1. Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan.
- Author
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SHIH-WEI HSU, CHI-LI GONG, HUAI-MEI HSU, CHIH-CHANG CHAO, YUN-CHI WANG, WEN-SHIN CHANG, YUEH-TING TSAI, LIANG-CHUN SHIH, CHIA-WEN TSAI, and DA-TIAN BAU
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NASOPHARYNX cancer ,CANCER susceptibility ,METASTASIS ,GENOTYPES ,CARCINOGENS - Abstract
Background/Aim: Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. Materials and Methods: In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. Results: There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C- 1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. Conclusion: CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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