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Gentamicin is an aminoglycoside antibiotic used for treatment of serious gram-negative bacterial infections. Aim: to investigate possible therapeutic effects of vitamin C and radish juice on gentamicin-induced nephrotoxicity in a rat model. Method: Thirty sexually mature male Sprague-Dawley rats were included in this study, divided randomly into 6 groups, each one included 5 rats. group 1 received saline & considered as control group, group 2 received vitamin C, group 3 received radish juice, group 4 received gentamicin, group 5 received gentamicin + vitamin C and group 6 received gentamicin + radish juice for five days. After treatment, blood samples were collected from animals for measuring of blood urea, serum creatinine and C- reactive protein. Results: gentamicin cause significant elevation in blood urea (p< 0.001), serum creatinine (p< 0.001) and C-reactive protein (p< 0.001). vitamin C and radish juice cause significant reduction in blood urea (p< 0.001), serum creatinine (p< 0.001) and C- reactive protein (p< 0.001) when co administered with gentamicin treatment. Conclusion: The toxic effects of gentamicin on kidney could be ameliorated by vitamin C and radish co administration & they can act as nephroprotective. [ABSTRACT FROM AUTHOR]