed-balance derivation of generalized Einstein relations between them that is based on the connection between spontaneous and stimulated emission. If two broadened levels or bands overlap in energy, transitions between them need not be purely absorptive or emissive. Consequently, spontaneous emission can occur in both transition directions, and four Einstein coefficient spectra replace the three Einstein coefficients for a line. At equilibrium, the four different spectra obey five pairwise relationships and one lineshape generates all four. These relationships are independent of molecular quantum statistics and predict the Stokes' shift between forward and reverse transitions required by equilibrium with blackbody radiation. For Boltzmann statistics, the relative strengths of forward and reverse transitions depend on the formal chemical potential difference between the initial and final bands, which becomes the standard chemical potential difference for ideal solutes. The formal chemical potential of a band replaces both the energy and degeneracy of a quantum level. Like the energies of quantum levels, the formal chemical potentials of bands obey the Rydberg-Ritz combination principle. Each stimulated Einstein coefficient spectrum gives a frequency-dependent transition cross-section. Transition cross-sections obey causality and a detailed-balance condition with spontaneous emission, but do not directly obey generalized Einstein relations. Even with an energetic width much less than the photon energy, a predominantly absorptive forward transition with an energetic width much greater than the thermal energy can have such an extreme Stokes' shift that its reverse transition cross-section becomes predominantly absorptive rather than emissive. [ABSTRACT FROM AUTHOR]

The inductive heating of a CMC susceptor for industrial applications can generate very high process temperatures. Thus, the behavior of a silicon carbide-based matrix with carbon-fiber-reinforced carbon (C/C-SiC) as a susceptor is investigated. Specifically, the influence of fiber length and the distribution of carbon fibers in the composite were investigated to find out the best parameters for the most efficient heating. For a multi-factorial set of requirements with a combination of filling levels and fiber lengths, a theoretical correlation of the material structure can be used as part of a digital model. Multi-physical simulation was performed to study the behavior of an alternating magnetic field generated by an inducing coil. The simulation results were verified by practical tests. It is shown that the inductive heating of a C/C-SiC susceptor can reach very high temperatures in a particularly fast and efficient way without oxidizing if it is ensured that a silicon carbide-based matrix completely encloses the fibers. [ABSTRACT FROM AUTHOR]

Background Multigene panel testing is an important component of cancer treatment plans and risk assessment, but there are many different panel options and choosing the most appropriate panel can be challenging for health care providers and patients. Electronic tools have been proposed to help patients make informed decisions about which gene panel to choose by considering their preferences and priorities. Materials and Methods An electronic decision aid (DA) tool was developed in line with the International Patient Decision Aids Standards collaboration. The multidisciplinary project team collaborated with an external health care communications agency and the MGH Cancer Center Patient and Family Advisory Council (PFAC) to develop the DA. Surveys of genetic counselors and patients were used to scope the content, and alpha testing was used to refine the design and content. Results Surveys of genetic counselors (n  = 12) and patients (n  = 228) identified common themes in discussing panel size and strategies for helping patients decide between panels and in identifying confusing terms for patients and distribution of patients' choices. The DA, organized into 2 major sections, provides educational text, graphics, and videos to guide patients through the decision-making process. Alpha testing feedback from the PFAC (n  = 4), genetic counselors (n  = 3) and a group of lay people (n  = 8) identified areas to improve navigation, simplify wording, and improve layout. Conclusion The DA developed in this study has the potential to facilitate informed decision-making by patients regarding cancer genetic testing. The distinctive feature of this DA is that it addresses the specific question of which multigene panel may be most suitable for the patient. Its acceptability and effectiveness will be evaluated in future studies. [ABSTRACT FROM AUTHOR]

Here, we report on the synthesis of discrete oligomers of alkyl‐bridged naphthalenediimides (NDIs) and study their molecular nanostructures both in bulk, in solution, and at the liquid‐solid interface. Via an iterative synthesis method, multiple NDI cores were bridged with short and saturated alkyl‐diamines (C3 and C12) or long and unsaturated alkyl‐diamines (u2C33 to u8C100) at their imide termini. The strong intermolecular interaction between the NDI cores was observed by probing their photophysical properties in solution. In bulk, the discrete NDI oligomers preferentially ordered in lamellar morphologies, irrespective of whether a saturated or unsaturated spacer was employed. Moreover, both the molecular architecture as well as the crystallization conditions play a significant role in the nanoscale ordering. The long unsaturated alkyl chains lead preferably to folded‐chain conformations while their saturated analogues form stretched arrangements. At the solution‐solid interface, well‐defined lamellar regions were observed. These results show that precision in chemical structure alone is not sufficient to reach well‐defined structures of discrete oligomers, but that it must be combined with precision in processing conditions. [ABSTRACT FROM AUTHOR]

Analyst sensemaking research typically focuses on individual or small groups conducting intelligence tasks. This has helped understand information retrieval tasks and how people communicate information. As a part of the grand challenge of the Summer Conference on Applied Data Science (SCADS) to build a system that can generate tailored daily reports (TLDR) for intelligence analysts, we conducted a qualitative interview study with analysts to increase understanding of information passing in the intelligence community. While our results are preliminary, we expect that this work will contribute to a better understanding of the information ecosystem of the intelligence community, how institutional dynamics affect information passing, and what implications this has for a TLDR system. This work describes our involvement in and work completed during SCADS. Although preliminary, we identify that information passing is both a formal and informal process and often follows professional networks due especially to the small population and specialization of work. We call attention to the need for future analysis of information ecosystems to better support tailored information retrieval features. [ABSTRACT FROM AUTHOR]

There is a growing consensus in the global health community that the use of communication technologies will be an essential factor in ensuring universal health coverage of the world's population. New technologies can only be used profitably if their accuracy is sufficient. Therefore, we explore the feasibility of using Apple's ARKit technology to accurately measure the distance from the user's eye to their smartphone screen. We developed an iOS application for measuring eyes-to-phone distances in various angles, using the built-in front-facing-camera and TrueDepth sensor. The actual position of the phone is precisely controlled and recorded, by fixing the head position and placing the phone in a robotic arm. Our results indicate that ARKit is capable of producing accurate measurements, with overall errors ranging between 0.88% and 9.07% from the actual distance, across various head positions. The accuracy of ARKit may be impacted by several factors such as head size, position, device model, and temperature. Our findings suggest that ARKit is a useful tool in the development of applications aimed at preventing eye damage caused by smartphone use. [ABSTRACT FROM AUTHOR]

Despite the physical limitations that characterize the older person population, the United Nations continues to rally for the recognition and appreciation of the talents among this group to boost global development goals. Evidently, the introduction and expansion of Got Talent® shows globally, with its inclusive format that allows older participants to showcase their talents are promising frontiers to facilitate the implementation of the 2030 Agenda for Sustainable Development and the Madrid International Plan of Action on Aging. This inquiry seeks to elucidate the trends in older person's participation in Got Talent® competitions from 2015 to 2020. Twenty-six (n = 26) purposively selected Got Talent® audition videos involving older persons, uploaded on YouTube were subjected to Manifest Content Analysis (MCA). Results indicate a growing number of auditions involving older adults, with singing as the most prevalent talent being showcased, for the last 5 years. Theoretical and practical implications, limitations, and recommendations were also discussed. [ABSTRACT FROM AUTHOR]

Background: Approximately 3.5 million children and adolescents worldwide are chronically infected with HCV. This study uses pharmacokinetic modeling to identify pediatric doses of elbasvir/grazoprevir (EBR/GZR) that achieve plasma concentrations similar to those seen in adults receiving the approved fixed-dose combination regimen of EBR/GZR. Patients and Methods: We conducted a nonrandomized, single-arm, multicenter, open-label phase 2b trial in children and adolescents aged 3 to <18 years with chronic HCV genotype 1 or 4 infection (NCT03379506). Pharmacokinetic data were used to bridge efficacy and safety data from adults to children in a stepwise (oldest to youngest) manner. A total of 57 participants were enrolled: cohort 1 (aged 12 to <18 y), n = 22; cohort 2 (aged 7 to <12 y), n =17; and cohort 3 (aged 3 to <7 y), n =18. Results: Steady-state plasma exposures were achieved by week 4 for EBR and GZR in all cohorts and daily dosing achieved geometric mean steady-state area under the concentration-time curve at 0-24 hours that fell within comparability bounds established for adults. All participants achieved sustained virologic response 12 weeks after completing treatment (ie, undetectable HCV RNA 12 wk following completion of treatment). Headache (n =4), fatigue (n =4), and nausea (n =2) were the most common treatment-related adverse events (all mild or moderate); no participant discontinued because of an adverse event. Conclusions: Pediatric EBR/GZR pharmacokinetic models were successfully developed based on complex adult population pharmacokinetic models. At appropriate age-related doses, EBR/GZR is safe and effective in pediatric and adolescent participants with HCV infection. [ABSTRACT FROM AUTHOR]

Composites made of carbon-fiber-reinforced carbon (C/C or CFC) are high-performance materials with a wide range of properties, making them especially suitable for the design of thermally and mechanically highly stressed components. As the production process of these high-performance materials is currently still very expensive, new concepts for an economical manufacturing process are required. This paper focusses on an innovative approach that uses the polymer-based pultrusion process for shaping with a subsequent carbonization step to C/C. In this process, carbon fibers (CF) and a phenolic resin were used to manufacture a semi-finished product made of unidirectional (UD) carbon-fiber-reinforced plastic (CFRP) with a fiber volume content of 66%. The C/C composite shows dimensional stability and has a flexural strength of approx. 240 MPa and a flexural modulus of approx. of 135 GPa with an elongation of 1.8%. [ABSTRACT FROM AUTHOR]

Background: Secondary lymphedema is a common complication after surgical or radiotherapeutic cancer treatment. (Micro) surgical intervention such as lymphovenous bypass and vascularized lymph node transfer is a possible solution in patients who are refractory to conventional treatment. Adequate imaging is needed to identify functional lymphatic vessels and nearby veins for surgical planning. Methods: A systematic literature search of the Embase, MEDLINE ALL via Ovid, Web of Science Core Collection and Cochrane CENTRAL Register of Trials databases was conducted in February 2022. Studies reporting on lymphatic vessel detection in healthy subjects or secondary lymphedema of the limbs or head and neck were analyzed. Results: Overall, 129 lymphatic vessel imaging studies were included, and six imaging modalities were identified. The aim of the studies was diagnosis, severity staging, and/or surgical planning. Conclusion: Due to its utility in surgical planning, near-infrared fluorescence lymphangiography (NIRF-L) has gained prominence in recent years relative to lymphoscintigraphy, the current gold standard for diagnosis and severity staging. Magnetic resonance lymphography (MRL) gives three-dimensional detailed information on the location of both lymphatic vessels and veins and the extent of fat hypertrophy; however, MRL is less practical for routine presurgical implementation due to its limited availability and high cost. High frequency ultrasound imaging can provide high resolution imaging of lymphatic vessels but is highly operator-dependent and accurate identification of lymphatic vessels is difficult. Finally, photoacoustic imaging (PAI) is a novel technique for visualization of functional lymphatic vessels and veins. More evidence is needed to evaluate the utility of PAI in surgical planning. [ABSTRACT FROM AUTHOR]

As climate change continues to affect global temperatures, organisms will need to not only adapt but evolve to survive the changing climate conditions. Temperature selection experiments were performed on Pseudomonas fluorescens to select for growth at lower temperatures. The P. fluorescens temperature selection experiment selected for cells that can grow at a new minimum temperature which is over 20°C lower than the optimal growth temperature (25-30°C). Previous experiments established the low end of P. fluorescens's growth temperature as 4°C. The genomes of the newly selected and reference strains of P. fluorescens were sent for sequencing, and the results showed differences in protein sequence between the two strains. This experiment is a model for evolution as a result of gradual temperature change (similar to climate change) over generations, and the resulting genomic changes recorded show which protein families could evolve as an organism adapts to a gradually changing temperature. [ABSTRACT FROM AUTHOR]

Populism is a powerful social force that has reshaped the political landscapes of many nations since the turn of the 21st century. Much of the success of populist movements is attributed to various social crises and a deep dissatisfaction with political systems. In the present issue, we sought to find papers that investigate what drives the demand for populist politics during crises on a psychological level and, correspondingly, how populist rhetoric influences the way individuals think about, and respond, to crises. In this editorial, we introduce a multidisciplinary issue and summarize the key themes stemming from the articles included. The contributions addressed various forms of crises; from identity issues to global transformations, and various aspects of populism; from the antiestablishment attitudes of the public, to the populist rhetoric of political actors. There was also a key theme centered on the role of emotions. We believe that these topics are of great interest to political psychologists of any mold. We hope that this special issue can play a part in increasing our understanding of how populism thrives during crises and in driving future research on this topic. [ABSTRACT FROM AUTHOR]

Data collected from interconnected devices offer wide-ranging opportunities for data-driven service innovation that delivers additional or new value to organizations' customers and clients. While previous studies have focused on traditional service innovation and servitization, few scholarly works have examined the influence of data on these two concepts. With the aim of deepening the understanding of data as a key resource for service innovation and overcoming challenges for a broader application, this study combines a systematic literature review and expert interviews. This study (a) synthesizes the various existing definitions of a data-driven service, (b) investigates attributes of data-driven service innovation, and (c) explores the corresponding organizational capabilities. The goal is to examine the repercussions of data utilization for service provision. The findings indicate that the use of data makes service innovation more complex. Data add new attributes, including a data-oriented culture; issues of data access, data ownership, privacy, and standardization; as well as the potential for new revenue models. The paper contributes to current discussions by providing an aligned perspective of theory and practice in data-driven service innovation and recommending that managers implement a culture and strategy that embraces the specifics of data usage. [ABSTRACT FROM AUTHOR]

Anchored on Dowling and Pfeffer's (1975) Legitimacy Theory, this thematic content analysis paper purports to understand the ontology of various social responsibility-driven initiatives of chefs in various countries. Specifically, YouTube videos and online news published by major search engines were content analysed. Interestingly, a concept dubbed as The Anatomy of a Caring Chef during the COVID-19 Pandemic, consisting of three constructs of chefs as the Community Supporter, Community Leverager, and Community Enabler, emerged that offers an interesting portrait of global chefs' corporate social responsibility in this challenging times. The implications of the study's findings to the food industry, limitations, and recommendations were also discussed. [ABSTRACT FROM AUTHOR]

The nonadiabatic states and dynamics are investigated for a linear vibronic coupling Hamiltonian with a static electronic splitting and weak off-diagonal Jahn-Teller coupling through a single vibration with a vibrational-electronic resonance. With a transformation of the electronic basis, this Hamiltonian is also applicable to the anti-correlated vibration in a symmetric homodimer with marginally strong constant off-diagonal coupling, where the non-adiabatic states and dynamics model electronic excitation energy transfer or self-exchange electron transfer. For parameters modeling a free-base naphthalocyanine, the nonadiabatic couplings are deeply quantum mechanical and depend on wavepacket width; scalar couplings are as important as the derivative couplings that are usually interpreted to depend on vibrational velocity in semiclassical curve crossing or surface hopping theories. A colored visualization scheme that fully characterizes the non-adiabatic states using the exact factorization is developed. The nonadiabatic states in this nested funnel have nodeless vibrational factors with strongly avoided zeroes in their vibrational probability densities. Vibronic dynamics are visualized through the vibrational coordinate dependent density of the time-dependent dipole moment in free induction decay. Vibrational motion is amplified by the nonadiabatic couplings, with asymmetric and anisotropic motions that depend upon the excitation polarization in the molecular frame and can be reversed by a change in polarization. This generates a vibrational quantum beat anisotropy in excess of 2/5. The amplitude of vibrational motion can be larger than that on the uncoupled potentials, and the electronic population transfer is maximized within one vibrational period. Most of these dynamics are missed by the adiabatic approximation, and some electronic and vibrational motions are completely suppressed by the Condon approximation of a coordinate-independent transition dipole between adiabatic states. For all initial conditions investigated, the initial nonadiabatic electronic motion is driven towards the lower adiabatic state, and criteria for this directed motion are discussed. [ABSTRACT FROM AUTHOR]

Featured Application: Mobile 3D motion capture frameworks can be integrated into a variety of mobile applications. Of particular interest are applications in the sports, health, and medical sector, where they enable use cases such as tracking of specific exercises in sports or rehabilitation, or initial health assessments before medical appointments. Computer-vision-based frameworks enable markerless human motion capture on consumer-grade devices in real-time. They open up new possibilities for application, such as in the health and medical sector. So far, research on mobile solutions has been focused on 2-dimensional motion capture frameworks. 2D motion analysis is limited by the viewing angle of the positioned camera. New frameworks enable 3-dimensional human motion capture and can be supported through additional smartphone sensors such as LiDAR. 3D motion capture promises to overcome the limitations of 2D frameworks by considering all three movement planes independent of the camera angle. In this study, we performed a laboratory experiment with ten subjects, comparing the joint angles in eight different body-weight exercises tracked by Apple ARKit, a mobile 3D motion capture framework, against a gold-standard system for motion capture: the Vicon system. The 3D motion capture framework exposed a weighted Mean Absolute Error of 18.80° ± 12.12° (ranging from 3.75° ± 0.99° to 47.06° ± 5.11° per tracked joint angle and exercise) and a Mean Spearman Rank Correlation Coefficient of 0.76 for the whole data set. The data set shows a high variance of those two metrics between the observed angles and performed exercises. The observed accuracy is influenced by the visibility of the joints and the observed motion. While the 3D motion capture framework is a promising technology that could enable several use cases in the entertainment, health, and medical area, its limitations should be considered for each potential application area. [ABSTRACT FROM AUTHOR]

Background: Reliable and objective assessment of psychomotor skills in physiotherapy students' education is essential for direct feedback and skill improvement. The aim of this study is to determine the interrater reliability in the assessment process of physiotherapy students and to analyse the assessment behaviour of the examiners. Methods: Physiotherapy teachers from two different schools assessed students from two different schools performing proprioceptive neuromuscular facilitation (PNF) patterns. An evaluation sheet with a 6-point rating scale and 20 evaluation criteria including an overall rating was used for assessment. The interrater reliability was determined calculating an intraclass-correlation coefficient (ICC) and Krippendorff's alpha. The assessment behaviour of the examiners was further analysed calculating the location parameters and showing the item response distribution over item in form of a Likert plot. Results: The ICC estimates were mostly below 0.4, indicating poor interrater reliability. This was confirmed by Krippendorff's alpha. The examiners showed a certain central tendency and intergroup bias. Discussion and conclusion: The interrater reliability in this assessment format was rather low. No difference between the two physiotherapy schools concerning the interrater reliability could be identified. Despite certain limitations of this study, there is a definite need for improvement of the assessment process in physiotherapy education to provide the students with reliable and objective feedback and ensure a certain level of professional competence in the students. Trial registration: The study was approved by the ethics committee of the Medical Faculty RWTH Aachen University (EK 340/16). [ABSTRACT FROM AUTHOR]

The commensal skin bacterium Staphylococcus epidermidis (S. epidermidis) provides a range of benefits to human hosts, contributing to skin equilibrium and good health, even though specific strains also act as pathogens if entering the host body. Therefore, skin‐applicable devices allowing to benefit from some factors secreted by S. epidermidis while keeping the bacteria at a desired location are important for the development of bacteriotherapeutical applications. Here, a membrane‐based gel patch is fabricated to trap S. epidermidis while keeping its metabolic activity. The pores of a track‐etched membrane are modified with layer‐by‐layer (LbL) multilayers to anchor bacteria, followed by coating the membrane with a thick layer of agarose gel, leading to a membrane‐in‐gel soft patch. LbL multilayers comprising antibacterial polycations are then deposited over the patch. By varying the multilayer composition, thickness and nature of the last layer, both probability of escape and metabolic activity of entrapped bacteria can be tuned. Poly(ethyleneimine)‐comprising multilayers prove to be particularly well‐suited for the fine control of bacterial escape and activity. These bacterial patches are thus complex living materials in which the living component is controlled by a careful combination of soft macromolecular components. [ABSTRACT FROM AUTHOR]

Copyright of HMD: Praxis der Wirtschaftsinformatik is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the growing statistics of older adults across societies, sustaining their health and well-being through active participation in sports cannot be neglected nor overlooked. This qualitative study purports to characterize the ontology of social media comments relative to older person's engagement in sports via latent content analysis. Specifically, a set of YouTube comments (n = 7,546), extracted from select videos featuring older adults in sports (n = 62), through YouTube Data Application Programming Interface (API) Version 3, was subjected to inductive analytic procedures of content analysis. Interestingly, this study afforded the emergence of a playing field model emanating from the dualistic perspectives of aging as engagement and aged as engaged that represent how YouTube users view older adult's continual involvement in sports. Limitations and future directions of this study are also discussed in this article. [ABSTRACT FROM AUTHOR]

Purpose of Review: Chronic hepatitis B (CHB) infection is a worldwide health problem with significant morbidity. Children with CHB require a lifetime of monitoring for infection activation, hepatic disease and its complications, and hepatocellular carcinoma (HCC). Children with CHB which is in the immune active stage are candidates for antiviral treatment. As new medications have been approved for children, the treatment recommendations have changed. This review summarizes the recent data. Recent Findings: With the demonstration of safety and efficacy of entecavir and tenofovir in children, previously used medications like lamivudine and adefovir are no longer recommended as the first-line treatments. Summary: Health care providers should provide counseling regarding monitoring, natural history, and transmission to children with CHB and their families. Children in the immune active stage are candidates for antiviral treatment. With more approved therapies over the last few years for a wider age range of children, there are safe, effective, and well-tolerated therapeutic options. [ABSTRACT FROM AUTHOR]

Background: While reviewing outcomes metrics and data from the SRTR, it became apparent that prospective assessment of the SRTR reporting cohorts would be an important proactive strategy for internal quality control. It was particularly important to identify the number of patient deaths and graft failures within 1 year of transplant that would result in being flagged by the UNOS and the MPSC. Methods: A simple Microsoft Excel line graph was created to visually display retrospective, current, and future SRTR cohorts. Data provided by the SRTR CUSUM (https://securesrtr.transplant.hrsa.gov/srtr‐reports/cusum‐charts/) Reports and the SRTR 1 Year Expected Survival Excel Worksheet (https://securesrtr.transplant.hrsa.gov/srtr‐reports/current‐release/) were leveraged to identify whether programs were in jeopardy of being flagged by UNOS/MPSC for outcomes. Results & Conclusions: The creation of this visual tool has greatly improved team understanding of SRTR report cohorts, as well as the risk of being flagged by regulatory agencies, for adverse outcomes. [ABSTRACT FROM AUTHOR]

We report measurement and modeling of two-dimensional (2D) electronic spectra of a silicon naphthalocyanine (SiNc) in benzonitrile, a system for which the polarization anisotropy reveals passage through a square-symmetric Jahn-Teller conical intersection in ~100 fs [D. A. Farrow, W. Qian, E. R. Smith, A. A. Ferro, and D. M. Jonas, J. Chem. Phys. 128, 144510 (2008)]. The measured 2D Fourier transform (FT) spectra indicate loss of electronic coherence on a similar timescale. The 2D spectra arising from femtosecond vibronic dynamics through the conical funnel are modeled by full non-adiabatic treatment of the coupled electronic and vibrational dynamics for a pair of un-damped Jahn-Teller active vibrations responsible for both electronic decoherence and population transfer. Additional damped Jahn-Teller active modes that can cause only decoherence or population transfer are treated with analytical response functions that can be incorporated into the numerical non-adiabatic calculation by exploiting symmetry assignment of degenerate vibronic eigenstates to one of two electronic states. Franck-Condon active totally symmetric modes are incorporated analytically. The calculations reveal that these conical intersection dynamics alone are incapable of destroying the coherence of the initially prepared wavepacket on the experimentally observed timescale and predict an unobserved recurrence in the photon echo slice at ~200 fs. Agreement with the experimental two-dimensional electronic spectra necessitates a role for totally symmetric vibrational dynamics in causing the echo slice to decay on a ~100 fs timescale. This extended model also reproduces the ~100 fs ultrafast electronic anisotropy decay in SiNc when an "asymmetric solvation mode" with a small stabilization energy of ~2 cm-1 is included. Although calculations show that inhomogeneities in the energy gap between excited states can broaden the anti-diagonal 2D lineshape, the anti-diagonal width is dominated by totally symmetric vibrational motions in SiNc. For this shallow conical intersection, the non-adiabatic dynamics destroy electronic coherence more slowly than they destroy electronic alignment. [ABSTRACT FROM AUTHOR]

Graves' disease (GD) is rare in children under age five years. Antithyroid drugs are typically first-line therapy but carry the risks of agranulocytosis and liver dysfunction. A male infant with multiple congenital anomalies, left ventricular hypertrophy, and neurologic dysfunction developed GD at five months of life. The presence of chronic hepatitis complicated medical management. Potassium iodide was effective temporarily, but urgent thyroidectomy was required at nine months of age. Postoperatively, the patient developed a thyroid function pattern consistent with impaired pituitary sensitivity to thyroid hormone (TH) that responded to the addition of liothyronine. Exome sequencing revealed a heterozygous de novo duplication of the ATAD3 gene cluster, suggesting a possible mitochondrial disorder. This case describes the youngest child to date to be diagnosed with endogenous GD and to successfully undergo definitive treatment with thyroidectomy. An underlying defect in mitochondrial function is suspected, suggesting a potential novel pathophysiologic link to early-onset thyroid autoimmunity. Additionally, this case illustrated the development of impaired pituitary sensitivity to TH following thyrotoxicosis of postnatal onset, which may contribute to our understanding of hypothalamic-pituitary-thyroid (HPT) axis development. [ABSTRACT FROM AUTHOR]

With the growing popularity of unobtrusive research methods vis-à-vis the unprecedented increase of user-generated content (UGC), this investigation purports to populate the knowledge base on the emerging field of gerontalentology introduced by de Guzman, Mesana and Roman in 2020. Specifically, a qualitative sentiment analysis (QSA) was performed on social media expressions (n = 10,056) that were extracted from top-viewed YouTube videos (n = 12) via Data Miner, involving older adults auditioning in Got Talent®. The intensity of emotions or sentiments of online viewers was examined through with-in and cross-case analyses of posted comments. The process of constant comparison of field texts afforded the emergence of distinct and interesting depreciative, inspirative, appreciative, and emulative spaces that typify how older adults and their showcase of talents are individually and collectively viewed by the global audience. Implications of the study to promoting intergenerational contact of younger adults with older adults and the promises of gerontalentogical studies are also discussed in this paper. [ABSTRACT FROM AUTHOR]

The outbreak of vaping-related acute lung injury in the United States, named EVALI (e-cigarette or vaping product use associated acute lung injury), has reignited concerns about the health effects of vaping. Initial case reports of vaping-related lung injury date back to 2012, but the ongoing outbreak of EVALI began in the summer of 2019 and has been implicated in 2,807 cases and 68 deaths as of this writing. Review of the scientific literature revealed 216 patient cases that spanned 41 reports of parenchymal lung injury attributed to vaping. In this review, we detail the clinical, radiographic, and pathologic patterns of lung injury that are attributable to vaping and provide an overview of the scientific literature to date on the effects of vaping on respiratory health. Tetrahydrocannabinol was the most commonly vaped substance, and vitamin E acetate was found in BAL specimens from many affected individuals. However, no specific component or contaminant has been identified conclusively to date as the cause for the injury. Patients present with cough, dyspnea, constitutional symptoms, and GI symptoms. Radiologic and histopathologic findings demonstrate a spectrum of nonspecific acute injury patterns. A high index of suspicion combined with a good history are the keys to an accurate diagnosis. Treatment is supportive; the mortality rate is low, and most patients recover. Corticosteroids have been used with apparent success in patients with severe disease, but more rigorous studies are needed to clarify their role in the treatment of vaping-related lung injury. [ABSTRACT FROM AUTHOR]

TE measures liver stiffness to assess fibrosis. Its use in post‐transplant patients was reported in few small pediatric studies. We evaluated TE ability to predict liver graft fibrosis in a large cohort while comparing it to the performance of APRI and FIB‐4. We also investigated the effect of graft type on LSMs. Patients at Boston Children's Hospital who underwent LT and LSM ≤ 1 year from biopsy (2007‐2018) were eligible. Ninety‐four patients (45%M) aged 1‐21 years (89% < 18 years; 13% < 2 years) were eligible. Median time between transplant/biopsy and LSM was 5.1 years and 52 days, respectively. Thirty‐nine percent received whole‐liver grafts, 54% TV grafts, and 6% as part of MV. At LSM, median ALT was 25 [IQR 16‐33] IU/L. Twenty‐one percent had METAVIR ≥ F2. LSM was statistically higher among those with significant fibrosis (METAVIR ≥ F2) compared to those with METAVIR F0/F1 (median [IQR] 7.5 [4.6, 13.6] vs 5.1 [4.0, 6.4] kPa, respectively) (P =.005 by Wilcoxon rank‐sum test). APRI and FIB‐4 distributions were not different across METAVIR stages. The AUROC for LSM was 0.71 (95% CI 0.56‐0.85) with an optimal cut‐point of 6.5 kPa. Graft type had no influence on the AUROC for LSM. TE is useful for assessing significant graft fibrosis in children and young adult LT recipients and performs better than APRI and FIB‐4. TV grafts demonstrate similar correlation with histology as whole‐liver grafts. [ABSTRACT FROM AUTHOR]

Introduction: To assess the safety, efficacy, and pharmacokinetics of mini-tablet formulations of ombitasvir (OBV), paritaprevir (PTV), ritonavir, and dasabuvir (DSV) with or without ribavirin for 12 weeks in children infected with chronic hepatitis C virus (HCV) genotype (GT) 1.Methods: This is an ongoing, open-label, Phase 2/3 study in children 3-11 years old infected with HCV GT1 who were HCV treatment-naïve and non-cirrhotic. Pediatric mini-tablet formulations of OBV, PTV, ritonavir, and DSV plus ribavirin oral solution were administered for 12 weeks based on body weight. Endpoints included SVR12, adverse events (AEs), and pharmacokinetic parameters.Results: Overall, 26 children received OBV, PTV, ritonavir, and DSV plus ribavirin; 14 were 3-8 years old and 12 were 9-11 years old; 35% were male; and all had chronic HCV GT1a infection. The SVR12 rate was 96% (25/26; 95% CI 81.1-99.3), with 1 child failing to achieve SVR12 due to non-adherence and treatment discontinuation. Treatment-emergent AEs of Grade ≥ 3 occurred in 3 children; 2 events in 1 child were considered serious; and none were considered treatment-related. No AEs led to discontinuation of study treatment. The most common AEs were headache (27%), fatigue (23%), pyrexia (19%), and vomiting (19%). Pharmacokinetic results showed mini-tablet formulations of OBV, PTV, DSV, and ritonavir drug exposures were comparable to the adult formulation.Conclusion: The mini-tablet combination of OBV, PTV, ritonavir, and DSV plus ribavirin to treat HCV GT1a infection for 12 weeks was highly effective and suitable in children 3-11 years of age.Trial Registration: ClinicalTrials.gov identifier, NCT02486406. [ABSTRACT FROM AUTHOR]

The difficulty to generate and control large strain gradients in materials hinders the investigation and application of flexoelectricity and flexomagnetism. This work demonstrates that thermal expansion can be used to induce very large non‐uniform strains at the nanoscale, resulting in giant strain gradients at moderate temperatures. This is demonstrated in a nanopatterned multiferroic hybrid layer consisting of a regular array of ferromagnetic metallic nanocylinders embedded in a ferroelectric polymer matrix. The thermally‐induced strain gradients can fully depolarize the ferroelectric component, and modify the magnetization of the ferromagnetic component via flexoelectric and flexomagnetic effects, respectively. Finite‐element analysis provides a quantitative view on thermal expansion‐induced strains and strain gradients supporting the experimental findings. This work shows that nanoscale thermal strain engineering provides an additional degree of freedom to control electrical polarization and magnetization, which paves the way for the design and operation of novel functional devices and nanostructures. [ABSTRACT FROM AUTHOR]