1. Tissue Sheet Engineered Using Human Umbilical Cord-Derived Mesenchymal Stem Cells Improves Diabetic Wound Healing.
- Author
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Zhang, Jingbo, Qu, Xiang, Li, Junjun, Harada, Akima, Hua, Ying, Yoshida, Noriko, Ishida, Masako, Sawa, Yoshiki, Liu, Li, and Miyagawa, Shigeru
- Subjects
MESENCHYMAL stem cells ,CELL sheets (Biology) ,CORD blood ,WOUND healing ,TISSUE engineering ,ERGONOMICS ,DIABETIC foot ,TRANSPLANTATION of organs, tissues, etc. - Abstract
Diabetic foot ulceration is a common chronic diabetic complication. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been widely used in regenerative medicine owing to their multipotency and easy availability. We developed poly(lactic-co-glycolic acid) (PLGA)-based scaffold to create hUC-MSC tissue sheets. In vitro immunostaining showed that hUC-MSC tissue sheets formed thick and solid tissue sheets with an abundance of extracellular matrix (ECM). Diabetic wounds in mice treated with or without either the hUC-MSC tissue sheet, hUC-MSC injection, or fiber only revealed that hUC-MSC tissue sheet transplantation promoted diabetic wound healing with improved re-epithelialization, collagen deposition, blood vessel formation and maturation, and alleviated inflammation compared to that observed in other groups. Taken collectively, our findings suggest that hUC-MSCs cultured on PLGA scaffolds improve diabetic wound healing, collagen deposition, and angiogenesis, and provide a novel and effective method for cell transplantation, and a promising alternative for diabetic skin wound treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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