1. Three new quinolizidine alkaloids from the roots of Sophora tonkinensis.
- Author
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An, Qiao, Zhang, Ji, Zhang, Peng, Chen, Lei, Yi, Ping, Yuan, Chun-Mao, Hu, Zhan-Xing, and Hao, Xiao-Jiang
- Subjects
ANTIFUNGAL agents ,HIGH performance liquid chromatography ,ALKALOIDS ,NUCLEAR magnetic resonance spectroscopy ,RESEARCH funding ,PLANT roots ,FUNGI ,PLANT extracts ,EXPERIMENTAL design ,INFRARED spectroscopy ,MOLECULAR structure ,SPECTRUM analysis ,PHARMACODYNAMICS - Abstract
Three new quinolizidine alkaloids (1 − 3), including one new naturally isoflavone and cytisine polymer (3), along with 6 known ones were isolated from the ethanol extract of Sophora tonkinensis Gagnep. Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, HRESIMS, 1D and 2D NMR), combined with ECD calculations. The antifungal activity against Phytophythora capsica, Botrytis cinerea, Gibberella zeae, and Alternaria alternata of the compounds was evaluated in a mycelial inhibition assay. Biological tests indicated that compound 3 exhibited strong antifungal activity against P. capsica with EC
50 values of 17.7 μg/ml. [ABSTRACT FROM AUTHOR]- Published
- 2024
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