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Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways of acquiring lipid and increasing lipid oxidation. In addition, stromal cells and immune cells in the tumor microenvironment also undergo lipid metabolic reprogramming, which further affects tumor functional phenotypes and immune responses. Given that lipid metabolism plays a critical role in supporting cancer progression and remodeling the tumor microenvironment, targeting the lipid metabolism pathway could provide a novel approach to cancer treatment. This review seeks to: (1) clarify the overall landscape and mechanisms of lipid metabolic reprogramming in cancer, (2) summarize the lipid metabolic landscapes within stromal cells and immune cells in the tumor microenvironment, and clarify their roles in tumor progression, and (3) summarize potential therapeutic targets for lipid metabolism, and highlight the potential for combining such approaches with other anti-tumor therapies to provide new therapeutic opportunities for cancer patients. [ABSTRACT FROM AUTHOR]

The demand for fluency in human–computer interaction is on an increase globally; thus, the active localization of the speaker by the machine has become a problem worth exploring. Considering that the stability and accuracy of the single-mode localization method are low, while the multi-mode localization method can utilize the redundancy of information to improve accuracy and anti-interference, a speaker localization method based on voice and image multimodal fusion is proposed. First, the voice localization method based on time differences of arrival (TDOA) in a microphone array and the face detection method based on the AdaBoost algorithm are presented herein. Second, a multimodal fusion method based on spatiotemporal fusion of speech and image is proposed, and it uses a coordinate system converter and frame rate tracker. The proposed method was tested by positioning the speaker stand at 15 different points, and each point was tested 50 times. The experimental results demonstrate that there is a high accuracy when the speaker stands in front of the positioning system within a certain range. [ABSTRACT FROM AUTHOR]