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The oxidizing ambient was built using high pressure H2O vapor at 550 °C. For the solid phase crystallization (SPC) polycrystalline silicon (poly-Si) that is annealed for 1 h at 2 MPa, the oxide thickness is about 150 Å. The oxide layer is approximately 90 Å above the original surface of the poly-Si and 60 Å below the original surface. The oxide layer is used as the first gate insulator layer of thin-film transistors (TFTs). The heating at 550 °C with 2 MPa H2O vapor increased the carrier mobility from 17.6 cm2/V s of the conventional SPC process to 30.4 cm2/V s, and it reduced the absolute value of the threshold voltage (Vth) from 4.13 to 3.62 V. The subthreshold swing also decreased from 0.72 to 0.60 V/decade. This improvement is attributed mainly to the reduction in defect density at the oxide/poly-Si interface and in the poly-Si film by the high pressure annealing (HPA) process. Since the realization of excellent performance at the oxide/poly-Si interface and in poly-Si depends on the defect density, the poly-Si having the thermal oxide formed by a combined process of SPC and HPA may be well suited for fabrication of poly-Si TFTs for flat panel displays such as active matrix organic light emitting diodes. [ABSTRACT FROM AUTHOR]

Hepatitis C virus (HCV) infection is a major worldwide problem that has emerged as one of the most significant diseases affecting humans. There are currently no vaccines or efficient therapies without side effects, despite today's advanced medical technology. Currently, the common therapy for most patients (i.e. genotype 1) is combination of HCV-specific direct-acting antivirals (DAAs). Up to 2011, the standard of care (SOC) was a combination of peg-IFNα with ribavirin (RBV). After approval of NS3/4A protease inhibitor, SOC was peg-IFNα and RBV with either the first-generation DAAs boceprevir or telaprevir. In the past several years, various novel small molecules have been discovered and some of them (i.e., HCV polymerase, protease, helicase and entry inhibitors) have undergone clinical trials. Between 2013 and 2016, the second-generation DAA drugs simeprevir, asunaprevir, daclatasvir, dasabuvir, sofosbuvir, and elbasvir were approved, as well as the combinational drugs Harvoni, Zepatier, Technivie, and Epclusa. A number of reviews have been recently published describing the structure-activity relationship (SAR) in the development of HCV inhibitors and outlining current therapeutic approaches to hepatitis C infection. Target identification involves studying a drug's mechanism of action (MOA), and a variety of target identification methods have been developed in the past few years. Chemical biology has emerged as a powerful tool for studying biological processes using small molecules. The use of chemical genetic methods is a valuable strategy for studying the molecular mechanisms of the viral lifecycle and screening for anti-viral agents. Two general screening approaches have been employed: forward and reverse chemical genetics. This review reveals information on the small molecules in HCV drug discovery by using chemical genetics for targeting the HCV protein and describes successful examples of targets identified with these methods. [ABSTRACT FROM AUTHOR]

A series of indole acrylamide derivatives were synthesized and evaluated for their inhibitory effects on hepatitis C virus (HCV) replication. Previously, we have identified ( E)- N-(4- tert-butylphenyl)-3-(5-cyano-1 H-indol-3-yl)-2-methylacrylamide ( 6c) as one of the promising leads for anti-HCV chemotherapy. Based on the structural features of indole acrylamide, we have explored extended structure-activity relationship study using analogs with substituted indoles, various amides, and N-substitution at the indole ring. Among the newly synthesized series, 5-cyanoindole acrylamide analog with N-acetyl substitution ( 13c) (EC50 = 0.98 μM, CC50 = 40.74 μM, and SI = 41.6) exhibited the most potent antiviral activity with reasonable cytotoxicity in a cell-based J6/JFH1 reporter assay using Huh7.5 cells. In addition, improved water solubility of 13c compared to 6c further merits consideration of 13c as a valuable candidate for anti-HCV therapeutics development. [ABSTRACT FROM AUTHOR]

Active matrix organic light-emitting diode (AMOLED) displays are fabricated from polycrystalline silicon, which is formed in the single and double (overlap) scanned area during the excimer laser annealing (ELA) process. A redundant pixel line (RPL) design is proposed to remove the overlapping mura and, as a result, a 5-in AMOLED display is successfully fabricated without any non-uniform line image on the overlapping scanned area. This result indicates that the fabrication of a large-sized AMOLED panel is possible using ELA crystallization through an RPL design. [ABSTRACT FROM PUBLISHER]

Presents a theoretical study of photonics. Methodology used to carry out the study; results of the study; Discussion of the results of the study.

In this work we investigated the material properties and electrical performance of polycrystalline silicon (poly-Si) films formed in the single and double (overlap) scanned area of excimer laser in the long axis direction at various energy densities. Poly-Si thin film transistors (TFTs) were fabricated by using the material formed by the excimer laser annealing (ELA) process. We found that the device performance of poly-Si films formed at the energy density of 200 mJ/cm2 is approximately equal to the single and double scanned area, whose overlapping irradiation does not change the characteristics of TFTs. Based on this result, a large poly-Si panel using the ELA method can be fabricated by overlapping the laser scans in the long axis direction. [ABSTRACT FROM AUTHOR]