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The immediately early gene product c-fos is known to be induced in neurons under noxious stimuli. Therefore, the immunohistochemistry of c-fos expression in human brains might offer information on the localization of stimulated neurons. In this study, the immunohistochemical localization of c-fos was studied in the neurons of the hypoglossal nucleus (XII), the dorsal motor nucleus of the vagal nerve (X), the nucleus solitarius (Sol), the accessory cuneate nucleus (Cun), the spinal trigeminal nucleus (V) and the inferior olive (Oli) of the human medulla oblongata from forensic autopsy cases. The neurons in the X nucleus showed the highest percentage of positive reactions for c-fos, followed in descending order by the Cun, V, Oli, XII and Sol. The c-fos immunoreactivity in the Cun and X was statistically significantly higher than in the Sol, XII and Oli. Although neurons in the Sol are known to be involved in respiration, there was no statistically significant difference in the c-fos immunoreactivity in the neurons in the Sol between asphyxia and non-asphyxia cases. On the other hand, the percentage of neurons positive for the c-fos immunoreactivity was statistically significantly higher in the Oli of asphyxia cases than of non-asphyxia cases. Our results indicate the difference in the immunoreactivity of c-fos among the nuclei of the human medulla oblongata and that the c-fos immunoreactivity in the Oli might assist the diagnosis of asphyxia. [ABSTRACT FROM AUTHOR]

- A specific red cell adherence test which can detect the cell surface ABH blood group antigens was performed on formalin-fixed frozen sections of 38 bladder tumours. In 27 tumours decreased glycosyltransferase activity was suggested, but the site and the degree of the blockade did not seem to be identical in every tumour. Blood group A and B tumours could be grouped into 4 types according to the presence of these 3 isoantigens. One group which showed A or B but no H activity (Type I) consisted only of grade 1, superficial tumours. All of the invasive tumours belonged to other types. For blood group 0 turnours no clear-cut correlation could be found between malignancy of the tumour and the presence of H activity. Eight of 22 grade 2 or 3 tumours and 9 of 21 invasive tumours retained the isoantigen, which seemed to invalidate the use of this test as a predictive indicator. Only where blood group A or B patients were concerned, and the presence of H activity was regarded as abnormal as well as the absence of A and B. could all grade 2 or 3 tumours and all invasive tumours be detected by this test. [ABSTRACT FROM AUTHOR]

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Copyright of Zeitschrift für Rechtsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Zeitschrift für Rechtsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The myoglobin content of chicken myocardial cells was studied using indirect-immunoperoxidase histochemistry. While ordinary myocardial cells exhibited a homogeneous reaction pattern, the reactions for ventricular Purkinje fibers were remarkably heterogeneous. On the basis of the degree of staining, three types of cells, i.e., dark, intermediate, and clear, were distinguishable. In addition, the cytological heterogeneity of Purkinje cells was confirmed using conventional and immunological electron microscopy. The dark cells contained more myofibrils, mitochondria, and other organelles (e.g., ribosomes) than the clear cells. [ABSTRACT FROM AUTHOR]

A strong immunological crossreactivity between the extracts of the albumin gland of snails ( Helix pomatia) and the content of snail eggs is described, suggesting that the former supplies the eggs with protective substances (agglutinins, protease-inhibitors). [ABSTRACT FROM AUTHOR]

Copyright of Blut: Zeitschrift für die Gesamte Blutforschung is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)