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Background: Caspofungin has shown efficacy in empirical antifungal therapy in neutropenic patients, refractory invasive Aspergillus infections and invasive candidiasis. Here we report the currently largest series of patients treated with caspofungin outside clinical trials.Methods: Centres in Germany that were known to treat patients with invasive fungal infections were asked to fill out detailed questionnaires for all patients treated with caspofungin. No effort was made to influence the decision to use caspofungin.Results: A total of 118 patients were evaluable (median age 48 years, interquartile range 3858), out of which 41 (35%) suffered from acute leukaemia, 31 (26%) had allogeneic stem cell transplants, 16 (14%) lymphoma or myeloma, 8 (7%) autologous stem cell transplants and 22 (19%) other causes for immunosuppression. One hundred and six patients were evaluable for efficacy out of which 68 (64%) patients achieved a complete or partial remission. A total of 81 out of 115 (70%) patients were alive 30 days after the end of caspofungin therapy. Response rates were similar in proven (20/32, 63%) and probable (27/46, 59%) infections, in neutropenic patients (41/55, 75%) and in patients who were (44/70, 63%) or were not (24/36, 67%) refractory to antifungal pre-treatment. The response rate in mechanically ventilated patients was 29% (7/24). Caspofungin was well tolerated, even in 14 patients, who were concomitantly treated with ciclosporin A, no drug-related elevations of bilirubin, alanine aminotransferase or creatinine were found.Conclusions: This open case study of severely ill patients with invasive fungal infections demonstrates both excellent efficacy and very low toxicity of caspofungin. [ABSTRACT FROM AUTHOR]

This paper presents a review of self-organizing feature maps (SOFMs), in particular, those based on the Kohonen algorithm, applied to adaptive modeling and control of robotic manipulators. Through a number of references we show how SOFMs can learn nonlinear input–output mappings needed to control robotic manipulators, thereby coping with important robotic issues such as the excess degrees of freedom, computation of inverse kinematics and dynamics, hand–eye coordination, path-planning, obstacle avoidance, and compliant motion. We conclude the paper arguing that SOFMs can be a much simpler, feasible alternative to MLP and RBF networks for function approximation and for the design of neurocontrollers. Comparison with other supervised/unsupervised approaches and directions for further work on the field are also provided. [ABSTRACT FROM AUTHOR]

This study examined the internal validity of the Wisconsin Card Sorting Test in two samples. In an alcohol-dependent sample (n= 151), exploratory factor analysis of internal validity, using Lisrel 8, showed that the six principal scores derived from the test could be fitted to a model with one factor and correlated errors. In a sample of university students (n= 75), we replicated the one factor internal validity model identified in the alcohol-dependent sample, and we also examined the alternate-form reliability of the Wisconsin. The reliability data, together with a reanalysis of information from the most recent edition of the test manual, suggest that the test should not be used for clinical purposes in its present form. [ABSTRACT FROM AUTHOR]