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The exploration of cannabis, particularly its legitimisation and multifaceted uses, is pivotal in understanding its historical significance, chemical composition, therapeutic potential, and societal implications. This narrative review traverses millennia of cannabis usage for medicinal, recreational, and spiritual purposes, juxtaposed with contemporary legislative shifts, notably in the United States. As perceptions evolve, especially with state-level legalisation contrasting federal prohibition, the review scrutinises the burgeoning use of cannabis products, particularly among youth, and the evolving regulatory frameworks. Neurological effects of cannabis use, including impacts on brain structure and function, are examined alongside potential benefits and risks in various medical contexts. Challenges in conducting rigorous clinical research, primarily due to legal and pharmaceutical constraints, are outlined. The review delves into the complexities of cannabis usage during pregnancy and the conflicting scientific data, presenting challenges in advising expectant mothers. Cannabis' diverse applications in treating various disorders, ranging from chronic pain to neurological conditions, are explored, shedding light on the potential benefits and limitations. The review highlights the pharmacological dynamics and clinical implications of cannabis-based therapies, emphasising the need for further research to elucidate their efficacy and long-term safety comprehensively. Moreover, the review discusses the pros and cons of CB therapy with high-Cannabidiol (CBD) medicinal cannabis, addressing challenges such as product quality, safety concerns, potential psychoactive effects, drug interactions, and limited research. It underscores the importance of informed decision-making and personalised guidance in navigating the complexities of CB therapy. In conclusion, while cannabis exhibits a wide range of potential medical applications, further research is essential to fully comprehend its therapeutic potential and weigh the associated risks. The review contributes to informed discourse and evidence-based policymaking, emphasising the need for continued research to unlock the full potential of cannabis in healthcare. [ABSTRACT FROM AUTHOR]